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Protein

F-box only protein 10

Gene

Fbxo10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:Fbxo10
Synonyms:Gm634
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2686937. Fbxo10.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077181 – 950F-box only protein 10Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TQF2.
PaxDbiQ7TQF2.
PeptideAtlasiQ7TQF2.
PRIDEiQ7TQF2.

PTM databases

iPTMnetiQ7TQF2.
PhosphoSitePlusiQ7TQF2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048232.
CleanExiMM_FBXO10.
ExpressionAtlasiQ7TQF2. baseline and differential.
GenevisibleiQ7TQF2. MM.

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2. Interacts with PRDM1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058233.

Structurei

3D structure databases

ProteinModelPortaliQ7TQF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati198 – 217PbH1 1Add BLAST20
Repeati238 – 260PbH1 2Add BLAST23
Repeati423 – 444PbH1 3Add BLAST22
Repeati467 – 489PbH1 4Add BLAST23
Repeati490 – 512PbH1 5Add BLAST23
Repeati513 – 535PbH1 6Add BLAST23
Repeati536 – 558PbH1 7Add BLAST23
Repeati559 – 581PbH1 8Add BLAST23
Repeati582 – 604PbH1 9Add BLAST23
Repeati605 – 627PbH1 10Add BLAST23
Repeati628 – 650PbH1 11Add BLAST23
Repeati651 – 673PbH1 12Add BLAST23
Repeati713 – 735PbH1 13Add BLAST23
Repeati736 – 758PbH1 14Add BLAST23
Repeati760 – 782PbH1 15Add BLAST23
Repeati783 – 805PbH1 16Add BLAST23
Repeati828 – 850PbH1 17Add BLAST23

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 17 PbH1 repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPED. Eukaryota.
ENOG410ZF90. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ7TQF2.
KOiK10296.
OMAiPRSDTKV.
OrthoDBiEOG091G0AXA.
PhylomeDBiQ7TQF2.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 2 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 17 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL
60 70 80 90 100
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL
110 120 130 140 150
FRRKKERRTL SVGPGHEFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK
160 170 180 190 200
VPVEIVGQGK LGEVALLASI DQHCSTTRVC NLVFMPAWFS PIMYKTTSGH
210 220 230 240 250
IQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THVFLHNVPL CMLENCEFVG
260 270 280 290 300
SENNCVTVEG HPSADKNWAY KYLLGLIKSS PIFLPAEDHD FLMSLDLESR
310 320 330 340 350
DQAWSPRTCD IVIEGSQSPT SPVCSSPKPG SKEAEVGSDG ERVAQTPDSS
360 370 380 390 400
DGGLSPSGED EDDEQLTYRL SYQVQGPRPV LGGSFLGPPL PGASIQLPSC
410 420 430 440 450
LVLNSLHQEL QKDKEAMALA SSVQGCLIRK CLFRDGKGGV FVCSYGRAKM
460 470 480 490 500
EGNVFRNLTY AVRCIHNSKI VMLRNDIYRC RASGIFLRLE GGGLIAGNNI
510 520 530 540 550
YHNAEAGVDI RKKSNPLILC NQIHHGLRSG IVVLGNGKGV IRNNQIFSNK
560 570 580 590 600
EAGIYILYHG NPIVSGNHIF KGRAAGIAVN ENGKGLITEN VIRENQWGGV
610 620 630 640 650
DIRRGGVPIL RSNLICFGYS DGVVVGDEGK GLIEGNTIYA NKGCGVWMMS
660 670 680 690 700
SSLPHVTSNH VSYNGLYGVA VFSQKDGEFP GGHGAQENFS EDGDAILWEA
710 720 730 740 750
ELEKEDDPLR RPITVALVES NSINHNGASG IFVQSSEALQ VVANVIHANG
760 770 780 790 800
DRGITIVQSS QLTRVANNSI SCNRQSGVKV EFQCKVELRG NGIYDNRGHG
810 820 830 840 850
IITKGDGTAV VENDIIGNRG SGLQLLPRSD TKVLKNRIHS FRAYGIAVRG
860 870 880 890 900
RVKALVQENI IFQGKTNKTI FQQITNNREC IMQNNKFLVF KKKSDTWRLV
910 920 930 940 950
NPPARPHLEN SLRGSSAAHS GHKVTAMATR ITARVEGGYH SNRSIFCTIL
Length:950
Mass (Da):104,478
Last modified:October 23, 2007 - v2
Checksum:iD526F93603113458
GO

Sequence cautioni

The sequence AAH54731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192I → T in AAH54731 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL824706 Genomic DNA. Translation: CAM17797.1.
BC052485 mRNA. Translation: AAH52485.1.
BC054731 mRNA. Translation: AAH54731.1. Different initiation.
BC079571 mRNA. Translation: AAH79571.1.
CCDSiCCDS51171.1.
RefSeqiNP_001019313.1. NM_001024142.1.
UniGeneiMm.389552.
Mm.490989.

Genome annotation databases

EnsembliENSMUST00000052236; ENSMUSP00000058233; ENSMUSG00000048232.
GeneIDi269529.
KEGGimmu:269529.
UCSCiuc008ssf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL824706 Genomic DNA. Translation: CAM17797.1.
BC052485 mRNA. Translation: AAH52485.1.
BC054731 mRNA. Translation: AAH54731.1. Different initiation.
BC079571 mRNA. Translation: AAH79571.1.
CCDSiCCDS51171.1.
RefSeqiNP_001019313.1. NM_001024142.1.
UniGeneiMm.389552.
Mm.490989.

3D structure databases

ProteinModelPortaliQ7TQF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058233.

PTM databases

iPTMnetiQ7TQF2.
PhosphoSitePlusiQ7TQF2.

Proteomic databases

MaxQBiQ7TQF2.
PaxDbiQ7TQF2.
PeptideAtlasiQ7TQF2.
PRIDEiQ7TQF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052236; ENSMUSP00000058233; ENSMUSG00000048232.
GeneIDi269529.
KEGGimmu:269529.
UCSCiuc008ssf.2. mouse.

Organism-specific databases

CTDi26267.
MGIiMGI:2686937. Fbxo10.

Phylogenomic databases

eggNOGiENOG410IPED. Eukaryota.
ENOG410ZF90. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ7TQF2.
KOiK10296.
OMAiPRSDTKV.
OrthoDBiEOG091G0AXA.
PhylomeDBiQ7TQF2.
TreeFamiTF313602.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ7TQF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048232.
CleanExiMM_FBXO10.
ExpressionAtlasiQ7TQF2. baseline and differential.
GenevisibleiQ7TQF2. MM.

Family and domain databases

Gene3Di2.160.20.10. 2 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 17 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX10_MOUSE
AccessioniPrimary (citable) accession number: Q7TQF2
Secondary accession number(s): A2ANI6, Q6AXG0, Q7TQM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.