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Q7TQA9

- TR135_MOUSE

UniProt

Q7TQA9 - TR135_MOUSE

Protein

Taste receptor type 2 member 135

Gene

Tas2r135

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Putative taste receptor which may play a role in the perception of bitterness.1 Publication

    GO - Molecular functioni

    1. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 135
    Short name:
    T2R135
    Alternative name(s):
    Taste receptor type 2 member 35
    Short name:
    T2R35
    Short name:
    mT2r38
    Gene namesi
    Name:Tas2r135
    Synonyms:T2r38, Tas2r35
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2681302. Tas2r135.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Taste receptor type 2 member 135PRO_0000082270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7TQA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TQA9.
    CleanExiMM_TAS2R135.
    GenevestigatoriQ7TQA9.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997553.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TQA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini41 – 6626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 9710ExtracellularSequence Analysis
    Topological domaini119 – 14022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 24425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 27712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31214CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45884.
    HOVERGENiHBG098568.
    InParanoidiA4FUQ3.
    KOiK08474.
    PhylomeDBiQ7TQA9.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TQA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR    50
    TLSAHNKLLI SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW 100
    DFLTAATIWL CSLLGFFYCV KIATLTHPVF VWLKYRLPGW VPWMLLSAVG 150
    MSSLTSILCF IGNYMIYQNH AKSGHQPWNV TGNSLRHSLE KFYFFSIKII 200
    MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ AHFKALLPLL 250
    SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN 300
    PVLRVVIKRG CC 312
    Length:312
    Mass (Da):35,591
    Last modified:January 16, 2004 - v2
    Checksum:i2B3811522589FC65
    GO

    Sequence cautioni

    The sequence AAP40336.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
    AC153022 Genomic DNA. No translation available.
    BC115532 mRNA. Translation: AAI15533.1.
    BC115533 mRNA. Translation: AAI15534.1.
    BK001097 Genomic DNA. Translation: DAA01236.1.
    RefSeqiNP_954610.1. NM_199159.1.
    UniGeneiMm.377919.

    Genome annotation databases

    GeneIDi387512.
    KEGGimmu:387512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532786 Genomic DNA. Translation: AAP40336.1 . Sequence problems.
    AC153022 Genomic DNA. No translation available.
    BC115532 mRNA. Translation: AAI15533.1 .
    BC115533 mRNA. Translation: AAI15534.1 .
    BK001097 Genomic DNA. Translation: DAA01236.1 .
    RefSeqi NP_954610.1. NM_199159.1.
    UniGenei Mm.377919.

    3D structure databases

    ProteinModelPortali Q7TQA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997553.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q7TQA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 387512.
    KEGGi mmu:387512.

    Organism-specific databases

    CTDi 387512.
    MGIi MGI:2681302. Tas2r135.

    Phylogenomic databases

    eggNOGi NOG45884.
    HOVERGENi HBG098568.
    InParanoidi A4FUQ3.
    KOi K08474.
    PhylomeDBi Q7TQA9.

    Miscellaneous databases

    NextBioi 405902.
    PROi Q7TQA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TQA9.
    CleanExi MM_TAS2R135.
    Genevestigatori Q7TQA9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiTR135_MOUSE
    AccessioniPrimary (citable) accession number: Q7TQA9
    Secondary accession number(s): A4FUQ3, Q7M705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3