ID GP141_MOUSE Reviewed; 305 AA. AC Q7TQP0; Q059N8; Q80UC5; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 24-JAN-2024, entry version 127. DE RecName: Full=Probable G-protein coupled receptor 141; DE AltName: Full=G-protein coupled receptor PGR13; GN Name=Gpr141; Synonyms=Pgr13; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=14623098; DOI=10.1016/s0014-5793(03)01196-7; RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., RA Schioeth H.B.; RT "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors RT lacking close relatives."; RL FEBS Lett. 554:381-388(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-304. RX PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY288427; AAP72136.1; -; mRNA. DR EMBL; BC125585; AAI25586.1; -; mRNA. DR EMBL; BC125587; AAI25588.1; -; mRNA. DR EMBL; AY255553; AAO85065.1; -; mRNA. DR CCDS; CCDS26264.1; -. DR RefSeq; NP_861419.3; NM_181754.4. DR RefSeq; XP_006516766.1; XM_006516703.3. DR RefSeq; XP_006516767.1; XM_006516704.3. DR RefSeq; XP_006516768.1; XM_006516705.3. DR RefSeq; XP_011242615.1; XM_011244313.2. DR RefSeq; XP_011242616.1; XM_011244314.2. DR RefSeq; XP_011242617.1; XM_011244315.2. DR RefSeq; XP_011242618.1; XM_011244316.2. DR AlphaFoldDB; Q7TQP0; -. DR SMR; Q7TQP0; -. DR STRING; 10090.ENSMUSP00000066921; -. DR GlyCosmos; Q7TQP0; 2 sites, No reported glycans. DR GlyGen; Q7TQP0; 2 sites. DR PhosphoSitePlus; Q7TQP0; -. DR PaxDb; 10090-ENSMUSP00000066921; -. DR Antibodypedia; 66618; 72 antibodies from 14 providers. DR DNASU; 353346; -. DR Ensembl; ENSMUST00000065335.3; ENSMUSP00000066921.3; ENSMUSG00000053101.4. DR GeneID; 353346; -. DR KEGG; mmu:353346; -. DR UCSC; uc007ppl.1; mouse. DR AGR; MGI:2672983; -. DR CTD; 353345; -. DR MGI; MGI:2672983; Gpr141. DR VEuPathDB; HostDB:ENSMUSG00000053101; -. DR eggNOG; ENOG502RXS2; Eukaryota. DR GeneTree; ENSGT01030000234518; -. DR HOGENOM; CLU_069285_0_0_1; -. DR InParanoid; Q7TQP0; -. DR OMA; FRIYYLY; -. DR OrthoDB; 4064164at2759; -. DR PhylomeDB; Q7TQP0; -. DR TreeFam; TF333221; -. DR BioGRID-ORCS; 353346; 1 hit in 76 CRISPR screens. DR PRO; PR:Q7TQP0; -. DR Proteomes; UP000000589; Chromosome 13. DR RNAct; Q7TQP0; Protein. DR Bgee; ENSMUSG00000053101; Expressed in granulocyte and 32 other cell types or tissues. DR ExpressionAtlas; Q7TQP0; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR GO; GO:0008142; F:oxysterol binding; IEA:InterPro. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR047160; GP183-like. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24237; G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24237:SF35; G-PROTEIN COUPLED RECEPTOR 141-RELATED; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..305 FT /note="Probable G-protein coupled receptor 141" FT /id="PRO_0000069619" FT TOPO_DOM 1..22 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 23..43 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 44..50 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 51..71 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 72..91 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 92..112 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 113..131 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 132..152 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 153..184 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 185..205 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 206..227 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 228..248 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 249..267 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 268..288 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 289..305 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 9 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 305 AA; 35284 MW; 74C7EB210158D554 CRC64; MDGYNTSENS SCDPILAHHL TSIYFIVLIG GLVGLISILF LLVKMNSRSV TTMAVINLVV VHGVFLLTVP FRLAYLIKGT WTFGLPFCKF VSAMLHIHMY LTFLFYVVIL VIRYLIFFKR RDKVEFYRKL HAVAASSAMW LLVIVIVVPL VVSQYGNSEE YNEQQCFRFH KELGHDSVRV INYMIVIVVI AVALILLGFQ VFITLSMVRK FRHSLLSHQE FWAQLKNLFF IGIIIICFLP YQFFRIYYLY VVAHSKSCKN KVAFYNEILL STTAISCCDL LLFVFGGSHW VKQKIVDMWN CLLCH //