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Q7TQN7 (GP135_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 135
Gene names
Name:Gpr135
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Probable G-protein coupled receptor 135
PRO_0000069614

Regions

Topological domain1 – 6464Extracellular Potential
Transmembrane65 – 8521Helical; Name=1; Potential
Topological domain86 – 10924Cytoplasmic Potential
Transmembrane110 – 13021Helical; Name=2; Potential
Topological domain131 – 15626Extracellular Potential
Transmembrane157 – 17721Helical; Name=3; Potential
Topological domain178 – 18912Cytoplasmic Potential
Transmembrane190 – 21021Helical; Name=4; Potential
Topological domain211 – 23525Extracellular Potential
Transmembrane236 – 25621Helical; Name=5; Potential
Topological domain257 – 29539Cytoplasmic Potential
Transmembrane296 – 31621Helical; Name=6; Potential
Topological domain317 – 32913Extracellular Potential
Transmembrane330 – 35021Helical; Name=7; Potential
Topological domain351 – 457107Cytoplasmic Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TQN7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 879BE6477F8EC0BA

FASTA45749,581
        10         20         30         40         50         60 
MEEQARPPSR PAASATLPGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD AGRPEAAGSR 

        70         80         90        100        110        120 
GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH RQLRTVTNAF ILSLSLSDLL 

       130        140        150        160        170        180 
TALLCLPAAF LDLFAPPGDS GPWRSFCAAS RFFSSCFGIV STFSVALISL DRYCAIVRPP 

       190        200        210        220        230        240 
RDKLGRRRAL QLLAGAWLAA LGFSLPWELL RAPREPPTPQ SFHRCLYRTS PDPAQLGAAY 

       250        260        270        280        290        300 
SVGLVVACYL LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI 

       310        320        330        340        350        360 
VFVICCWGPY CFLVLLAATR QGQTTQAPSL LNVAAVWLTW ANGAINPVIY AIRNPNISMF 

       370        380        390        400        410        420 
LGRNREEGYR TRNMDVFLPS QGLGFQARSR NRLRNGCANR LGACSRMPSS NPASGSGGEV 

       430        440        450 
VMWARKNPVV LFFREDPPDP VMAVYKQHKS ETRDSSI

« Hide

References

[1]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed: 14623098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY288430 mRNA. Translation: AAP72139.1.
IPIIPI00337100.
RefSeqNP_861436.1. NM_181771.1.
UniGeneRn.56673.

3D structure databases

ProteinModelPortalQ7TQN7.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ7TQN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005933; ENSRNOP00000005933; ENSRNOG00000004499.
GeneID314213.
KEGGrno:314213.

Organism-specific databases

CTD64582.
RGD727844. Gpr135.

Phylogenomic databases

eggNOGroNOG12557.
GeneTreeENSGT00390000008078.
HOVERGENHBG051780.
InParanoidQ7TQN7.
OMAANRLGAC.
OrthoDBEOG4VX25G.
PhylomeDBQ7TQN7.

Gene expression databases

ArrayExpressQ7TQN7.
GenevestigatorQ7TQN7.
GermOnlineENSRNOG00000004499. Rattus norvegicus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK08427.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio667297.

Entry information

Entry nameGP135_RAT
AccessionPrimary (citable) accession number: Q7TQN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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