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Q7TQA6

- T2R38_MOUSE

UniProt

Q7TQA6 - T2R38_MOUSE

Protein

Taste receptor type 2 member 38

Gene

Tas2r38

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Putative taste receptor which may play a role in the perception of bitterness.1 Publication

    GO - Molecular functioni

    1. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 38
    Short name:
    T2R38
    Alternative name(s):
    T2R138
    mT2R31
    Gene namesi
    Name:Tas2r38
    Synonyms:T2r31, Tas2r138
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2681306. Tas2r138.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Taste receptor type 2 member 38PRO_0000082279Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ7TQA6.

    PTM databases

    PhosphoSiteiQ7TQA6.

    Expressioni

    Tissue specificityi

    Low levels in tongue, stomach and duodenum.1 Publication

    Gene expression databases

    CleanExiMM_TAS2R138.
    GenevestigatoriQ7TQA6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TQA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini39 – 5517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 14227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 18926ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini211 – 24333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 33134CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43295.
    GeneTreeiENSGT00560000076937.
    HOGENOMiHOG000041379.
    HOVERGENiHBG098741.
    InParanoidiA0PK79.
    KOiK08474.
    OMAiRHMRTMR.
    OrthoDBiEOG7J447B.
    PhylomeDBiQ7TQA6.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TQA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL    50
    NNCDIALLCL SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM 100
    IANQVSLWLA ACLSLLYCSK IVRFSHTFPL HVASWVSRRF LQMLLVVLLL 150
    SCICTALCLW DFFCRSHSTV TSLLHLNSTE FSLQIAKLNF FYSFIFCNVG 200
    SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA HIRAIIFLIS 250
    FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN 300
    AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L 331
    Length:331
    Mass (Da):36,966
    Last modified:October 1, 2003 - v1
    Checksum:i37A9B6D0885BF9C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532789 Genomic DNA. Translation: AAP40339.1.
    AY916509 mRNA. Translation: AAX99132.1.
    AC153378 Genomic DNA. No translation available.
    BC128016 mRNA. Translation: AAI28017.1.
    BK001093 Genomic DNA. Translation: DAA01232.1.
    CCDSiCCDS20038.1.
    RefSeqiNP_001001451.1. NM_001001451.1.
    UniGeneiMm.377920.

    Genome annotation databases

    EnsembliENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
    GeneIDi387513.
    KEGGimmu:387513.
    UCSCiuc009bne.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532789 Genomic DNA. Translation: AAP40339.1 .
    AY916509 mRNA. Translation: AAX99132.1 .
    AC153378 Genomic DNA. No translation available.
    BC128016 mRNA. Translation: AAI28017.1 .
    BK001093 Genomic DNA. Translation: DAA01232.1 .
    CCDSi CCDS20038.1.
    RefSeqi NP_001001451.1. NM_001001451.1.
    UniGenei Mm.377920.

    3D structure databases

    ProteinModelPortali Q7TQA6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7TQA6.

    Proteomic databases

    PRIDEi Q7TQA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076565 ; ENSMUSP00000075876 ; ENSMUSG00000058250 .
    GeneIDi 387513.
    KEGGi mmu:387513.
    UCSCi uc009bne.1. mouse.

    Organism-specific databases

    CTDi 387513.
    MGIi MGI:2681306. Tas2r138.

    Phylogenomic databases

    eggNOGi NOG43295.
    GeneTreei ENSGT00560000076937.
    HOGENOMi HOG000041379.
    HOVERGENi HBG098741.
    InParanoidi A0PK79.
    KOi K08474.
    OMAi RHMRTMR.
    OrthoDBi EOG7J447B.
    PhylomeDBi Q7TQA6.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 405906.
    PROi Q7TQA6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TAS2R138.
    Genevestigatori Q7TQA6.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. "Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat."
      Wu S.V., Chen M.C., Rozengurt E.
      Physiol. Genomics 22:139-149(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiT2R38_MOUSE
    AccessioniPrimary (citable) accession number: Q7TQA6
    Secondary accession number(s): A0PK79, Q4VHF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3