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Q7TQ69 (TMC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane channel-like protein 3
Gene names
Name:Tmc3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1130 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable ion channel By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Detected in most neuronal organs and also in some non-neuronal tissues. Ref.1

Sequence similarities

Belongs to the TMC family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q7TQ69-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: Q7TQ69-2)

The sequence of this isoform differs from the canonical sequence as follows:
     723-725: RSE → SII
     726-1130: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11301130Transmembrane channel-like protein 3
PRO_0000259603

Regions

Topological domain1 – 148148Cytoplasmic Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 19223Extracellular Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 22512Cytoplasmic Potential
Transmembrane226 – 24621Helical; Potential
Topological domain247 – 31973Extracellular Potential
Transmembrane320 – 34021Helical; Potential
Topological domain341 – 36121Cytoplasmic Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 39311Extracellular Potential
Transmembrane394 – 41421Helical; Potential
Topological domain415 – 50995Cytoplasmic Potential
Transmembrane510 – 53021Helical; Potential
Topological domain531 – 57040Extracellular Potential
Transmembrane571 – 59121Helical; Potential
Topological domain592 – 61928Cytoplasmic Potential
Transmembrane620 – 64021Helical; Potential
Topological domain641 – 68040Extracellular Potential
Transmembrane681 – 70121Helical; Potential
Topological domain702 – 1130429Cytoplasmic Potential

Amino acid modifications

Glycosylation2641N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence723 – 7253RSE → SII in isoform 2. Ref.2
VSP_052203
Alternative sequence726 – 1130405Missing in isoform 2. Ref.2
VSP_052204

Experimental info

Sequence conflict2481R → K in AAP69869. Ref.2
Sequence conflict5511P → L in AAP69869. Ref.2
Sequence conflict6951Missing in AAP69869. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 9FE2B2D4FD501FE1

FASTA1,130128,691
        10         20         30         40         50         60 
MKTSKASQRY RSIRRNASQC YLYQDSLLLG NSDDSFNADE TGDSSDPEQI FQNIQFQKDL 

        70         80         90        100        110        120 
MANIRCRPWT MGQKLRALRR AKEIVLKFEG RLTRTRGYQA AGAELWRKFA RLACNFVVIF 

       130        140        150        160        170        180 
IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG INIVLTVMTG AFVVLPELIA GQPFGSTASK 

       190        200        210        220        230        240 
TIPREQITSA QDLDTVWSLG GYLQYSVLFY GYYGRERRIG RAGYRLPLAY FLVGMAVFAY 

       250        260        270        280        290        300 
SFIVLLKRMA KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AILNSIREAI 

       310        320        330        340        350        360 
LEEQEKKKNK NMAVTVCLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS KKELTLWEKN 

       370        380        390        400        410        420 
EVSVVVSLVT MLAPSAFDLI AALEMYHPRT TLRFQLARVL VLYLGNLYSL IIALLDKVNS 

       430        440        450        460        470        480 
MNIEEAATKN ITSHWADAPT FSATRTVPEE GQWPTPGSGA ELRRNTSTWV VEETSFLTSI 

       490        500        510        520        530        540 
TPHTKANKTV PYMQGPQGQC WETYVGQEML KLSVIDMLFT VASILLIDFF RGLFVRYLSD 

       550        560        570        580        590        600 
YWCWDLESKF PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA 

       610        620        630        640        650        660 
VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VHYKPSLNCG PFSGQEKIYD 

       670        680        690        700        710        720 
IVSETIENDF PTWFHAVVGH ISSPVVILPA VLLLFMLIYY LQSIARSLKL SSQQLRMQIQ 

       730        740        750        760        770        780 
NARSEDKKKV AQMVEALAIP SDARQAGSAT EAESSENSKP KTLQARIQTH EESSKRLLKD 

       790        800        810        820        830        840 
SDLISQLSSV YMATSPNNGH MLNFDSLSSK SLRMEAITRS LPQSPGQGSR DPCSPLLDGS 

       850        860        870        880        890        900 
RSRPEQDTNR HPHRPCSSTS NLHKNRSCSS VTQTQPLKDV RSEPLSRKDF QPISPPFCGS 

       910        920        930        940        950        960 
GVSTLMTHDH SPRAPRYYVV NERDSHKKTH RAFWPERHFK IDALGDIVEL YPRNVQQYMS 

       970        980        990       1000       1010       1020 
WVPNQPCSPQ LSEEEEEMLR RDLVQWSIPA SSLTDLPRSS CFYTGDRSEN NTRDPKYQRR 

      1030       1040       1050       1060       1070       1080 
VYYRSGDNSF EDQLERPTFV HRKPRSRNGQ YPQHALKARV KAKFEPSFTE SDSVSAASSS 

      1090       1100       1110       1120       1130 
DHQNSNNDQY LHVMSSQGRF PRSASQLGRR KAKSRQVLPT DLNDLICSNV

« Hide

Isoform 2 [UniParc].

Checksum: 8660A3021427E0E9
Show »

FASTA72582,735

References

[1]"TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins."
Keresztes G., Mutai H., Heller S.
BMC Genomics 4:24-24(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."
Kurima K., Yang Y., Sorber K., Griffith A.J.
Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY263157 mRNA. Translation: AAP78772.1.
AY236491 mRNA. Translation: AAP69869.1.
IPIIPI00408182.
IPI00798503.
RefSeqNP_808363.3. NM_177695.4.
UniGeneMm.486619.

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ7TQ69.

Proteomic databases

PRIDEQ7TQ69.

Protocols and materials databases

DNASU233424.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID233424.
KEGGmmu:233424.

Organism-specific databases

CTD342125.
MGIMGI:2669033. Tmc3.

Phylogenomic databases

eggNOGNOG78939.
HOGENOMHOG000168231.
HOVERGENHBG036209.
InParanoidQ7TQ69.
OrthoDBEOG4VX24J.

Gene expression databases

CleanExMM_TMC3.
GenevestigatorQ7TQ69.

Family and domain databases

InterProIPR012496. TMC.
[Graphical view]
PfamPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381704.
SOURCESearch...

Entry information

Entry nameTMC3_MOUSE
AccessionPrimary (citable) accession number: Q7TQ69
Secondary accession number(s): Q7TN63
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents