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Protein

F-box only protein 10

Gene

Fbxo10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:Fbxo10
Synonyms:Gm634
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2686937 Fbxo10

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077181 – 950F-box only protein 10Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TQF2
PaxDbiQ7TQF2
PeptideAtlasiQ7TQF2
PRIDEiQ7TQF2

PTM databases

iPTMnetiQ7TQF2
PhosphoSitePlusiQ7TQF2

Expressioni

Gene expression databases

BgeeiENSMUSG00000048232
CleanExiMM_FBXO10
ExpressionAtlasiQ7TQF2 baseline and differential
GenevisibleiQ7TQF2 MM

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2. Interacts with PRDM1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058233

Structurei

3D structure databases

ProteinModelPortaliQ7TQF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati198 – 217PbH1 1Add BLAST20
Repeati238 – 260PbH1 2Add BLAST23
Repeati423 – 444PbH1 3Add BLAST22
Repeati467 – 489PbH1 4Add BLAST23
Repeati490 – 512PbH1 5Add BLAST23
Repeati513 – 535PbH1 6Add BLAST23
Repeati536 – 558PbH1 7Add BLAST23
Repeati559 – 581PbH1 8Add BLAST23
Repeati582 – 604PbH1 9Add BLAST23
Repeati605 – 627PbH1 10Add BLAST23
Repeati628 – 650PbH1 11Add BLAST23
Repeati651 – 673PbH1 12Add BLAST23
Repeati713 – 735PbH1 13Add BLAST23
Repeati736 – 758PbH1 14Add BLAST23
Repeati760 – 782PbH1 15Add BLAST23
Repeati783 – 805PbH1 16Add BLAST23
Repeati828 – 850PbH1 17Add BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPED Eukaryota
ENOG410ZF90 LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000112542
HOVERGENiHBG080399
InParanoidiQ7TQF2
KOiK10296
OMAiDVEPESW
OrthoDBiEOG091G0AXA
PhylomeDBiQ7TQF2
TreeFamiTF313602

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 17 hits
SUPFAMiSSF51126 SSF51126, 4 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL
60 70 80 90 100
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL
110 120 130 140 150
FRRKKERRTL SVGPGHEFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK
160 170 180 190 200
VPVEIVGQGK LGEVALLASI DQHCSTTRVC NLVFMPAWFS PIMYKTTSGH
210 220 230 240 250
IQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THVFLHNVPL CMLENCEFVG
260 270 280 290 300
SENNCVTVEG HPSADKNWAY KYLLGLIKSS PIFLPAEDHD FLMSLDLESR
310 320 330 340 350
DQAWSPRTCD IVIEGSQSPT SPVCSSPKPG SKEAEVGSDG ERVAQTPDSS
360 370 380 390 400
DGGLSPSGED EDDEQLTYRL SYQVQGPRPV LGGSFLGPPL PGASIQLPSC
410 420 430 440 450
LVLNSLHQEL QKDKEAMALA SSVQGCLIRK CLFRDGKGGV FVCSYGRAKM
460 470 480 490 500
EGNVFRNLTY AVRCIHNSKI VMLRNDIYRC RASGIFLRLE GGGLIAGNNI
510 520 530 540 550
YHNAEAGVDI RKKSNPLILC NQIHHGLRSG IVVLGNGKGV IRNNQIFSNK
560 570 580 590 600
EAGIYILYHG NPIVSGNHIF KGRAAGIAVN ENGKGLITEN VIRENQWGGV
610 620 630 640 650
DIRRGGVPIL RSNLICFGYS DGVVVGDEGK GLIEGNTIYA NKGCGVWMMS
660 670 680 690 700
SSLPHVTSNH VSYNGLYGVA VFSQKDGEFP GGHGAQENFS EDGDAILWEA
710 720 730 740 750
ELEKEDDPLR RPITVALVES NSINHNGASG IFVQSSEALQ VVANVIHANG
760 770 780 790 800
DRGITIVQSS QLTRVANNSI SCNRQSGVKV EFQCKVELRG NGIYDNRGHG
810 820 830 840 850
IITKGDGTAV VENDIIGNRG SGLQLLPRSD TKVLKNRIHS FRAYGIAVRG
860 870 880 890 900
RVKALVQENI IFQGKTNKTI FQQITNNREC IMQNNKFLVF KKKSDTWRLV
910 920 930 940 950
NPPARPHLEN SLRGSSAAHS GHKVTAMATR ITARVEGGYH SNRSIFCTIL
Length:950
Mass (Da):104,478
Last modified:October 23, 2007 - v2
Checksum:iD526F93603113458
GO

Sequence cautioni

The sequence AAH54731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192I → T in AAH54731 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL824706 Genomic DNA No translation available.
BC052485 mRNA Translation: AAH52485.1
BC054731 mRNA Translation: AAH54731.1 Different initiation.
BC079571 mRNA Translation: AAH79571.1
CCDSiCCDS51171.1
RefSeqiNP_001019313.1, NM_001024142.1
UniGeneiMm.389552
Mm.490989

Genome annotation databases

EnsembliENSMUST00000052236; ENSMUSP00000058233; ENSMUSG00000048232
GeneIDi269529
KEGGimmu:269529
UCSCiuc008ssf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFBX10_MOUSE
AccessioniPrimary (citable) accession number: Q7TQF2
Secondary accession number(s): A2ANI6, Q6AXG0, Q7TQM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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