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Protein

Glucose-dependent insulinotropic receptor

Gene

Gpr119

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-RNO-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:Gpr119
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi727808. Gpr119.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence analysis
Transmembranei7 – 2721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini28 – 3710CytoplasmicSequence analysis
Transmembranei38 – 5821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini59 – 8123ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12523CytoplasmicSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 16418ExtracellularSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini186 – 22641CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini248 – 26215ExtracellularSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini284 – 468185CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Glucose-dependent insulinotropic receptorPRO_0000069609Add
BLAST

Proteomic databases

PaxDbiQ7TQN8.
PRIDEiQ7TQN8.

PTM databases

iPTMnetiQ7TQN8.
PhosphoSiteiQ7TQN8.

Expressioni

Tissue specificityi

Expression restricted to the beta-cells of pancreatic islets.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036164.

Chemistry

BindingDBiQ7TQN8.

Structurei

3D structure databases

ProteinModelPortaliQ7TQN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi323 – 452130Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
InParanoidiQ7TQN8.
KOiK08424.
OrthoDBiEOG75B85V.
PhylomeDBiQ7TQN8.
TreeFamiTF325411.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA
110 120 130 140 150
FDRYLAIKQP LRYFQIMNGL VAGGCIAGLW LISYLIGFLP LGVSIFQQTT
160 170 180 190 200
YHGPCTFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQHIR
210 220 230 240 250
KMEHAGAMVG ACRPPRPVND FKAVRTVSVL IGSFTLSWSP FLITSIVQVA
260 270 280 290 300
CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL CHMALGLLAD
310 320 330 340 350
GSTQPQIETL KGKEERKKVG RKTLYTCDAQ TLYTCDAQTL YTCDAQTLYT
360 370 380 390 400
CDACDTQTLY TCDAQTLYTC DAQTLYTCDA QTLYTCDAQT LYTCDAQTLY
410 420 430 440 450
TCDTQTLYTC DAQTLYTCDA QTLYTCDAQT LYTCDAQTLY TSSLVTGQTE
460
QTPLKRANMS DPLRTCRG
Length:468
Mass (Da):51,686
Last modified:October 1, 2003 - v1
Checksum:i6D5E607B572BE45A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288429 mRNA. Translation: AAP72138.1.
RefSeqiNP_861435.1. NM_181770.1.
UniGeneiRn.96430.

Genome annotation databases

EnsembliENSRNOT00000033619; ENSRNOP00000036164; ENSRNOG00000024517.
GeneIDi302813.
KEGGirno:302813.
UCSCiRGD:727808. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288429 mRNA. Translation: AAP72138.1.
RefSeqiNP_861435.1. NM_181770.1.
UniGeneiRn.96430.

3D structure databases

ProteinModelPortaliQ7TQN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036164.

Chemistry

BindingDBiQ7TQN8.
ChEMBLiCHEMBL5262.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7TQN8.
PhosphoSiteiQ7TQN8.

Proteomic databases

PaxDbiQ7TQN8.
PRIDEiQ7TQN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033619; ENSRNOP00000036164; ENSRNOG00000024517.
GeneIDi302813.
KEGGirno:302813.
UCSCiRGD:727808. rat.

Organism-specific databases

CTDi139760.
RGDi727808. Gpr119.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
InParanoidiQ7TQN8.
KOiK08424.
OrthoDBiEOG75B85V.
PhylomeDBiQ7TQN8.
TreeFamiTF325411.

Enzyme and pathway databases

ReactomeiR-RNO-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-RNO-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Miscellaneous databases

NextBioi650189.
PROiQ7TQN8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor."
    Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K.
    Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, CHARACTERIZATION.
  3. "A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release."
    Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J.
    Endocrinology 148:2601-2609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiGP119_RAT
AccessioniPrimary (citable) accession number: Q7TQN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: January 20, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.