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Protein

Taste receptor type 2 member 135

Gene

Tas2r135

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 135
Short name:
T2R135
Alternative name(s):
Taste receptor type 2 member 35
Short name:
T2R35
Short name:
mT2r38
Gene namesi
Name:Tas2r135
Synonyms:T2r38, Tas2r35
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2681302. Tas2r135.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 66CytoplasmicSequence analysisAdd BLAST26
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 97ExtracellularSequence analysis10
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 140CytoplasmicSequence analysisAdd BLAST22
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 244CytoplasmicSequence analysisAdd BLAST25
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 277ExtracellularSequence analysisAdd BLAST12
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 312CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822701 – 312Taste receptor type 2 member 135Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQA9.
PRIDEiQ7TQA9.

PTM databases

PhosphoSitePlusiQ7TQA9.

Expressioni

Gene expression databases

CleanExiMM_TAS2R135.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997553.
STRINGi10090.ENSMUSP00000070247.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW8Z. Eukaryota.
ENOG411156S. LUCA.
HOVERGENiHBG098568.
InParanoidiQ7TQA9.
KOiK08474.
PhylomeDBiQ7TQA9.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR
60 70 80 90 100
TLSAHNKLLI SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW
110 120 130 140 150
DFLTAATIWL CSLLGFFYCV KIATLTHPVF VWLKYRLPGW VPWMLLSAVG
160 170 180 190 200
MSSLTSILCF IGNYMIYQNH AKSGHQPWNV TGNSLRHSLE KFYFFSIKII
210 220 230 240 250
MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ AHFKALLPLL
260 270 280 290 300
SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN
310
PVLRVVIKRG CC
Length:312
Mass (Da):35,591
Last modified:January 16, 2004 - v2
Checksum:i2B3811522589FC65
GO

Sequence cautioni

The sequence AAP40336 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
RefSeqiNP_954610.1. NM_199159.1.
UniGeneiMm.377919.

Genome annotation databases

GeneIDi387512.
KEGGimmu:387512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
RefSeqiNP_954610.1. NM_199159.1.
UniGeneiMm.377919.

3D structure databases

ProteinModelPortaliQ7TQA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997553.
STRINGi10090.ENSMUSP00000070247.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ7TQA9.

Proteomic databases

PaxDbiQ7TQA9.
PRIDEiQ7TQA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi387512.
KEGGimmu:387512.

Organism-specific databases

CTDi387512.
MGIiMGI:2681302. Tas2r135.

Phylogenomic databases

eggNOGiENOG410IW8Z. Eukaryota.
ENOG411156S. LUCA.
HOVERGENiHBG098568.
InParanoidiQ7TQA9.
KOiK08474.
PhylomeDBiQ7TQA9.

Miscellaneous databases

PROiQ7TQA9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAS2R135.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR135_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA9
Secondary accession number(s): A4FUQ3, Q7M705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.