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Protein

Taste receptor type 2 member 39

Gene

Tas2r39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative taste receptor which may play a role in the perception of bitterness.1 Publication

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 39
Short name:
T2R39
Short name:
mT2R34
Gene namesi
Name:Tas2r39
Synonyms:T2r34, Tas2r139
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681308. Tas2r139.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 65CytoplasmicSequence analysisAdd BLAST28
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 97ExtracellularSequence analysisAdd BLAST11
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 247CytoplasmicSequence analysisAdd BLAST32
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 273ExtracellularSequence analysis5
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 319CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822861 – 319Taste receptor type 2 member 39Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQA5.
PRIDEiQ7TQA5.

PTM databases

iPTMnetiQ7TQA5.
PhosphoSitePlusiQ7TQA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047102.
CleanExiMM_TAS2R139.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062919.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEI. Eukaryota.
ENOG410YMY3. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ7TQA5.
KOiK08474.
OMAiWRISELM.
OrthoDBiEOG091G0FKI.
PhylomeDBiQ7TQA5.
TreeFamiTF335891.

Family and domain databases

InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TQA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPSNYWKQ DVLPLSILML TLVATECTIG IIASGIVMAV NAVSWVQKKA
60 70 80 90 100
ISITTRILLL LSVSRIGLQS IMLIEITSSI FNVAFYNSVL YRVSNVSFVF
110 120 130 140 150
LNYCSLWFAA LLSFFHFVKI ANFSYPLFFK LKWRISELMP WLLWLSVFIS
160 170 180 190 200
FSSSMFFSKH KFTVNNNNSL SNNICNFTMK LYVVETNVVN VSFLFISGIL
210 220 230 240 250
PPLTMFVATA TLLIFSLRRH TLNMRNSATG SRNPCIEAHM QAIKETSCFL
260 270 280 290 300
FLYILNAAAL LLSTSNIVDA SLFWSIVIRI VLPVYPAGHS VLLIQNNPGL
310
RRTWKHLQSQ IHLYLQNRF
Length:319
Mass (Da):36,308
Last modified:October 1, 2003 - v1
Checksum:i4D29965B184242D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532790 Genomic DNA. Translation: AAP40340.1.
AC157218 Genomic DNA. No translation available.
BK001094 Genomic DNA. Translation: DAA01233.1.
CCDSiCCDS20061.1.
RefSeqiNP_851792.1. NM_181275.1.
UniGeneiMm.377887.

Genome annotation databases

EnsembliENSMUST00000057686; ENSMUSP00000062919; ENSMUSG00000047102.
GeneIDi353148.
KEGGimmu:353148.
UCSCiuc009bqm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiT2R39_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families