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Q7TQA6

- T2R38_MOUSE

UniProt

Q7TQA6 - T2R38_MOUSE

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Protein

Taste receptor type 2 member 38

Gene

Tas2r38

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.1 Publication

GO - Molecular functioni

  1. bitter taste receptor activity Source: Ensembl
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 38
Short name:
T2R38
Alternative name(s):
T2R138
mT2R31
Gene namesi
Name:Tas2r38
Synonyms:T2r31, Tas2r138
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681306. Tas2r138.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Taste receptor type 2 member 38PRO_0000082279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ7TQA6.

PTM databases

PhosphoSiteiQ7TQA6.

Expressioni

Tissue specificityi

Low levels in tongue, stomach and duodenum.1 Publication

Gene expression databases

CleanExiMM_TAS2R138.
GenevestigatoriQ7TQA6.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence AnalysisAdd
BLAST
Topological domaini39 – 5517CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini77 – 9418ExtracellularSequence AnalysisAdd
BLAST
Topological domaini116 – 14227CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini164 – 18926ExtracellularSequence AnalysisAdd
BLAST
Topological domaini211 – 24333CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 27612ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 33134CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43295.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000041379.
HOVERGENiHBG098741.
InParanoidiQ7TQA6.
KOiK08474.
OMAiRHMRTMR.
OrthoDBiEOG7J447B.
PhylomeDBiQ7TQA6.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL
60 70 80 90 100
NNCDIALLCL SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM
110 120 130 140 150
IANQVSLWLA ACLSLLYCSK IVRFSHTFPL HVASWVSRRF LQMLLVVLLL
160 170 180 190 200
SCICTALCLW DFFCRSHSTV TSLLHLNSTE FSLQIAKLNF FYSFIFCNVG
210 220 230 240 250
SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA HIRAIIFLIS
260 270 280 290 300
FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN
310 320 330
AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L
Length:331
Mass (Da):36,966
Last modified:October 1, 2003 - v1
Checksum:i37A9B6D0885BF9C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532789 Genomic DNA. Translation: AAP40339.1.
AY916509 mRNA. Translation: AAX99132.1.
AC153378 Genomic DNA. No translation available.
BC128016 mRNA. Translation: AAI28017.1.
BK001093 Genomic DNA. Translation: DAA01232.1.
CCDSiCCDS20038.1.
RefSeqiNP_001001451.1. NM_001001451.1.
UniGeneiMm.377920.

Genome annotation databases

EnsembliENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
GeneIDi387513.
KEGGimmu:387513.
UCSCiuc009bne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532789 Genomic DNA. Translation: AAP40339.1 .
AY916509 mRNA. Translation: AAX99132.1 .
AC153378 Genomic DNA. No translation available.
BC128016 mRNA. Translation: AAI28017.1 .
BK001093 Genomic DNA. Translation: DAA01232.1 .
CCDSi CCDS20038.1.
RefSeqi NP_001001451.1. NM_001001451.1.
UniGenei Mm.377920.

3D structure databases

ProteinModelPortali Q7TQA6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q7TQA6.

Proteomic databases

PRIDEi Q7TQA6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076565 ; ENSMUSP00000075876 ; ENSMUSG00000058250 .
GeneIDi 387513.
KEGGi mmu:387513.
UCSCi uc009bne.1. mouse.

Organism-specific databases

CTDi 387513.
MGIi MGI:2681306. Tas2r138.

Phylogenomic databases

eggNOGi NOG43295.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000041379.
HOVERGENi HBG098741.
InParanoidi Q7TQA6.
KOi K08474.
OMAi RHMRTMR.
OrthoDBi EOG7J447B.
PhylomeDBi Q7TQA6.
TreeFami TF335891.

Miscellaneous databases

NextBioi 405906.
PROi Q7TQA6.
SOURCEi Search...

Gene expression databases

CleanExi MM_TAS2R138.
Genevestigatori Q7TQA6.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. "Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat."
    Wu S.V., Chen M.C., Rozengurt E.
    Physiol. Genomics 22:139-149(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiT2R38_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA6
Secondary accession number(s): A0PK79, Q4VHF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3