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Protein

Immunoglobulin superfamily member 1

Gene

Igsf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 1
Short name:
IgSF1
Alternative name(s):
Inhibin-binding protein
Short name:
InhBP
Gene namesi
Name:Igsf1
Synonyms:Kiaa0364
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2147913. Igsf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 499479ExtracellularSequence analysisAdd
BLAST
Transmembranei500 – 52021HelicalSequence analysisAdd
BLAST
Topological domaini521 – 53111CytoplasmicSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 1317765ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile and show no alterations in FSH synthesis or secretion or in ovarian and testicular function. According to PubMed:23143598 male mice show diminished pituitary and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 13171297Immunoglobulin superfamily member 1PRO_0000318513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi48 ↔ 96PROSITE-ProRule annotation
Disulfide bondi238 ↔ 286PROSITE-ProRule annotation
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi333 ↔ 382PROSITE-ProRule annotation
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi422 ↔ 465PROSITE-ProRule annotation
Disulfide bondi780 ↔ 830PROSITE-ProRule annotation
Glycosylationi871 – 8711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi876 ↔ 923PROSITE-ProRule annotation
Glycosylationi967 – 9671N-linked (GlcNAc...)Sequence analysis
Glycosylationi1063 – 10631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1068 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TQA1.
PaxDbiQ7TQA1.
PRIDEiQ7TQA1.

PTM databases

iPTMnetiQ7TQA1.
PhosphoSiteiQ7TQA1.

Expressioni

Developmental stagei

Expressed at embryonic day (E) 12.5 in embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000031111.
CleanExiMM_IGSF1.
GenevisibleiQ7TQA1. MM.

Interactioni

Subunit structurei

Interacts with INHA; the interaction is not confirmed by standard receptor binding assays (By similarity). Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity). Interacts with HECTD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033442.

Structurei

3D structure databases

ProteinModelPortaliQ7TQA1.
SMRiQ7TQA1. Positions 43-485, 571-1228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11292Ig-like C2-type 1Add
BLAST
Domaini114 – 21198Ig-like C2-type 2Add
BLAST
Domaini216 – 30287Ig-like C2-type 3Add
BLAST
Domaini311 – 39888Ig-like C2-type 4Add
BLAST
Domaini400 – 48182Ig-like C2-type 5Add
BLAST
Domaini570 – 65889Ig-like C2-type 6Add
BLAST
Domaini659 – 75395Ig-like C2-type 7Add
BLAST
Domaini758 – 85093Ig-like C2-type 8Add
BLAST
Domaini854 – 93885Ig-like C2-type 9Add
BLAST
Domaini946 – 104196Ig-like C2-type 10Add
BLAST
Domaini1046 – 113186Ig-like C2-type 11Add
BLAST
Domaini1142 – 122382Ig-like C2-type 12Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIFF. Eukaryota.
ENOG410YSQG. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000113017.
HOVERGENiHBG098292.
InParanoidiQ7TQA1.
OMAiPWENITL.
OrthoDBiEOG091G020P.
PhylomeDBiQ7TQA1.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 11 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TQA1-1) [UniParc]FASTAAdd to basket
Also known as: InhBP-L, long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLRTFTLLL LCIWLNPGMT SLAVESQPEL WIESNYPQAP WENITLWCKS
60 70 80 90 100
PSRVSSKFLL LKDNSQMTWI RPPYKTFQVS FFIGALTESN TGLYRCCYWK
110 120 130 140 150
EKGWSKPSKI LELEAPGQLP KPIFWIQAET PPLPGCNVNI FCHGWLQDLV
160 170 180 190 200
FMLFKEGYTE PVDYQVPTGT MAIFSIDNLA PENEGVYICR THIQMLPTLW
210 220 230 240 250
SEPSNPLKLV VAGLYPKPTL TAHPGPILAP GESLSLRCQG PIYGMTFALM
260 270 280 290 300
RLEDLKKSFY HKKPIKNEAY FYFQDLKIQD TGHYLCFYYD GSYRGSLLSD
310 320 330 340 350
ILKIWVTDTF PKTWLLVQPS PVIQMGQNVS LRCGGLMDGV GLALYKKGEE
360 370 380 390 400
KPLQFLDASS NTGNNSFFLK NVTYRDAGIY SCHYYLTWKT SIKMATYNTV
410 420 430 440 450
ELMVVAWPSS VFKVGKTITL QCRVSHPVLE FSLEWEERTT FQKFSVDGDF
460 470 480 490 500
LITDIEGQGT GTYSCSYRIE AHPNTWSHRS KPLKLVGPAG FLTWNSILNE
510 520 530 540 550
AVRVSLTMQL ASLLLLVVWI RWKCRRLRLR EAWLLGTAQG VAMLFILMAL
560 570 580 590 600
LCCGLCNGAL TEEIEIVMPT PKPELWAETN FPLAPWKNLT LWCRSPSGST
610 620 630 640 650
KEFVLLKDGT GWIATRPASE QVRAAFPLGA LTHSHTGSYH CHSWEEMAVS
660 670 680 690 700
EPSEALELVG TDILPKPVIS ASLPIRGQEL QIRCKGWLEG LGFALYKKGE
710 720 730 740 750
QEPVQQLGAV GREAFFTIQR MEDKDEGNYS CRTHTEMQPF KWSEPSEPLE
760 770 780 790 800
LVIKEMYPKP FFKTWASPVV TPGSRVTFNC STSHEHMSFI LYKDGNEIAS
810 820 830 840 850
SDLAWGNPGG STAHFLIISV GIGDGGNYSC RYYDFSIWSE PSNPVELVVT
860 870 880 890 900
EFYPKPTLLA QPGPVVLPGK NVTLRCQGIF QGMRFALLQE GTHTPLQFQS
910 920 930 940 950
TSGTSADFLL HTVGAQDFGN YSCVYYETTM SNRGSSLSTP LMIWVTDTFP
960 970 980 990 1000
RPWLSAEPSS VVTMGQNVTL WCQGPVRGVG YILHKEGEAT SMQLWGSTSN
1010 1020 1030 1040 1050
EGAFPIINIS GASIGRYSCC YHPDWMSPIK IQPSNTLELI VTGLLPKPSL
1060 1070 1080 1090 1100
LVQPGPMVAP GENVTLQCQG ELPDSTFVLL KEGTRQPLEQ QRPSGYRADF
1110 1120 1130 1140 1150
WMPVVRDQDS GVYSCVYYLD SAPLVASNHS NSLEIWVTDK PPKPSLSAWP
1160 1170 1180 1190 1200
STIFKLGKDI TLQCRGPLPG VEFVLEHDGE EAPQQFSEDG DFVIDNLEGK
1210 1220 1230 1240 1250
GIGNYSCSYR LQAYPDIWSE PSDTLELVGA AGPVAQECTV GNIVRSTLIV
1260 1270 1280 1290 1300
VVVVALGIVL AVEWKKWPRL RTRGSETDGR DQTVVLEECN QEGEPGTTTN
1310
SPSSASQEVS VELTVPI
Note: Produced by alternative promoter usage.
Length:1,317
Mass (Da):147,010
Last modified:October 1, 2003 - v1
Checksum:i09D1E7A89ADCB04D
GO
Isoform 2 (identifier: Q7TQA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     865-1156: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:1,025
Mass (Da):114,958
Checksum:i31356E87AAFAE992
GO
Isoform 3 (identifier: Q7TQA1-3) [UniParc]FASTAAdd to basket
Also known as: InhBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     755-762: EMYPKPFF → DGRTKAQN
     763-1317: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:762
Mass (Da):86,395
Checksum:iE83752668D596F82
GO
Isoform 4 (identifier: Q7TQA1-4) [UniParc]FASTAAdd to basket
Also known as: InhBP-S, short

The sequence of this isoform differs from the canonical sequence as follows:
     214-232: LYPKPTLTAHPGPILAPGE → GCGHGCWHLTIVIPGIMAG
     233-1317: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:232
Mass (Da):26,331
Checksum:iE34ABA3305FFB65E
GO
Isoform 5 (identifier: Q7TQA1-5) [UniParc]FASTAAdd to basket
Also known as: InhBP-4, variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-542: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:775
Mass (Da):85,159
Checksum:i26E89EB2AD2CB07C
GO

Sequence cautioni

The sequence BAC97936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771K → E in AAP57081 (PubMed:12832474).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 542542Missing in isoform 5. 1 PublicationVSP_031198Add
BLAST
Alternative sequencei214 – 23219LYPKP…LAPGE → GCGHGCWHLTIVIPGIMAG in isoform 4. 2 PublicationsVSP_031199Add
BLAST
Alternative sequencei233 – 13171085Missing in isoform 4. 2 PublicationsVSP_031200Add
BLAST
Alternative sequencei755 – 7628EMYPKPFF → DGRTKAQN in isoform 3. 1 PublicationVSP_031201
Alternative sequencei763 – 1317555Missing in isoform 3. 1 PublicationVSP_031202Add
BLAST
Alternative sequencei865 – 1156292Missing in isoform 2. 1 PublicationVSP_031203Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227771 mRNA. Translation: AAP57079.1.
AY227772 mRNA. Translation: AAP57080.1.
AY227773 mRNA. Translation: AAP57081.1.
AY227774 mRNA. Translation: AAP57082.1.
AK129126 mRNA. Translation: BAC97936.1. Different initiation.
AK030452 mRNA. Translation: BAC26969.1.
CCDSiCCDS40964.1. [Q7TQA1-1]
CCDS40965.1. [Q7TQA1-5]
CCDS40966.1. [Q7TQA1-3]
CCDS40967.1. [Q7TQA1-4]
RefSeqiNP_808259.2. NM_177591.4. [Q7TQA1-1]
NP_808583.1. NM_177915.4. [Q7TQA1-4]
NP_899178.2. NM_183335.2. [Q7TQA1-3]
NP_899179.1. NM_183336.2. [Q7TQA1-5]
XP_006541550.1. XM_006541487.2. [Q7TQA1-3]
UniGeneiMm.110505.

Genome annotation databases

EnsembliENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111. [Q7TQA1-1]
ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111. [Q7TQA1-3]
ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111. [Q7TQA1-4]
ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111. [Q7TQA1-5]
GeneIDi209268.
KEGGimmu:209268.
UCSCiuc009tdg.2. mouse. [Q7TQA1-1]
uc009tdi.1. mouse. [Q7TQA1-3]
uc009tdj.2. mouse. [Q7TQA1-4]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227771 mRNA. Translation: AAP57079.1.
AY227772 mRNA. Translation: AAP57080.1.
AY227773 mRNA. Translation: AAP57081.1.
AY227774 mRNA. Translation: AAP57082.1.
AK129126 mRNA. Translation: BAC97936.1. Different initiation.
AK030452 mRNA. Translation: BAC26969.1.
CCDSiCCDS40964.1. [Q7TQA1-1]
CCDS40965.1. [Q7TQA1-5]
CCDS40966.1. [Q7TQA1-3]
CCDS40967.1. [Q7TQA1-4]
RefSeqiNP_808259.2. NM_177591.4. [Q7TQA1-1]
NP_808583.1. NM_177915.4. [Q7TQA1-4]
NP_899178.2. NM_183335.2. [Q7TQA1-3]
NP_899179.1. NM_183336.2. [Q7TQA1-5]
XP_006541550.1. XM_006541487.2. [Q7TQA1-3]
UniGeneiMm.110505.

3D structure databases

ProteinModelPortaliQ7TQA1.
SMRiQ7TQA1. Positions 43-485, 571-1228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033442.

PTM databases

iPTMnetiQ7TQA1.
PhosphoSiteiQ7TQA1.

Proteomic databases

MaxQBiQ7TQA1.
PaxDbiQ7TQA1.
PRIDEiQ7TQA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111. [Q7TQA1-1]
ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111. [Q7TQA1-3]
ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111. [Q7TQA1-4]
ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111. [Q7TQA1-5]
GeneIDi209268.
KEGGimmu:209268.
UCSCiuc009tdg.2. mouse. [Q7TQA1-1]
uc009tdi.1. mouse. [Q7TQA1-3]
uc009tdj.2. mouse. [Q7TQA1-4]

Organism-specific databases

CTDi3547.
MGIiMGI:2147913. Igsf1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IIFF. Eukaryota.
ENOG410YSQG. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000113017.
HOVERGENiHBG098292.
InParanoidiQ7TQA1.
OMAiPWENITL.
OrthoDBiEOG091G020P.
PhylomeDBiQ7TQA1.
TreeFamiTF336644.

Miscellaneous databases

ChiTaRSiIgsf1. mouse.
PROiQ7TQA1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031111.
CleanExiMM_IGSF1.
GenevisibleiQ7TQA1. MM.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 11 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGSF1_MOUSE
AccessioniPrimary (citable) accession number: Q7TQA1
Secondary accession number(s): Q6ZQD0
, Q7TQ99, Q7TQA0, Q8BMN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.