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Q7TQP0

- GP141_MOUSE

UniProt

Q7TQP0 - GP141_MOUSE

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Protein
Probable G-protein coupled receptor 141
Gene
Gpr141, Pgr13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 141
    Alternative name(s):
    G-protein coupled receptor PGR13
    Gene namesi
    Name:Gpr141
    Synonyms:Pgr13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2672983. Gpr141.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei23 – 4321Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini44 – 507Cytoplasmic Reviewed prediction
    Transmembranei51 – 7121Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini72 – 9120Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei92 – 11221Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini113 – 13119Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei132 – 15221Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini153 – 18432Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei185 – 20521Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini206 – 22722Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei228 – 24821Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini249 – 26719Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei268 – 28821Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini289 – 30517Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Probable G-protein coupled receptor 141
    PRO_0000069619Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7TQP0.

    PTM databases

    PhosphoSiteiQ7TQP0.

    Expressioni

    Gene expression databases

    BgeeiQ7TQP0.
    CleanExiMM_GPR141.
    GenevestigatoriQ7TQP0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TQP0.
    SMRiQ7TQP0. Positions 22-154.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG139824.
    GeneTreeiENSGT00730000111106.
    HOGENOMiHOG000090258.
    HOVERGENiHBG051782.
    InParanoidiQ059N8.
    KOiK08429.
    OMAiHQEFWAQ.
    OrthoDBiEOG7CNZGZ.
    PhylomeDBiQ7TQP0.
    TreeFamiTF333221.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TQP0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGYNTSENS SCDPILAHHL TSIYFIVLIG GLVGLISILF LLVKMNSRSV    50
    TTMAVINLVV VHGVFLLTVP FRLAYLIKGT WTFGLPFCKF VSAMLHIHMY 100
    LTFLFYVVIL VIRYLIFFKR RDKVEFYRKL HAVAASSAMW LLVIVIVVPL 150
    VVSQYGNSEE YNEQQCFRFH KELGHDSVRV INYMIVIVVI AVALILLGFQ 200
    VFITLSMVRK FRHSLLSHQE FWAQLKNLFF IGIIIICFLP YQFFRIYYLY 250
    VVAHSKSCKN KVAFYNEILL STTAISCCDL LLFVFGGSHW VKQKIVDMWN 300
    CLLCH 305
    Length:305
    Mass (Da):35,284
    Last modified:October 1, 2003 - v1
    Checksum:i74C7EB210158D554
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288427 mRNA. Translation: AAP72136.1.
    BC125585 mRNA. Translation: AAI25586.1.
    BC125587 mRNA. Translation: AAI25588.1.
    AY255553 mRNA. Translation: AAO85065.1.
    CCDSiCCDS26264.1.
    RefSeqiNP_861419.3. NM_181754.4.
    XP_006516766.1. XM_006516703.1.
    XP_006516767.1. XM_006516704.1.
    XP_006516768.1. XM_006516705.1.
    XP_006516769.1. XM_006516706.1.
    UniGeneiMm.239268.

    Genome annotation databases

    EnsembliENSMUST00000065335; ENSMUSP00000066921; ENSMUSG00000053101.
    GeneIDi353346.
    KEGGimmu:353346.
    UCSCiuc007ppl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288427 mRNA. Translation: AAP72136.1 .
    BC125585 mRNA. Translation: AAI25586.1 .
    BC125587 mRNA. Translation: AAI25588.1 .
    AY255553 mRNA. Translation: AAO85065.1 .
    CCDSi CCDS26264.1.
    RefSeqi NP_861419.3. NM_181754.4.
    XP_006516766.1. XM_006516703.1.
    XP_006516767.1. XM_006516704.1.
    XP_006516768.1. XM_006516705.1.
    XP_006516769.1. XM_006516706.1.
    UniGenei Mm.239268.

    3D structure databases

    ProteinModelPortali Q7TQP0.
    SMRi Q7TQP0. Positions 22-154.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7TQP0.

    Proteomic databases

    PRIDEi Q7TQP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065335 ; ENSMUSP00000066921 ; ENSMUSG00000053101 .
    GeneIDi 353346.
    KEGGi mmu:353346.
    UCSCi uc007ppl.1. mouse.

    Organism-specific databases

    CTDi 353345.
    MGIi MGI:2672983. Gpr141.

    Phylogenomic databases

    eggNOGi NOG139824.
    GeneTreei ENSGT00730000111106.
    HOGENOMi HOG000090258.
    HOVERGENi HBG051782.
    InParanoidi Q059N8.
    KOi K08429.
    OMAi HQEFWAQ.
    OrthoDBi EOG7CNZGZ.
    PhylomeDBi Q7TQP0.
    TreeFami TF333221.

    Miscellaneous databases

    NextBioi 400421.
    PROi Q7TQP0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TQP0.
    CleanExi MM_GPR141.
    Genevestigatori Q7TQP0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-304.

    Entry informationi

    Entry nameiGP141_MOUSE
    AccessioniPrimary (citable) accession number: Q7TQP0
    Secondary accession number(s): Q059N8, Q80UC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2003
    Last modified: July 9, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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