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Protein

Zinc finger and BTB domain-containing protein 5

Gene

Zbtb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri606 – 628C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 657C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 5
Alternative name(s):
Transcription factor ZNF-POZ
Gene namesi
Name:Zbtb5
Synonyms:Kiaa0354
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924601. Zbtb5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477141 – 670Zinc finger and BTB domain-containing protein 5Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7TQG0.
PRIDEiQ7TQG0.

PTM databases

iPTMnetiQ7TQG0.
PhosphoSitePlusiQ7TQG0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049657.
CleanExiMM_ZBTB5.
ExpressionAtlasiQ7TQG0. baseline and differential.
GenevisibleiQ7TQG0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059919.

Structurei

3D structure databases

ProteinModelPortaliQ7TQG0.
SMRiQ7TQG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 93BTBPROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri606 – 628C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 657C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiQ7TQG0.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG091G0570.
PhylomeDBiQ7TQG0.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPSS ERAQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALSS SQSAEEPTAP MSSSMRSSLD QRTPFPMRRL HKRKQSVEER
210 220 230 240 250
ARQRLRSSME ESAISDVTPE SGPAGVHSRE EFFSPDSLKI VDNPKPDGMA
260 270 280 290 300
DNQEDGAMMF DRPFGAQEDA QVPSQSDGSA GNMASRATQV ETSFEQEAVA
310 320 330 340 350
EKGSFQCENP EVGLGEKEHM RVVVKSEPLS SPEPQDEVSD VTSQAEGSES
360 370 380 390 400
VEVEGVVVSA EKIDLSPESS DRSFSDPQSS TDRVGDIHIL EVTNNLEHKT
410 420 430 440 450
SFSISNFLNK SRGSNFSASQ STDDNLPNTT SDCRLEGEAP YLLSPEAGPA
460 470 480 490 500
GGPSSAPGSH VENPFSEPAD SHFVRPMQEV MGLPCVQTSG YQGEQFGMDF
510 520 530 540 550
SRSGLGLHSS FSRAMMGSPR GGASNFPYYR RIAPKMPVVT SVRSSQISEN
560 570 580 590 600
SASSQLMMNG ATSFENGHTS QPGPPQLTRA SADVLSKCKK ALSEHNVLVV
610 620 630 640 650
EGARKYACKI CCKTFLTLTD CKKHIRVHTG EKPYACLKCG KRFSQSSHLY
660 670
KHSKTTCLRW QSSNLPSTLL
Length:670
Mass (Da):73,215
Last modified:October 1, 2003 - v1
Checksum:i0DFD572C5B01B2AE
GO

Sequence cautioni

The sequence BAC97934 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → W in BAE35551 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635051 mRNA. Translation: AAT47717.1.
AK160003 mRNA. Translation: BAE35551.1.
AK129124 mRNA. Translation: BAC97934.1. Different initiation.
BC054551 mRNA. Translation: AAH54551.1.
BC057545 mRNA. Translation: AAH57545.1.
CCDSiCCDS18129.1.
RefSeqiNP_001156755.1. NM_001163283.1.
NP_001156756.1. NM_001163284.1.
NP_775575.2. NM_173399.3.
UniGeneiMm.44222.

Genome annotation databases

EnsembliENSMUST00000055028; ENSMUSP00000059919; ENSMUSG00000049657.
ENSMUST00000107817; ENSMUSP00000103447; ENSMUSG00000049657.
ENSMUST00000180217; ENSMUSP00000136507; ENSMUSG00000049657.
GeneIDi230119.
KEGGimmu:230119.
UCSCiuc008ssc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635051 mRNA. Translation: AAT47717.1.
AK160003 mRNA. Translation: BAE35551.1.
AK129124 mRNA. Translation: BAC97934.1. Different initiation.
BC054551 mRNA. Translation: AAH54551.1.
BC057545 mRNA. Translation: AAH57545.1.
CCDSiCCDS18129.1.
RefSeqiNP_001156755.1. NM_001163283.1.
NP_001156756.1. NM_001163284.1.
NP_775575.2. NM_173399.3.
UniGeneiMm.44222.

3D structure databases

ProteinModelPortaliQ7TQG0.
SMRiQ7TQG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059919.

PTM databases

iPTMnetiQ7TQG0.
PhosphoSitePlusiQ7TQG0.

Proteomic databases

PaxDbiQ7TQG0.
PRIDEiQ7TQG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055028; ENSMUSP00000059919; ENSMUSG00000049657.
ENSMUST00000107817; ENSMUSP00000103447; ENSMUSG00000049657.
ENSMUST00000180217; ENSMUSP00000136507; ENSMUSG00000049657.
GeneIDi230119.
KEGGimmu:230119.
UCSCiuc008ssc.2. mouse.

Organism-specific databases

CTDi9925.
MGIiMGI:1924601. Zbtb5.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234181.
HOVERGENiHBG058500.
InParanoidiQ7TQG0.
KOiK10492.
OMAiSFGAQED.
OrthoDBiEOG091G0570.
PhylomeDBiQ7TQG0.
TreeFamiTF330979.

Miscellaneous databases

PROiQ7TQG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049657.
CleanExiMM_ZBTB5.
ExpressionAtlasiQ7TQG0. baseline and differential.
GenevisibleiQ7TQG0. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB5_MOUSE
AccessioniPrimary (citable) accession number: Q7TQG0
Secondary accession number(s): Q3TVR7, Q6GV09, Q8BIB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.