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Protein

Probable G-protein coupled receptor 141

Gene

Gpr141

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 141
Alternative name(s):
G-protein coupled receptor PGR13
Gene namesi
Name:Gpr141
Synonyms:Pgr13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2672983. Gpr141.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 507CytoplasmicSequence Analysis
Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini72 – 9120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini113 – 13119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini153 – 18432ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 22722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini249 – 26719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini289 – 30517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Probable G-protein coupled receptor 141PRO_0000069619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7TQP0.

PTM databases

PhosphoSiteiQ7TQP0.

Expressioni

Gene expression databases

BgeeiQ7TQP0.
CleanExiMM_GPR141.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP0.
SMRiQ7TQP0. Positions 22-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG139824.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7TQP0.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG7CNZGZ.
PhylomeDBiQ7TQP0.
TreeFamiTF333221.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGYNTSENS SCDPILAHHL TSIYFIVLIG GLVGLISILF LLVKMNSRSV
60 70 80 90 100
TTMAVINLVV VHGVFLLTVP FRLAYLIKGT WTFGLPFCKF VSAMLHIHMY
110 120 130 140 150
LTFLFYVVIL VIRYLIFFKR RDKVEFYRKL HAVAASSAMW LLVIVIVVPL
160 170 180 190 200
VVSQYGNSEE YNEQQCFRFH KELGHDSVRV INYMIVIVVI AVALILLGFQ
210 220 230 240 250
VFITLSMVRK FRHSLLSHQE FWAQLKNLFF IGIIIICFLP YQFFRIYYLY
260 270 280 290 300
VVAHSKSCKN KVAFYNEILL STTAISCCDL LLFVFGGSHW VKQKIVDMWN

CLLCH
Length:305
Mass (Da):35,284
Last modified:October 1, 2003 - v1
Checksum:i74C7EB210158D554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288427 mRNA. Translation: AAP72136.1.
BC125585 mRNA. Translation: AAI25586.1.
BC125587 mRNA. Translation: AAI25588.1.
AY255553 mRNA. Translation: AAO85065.1.
CCDSiCCDS26264.1.
RefSeqiNP_861419.3. NM_181754.4.
XP_006516766.1. XM_006516703.2.
XP_006516767.1. XM_006516704.2.
XP_006516768.1. XM_006516705.2.
XP_011242615.1. XM_011244313.1.
XP_011242616.1. XM_011244314.1.
XP_011242617.1. XM_011244315.1.
XP_011242618.1. XM_011244316.1.
UniGeneiMm.239268.

Genome annotation databases

EnsembliENSMUST00000065335; ENSMUSP00000066921; ENSMUSG00000053101.
GeneIDi353346.
KEGGimmu:353346.
UCSCiuc007ppl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288427 mRNA. Translation: AAP72136.1.
BC125585 mRNA. Translation: AAI25586.1.
BC125587 mRNA. Translation: AAI25588.1.
AY255553 mRNA. Translation: AAO85065.1.
CCDSiCCDS26264.1.
RefSeqiNP_861419.3. NM_181754.4.
XP_006516766.1. XM_006516703.2.
XP_006516767.1. XM_006516704.2.
XP_006516768.1. XM_006516705.2.
XP_011242615.1. XM_011244313.1.
XP_011242616.1. XM_011244314.1.
XP_011242617.1. XM_011244315.1.
XP_011242618.1. XM_011244316.1.
UniGeneiMm.239268.

3D structure databases

ProteinModelPortaliQ7TQP0.
SMRiQ7TQP0. Positions 22-154.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7TQP0.

Proteomic databases

PRIDEiQ7TQP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065335; ENSMUSP00000066921; ENSMUSG00000053101.
GeneIDi353346.
KEGGimmu:353346.
UCSCiuc007ppl.1. mouse.

Organism-specific databases

CTDi353345.
MGIiMGI:2672983. Gpr141.

Phylogenomic databases

eggNOGiNOG139824.
GeneTreeiENSGT00730000111106.
HOGENOMiHOG000090258.
HOVERGENiHBG051782.
InParanoidiQ7TQP0.
KOiK08429.
OMAiHQEFWAQ.
OrthoDBiEOG7CNZGZ.
PhylomeDBiQ7TQP0.
TreeFamiTF333221.

Miscellaneous databases

NextBioi400421.
PROiQ7TQP0.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TQP0.
CleanExiMM_GPR141.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-304.

Entry informationi

Entry nameiGP141_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP0
Secondary accession number(s): Q059N8, Q80UC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.