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Q7TQA9 (TR135_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 135
Short name=T2R135
Alternative name(s):
Taste receptor type 2 member 35
Short name=T2R35
Short name=mT2r38
Gene names
Name:Tas2r135
Synonyms:T2r38, Tas2r35
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor which may play a role in the perception of bitterness. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence caution

The sequence AAP40336.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdetection of chemical stimulus involved in sensory perception of bitter taste

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentintegral to membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functiontaste receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Taste receptor type 2 member 135
PRO_0000082270

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4021Helical; Name=1; Potential
Topological domain41 – 6626Cytoplasmic Potential
Transmembrane67 – 8721Helical; Name=2; Potential
Topological domain88 – 9710Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 14022Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 24425Cytoplasmic Potential
Transmembrane245 – 26521Helical; Name=6; Potential
Topological domain266 – 27712Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31214Cytoplasmic Potential

Amino acid modifications

Glycosylation1791N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TQA9 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: 2B3811522589FC65

FASTA31235,591
        10         20         30         40         50         60 
MSTGHTVLGC QTTDKTVVTL FIILVLLCLV AVVGNGFIII ALGMKWLLRR TLSAHNKLLI 

        70         80         90        100        110        120 
SLAASRFCLQ CVVIGKNIYV FLNPTSFPYN PVIQLLNLMW DFLTAATIWL CSLLGFFYCV 

       130        140        150        160        170        180 
KIATLTHPVF VWLKYRLPGW VPWMLLSAVG MSSLTSILCF IGNYMIYQNH AKSGHQPWNV 

       190        200        210        220        230        240 
TGNSLRHSLE KFYFFSIKII MWTIPTVVFS IFMSLLLVSL VRHMKKTFLA LSELRDVWAQ 

       250        260        270        280        290        300 
AHFKALLPLL SFIVLFISCF LTLVLSSASN TPYQEFRYWM WQVVIHLCTV IHPIVILFSN 

       310 
PVLRVVIKRG CC

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF532786 Genomic DNA. Translation: AAP40336.1. Sequence problems.
AC153022 Genomic DNA. No translation available.
BC115532 mRNA. Translation: AAI15533.1.
BC115533 mRNA. Translation: AAI15534.1.
BK001097 Genomic DNA. Translation: DAA01236.1.
IPIIPI00396810.
RefSeqNP_954610.1. NM_199159.1.
UniGeneMm.377919.

3D structure databases

ProteinModelPortalQ7TQA9.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4997553.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ7TQA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID387512.
KEGGmmu:387512.

Organism-specific databases

CTD387512.
MGIMGI:2681302. Tas2r135.

Phylogenomic databases

eggNOGNOG45884.
HOVERGENHBG098568.
InParanoidA4FUQ3.
KOK08474.
OrthoDBEOG4P5K9P.

Gene expression databases

ArrayExpressQ7TQA9.
CleanExMM_TAS2R135.
GenevestigatorQ7TQA9.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405902.
SOURCESearch...

Entry information

Entry nameTR135_MOUSE
AccessionPrimary (citable) accession number: Q7TQA9
Secondary accession number(s): A4FUQ3, Q7M705
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 29, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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