ID   TR135_MOUSE             Reviewed;         312 AA.
AC   Q7TQA9; A4FUQ3; Q7M705;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   08-NOV-2023, entry version 111.
DE   RecName: Full=Taste receptor type 2 member 135;
DE            Short=T2R135;
DE   AltName: Full=Taste receptor type 2 member 35;
DE            Short=T2R35;
DE            Short=mT2r38;
GN   Name=Tas2r135; Synonyms=T2r38, Tas2r35;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40336.1};
RN   [1] {ECO:0000312|EMBL:AAP40336.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40336.1};
RX   PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA   Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT   "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT   and human.";
RL   Physiol. Genomics 14:73-82(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=12679530; DOI=10.1093/molbev/msg083;
RA   Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT   "Adaptive diversification of bitter taste receptor genes in mammalian
RT   evolution.";
RL   Mol. Biol. Evol. 20:805-814(2003).
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP40336.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF532786; AAP40336.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC153022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC115532; AAI15533.1; -; mRNA.
DR   EMBL; BC115533; AAI15534.1; -; mRNA.
DR   EMBL; BK001097; DAA01236.1; -; Genomic_DNA.
DR   RefSeq; NP_954610.1; NM_199159.1.
DR   AlphaFoldDB; Q7TQA9; -.
DR   SMR; Q7TQA9; -.
DR   STRING; 10090.ENSMUSP00000070247; -.
DR   GlyCosmos; Q7TQA9; 1 site, No reported glycans.
DR   GlyGen; Q7TQA9; 1 site.
DR   PhosphoSitePlus; Q7TQA9; -.
DR   PaxDb; 10090-ENSMUSP00000070247; -.
DR   DNASU; 387512; -.
DR   GeneID; 387512; -.
DR   KEGG; mmu:387512; -.
DR   AGR; MGI:2681302; -.
DR   CTD; 387512; -.
DR   MGI; MGI:2681302; Tas2r135.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   InParanoid; Q7TQA9; -.
DR   OrthoDB; 4642354at2759; -.
DR   PhylomeDB; Q7TQA9; -.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   BioGRID-ORCS; 387512; 2 hits in 75 CRISPR screens.
DR   PRO; PR:Q7TQA9; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q7TQA9; Protein.
DR   GO; GO:0016020; C:membrane; ISO:MGI.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   CDD; cd15018; 7tm_TAS2R41-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR007960; TAS2R.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF32; TASTE RECEPTOR TYPE 2 MEMBER 60; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 135"
FT                   /id="PRO_0000082270"
FT   TOPO_DOM        1..19
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  35591 MW;  2B3811522589FC65 CRC64;
     MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR TLSAHNKLLI
     SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW DFLTAATIWL CSLLGFFYCV
     KIATLTHPVF VWLKYRLPGW VPWMLLSAVG MSSLTSILCF IGNYMIYQNH AKSGHQPWNV
     TGNSLRHSLE KFYFFSIKII MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ
     AHFKALLPLL SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN
     PVLRVVIKRG CC
//