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Q7TQN4

- Q7TQN4_RAT

UniProt

Q7TQN4 - Q7TQN4_RAT

Protein
Submitted name:

Protein Rela

Gene

Rela

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. phosphate ion binding Source: Ensembl
    3. protein binding Source: RGD
    4. protein complex binding Source: RGD
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. sequence-specific DNA binding Source: RGD
    7. transcription factor binding Source: RGD
    8. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. acetaldehyde metabolic process Source: RGD
    2. aging Source: RGD
    3. cellular response to hydrogen peroxide Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to lipopolysaccharide Source: RGD
    6. cellular response to tumor necrosis factor Source: Ensembl
    7. cytokine-mediated signaling pathway Source: Ensembl
    8. hair follicle development Source: Ensembl
    9. inflammatory response Source: Ensembl
    10. liver development Source: Ensembl
    11. negative regulation of apoptotic process Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    13. negative regulation of insulin receptor signaling pathway Source: RGD
    14. negative regulation of protein catabolic process Source: Ensembl
    15. negative regulation of transcription, DNA-templated Source: Ensembl
    16. nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
    17. organ morphogenesis Source: Ensembl
    18. positive regulation of cell proliferation Source: RGD
    19. positive regulation of chondrocyte differentiation Source: RGD
    20. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    21. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    22. positive regulation of Schwann cell differentiation Source: RGD
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. regulation of inflammatory response Source: Ensembl
    25. response to amino acid Source: RGD
    26. response to cAMP Source: RGD
    27. response to cobalamin Source: RGD
    28. response to cytokine Source: RGD
    29. response to drug Source: RGD
    30. response to hydrogen peroxide Source: RGD
    31. response to inorganic substance Source: RGD
    32. response to insulin Source: RGD
    33. response to lipopolysaccharide Source: RGD
    34. response to mechanical stimulus Source: RGD
    35. response to morphine Source: RGD
    36. response to muramyl dipeptide Source: Ensembl
    37. response to organic cyclic compound Source: RGD
    38. response to organic substance Source: RGD
    39. response to progesterone Source: RGD
    40. response to UV-B Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_194364. RIP-mediated NFkB activation via ZBP1.
    REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_196375. Interleukin-1 processing.
    REACT_197513. FCERI mediated NF-kB activation.
    REACT_199247. Activation of NF-kappaB in B cells.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein RelaImported
    Submitted name:
    RELAImported
    Submitted name:
    V-rel reticuloendotheliosis viral oncogene homolog A (Avian)Imported
    Gene namesi
    Name:RelaImported
    Synonyms:RelAImported
    ORF Names:rCG_48632Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi727889. Rela.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytosol Source: RGD
    3. nucleus Source: RGD
    4. protein complex Source: RGD
    5. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TQN4.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38953N.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00500000044765.
    HOGENOMiHOG000230474.
    HOVERGENiHBG017916.
    InParanoidiQ7TQN4.
    KOiK04735.
    OMAiEFSPMVF.
    OrthoDBiEOG7VHSWT.
    TreeFamiTF325632.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PfamiPF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR00057. NFKBTNSCPFCT.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TQN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER    50
    STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 100
    EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG 150
    DYDLNAVRLC FQVTVRDPSG RPLRLTPVLS HPIFDNRAPN TAELKICRVN 200
    RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI 250
    VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 300
    KRKRTYETFK SIMKKSPFNG PTEPRPPPRR IAVPSRGPTS VPKPAPQPYA 350
    FSTSLSTINF DEFSPMVLPP GQISNQALAL APSSAPVLAQ TMVPSSAMVP 400
    SLAQPPAPVP VLAPGPPQSL SAPVPKSTQA GEGTLSEALL HLQFDADEDL 450
    GALLGNNTDP GVFTDLASVD NSEFQQLLNQ GVAMSHSTAE PMLMEYPEAI 500
    TRLVTGSQRP PDPAPATLGT SGLPNGLSGD EDFSSIADMD FSALLSQISS 550
    Length:550
    Mass (Da):60,267
    Last modified:October 1, 2003 - v1
    Checksum:i2C6A8FD68F667A64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009537 Genomic DNA. No translation available.
    BC079457 mRNA. Translation: AAH79457.1.
    AY307375 mRNA. Translation: AAP72180.1.
    CH473953 Genomic DNA. Translation: EDM12513.1.
    RefSeqiNP_954888.1. NM_199267.2.
    UniGeneiRn.19480.

    Genome annotation databases

    EnsembliENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888.
    GeneIDi309165.
    KEGGirno:309165.
    UCSCiRGD:727889. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009537 Genomic DNA. No translation available.
    BC079457 mRNA. Translation: AAH79457.1 .
    AY307375 mRNA. Translation: AAP72180.1 .
    CH473953 Genomic DNA. Translation: EDM12513.1 .
    RefSeqi NP_954888.1. NM_199267.2.
    UniGenei Rn.19480.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38953N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000045233 ; ENSRNOP00000044552 ; ENSRNOG00000030888 .
    GeneIDi 309165.
    KEGGi rno:309165.
    UCSCi RGD:727889. rat.

    Organism-specific databases

    CTDi 5970.
    RGDi 727889. Rela.

    Phylogenomic databases

    GeneTreei ENSGT00500000044765.
    HOGENOMi HOG000230474.
    HOVERGENi HBG017916.
    InParanoidi Q7TQN4.
    KOi K04735.
    OMAi EFSPMVF.
    OrthoDBi EOG7VHSWT.
    TreeFami TF325632.

    Enzyme and pathway databases

    Reactomei REACT_194364. RIP-mediated NFkB activation via ZBP1.
    REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_196375. Interleukin-1 processing.
    REACT_197513. FCERI mediated NF-kB activation.
    REACT_199247. Activation of NF-kappaB in B cells.

    Miscellaneous databases

    NextBioi 660308.
    PROi Q7TQN4.

    Gene expression databases

    Genevestigatori Q7TQN4.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    Pfami PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR00057. NFKBTNSCPFCT.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning RelA gene from rat microglia and cortical neurons."
      Mao X., Barger S.W.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ7TQN4_RAT
    AccessioniPrimary (citable) accession number: Q7TQN4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3