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Protein

Integrator complex subunit 7

Gene

Ints7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 7
Short name:
Int7
Gene namesi
Name:Ints7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924315. Ints7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595501 – 966Integrator complex subunit 7Add BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338PhosphoserineBy similarity1
Modified residuei809PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TQK1.
PaxDbiQ7TQK1.
PeptideAtlasiQ7TQK1.
PRIDEiQ7TQK1.

PTM databases

iPTMnetiQ7TQK1.
PhosphoSitePlusiQ7TQK1.

Expressioni

Gene expression databases

CleanExiMM_INTS7.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with NABP2.By similarity

Protein-protein interaction databases

BioGridi218493. 3 interactors.
IntActiQ7TQK1. 1 interactor.
MINTiMINT-4114246.
STRINGi10090.ENSMUSP00000036277.

Structurei

3D structure databases

ProteinModelPortaliQ7TQK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi937 – 958Gln-richAdd BLAST22

Sequence similaritiesi

Belongs to the Integrator subunit 7 family.Curated

Phylogenomic databases

eggNOGiKOG1988. Eukaryota.
ENOG410XSMR. LUCA.
HOGENOMiHOG000063719.
HOVERGENiHBG079489.
InParanoidiQ7TQK1.
KOiK13144.
PhylomeDBiQ7TQK1.
TreeFamiTF106105.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033060. INTS7.
PANTHERiPTHR13322. PTHR13322. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TQK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR
60 70 80 90 100
LFQKYPFPIL INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV
110 120 130 140 150
DEFVKRVFSV IHSNDPVARA ITLRMLGSLA SIIPERKNAH HSIRQSLDSH
160 170 180 190 200
DNVEVEAAVF AAANFSAQSK DFAVGICNKI SEMIQGLATP VDLKLKLIPI
210 220 230 240 250
LQHMHHDALL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL LAASSLVDTP
260 270 280 290 300
KQIQLLLQYL KNDPRKAVKR LAVQDLKLLA SKTPHTWSKE NIQALCECAL
310 320 330 340 350
HTPYDSLKLG MLSVLSTLSG TIAIKHYFSV VPGNVGSSPR SSDLVKLAQE
360 370 380 390 400
CCYHSNRGIA AHGVRVLTNI TVSCQEKDLL SLEQDAVFGL ESLLVLCSQD
410 420 430 440 450
DSPGAQSTVK SALSCMVKLA KGRPHLSRSV VDTLLTQLHS SQDAARILMC
460 470 480 490 500
HCLAAIAMQL PVLGDGMLGD LVELYKVIGR SATDKQQELL VSLATVIFVA
510 520 530 540 550
SQKALSAEVK AVIKQQLESV SSGWTVYRIA RQASRMGNHD MARELYQSLL
560 570 580 590 600
TQVASEHFYF WLNSLKEFSH AEQCLTGLQE DSFSSALSCI AESLKFYHKG
610 620 630 640 650
IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA
660 670 680 690 700
TTIAMTLGND LQRCGRISNQ MKQSMEEFRS LASRYRDLYQ ASFDADSATL
710 720 730 740 750
RNVELQQQSC LLIAHAIEAL VLDPESASFQ EYGSTGAAHA DSEYERRMMS
760 770 780 790 800
VYSRVLEEVE SLNRKYAPVS YMHTACLCNA IIALLKVPLS FQRYFFQKLQ
810 820 830 840 850
STSIKLALSP SPRSPAEPIA VQNNQQLALK VEGVVQHGSK PGLFRRVQSV
860 870 880 890 900
CLNVSSTLQS KSGQDYKIPI DSMTNEMEQR VEPHNDYFST QFLLNFAVLG
910 920 930 940 950
THSITVESSV RDANGIVWKT GPRTTMFVKS LEDPYSQQIR LQQQAQQPLQ
960
PQPLPQPQPR SAYTRF
Length:966
Mass (Da):106,861
Last modified:October 1, 2003 - v1
Checksum:i6A5D6DFC30E6447B
GO
Isoform 2 (identifier: Q7TQK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-498: SLATVIF → RNCFFLL
     499-966: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,617
Checksum:i8ED812863966A36A
GO

Sequence cautioni

The sequence BAC39426 differs from that shown. Reason: Frameshift at positions 552, 779 and 947.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti870I → L in BAC39426 (PubMed:16141072).Curated1
Sequence conflicti954L → Q in BAC39426 (PubMed:16141072).Curated1
Sequence conflicti954L → Q in BAC39671 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021465492 – 498SLATVIF → RNCFFLL in isoform 2. 1 Publication7
Alternative sequenceiVSP_021466499 – 966Missing in isoform 2. 1 PublicationAdd BLAST468

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085336 mRNA. Translation: BAC39426.1. Sequence problems.
AK085362 mRNA. Translation: BAC39430.1.
AK086462 mRNA. Translation: BAC39671.1.
BC054120 mRNA. Translation: AAH54120.1.
CCDSiCCDS35825.1. [Q7TQK1-1]
RefSeqiNP_001293132.1. NM_001306203.1.
NP_001293133.1. NM_001306204.1.
NP_848747.4. NM_178632.6.
UniGeneiMm.338175.
Mm.483145.

Genome annotation databases

GeneIDi77065.
KEGGimmu:77065.
UCSCiuc007eco.1. mouse. [Q7TQK1-2]
uc007ecp.1. mouse. [Q7TQK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiINT7_MOUSE
AccessioniPrimary (citable) accession number: Q7TQK1
Secondary accession number(s): Q8C3A9, Q8C3N4, Q8C3N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families