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Protein

Pleckstrin homology domain-containing family A member 6

Gene

Plekha6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 6
Short name:
PH domain-containing family A member 6
Alternative name(s):
Phosphoinositol 3-phosphate-binding protein 3
Short name:
PEPP-3
Gene namesi
Name:Plekha6
Synonyms:Pepp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2388662. Plekha6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11731173Pleckstrin homology domain-containing family A member 6PRO_0000053885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei251 – 2511PhosphoserineCombined sources
Modified residuei314 – 3141PhosphoserineCombined sources
Modified residuei459 – 4591PhosphoserineBy similarity
Modified residuei461 – 4611PhosphoserineBy similarity
Modified residuei472 – 4721PhosphoserineBy similarity
Modified residuei492 – 4921PhosphotyrosineCombined sources
Modified residuei665 – 6651PhosphoserineBy similarity
Modified residuei864 – 8641PhosphoserineCombined sources
Modified residuei868 – 8681PhosphothreonineCombined sources
Modified residuei901 – 9011PhosphoserineCombined sources
Modified residuei908 – 9081PhosphothreonineCombined sources
Modified residuei925 – 9251PhosphoserineCombined sources
Modified residuei973 – 9731PhosphoserineBy similarity
Modified residuei979 – 9791PhosphoserineBy similarity
Modified residuei992 – 9921PhosphoserineCombined sources
Modified residuei1140 – 11401PhosphothreonineCombined sources
Modified residuei1142 – 11421PhosphoserineCombined sources
Modified residuei1145 – 11451PhosphothreonineCombined sources
Modified residuei1146 – 11461PhosphoserineCombined sources
Modified residuei1149 – 11491PhosphoserineCombined sources
Modified residuei1151 – 11511PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TQG1.
PaxDbiQ7TQG1.
PRIDEiQ7TQG1.

PTM databases

iPTMnetiQ7TQG1.
PhosphoSiteiQ7TQG1.

Expressioni

Gene expression databases

BgeeiQ7TQG1.
ExpressionAtlasiQ7TQG1. baseline and differential.
GenevisibleiQ7TQG1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ7TQG1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7TQG1.
SMRiQ7TQG1. Positions 47-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 158100PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi791 – 83646Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ7TQG1.
OMAiKHTFKVT.
OrthoDBiEOG7VDXNZ.
PhylomeDBiQ7TQG1.
TreeFamiTF329090.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKTGGKRS ATINSDIANH NMVSEVPPER PNIRATRTSR KAIAFGKRAH
60 70 80 90 100
SMKRNPNAPV TKAGWLYKQA SSGVKQWNKR WFVLVDRCLF YYKDEKQESI
110 120 130 140 150
LGSIPLLSFR VAAVQPSDNI SRKHTFKAEH AGVRTYFFSA ESPEEQEAWI
160 170 180 190 200
QAMGEAARVQ IPPAQKSVPQ PVRHSLEKPD SENIPPSKHH QQPPHNNLTK
210 220 230 240 250
LEPEAKTRGE GDGRGCEKAE RRPERPEVKK ETLVKANGLP SGPETASEPG
260 270 280 290 300
SPYPDGPRVP GGGEHPAQPN GWQYSSPSRP GSTAFPPHDG DSGGQRRSFP
310 320 330 340 350
PRTDPDKIAQ RKSSMNQLQQ WVNLRRGVPP PEDLRSPSRF YPMPRRVPDY
360 370 380 390 400
YNPYSSQYPD DYQYYPPGVR PDSICSMPAY DRISPPWALE DKRHSFRNGG
410 420 430 440 450
GPTYQLHEWK ESTSYGRQDG TVWIPSPSRQ PVFYDELDAA SGSLRRLSLQ
460 470 480 490 500
PRSHSVPRSP SQGSYSRARI YSPVRSPSAR FDRLPPRSED IYADPAAYVM
510 520 530 540 550
RRSISSPKYD YLGDRRPVPA GLFPYNYPSS PTVHDKMDEL LDLQLQRNLE
560 570 580 590 600
YLDQQMSESE TLISMVNRMV ENSSPRAHLF MQVPAYPEVF RDGLHTFKLN
610 620 630 640 650
EQDTDKLLGK LCEQNKVVRE QERLVQQLRA EKESLESALM GTHQELEMFG
660 670 680 690 700
SQPAYPEKLL HKKESLQNQL INIRVELSQA TTALTNSTVV YENLESEVSA
710 720 730 740 750
LHDELWEQLN LDIQNEVLNR QIQKEIWRIQ DVMEGLRKNN PSRGTDTAKH
760 770 780 790 800
RGGLGPSATY SSNSPASPLS SASLTSPLSP FSMVSGSQGS PTKPGSSEEP
810 820 830 840 850
GPPRPPLPKA YVPLESPPTV PPLPNESRFW PYPNSPSWHR SGETAKGQPK
860 870 880 890 900
TGYETSKKDP SQTSPLGTPR DINLVPTRQE VEAEKQAALN KVGIVPPRTK
910 920 930 940 950
SPAEEELTPS AVVRRTTNGL TNGLSSRQER PKSAVFSGEG KVKMSVEEQM
960 970 980 990 1000
DRMRRHQSGS MKEKRRSLQL PASPAPEPST RPAYKVVRRH RSIHEVDISN
1010 1020 1030 1040 1050
LEAALRAEEP GGQAYETPRE EIARLRKMEL EPQHYDVDIS KELSTPDKVL
1060 1070 1080 1090 1100
IPERYIDLEP DTPLSPEELK EKQKKVERIK TLIAKSSMQN VVPIGEGDSV
1110 1120 1130 1140 1150
DVPQDSESQL QEQEKRIEIS CALATEASRR GRMLSVQCAT PSPPTSPASP
1160 1170
TPPVNPLSSD RPRGADSSHT MRV
Length:1,173
Mass (Da):131,427
Last modified:October 1, 2003 - v1
Checksum:iA71B82D513EE8B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031183 mRNA. Translation: AAH31183.1.
BC054547 mRNA. Translation: AAH54547.1.
CCDSiCCDS15292.1.
RefSeqiNP_891846.1. NM_182930.2.
UniGeneiMm.253559.

Genome annotation databases

EnsembliENSMUST00000038295; ENSMUSP00000048214; ENSMUSG00000041757.
GeneIDi240753.
KEGGimmu:240753.
UCSCiuc007cpu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031183 mRNA. Translation: AAH31183.1.
BC054547 mRNA. Translation: AAH54547.1.
CCDSiCCDS15292.1.
RefSeqiNP_891846.1. NM_182930.2.
UniGeneiMm.253559.

3D structure databases

ProteinModelPortaliQ7TQG1.
SMRiQ7TQG1. Positions 47-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TQG1. 1 interaction.

PTM databases

iPTMnetiQ7TQG1.
PhosphoSiteiQ7TQG1.

Proteomic databases

MaxQBiQ7TQG1.
PaxDbiQ7TQG1.
PRIDEiQ7TQG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038295; ENSMUSP00000048214; ENSMUSG00000041757.
GeneIDi240753.
KEGGimmu:240753.
UCSCiuc007cpu.2. mouse.

Organism-specific databases

CTDi22874.
MGIiMGI:2388662. Plekha6.

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ7TQG1.
OMAiKHTFKVT.
OrthoDBiEOG7VDXNZ.
PhylomeDBiQ7TQG1.
TreeFamiTF329090.

Miscellaneous databases

PROiQ7TQG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TQG1.
ExpressionAtlasiQ7TQG1. baseline and differential.
GenevisibleiQ7TQG1. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon and Fetal brain.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-868; SER-901 AND SER-992, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-492, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-925, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247; SER-251; SER-314; SER-864; THR-868; SER-901; THR-908; SER-992; THR-1140; SER-1142; THR-1145; SER-1146; SER-1149 AND THR-1151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPKHA6_MOUSE
AccessioniPrimary (citable) accession number: Q7TQG1
Secondary accession number(s): Q8K0J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.