Q7TQA6 (T2R38_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 38
Short name=T2R38

Alternative name(s):
T2R138
mT2R31

Gene names

Name:	Tas2r38
Synonyms:	T2r31, Tas2r138

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative taste receptor which may play a role in the perception of bitterness. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Low levels in tongue, stomach and duodenum. Ref.2
Miscellaneous	Several bitter taste receptors are expressed in a single taste receptor cell.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of bitter taste Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	taste receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Taste receptor type 2 member 38		PRO_0000082279
Regions
	Topological domain	1 – 17	17	Extracellular Potential
	Transmembrane	18 – 38	21	Helical; Name=1; Potential
	Topological domain	39 – 55	17	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 94	18	Extracellular Potential
	Transmembrane	95 – 115	21	Helical; Name=3; Potential
	Topological domain	116 – 142	27	Cytoplasmic Potential
	Transmembrane	143 – 163	21	Helical; Name=4; Potential
	Topological domain	164 – 189	26	Extracellular Potential
	Transmembrane	190 – 210	21	Helical; Name=5; Potential
	Topological domain	211 – 243	33	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Name=6; Potential
	Topological domain	265 – 276	12	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=7; Potential
	Topological domain	298 – 331	34	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	177	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7TQA6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 37A9B6D0885BF9C0	FASTA	331	36,966
	10 20 30 40 50 60 MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL NNCDIALLCL 70 80 90 100 110 120 SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM IANQVSLWLA ACLSLLYCSK 130 140 150 160 170 180 IVRFSHTFPL HVASWVSRRF LQMLLVVLLL SCICTALCLW DFFCRSHSTV TSLLHLNSTE 190 200 210 220 230 240 FSLQIAKLNF FYSFIFCNVG SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA 250 260 270 280 290 300 HIRAIIFLIS FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN 310 320 330 AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary relationships of the Tas2r receptor gene families in mouse and human." Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J. Physiol. Genomics 14:73-82(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat." Wu S.V., Chen M.C., Rozengurt E. Physiol. Genomics 22:139-149(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: C57BL/6.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Adaptive diversification of bitter taste receptor genes in mammalian evolution." Shi P., Zhang J., Yang H., Zhang Y.-P. Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF532789 Genomic DNA. Translation: AAP40339.1. AY916509 mRNA. Translation: AAX99132.1. AC153378 Genomic DNA. No translation available. BC128016 mRNA. Translation: AAI28017.1. BK001093 Genomic DNA. Translation: DAA01232.1.
IPI	IPI00416909.
RefSeq	NP_001001451.1. NM_001001451.1.
UniGene	Mm.377920.
3D structure databases
ProteinModelPortal	Q7TQA6.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q7TQA6.
Proteomic databases
PRIDE	Q7TQA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
GeneID	387513.
KEGG	mmu:387513.
UCSC	uc009bne.1. mouse.
Organism-specific databases
CTD	387513.
MGI	MGI:2681306. Tas2r138.
Phylogenomic databases
eggNOG	NOG43295.
GeneTree	ENSGT00560000076937.
HOGENOM	HOG000041379.
HOVERGEN	HBG098741.
InParanoid	A0PK79.
KO	K08474.
OMA	WMIANQV.
OrthoDB	EOG4D7Z6B.
Gene expression databases
CleanEx	MM_TAS2R138.
Genevestigator	Q7TQA6.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	405906.
SOURCE	Search...

Entry information

Entry name

T2R38_MOUSE

Accession

Primary (citable) accession number: Q7TQA6
Secondary accession number(s): A0PK79, Q4VHF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program