Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology domain-containing family A member 6

Gene

Plekha6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 6
Short name:
PH domain-containing family A member 6
Alternative name(s):
Phosphoinositol 3-phosphate-binding protein 3
Short name:
PEPP-3
Gene namesi
Name:Plekha6
Synonyms:Pepp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2388662. Plekha6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538851 – 1173Pleckstrin homology domain-containing family A member 6Add BLAST1173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei247PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei459PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Modified residuei492PhosphotyrosineCombined sources1
Modified residuei665PhosphoserineBy similarity1
Modified residuei864PhosphoserineCombined sources1
Modified residuei868PhosphothreonineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei908PhosphothreonineCombined sources1
Modified residuei925PhosphoserineCombined sources1
Modified residuei973PhosphoserineBy similarity1
Modified residuei979PhosphoserineBy similarity1
Modified residuei992PhosphoserineCombined sources1
Modified residuei1045PhosphothreonineBy similarity1
Modified residuei1065PhosphoserineBy similarity1
Modified residuei1140PhosphothreonineCombined sources1
Modified residuei1142PhosphoserineCombined sources1
Modified residuei1145PhosphothreonineCombined sources1
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TQG1.
PaxDbiQ7TQG1.
PRIDEiQ7TQG1.

PTM databases

iPTMnetiQ7TQG1.
PhosphoSitePlusiQ7TQG1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041757.
ExpressionAtlasiQ7TQG1. baseline and differential.
GenevisibleiQ7TQG1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ7TQG1. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ7TQG1.
SMRiQ7TQG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 158PHPROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi791 – 836Pro-richAdd BLAST46

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ7TQG1.
OMAiKHTFKVT.
OrthoDBiEOG091G01D9.
PhylomeDBiQ7TQG1.
TreeFamiTF329090.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKTGGKRS ATINSDIANH NMVSEVPPER PNIRATRTSR KAIAFGKRAH
60 70 80 90 100
SMKRNPNAPV TKAGWLYKQA SSGVKQWNKR WFVLVDRCLF YYKDEKQESI
110 120 130 140 150
LGSIPLLSFR VAAVQPSDNI SRKHTFKAEH AGVRTYFFSA ESPEEQEAWI
160 170 180 190 200
QAMGEAARVQ IPPAQKSVPQ PVRHSLEKPD SENIPPSKHH QQPPHNNLTK
210 220 230 240 250
LEPEAKTRGE GDGRGCEKAE RRPERPEVKK ETLVKANGLP SGPETASEPG
260 270 280 290 300
SPYPDGPRVP GGGEHPAQPN GWQYSSPSRP GSTAFPPHDG DSGGQRRSFP
310 320 330 340 350
PRTDPDKIAQ RKSSMNQLQQ WVNLRRGVPP PEDLRSPSRF YPMPRRVPDY
360 370 380 390 400
YNPYSSQYPD DYQYYPPGVR PDSICSMPAY DRISPPWALE DKRHSFRNGG
410 420 430 440 450
GPTYQLHEWK ESTSYGRQDG TVWIPSPSRQ PVFYDELDAA SGSLRRLSLQ
460 470 480 490 500
PRSHSVPRSP SQGSYSRARI YSPVRSPSAR FDRLPPRSED IYADPAAYVM
510 520 530 540 550
RRSISSPKYD YLGDRRPVPA GLFPYNYPSS PTVHDKMDEL LDLQLQRNLE
560 570 580 590 600
YLDQQMSESE TLISMVNRMV ENSSPRAHLF MQVPAYPEVF RDGLHTFKLN
610 620 630 640 650
EQDTDKLLGK LCEQNKVVRE QERLVQQLRA EKESLESALM GTHQELEMFG
660 670 680 690 700
SQPAYPEKLL HKKESLQNQL INIRVELSQA TTALTNSTVV YENLESEVSA
710 720 730 740 750
LHDELWEQLN LDIQNEVLNR QIQKEIWRIQ DVMEGLRKNN PSRGTDTAKH
760 770 780 790 800
RGGLGPSATY SSNSPASPLS SASLTSPLSP FSMVSGSQGS PTKPGSSEEP
810 820 830 840 850
GPPRPPLPKA YVPLESPPTV PPLPNESRFW PYPNSPSWHR SGETAKGQPK
860 870 880 890 900
TGYETSKKDP SQTSPLGTPR DINLVPTRQE VEAEKQAALN KVGIVPPRTK
910 920 930 940 950
SPAEEELTPS AVVRRTTNGL TNGLSSRQER PKSAVFSGEG KVKMSVEEQM
960 970 980 990 1000
DRMRRHQSGS MKEKRRSLQL PASPAPEPST RPAYKVVRRH RSIHEVDISN
1010 1020 1030 1040 1050
LEAALRAEEP GGQAYETPRE EIARLRKMEL EPQHYDVDIS KELSTPDKVL
1060 1070 1080 1090 1100
IPERYIDLEP DTPLSPEELK EKQKKVERIK TLIAKSSMQN VVPIGEGDSV
1110 1120 1130 1140 1150
DVPQDSESQL QEQEKRIEIS CALATEASRR GRMLSVQCAT PSPPTSPASP
1160 1170
TPPVNPLSSD RPRGADSSHT MRV
Length:1,173
Mass (Da):131,427
Last modified:October 1, 2003 - v1
Checksum:iA71B82D513EE8B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031183 mRNA. Translation: AAH31183.1.
BC054547 mRNA. Translation: AAH54547.1.
CCDSiCCDS15292.1.
RefSeqiNP_891846.1. NM_182930.2.
UniGeneiMm.253559.

Genome annotation databases

EnsembliENSMUST00000038295; ENSMUSP00000048214; ENSMUSG00000041757.
GeneIDi240753.
KEGGimmu:240753.
UCSCiuc007cpu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031183 mRNA. Translation: AAH31183.1.
BC054547 mRNA. Translation: AAH54547.1.
CCDSiCCDS15292.1.
RefSeqiNP_891846.1. NM_182930.2.
UniGeneiMm.253559.

3D structure databases

ProteinModelPortaliQ7TQG1.
SMRiQ7TQG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TQG1. 1 interactor.

PTM databases

iPTMnetiQ7TQG1.
PhosphoSitePlusiQ7TQG1.

Proteomic databases

MaxQBiQ7TQG1.
PaxDbiQ7TQG1.
PRIDEiQ7TQG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038295; ENSMUSP00000048214; ENSMUSG00000041757.
GeneIDi240753.
KEGGimmu:240753.
UCSCiuc007cpu.2. mouse.

Organism-specific databases

CTDi22874.
MGIiMGI:2388662. Plekha6.

Phylogenomic databases

eggNOGiENOG410IKMF. Eukaryota.
ENOG410ZX2B. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115554.
HOVERGENiHBG099912.
InParanoidiQ7TQG1.
OMAiKHTFKVT.
OrthoDBiEOG091G01D9.
PhylomeDBiQ7TQG1.
TreeFamiTF329090.

Miscellaneous databases

PROiQ7TQG1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041757.
ExpressionAtlasiQ7TQG1. baseline and differential.
GenevisibleiQ7TQG1. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHA6_MOUSE
AccessioniPrimary (citable) accession number: Q7TQG1
Secondary accession number(s): Q8K0J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.