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Q7TQA6 (T2R38_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 38

Short name=T2R38
Alternative name(s):
T2R138
mT2R31
Gene names
Name:Tas2r38
Synonyms:T2r31, Tas2r138
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor which may play a role in the perception of bitterness. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Low levels in tongue, stomach and duodenum. Ref.2

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Taste receptor type 2 member 38
PRO_0000082279

Regions

Topological domain1 – 1717Extracellular Potential
Transmembrane18 – 3821Helical; Name=1; Potential
Topological domain39 – 5517Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9418Extracellular Potential
Transmembrane95 – 11521Helical; Name=3; Potential
Topological domain116 – 14227Cytoplasmic Potential
Transmembrane143 – 16321Helical; Name=4; Potential
Topological domain164 – 18926Extracellular Potential
Transmembrane190 – 21021Helical; Name=5; Potential
Topological domain211 – 24333Cytoplasmic Potential
Transmembrane244 – 26421Helical; Name=6; Potential
Topological domain265 – 27612Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 33134Cytoplasmic Potential

Amino acid modifications

Glycosylation1771N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TQA6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 37A9B6D0885BF9C0

FASTA33136,966
        10         20         30         40         50         60 
MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL NNCDIALLCL 

        70         80         90        100        110        120 
SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM IANQVSLWLA ACLSLLYCSK 

       130        140        150        160        170        180 
IVRFSHTFPL HVASWVSRRF LQMLLVVLLL SCICTALCLW DFFCRSHSTV TSLLHLNSTE 

       190        200        210        220        230        240 
FSLQIAKLNF FYSFIFCNVG SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA 

       250        260        270        280        290        300 
HIRAIIFLIS FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN 

       310        320        330 
AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary relationships of the Tas2r receptor gene families in mouse and human."
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J.
[2]"Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat."
Wu S.V., Chen M.C., Rozengurt E.
Physiol. Genomics 22:139-149(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: C57BL/6.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF532789 Genomic DNA. Translation: AAP40339.1.
AY916509 mRNA. Translation: AAX99132.1.
AC153378 Genomic DNA. No translation available.
BC128016 mRNA. Translation: AAI28017.1.
BK001093 Genomic DNA. Translation: DAA01232.1.
RefSeqNP_001001451.1. NM_001001451.1.
UniGeneMm.377920.

3D structure databases

ProteinModelPortalQ7TQA6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ7TQA6.

Proteomic databases

PRIDEQ7TQA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
GeneID387513.
KEGGmmu:387513.
UCSCuc009bne.1. mouse.

Organism-specific databases

CTD387513.
MGIMGI:2681306. Tas2r138.

Phylogenomic databases

eggNOGNOG43295.
GeneTreeENSGT00560000076937.
HOGENOMHOG000041379.
HOVERGENHBG098741.
InParanoidA0PK79.
KOK08474.
OMARHMRTMR.
OrthoDBEOG7J447B.
PhylomeDBQ7TQA6.
TreeFamTF335891.

Gene expression databases

CleanExMM_TAS2R138.
GenevestigatorQ7TQA6.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405906.
PROQ7TQA6.
SOURCESearch...

Entry information

Entry nameT2R38_MOUSE
AccessionPrimary (citable) accession number: Q7TQA6
Secondary accession number(s): A0PK79, Q4VHF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries