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Protein

Probable G-protein coupled receptor 142

Gene

Gpr142

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 142
Gene namesi
Name:Gpr142
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2668437. Gpr142.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66ExtracellularSequence analysisAdd BLAST66
Transmembranei67 – 87Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini88 – 102CytoplasmicSequence analysisAdd BLAST15
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 140ExtracellularSequence analysisAdd BLAST17
Transmembranei141 – 161Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini162 – 185CytoplasmicSequence analysisAdd BLAST24
Transmembranei186 – 206Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini207 – 224ExtracellularSequence analysisAdd BLAST18
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini246 – 264CytoplasmicSequence analysisAdd BLAST19
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 304ExtracellularSequence analysisAdd BLAST19
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 365CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • cell junction Source: MGI
  • cytoplasm Source: MGI
  • integral component of membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2069162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696211 – 365Probable G-protein coupled receptor 142Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQN9.
PRIDEiQ7TQN9.

PTM databases

PhosphoSitePlusiQ7TQN9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034677.
CleanExiMM_GPR142.
ExpressionAtlasiQ7TQN9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045029.

Chemistry databases

BindingDBiQ7TQN9.

Structurei

3D structure databases

ProteinModelPortaliQ7TQN9.
SMRiQ7TQN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7TQN9.
KOiK08430.
PhylomeDBiQ7TQN9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLNSNPNSY ICDAYQHADL LWSLSPHVLT KAVQPQVTLL PTVNGSNPRY
60 70 80 90 100
DGVDGHWPES PERSPCVAGI IPVIYYSVLL SLGLPVALAR LAARTRKPSY
110 120 130 140 150
HYLLALTASD IVTQVIIVFV GFLLQGAVLA RQVPQAVVRT ANILEFAANH
160 170 180 190 200
ASVWIAVLFT VDRYNALCRP LRHRATSSPG RTHRAIAAVI GVTLLTGIPF
210 220 230 240 250
YWWLDVWRDA DPPSTMDKLL KWAHCLIVYF IPCNVFLVTN SAIILRLRKR
260 270 280 290 300
GQRGLRPLVS KSTAILLGVT SLFALLWAPR IIVMLYHLYV APVHRDWRVH
310 320 330 340 350
LALDIANMLA MLNTEVNFGL YCFISKTFRA TVRQVICDVH MACALKSQPK
360
QTVVELMLKS VGTEL
Length:365
Mass (Da):40,758
Last modified:October 1, 2003 - v1
Checksum:iACA8649245CDAE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288428 mRNA. Translation: AAP72137.1.
CCDSiCCDS25611.1.
RefSeqiNP_861414.1. NM_181749.1.
UniGeneiMm.269127.

Genome annotation databases

EnsembliENSMUST00000045319; ENSMUSP00000045029; ENSMUSG00000034677.
GeneIDi217302.
KEGGimmu:217302.
UCSCiuc007mfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288428 mRNA. Translation: AAP72137.1.
CCDSiCCDS25611.1.
RefSeqiNP_861414.1. NM_181749.1.
UniGeneiMm.269127.

3D structure databases

ProteinModelPortaliQ7TQN9.
SMRiQ7TQN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045029.

Chemistry databases

BindingDBiQ7TQN9.
ChEMBLiCHEMBL2069162.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ7TQN9.

Proteomic databases

PaxDbiQ7TQN9.
PRIDEiQ7TQN9.

Protocols and materials databases

DNASUi217302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045319; ENSMUSP00000045029; ENSMUSG00000034677.
GeneIDi217302.
KEGGimmu:217302.
UCSCiuc007mfu.1. mouse.

Organism-specific databases

CTDi350383.
MGIiMGI:2668437. Gpr142.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG051783.
InParanoidiQ7TQN9.
KOiK08430.
PhylomeDBiQ7TQN9.

Miscellaneous databases

PROiQ7TQN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034677.
CleanExiMM_GPR142.
ExpressionAtlasiQ7TQN9. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP142_MOUSE
AccessioniPrimary (citable) accession number: Q7TQN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.