ID   T2R38_MOUSE             Reviewed;         331 AA.
AC   Q7TQA6; A0PK79; Q4VHF0;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   24-JAN-2024, entry version 127.
DE   RecName: Full=Taste receptor type 2 member 38;
DE            Short=T2R38;
DE   AltName: Full=T2R138;
DE   AltName: Full=mT2R31;
GN   Name=Tas2r38; Synonyms=T2r31, Tas2r138;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40339.1};
RN   [1] {ECO:0000312|EMBL:AAP40339.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40339.1};
RX   PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA   Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT   "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT   and human.";
RL   Physiol. Genomics 14:73-82(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA   Wu S.V., Chen M.C., Rozengurt E.;
RT   "Genomic organization, expression, and function of bitter taste receptors
RT   (T2R) in mouse and rat.";
RL   Physiol. Genomics 22:139-149(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=12679530; DOI=10.1093/molbev/msg083;
RA   Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT   "Adaptive diversification of bitter taste receptor genes in mammalian
RT   evolution.";
RL   Mol. Biol. Evol. 20:805-814(2003).
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Low levels in tongue, stomach and duodenum.
CC       {ECO:0000269|PubMed:15886333}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AF532789; AAP40339.1; -; Genomic_DNA.
DR   EMBL; AY916509; AAX99132.1; -; mRNA.
DR   EMBL; AC153378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC128016; AAI28017.1; -; mRNA.
DR   EMBL; BK001093; DAA01232.1; -; Genomic_DNA.
DR   CCDS; CCDS20038.1; -.
DR   RefSeq; NP_001001451.1; NM_001001451.1.
DR   AlphaFoldDB; Q7TQA6; -.
DR   SMR; Q7TQA6; -.
DR   STRING; 10090.ENSMUSP00000075876; -.
DR   GlyCosmos; Q7TQA6; 1 site, No reported glycans.
DR   GlyGen; Q7TQA6; 1 site.
DR   PhosphoSitePlus; Q7TQA6; -.
DR   PaxDb; 10090-ENSMUSP00000075876; -.
DR   Antibodypedia; 50262; 170 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000076565.3; ENSMUSP00000075876.3; ENSMUSG00000058250.3.
DR   GeneID; 387513; -.
DR   KEGG; mmu:387513; -.
DR   UCSC; uc009bne.1; mouse.
DR   AGR; MGI:2681306; -.
DR   CTD; 387513; -.
DR   MGI; MGI:2681306; Tas2r138.
DR   VEuPathDB; HostDB:ENSMUSG00000058250; -.
DR   eggNOG; ENOG502T15G; Eukaryota.
DR   GeneTree; ENSGT01100000263477; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q7TQA6; -.
DR   OMA; LCLWDFF; -.
DR   OrthoDB; 4867455at2759; -.
DR   PhylomeDB; Q7TQA6; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   BioGRID-ORCS; 387513; 1 hit in 77 CRISPR screens.
DR   PRO; PR:Q7TQA6; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q7TQA6; Protein.
DR   Bgee; ENSMUSG00000058250; Expressed in proximal tubule.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR   CDD; cd15025; 7tm_TAS2R38; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030050; TAS2R38.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF52; TASTE RECEPTOR TYPE 2 MEMBER 38; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..331
FT                   /note="Taste receptor type 2 member 38"
FT                   /id="PRO_0000082279"
FT   TOPO_DOM        1..17
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  36966 MW;  37A9B6D0885BF9C0 CRC64;
     MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL NNCDIALLCL
     SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM IANQVSLWLA ACLSLLYCSK
     IVRFSHTFPL HVASWVSRRF LQMLLVVLLL SCICTALCLW DFFCRSHSTV TSLLHLNSTE
     FSLQIAKLNF FYSFIFCNVG SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA
     HIRAIIFLIS FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN
     AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L
//