Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene

Abtb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the initiation of hepatocyte growth.By similarity

GO - Biological processi

  • cellular response to toxic substance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
Gene namesi
Name:Abtb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139365. Abtb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10241024Ankyrin repeat and BTB/POZ domain-containing protein 2PRO_0000066888Add
BLAST

Proteomic databases

EPDiQ7TQI7.
MaxQBiQ7TQI7.
PaxDbiQ7TQI7.
PRIDEiQ7TQI7.

PTM databases

iPTMnetiQ7TQI7.
PhosphoSiteiQ7TQI7.

Expressioni

Gene expression databases

BgeeiQ7TQI7.
CleanExiMM_ABTB2.
ExpressionAtlasiQ7TQI7. baseline and differential.
GenevisibleiQ7TQI7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075566.

Structurei

3D structure databases

ProteinModelPortaliQ7TQI7.
SMRiQ7TQI7. Positions 522-680, 840-991.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati521 – 55030ANK 1Add
BLAST
Repeati567 – 59630ANK 2Add
BLAST
Repeati606 – 63530ANK 3Add
BLAST
Repeati649 – 67830ANK 4Add
BLAST
Domaini844 – 91370BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IESM. Eukaryota.
ENOG410XRDX. LUCA.
GeneTreeiENSGT00550000074669.
HOGENOMiHOG000033776.
HOVERGENiHBG050447.
InParanoidiQ7TQI7.
KOiK10521.
OMAiTYKYAKI.
OrthoDBiEOG773XF8.
PhylomeDBiQ7TQI7.
TreeFamiTF106437.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009072. Histone-fold.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR
60 70 80 90 100
GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT
110 120 130 140 150
EGDVARVLRK SVGGRRLPSF SAEAVRRLAG LLRRALIRVA REAQRLSVLH
160 170 180 190 200
AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR
210 220 230 240 250
CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVLASQ
260 270 280 290 300
SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
310 320 330 340 350
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA
360 370 380 390 400
MHHMQGRHPL CPGTSPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME
410 420 430 440 450
NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSP TVDSGDIRQA
460 470 480 490 500
ARLLLPGLDC EPRQLKPECC FSSFRRLDAR AATERFNQDL GFRMLNCGRT
510 520 530 540 550
DLISQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM LIDAGANLDI
560 570 580 590 600
QVPSHSPRHP SVHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
610 620 630 640 650
SGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA NGMASSLHEE
660 670 680 690 700
MNCFSHSAAH GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDTSSQG
710 720 730 740 750
SSEGPVRLSR TRTKALQEAM YYSAEHGYLD ITMELRALGV PWKLHIWIES
760 770 780 790 800
LRTSFSQSRY SVVQSLLKDF SSIKEEEYNE ELVTEGLQLM FDILKTSKND
810 820 830 840 850
SVLQQLATIF THCYGTSPIP SIPEIRKTLP ARLDPHFLNN KEMSDVTFLV
860 870 880 890 900
EGKLFYAHKV LLVTASNRFK TLMTNKSEQD GDSSKTIEIS DIKYHIFQML
910 920 930 940 950
MQYLYYGGTE SMEIPTADIL QLLSAANLFQ LDALQRHCEI LCSQTLSVES
960 970 980 990 1000
AVNTYKYAKI HNAPELALFC EGFFLKHMKA LLEQDAFRQL IYGRSSKVQG
1010 1020
LDPLQDLQST LAERVHSVYV TSRV
Length:1,024
Mass (Da):113,503
Last modified:October 1, 2003 - v1
Checksum:i39509A02F0DE093A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054399 mRNA. Translation: AAH54399.1.
CCDSiCCDS16479.1.
RefSeqiNP_849221.2. NM_178890.3.
UniGeneiMm.35850.

Genome annotation databases

EnsembliENSMUST00000076212; ENSMUSP00000075566; ENSMUSG00000032724.
GeneIDi99382.
KEGGimmu:99382.
UCSCiuc008lix.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054399 mRNA. Translation: AAH54399.1.
CCDSiCCDS16479.1.
RefSeqiNP_849221.2. NM_178890.3.
UniGeneiMm.35850.

3D structure databases

ProteinModelPortaliQ7TQI7.
SMRiQ7TQI7. Positions 522-680, 840-991.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075566.

PTM databases

iPTMnetiQ7TQI7.
PhosphoSiteiQ7TQI7.

Proteomic databases

EPDiQ7TQI7.
MaxQBiQ7TQI7.
PaxDbiQ7TQI7.
PRIDEiQ7TQI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076212; ENSMUSP00000075566; ENSMUSG00000032724.
GeneIDi99382.
KEGGimmu:99382.
UCSCiuc008lix.1. mouse.

Organism-specific databases

CTDi25841.
MGIiMGI:2139365. Abtb2.

Phylogenomic databases

eggNOGiENOG410IESM. Eukaryota.
ENOG410XRDX. LUCA.
GeneTreeiENSGT00550000074669.
HOGENOMiHOG000033776.
HOVERGENiHBG050447.
InParanoidiQ7TQI7.
KOiK10521.
OMAiTYKYAKI.
OrthoDBiEOG773XF8.
PhylomeDBiQ7TQI7.
TreeFamiTF106437.

Miscellaneous databases

ChiTaRSiAbtb2. mouse.
PROiQ7TQI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TQI7.
CleanExiMM_ABTB2.
ExpressionAtlasiQ7TQI7. baseline and differential.
GenevisibleiQ7TQI7. MM.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009072. Histone-fold.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Liver and Testis.

Entry informationi

Entry nameiABTB2_MOUSE
AccessioniPrimary (citable) accession number: Q7TQI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.