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Q7TQA9

- TR135_MOUSE

UniProt

Q7TQA9 - TR135_MOUSE

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Protein

Taste receptor type 2 member 135

Gene

Tas2r135

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.1 Publication

GO - Molecular functioni

  1. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 135
Short name:
T2R135
Alternative name(s):
Taste receptor type 2 member 35
Short name:
T2R35
Short name:
mT2r38
Gene namesi
Name:Tas2r135
Synonyms:T2r38, Tas2r35
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2681302. Tas2r135.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 135PRO_0000082270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7TQA9.

Expressioni

Gene expression databases

CleanExiMM_TAS2R135.
ExpressionAtlasiQ7TQA9. differential.
GenevestigatoriQ7TQA9.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997553.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Topological domaini41 – 6626CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini88 – 9710ExtracellularSequence Analysis
Topological domaini119 – 14022CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 24425CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini266 – 27712ExtracellularSequence AnalysisAdd
BLAST
Topological domaini299 – 31214CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45884.
HOVERGENiHBG098568.
InParanoidiQ7TQA9.
KOiK08474.
PhylomeDBiQ7TQA9.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR
60 70 80 90 100
TLSAHNKLLI SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW
110 120 130 140 150
DFLTAATIWL CSLLGFFYCV KIATLTHPVF VWLKYRLPGW VPWMLLSAVG
160 170 180 190 200
MSSLTSILCF IGNYMIYQNH AKSGHQPWNV TGNSLRHSLE KFYFFSIKII
210 220 230 240 250
MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ AHFKALLPLL
260 270 280 290 300
SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN
310
PVLRVVIKRG CC
Length:312
Mass (Da):35,591
Last modified:January 16, 2004 - v2
Checksum:i2B3811522589FC65
GO

Sequence cautioni

The sequence AAP40336.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
RefSeqiNP_954610.1. NM_199159.1.
UniGeneiMm.377919.

Genome annotation databases

GeneIDi387512.
KEGGimmu:387512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1 . Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1 .
BC115533 mRNA. Translation: AAI15534.1 .
BK001097 Genomic DNA. Translation: DAA01236.1 .
RefSeqi NP_954610.1. NM_199159.1.
UniGenei Mm.377919.

3D structure databases

ProteinModelPortali Q7TQA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997553.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q7TQA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 387512.
KEGGi mmu:387512.

Organism-specific databases

CTDi 387512.
MGIi MGI:2681302. Tas2r135.

Phylogenomic databases

eggNOGi NOG45884.
HOVERGENi HBG098568.
InParanoidi Q7TQA9.
KOi K08474.
PhylomeDBi Q7TQA9.

Miscellaneous databases

NextBioi 405902.
PROi Q7TQA9.
SOURCEi Search...

Gene expression databases

CleanExi MM_TAS2R135.
ExpressionAtlasi Q7TQA9. differential.
Genevestigatori Q7TQA9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTR135_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA9
Secondary accession number(s): A4FUQ3, Q7M705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3