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Protein

Glucose-dependent insulinotropic receptor

Gene

Gpr119

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-RNO-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:Gpr119
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi727808 Gpr119

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini28 – 37CytoplasmicSequence analysis10
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 468CytoplasmicSequence analysisAdd BLAST185

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5262

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696091 – 468Glucose-dependent insulinotropic receptorAdd BLAST468

Proteomic databases

PaxDbiQ7TQN8
PRIDEiQ7TQN8

PTM databases

PhosphoSitePlusiQ7TQN8

Expressioni

Tissue specificityi

Expression restricted to the beta-cells of pancreatic islets.2 Publications

Gene expression databases

BgeeiENSRNOG00000024517

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036164

Chemistry databases

BindingDBiQ7TQN8

Structurei

3D structure databases

ProteinModelPortaliQ7TQN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi323 – 452Thr-richAdd BLAST130

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
InParanoidiQ7TQN8
KOiK08424
OrthoDBiEOG091G0I71
PhylomeDBiQ7TQN8
TreeFamiTF325411

Family and domain databases

CDDicd15104 7tmA_GPR119_R_insulinotropic_r, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028336 GPR119
PANTHERiPTHR22750:SF7 PTHR22750:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA
110 120 130 140 150
FDRYLAIKQP LRYFQIMNGL VAGGCIAGLW LISYLIGFLP LGVSIFQQTT
160 170 180 190 200
YHGPCTFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQHIR
210 220 230 240 250
KMEHAGAMVG ACRPPRPVND FKAVRTVSVL IGSFTLSWSP FLITSIVQVA
260 270 280 290 300
CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL CHMALGLLAD
310 320 330 340 350
GSTQPQIETL KGKEERKKVG RKTLYTCDAQ TLYTCDAQTL YTCDAQTLYT
360 370 380 390 400
CDACDTQTLY TCDAQTLYTC DAQTLYTCDA QTLYTCDAQT LYTCDAQTLY
410 420 430 440 450
TCDTQTLYTC DAQTLYTCDA QTLYTCDAQT LYTCDAQTLY TSSLVTGQTE
460
QTPLKRANMS DPLRTCRG
Length:468
Mass (Da):51,686
Last modified:October 1, 2003 - v1
Checksum:i6D5E607B572BE45A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288429 mRNA Translation: AAP72138.1
RefSeqiNP_861435.1, NM_181770.1
UniGeneiRn.96430

Genome annotation databases

EnsembliENSRNOT00000033619; ENSRNOP00000036164; ENSRNOG00000024517
GeneIDi302813
KEGGirno:302813
UCSCiRGD:727808 rat

Entry informationi

Entry nameiGP119_RAT
AccessioniPrimary (citable) accession number: Q7TQN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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