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Protein

Fibroblast growth factor receptor-like 1

Gene

Fgfrl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has a negative effect on cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-5658623. FGFRL1 modulation of FGFR1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Gene namesi
Name:Fgfrl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi735156. Fgfrl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 374ExtracellularSequence analysisAdd BLAST354
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 529CytoplasmicSequence analysisAdd BLAST134

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002125221 – 529Fibroblast growth factor receptor-like 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi264 ↔ 334PROSITE-ProRule annotation
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TQM3.
PRIDEiQ7TQM3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024207.
GenevisibleiQ7TQM3. RN.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000037.

Structurei

3D structure databases

ProteinModelPortaliQ7TQM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 111Ig-like C2-type 1Add BLAST87
Domaini143 – 233Ig-like C2-type 2Add BLAST91
Domaini242 – 350Ig-like C2-type 3Add BLAST109

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ7TQM3.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ7TQM3.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE
60 70 80 90 100
GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG
110 120 130 140 150
FGSLSVNYTL IIMDDISPGK ENPGPGGSSG GQEDPVSQQW ARPRFTQPSK
160 170 180 190 200
MRRRVIARPV GSSVRLKCVA SGHPRPDIMW MKDDQTLTRL EASEHRKKKW
210 220 230 240 250
TLSLKNLKPE DSGKYTCRVS NRAGAINATY KVDVIQRTRS KPVLTGTHPV
260 270 280 290 300
NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV
310 320 330 340 350
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT
360 370 380 390 400
VLPDPKPPGP PVAHSSSTTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK
410 420 430 440 450
PCAPASTLPV PGHRPPGTSR ERSGDKDLPS LAVGICEEHG STMAPQHILA
460 470 480 490 500
PGSTAGPKLY PKLYTDVHTH THTHTCTHTL SCGGQGSSAP ACPLSVLNTA
510 520
NLQALCPEVG VWGPRQQVGR IENNGGRVS
Length:529
Mass (Da):57,144
Last modified:October 1, 2003 - v1
Checksum:i23D67B419335FFFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536020 mRNA. Translation: CAD59914.1.
BC097261 mRNA. Translation: AAH97261.1.
RefSeqiNP_954545.1. NM_199114.1.
UniGeneiRn.44953.

Genome annotation databases

EnsembliENSRNOT00000000037; ENSRNOP00000000037; ENSRNOG00000024207.
GeneIDi360903.
KEGGirno:360903.
UCSCiRGD:735156. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536020 mRNA. Translation: CAD59914.1.
BC097261 mRNA. Translation: AAH97261.1.
RefSeqiNP_954545.1. NM_199114.1.
UniGeneiRn.44953.

3D structure databases

ProteinModelPortaliQ7TQM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000037.

Proteomic databases

PaxDbiQ7TQM3.
PRIDEiQ7TQM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000037; ENSRNOP00000000037; ENSRNOG00000024207.
GeneIDi360903.
KEGGirno:360903.
UCSCiRGD:735156. rat.

Organism-specific databases

CTDi53834.
RGDi735156. Fgfrl1.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ7TQM3.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ7TQM3.

Enzyme and pathway databases

ReactomeiR-RNO-5658623. FGFRL1 modulation of FGFR1 signaling.

Miscellaneous databases

PROiQ7TQM3.

Gene expression databases

BgeeiENSRNOG00000024207.
GenevisibleiQ7TQM3. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGRL1_RAT
AccessioniPrimary (citable) accession number: Q7TQM3
Secondary accession number(s): Q4V8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.