Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

RELA

Gene

Rela

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1810476. RIP-mediated NFkB activation via ZBP1.
R-RNO-193692. Regulated proteolysis of p75NTR.
R-RNO-202424. Downstream TCR signaling.
R-RNO-209560. NF-kB is activated and signals survival.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-RNO-3214841. PKMTs methylate histone lysines.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-448706. Interleukin-1 processing.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5621575. CD209 (DC-SIGN) signaling.
R-RNO-933542. TRAF6 mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Submitted name:
RELAImported
Submitted name:
RELA proto-oncogene, NF-kB subunitImported
Submitted name:
V-rel reticuloendotheliosis viral oncogene homolog A (Avian)Imported
Gene namesi
Name:RelaImported
Synonyms:RelAImported
ORF Names:rCG_48632Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi727889. Rela.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • I-kappaB/NF-kappaB complex Source: GO_Central
  • NF-kappaB p50/p65 complex Source: Ensembl
  • nuclear chromatin Source: ParkinsonsUK-UCL
  • nucleus Source: BHF-UCL
  • protein complex Source: RGD
  • transcription factor complex Source: Ensembl

Expressioni

Gene expression databases

BgeeiENSRNOG00000030888.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-38953N.
IntActiQ7TQN4. 3 interactors.
STRINGi10116.ENSRNOP00000044552.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 190RHD (Rel-like)InterPro annotationAdd BLAST175

Phylogenomic databases

eggNOGiENOG410IG8F. Eukaryota.
ENOG410XT64. LUCA.
GeneTreeiENSGT00500000044765.
HOGENOMiHOG000230474.
HOVERGENiHBG017916.
KOiK04735.
OMAiEFSPMVF.
OrthoDBiEOG091G08JD.
TreeFamiTF325632.

Family and domain databases

CDDicd01177. IPT_NFkappaB. 1 hit.
Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR033926. IPT_NFkappaB.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030495. RelA.
IPR030492. RHD_CS.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF23. PTHR24169:SF23. 1 hit.
PfamiView protein in Pfam
PF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiView protein in SMART
SM00429. IPT. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPSG RPLRLTPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFNG PTEPRPPPRR IAVPSRGPTS VPKPAPQPYA
360 370 380 390 400
FSTSLSTINF DEFSPMVLPP GQISNQALAL APSSAPVLAQ TMVPSSAMVP
410 420 430 440 450
SLAQPPAPVP VLAPGPPQSL SAPVPKSTQA GEGTLSEALL HLQFDADEDL
460 470 480 490 500
GALLGNNTDP GVFTDLASVD NSEFQQLLNQ GVAMSHSTAE PMLMEYPEAI
510 520 530 540 550
TRLVTGSQRP PDPAPATLGT SGLPNGLSGD EDFSSIADMD FSALLSQISS
Length:550
Mass (Da):60,267
Last modified:October 1, 2003 - v1
Checksum:i2C6A8FD68F667A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134224 Genomic DNA. No translation available.
BC079457 mRNA. Translation: AAH79457.1.
AY307375 mRNA. Translation: AAP72180.1.
CH473953 Genomic DNA. Translation: EDM12513.1.
RefSeqiNP_954888.1. NM_199267.2.
UniGeneiRn.19480.

Genome annotation databases

EnsembliENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888.
GeneIDi309165.
KEGGirno:309165.
UCSCiRGD:727889. rat.

Similar proteinsi

Entry informationi

Entry nameiQ7TQN4_RAT
AccessioniPrimary (citable) accession number: Q7TQN4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported