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Protein

Taste receptor type 2 member 135

Gene

Tas2r135

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.1 Publication

GO - Molecular functioni

  1. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 135
Short name:
T2R135
Alternative name(s):
Taste receptor type 2 member 35
Short name:
T2R35
Short name:
mT2r38
Gene namesi
Name:Tas2r135
Synonyms:T2r38, Tas2r35
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2681302. Tas2r135.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 6626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 9710ExtracellularSequence Analysis
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 14022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 24425CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 27712ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 31214CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 135PRO_0000082270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7TQA9.

Expressioni

Gene expression databases

CleanExiMM_TAS2R135.
ExpressionAtlasiQ7TQA9. differential.
GenevestigatoriQ7TQA9.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997553.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45884.
HOVERGENiHBG098568.
InParanoidiQ7TQA9.
KOiK08474.
PhylomeDBiQ7TQA9.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR
60 70 80 90 100
TLSAHNKLLI SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW
110 120 130 140 150
DFLTAATIWL CSLLGFFYCV KIATLTHPVF VWLKYRLPGW VPWMLLSAVG
160 170 180 190 200
MSSLTSILCF IGNYMIYQNH AKSGHQPWNV TGNSLRHSLE KFYFFSIKII
210 220 230 240 250
MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ AHFKALLPLL
260 270 280 290 300
SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN
310
PVLRVVIKRG CC
Length:312
Mass (Da):35,591
Last modified:January 16, 2004 - v2
Checksum:i2B3811522589FC65
GO

Sequence cautioni

The sequence AAP40336.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
RefSeqiNP_954610.1. NM_199159.1.
UniGeneiMm.377919.

Genome annotation databases

GeneIDi387512.
KEGGimmu:387512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
RefSeqiNP_954610.1. NM_199159.1.
UniGeneiMm.377919.

3D structure databases

ProteinModelPortaliQ7TQA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997553.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ7TQA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi387512.
KEGGimmu:387512.

Organism-specific databases

CTDi387512.
MGIiMGI:2681302. Tas2r135.

Phylogenomic databases

eggNOGiNOG45884.
HOVERGENiHBG098568.
InParanoidiQ7TQA9.
KOiK08474.
PhylomeDBiQ7TQA9.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi405902.
PROiQ7TQA9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAS2R135.
ExpressionAtlasiQ7TQA9. differential.
GenevestigatoriQ7TQA9.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Physiol. Genomics 14:73-82(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTR135_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA9
Secondary accession number(s): A4FUQ3, Q7M705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: April 1, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.