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Protein

Epidermal retinol dehydrogenase 2

Gene

Sdr16c5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH (By similarity).By similarity

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei177SubstrateSequence analysis1
Active sitei190Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 68NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859 RA biosynthesis pathway
UniPathwayiUPA00912

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal retinol dehydrogenase 2 (EC:1.1.1.105)
Short name:
EPHD-2
Short name:
RDH-E2
Alternative name(s):
Retinal short-chain dehydrogenase reductase 2
Short name:
retSDR2
Short-chain dehydrogenase reductase 9
Short-chain dehydrogenase/reductase family 16C member 5
Gene namesi
Name:Sdr16c5
Synonyms:Rdhe2, Scdr9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2668443 Sdr16c5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059741 – 309Epidermal retinol dehydrogenase 2Add BLAST309

Proteomic databases

PaxDbiQ7TQA3
PRIDEiQ7TQA3

Expressioni

Gene expression databases

BgeeiENSMUSG00000028236
GenevisibleiQ7TQA3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046298

Structurei

3D structure databases

ProteinModelPortaliQ7TQA3
SMRiQ7TQA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000143991
HOVERGENiHBG051352
InParanoidiQ7TQA3
KOiK15734
OMAiQGVRTDM
OrthoDBiEOG091G0825
PhylomeDBiQ7TQA3
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNLESVKN LLVFLGKSLL SVLEALLFHV ISKPRKNVAG EIVLITGAGS
60 70 80 90 100
GLGRLLALQF ARLGAVLVLW DVNKEANDET HQLAREAGAA RVHAYTCDCS
110 120 130 140 150
RREEVYRVAD QVKKEVGDVS ILINNAGIVT GRNFLDCPDD LMEKSFDVNF
160 170 180 190 200
KAHLWMYKAF LPAMIANNHG HLVCISSSAG LIGVNGLSDY CASKFAALGF
210 220 230 240 250
AESMFIETLA KKQWGIKTTI VCPFFIKTGM FEGCTTKCPT LLPILDPEYA
260 270 280 290 300
VRKIIDAILQ EQLYLYMPKF LYFIVFLKSI LPIKTGILIA DYLGVFHMTE

GFTGQKKKT
Length:309
Mass (Da):34,193
Last modified:October 1, 2003 - v1
Checksum:iC5DE4B63AB35A665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY277588 mRNA Translation: AAP41074.1
AK136508 mRNA Translation: BAE23016.1
AL807387 Genomic DNA No translation available.
BC104134 mRNA Translation: AAI04135.1
BC104135 mRNA Translation: AAI04136.1
CCDSiCCDS17944.1
RefSeqiNP_871789.1, NM_181989.1
UniGeneiMm.98096

Genome annotation databases

EnsembliENSMUST00000040925; ENSMUSP00000046298; ENSMUSG00000028236
GeneIDi242285
KEGGimmu:242285
UCSCiuc008rww.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRDHE2_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health