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Protein

Sterol O-acyltransferase 2

Gene

Soat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (By similarity).By similarity

Catalytic activityi

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei436Sequence analysis1

GO - Molecular functioni

  • cholesterol O-acyltransferase activity Source: GO_Central
  • sterol O-acyltransferase activity Source: RGD

GO - Biological processi

  • cholesterol esterification Source: InterPro
  • cholesterol homeostasis Source: InterPro
  • cholesterol metabolic process Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol O-acyltransferase 2 (EC:2.3.1.26)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name:
ACAT-2
Cholesterol acyltransferase 2
Gene namesi
Name:Soat2
Synonyms:Acat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628865 Soat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 121CytoplasmicSequence analysisAdd BLAST121
Transmembranei122 – 140HelicalSequence analysisAdd BLAST19
Topological domaini141 – 159LumenalSequence analysisAdd BLAST19
Transmembranei160 – 178HelicalSequence analysisAdd BLAST19
Topological domaini179 – 202CytoplasmicSequence analysisAdd BLAST24
Transmembranei203 – 221HelicalSequence analysisAdd BLAST19
Topological domaini222 – 342LumenalSequence analysisAdd BLAST121
Transmembranei343 – 365HelicalSequence analysisAdd BLAST23
Topological domaini366 – 477CytoplasmicSequence analysisAdd BLAST112
Transmembranei478 – 496HelicalSequence analysisAdd BLAST19
Topological domaini497 – 524LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002557131 – 524Sterol O-acyltransferase 2Add BLAST524

Proteomic databases

PaxDbiQ7TQM4
PRIDEiQ7TQM4

PTM databases

CarbonylDBiQ7TQM4

Interactioni

Subunit structurei

May form homo- or heterodimers.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015367

Chemistry databases

BindingDBiQ7TQM4

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiQ7TQM4
KOiK00637
PhylomeDBiQ7TQM4

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPKAPQLRR RERQGEEQEN GACGEGNTRT HRAPDLVQWT RHMEAVKTQC
60 70 80 90 100
LEQAQRELAE LMDRAIWEAV QAYPKQDRPL PSTASDSTRK TQELHPGKRK
110 120 130 140 150
VFITRKSLLD ELMGVQHFRT IYHMFIAGLC VLIISTLAID FIDEGRLMLE
160 170 180 190 200
FDLLLFSFGQ LPLALMMWVP MFLSTLLLPY QTLRLWARPR SGGAWTLGAS
210 220 230 240 250
LGCVLLAAHA AVLCVLPVHV SVKHELPPAS RCVLVFEQVR FLMKSYSFLR
260 270 280 290 300
ETVPGIFCVR GGKGICTPSF SSYLYFLFCP TLIYRETYPR TPSIRWNYVA
310 320 330 340 350
KNFAQALGCL LYACFILGRL CVPVFANMSR EPFSTRALLL SILHATGPGI
360 370 380 390 400
FMLLLIFFAF LHCWLNAFAE MLRFGDRMFY RDWWNSTSFS NYYRTWNVVV
410 420 430 440 450
HDWLYSYVYQ DGLWLLGRQG RGAAMLGVFL VSALVHEYIF CFVLGFFYPV
460 470 480 490 500
MLILFLVVGG LLNFTMNDRH TGPAWNILMW TFLFLGQGIQ VSLYCQEWYA
510 520
RRHCPLPQPT FWELVTPRSW SCHP
Length:524
Mass (Da):60,498
Last modified:October 1, 2003 - v1
Checksum:i75CE7DE53F03C88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB101480 mRNA Translation: BAC78210.1
RefSeqiNP_714950.2, NM_153728.2
UniGeneiRn.83628

Genome annotation databases

GeneIDi266770
KEGGirno:266770

Similar proteinsi

Entry informationi

Entry nameiSOAT2_RAT
AccessioniPrimary (citable) accession number: Q7TQM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health