Q7TQK4 (EXOS3_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 84. History...
Names and origin
|Protein names||Recommended name:|
Exosome complex component RRP40
Exosome component 3
Ribosomal RNA-processing protein 40
|Organism||Mus musculus (Mouse) [Reference proteome]|
|Taxonomic identifier||10090 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus|
|Sequence length||274 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 By similarity. Ref.3
Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with GTPBP1 By similarity. Interacts with ZC3HAV1 By similarity. Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner By similarity.
Belongs to the RRP40 family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Initiator methionine||1||1||Removed By similarity|
|Chain||2 – 274||273||Exosome complex component RRP40||PRO_0000087132|
Amino acid modifications
|Modified residue||2||1||N-acetylalanine By similarity|
|Sequence conflict||32||1||E → P in BAB24501. Ref.2|
|BC023669 mRNA. Translation: AAH23669.1.|
BC054085 mRNA. Translation: AAH54085.1.
AK006281 mRNA. Translation: BAB24501.1.
AK009165 mRNA. Translation: BAB26116.1.
|RefSeq||NP_079789.1. NM_025513.3. |
3D structure databases
|SMR||Q7TQK4. Positions 17-274. |
Protein-protein interaction databases
|IntAct||Q7TQK4. 2 interactions.|
Protocols and materials databases
Genome annotation databases
|Ensembl||ENSMUST00000030003; ENSMUSP00000030003; ENSMUSG00000028322. |
|UCSC||uc008ssk.1. mouse. |
|MGI||MGI:1913612. Exosc3. |
Gene expression databases
Family and domain databases
|InterPro||IPR026699. Exosome_RNA_bind1/RRP40/RRP4. |
|PANTHER||PTHR21321. PTHR21321. 1 hit. |
|SUPFAM||SSF50249. SSF50249. 1 hit. |
|ChiTaRS||EXOSC3. mouse. |
|Accession||Primary (citable) accession number: Q7TQK4|
Secondary accession number(s): Q9CV81, Q9CVW2
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|