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Protein

MARVEL domain-containing protein 1

Gene

Marveld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147570. Marveld1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 599ExtracellularSequence analysis
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9414CytoplasmicSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Topological domaini116 – 13823ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 17314CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173MARVEL domain-containing protein 1PRO_0000271523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TQJ1.
PaxDbiQ7TQJ1.
PeptideAtlasiQ7TQJ1.
PRIDEiQ7TQJ1.

PTM databases

PhosphoSiteiQ7TQJ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044345.
CleanExiMM_MARVELD1.
ExpressionAtlasiQ7TQJ1. baseline and differential.
GenevisibleiQ7TQJ1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 166141MARVELPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Pro

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000049375.
HOGENOMiHOG000004795.
HOVERGENiHBG081949.
InParanoidiQ7TQJ1.
OMAiALYGCCR.
OrthoDBiEOG091G11L9.
PhylomeDBiQ7TQJ1.
TreeFamiTF316174.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPPPRQPP PQARTARGSL RLQRAFLRGP LGVLRLLQLL AGAAFWITIA
60 70 80 90 100
TSKYQGPVHF ALFVSVLFWL LTLGLYFITL LGKQELVPVL GSRWLVVNVA
110 120 130 140 150
HDLLAAALYG AATGIMIDQT QRHSYCNLKN YRLPCAYHAF LAASVCGGLC
160 170
LGLYLLSALY GCCRRYQGKE EVV
Length:173
Mass (Da):19,087
Last modified:October 1, 2003 - v1
Checksum:i7BA77E5316ED4BE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201L → W in BAC38165 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081212 mRNA. Translation: BAC38165.1.
AK132243 mRNA. Translation: BAE21054.1.
BC054384 mRNA. Translation: AAH54384.1.
CCDSiCCDS50439.1.
RefSeqiNP_899018.1. NM_183195.2.
UniGeneiMm.206250.

Genome annotation databases

EnsembliENSMUST00000061111; ENSMUSP00000053733; ENSMUSG00000044345.
GeneIDi277010.
KEGGimmu:277010.
UCSCiuc008hni.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081212 mRNA. Translation: BAC38165.1.
AK132243 mRNA. Translation: BAE21054.1.
BC054384 mRNA. Translation: AAH54384.1.
CCDSiCCDS50439.1.
RefSeqiNP_899018.1. NM_183195.2.
UniGeneiMm.206250.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053733.

PTM databases

PhosphoSiteiQ7TQJ1.

Proteomic databases

MaxQBiQ7TQJ1.
PaxDbiQ7TQJ1.
PeptideAtlasiQ7TQJ1.
PRIDEiQ7TQJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061111; ENSMUSP00000053733; ENSMUSG00000044345.
GeneIDi277010.
KEGGimmu:277010.
UCSCiuc008hni.2. mouse.

Organism-specific databases

CTDi83742.
MGIiMGI:2147570. Marveld1.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000049375.
HOGENOMiHOG000004795.
HOVERGENiHBG081949.
InParanoidiQ7TQJ1.
OMAiALYGCCR.
OrthoDBiEOG091G11L9.
PhylomeDBiQ7TQJ1.
TreeFamiTF316174.

Miscellaneous databases

PROiQ7TQJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044345.
CleanExiMM_MARVELD1.
ExpressionAtlasiQ7TQJ1. baseline and differential.
GenevisibleiQ7TQJ1. MM.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALD1_MOUSE
AccessioniPrimary (citable) accession number: Q7TQJ1
Secondary accession number(s): Q8BHQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.