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Q7TQN4 (Q7TQN4_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

RELA EMBL AAP72180.1

V-rel reticuloendotheliosis viral oncogene homolog A (Avian) EMBL AAH79457.1
Gene names
Name:Rela RGD 727889 Ensembl ENSRNOP00000044552 EMBL AAH79457.1
Synonyms:RelA EMBL AAP72180.1
ORF Names:rCG_48632 EMBL EDM12513.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RHD (Rel-like) domain. RuleBase RU003997

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU003998
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetaldehyde metabolic process

Inferred from expression pattern PubMed 9918814. Source: RGD

aging

Inferred from expression pattern PubMed 18338625. Source: RGD

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 9918814. Source: RGD

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

hair follicle development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin receptor signaling pathway

Inferred from mutant phenotype PubMed 18073321. Source: RGD

negative regulation of protein catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

nucleotide-binding oligomerization domain containing 2 signaling pathway

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of Schwann cell differentiation

Inferred from mutant phenotype PubMed 18385332. Source: RGD

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 17884819. Source: RGD

positive regulation of chondrocyte differentiation

Inferred from mutant phenotype PubMed 17884819. Source: RGD

positive regulation of interleukin-12 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

response to UV-B

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from expression pattern PubMed 18288455. Source: RGD

response to cAMP

Inferred from expression pattern PubMed 18385332. Source: RGD

response to cobalamin

Inferred from expression pattern PubMed 18183619. Source: RGD

response to cytokine

Inferred from expression pattern PubMed 10715573. Source: RGD

response to drug

Inferred from expression pattern PubMed 18543397. Source: RGD

response to hydrogen peroxide

Inferred from expression pattern PubMed 17454138. Source: RGD

response to inorganic substance

Inferred from expression pattern PubMed 18636044. Source: RGD

response to insulin

Inferred from expression pattern PubMed 18500427. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern PubMed 17915214. Source: RGD

response to mechanical stimulus

Inferred from expression pattern PubMed 17525357. Source: RGD

response to morphine

Inferred from expression pattern PubMed 18400403. Source: RGD

response to muramyl dipeptide

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from expression pattern PubMed 18400403. Source: RGD

response to organic substance

Inferred from expression pattern PubMed 18637019. Source: RGD

response to progesterone

Inferred from expression pattern PubMed 18274644. Source: RGD

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 18722355. Source: RGD

cytosol

Inferred from direct assay PubMed 10841371PubMed 12672265PubMed 9918814. Source: RGD

nucleus

Inferred from direct assay PubMed 10841371PubMed 17454138PubMed 18722355PubMed 9343439PubMed 9918814. Source: RGD

protein complex

Inferred from direct assay PubMed 10620707PubMed 12672265PubMed 9343439. Source: RGD

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from electronic annotation. Source: Ensembl

phosphate ion binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 17280489. Source: RGD

protein complex binding

Inferred from physical interaction PubMed 12672265. Source: RGD

sequence-specific DNA binding

Inferred from direct assay PubMed 10620707PubMed 9918814. Source: RGD

transcription factor binding

Inferred from physical interaction PubMed 17252537. Source: RGD

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7TQN4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2C6A8FD68F667A64

FASTA55060,267
        10         20         30         40         50         60 
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 

        70         80         90        100        110        120 
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC 

       130        140        150        160        170        180 
VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLTPVLS 

       190        200        210        220        230        240 
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 

       250        260        270        280        290        300 
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 

       310        320        330        340        350        360 
KRKRTYETFK SIMKKSPFNG PTEPRPPPRR IAVPSRGPTS VPKPAPQPYA FSTSLSTINF 

       370        380        390        400        410        420 
DEFSPMVLPP GQISNQALAL APSSAPVLAQ TMVPSSAMVP SLAQPPAPVP VLAPGPPQSL 

       430        440        450        460        470        480 
SAPVPKSTQA GEGTLSEALL HLQFDADEDL GALLGNNTDP GVFTDLASVD NSEFQQLLNQ 

       490        500        510        520        530        540 
GVAMSHSTAE PMLMEYPEAI TRLVTGSQRP PDPAPATLGT SGLPNGLSGD EDFSSIADMD 

       550 
FSALLSQISS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning RelA gene from rat microglia and cortical neurons."
Mao X., Barger S.W.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAP72180.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung EMBL AAH79457.1.
[3]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000044552.
[4]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDM12513.1.
[5]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDM12513.1.
[6]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000044552.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06009537 Genomic DNA. No translation available.
BC079457 mRNA. Translation: AAH79457.1.
AY307375 mRNA. Translation: AAP72180.1.
CH473953 Genomic DNA. Translation: EDM12513.1.
RefSeqNP_954888.1. NM_199267.2.
UniGeneRn.19480.

3D structure databases

ProteinModelPortalQ7TQN4.
SMRQ7TQN4. Positions 20-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-38953N.
IntActQ7TQN4. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888.
GeneID309165.
KEGGrno:309165.
UCSCRGD:727889. rat.

Organism-specific databases

CTD5970.
RGD727889. Rela.

Phylogenomic databases

GeneTreeENSGT00500000044765.
HOGENOMHOG000230474.
HOVERGENHBG017916.
InParanoidQ7TQN4.
KOK04735.
OMAEFSPMVF.
OrthoDBEOG7VHSWT.
PhylomeDBQ7TQN4.
TreeFamTF325632.

Gene expression databases

GenevestigatorQ7TQN4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NF_Rel_Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PfamPF00554. RHD. 1 hit.
[Graphical view]
PRINTSPR00057. NFKBTNSCPFCT.
SMARTSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio660308.
PROQ7TQN4.

Entry information

Entry nameQ7TQN4_RAT
AccessionPrimary (citable) accession number: Q7TQN4
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)