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Protein

Sarcalumenin

Gene

Srl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of calcium transport.

GO - Molecular functioni

  1. GTP binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:Srl
Synonyms:Sar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146620. Srl.

Subcellular locationi

  1. Sarcoplasmic reticulum lumen By similarity

  2. Note: Associated through calcium with the membrane.By similarity

GO - Cellular componenti

  1. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 910890SarcalumeninPRO_0000045427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi826 – 8261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7TQ48.
PaxDbiQ7TQ48.
PRIDEiQ7TQ48.

PTM databases

PhosphoSiteiQ7TQ48.

Expressioni

Gene expression databases

BgeeiQ7TQ48.
CleanExiMM_SRL.
GenevestigatoriQ7TQ48.

Interactioni

Protein-protein interaction databases

BioGridi223048. 1 interaction.
IntActiQ7TQ48. 1 interaction.
MINTiMINT-4112166.
STRINGi10090.ENSMUSP00000023161.

Structurei

3D structure databases

ProteinModelPortaliQ7TQ48.
SMRiQ7TQ48. Positions 493-880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini527 – 768242Dynamin-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 459439Acidic domain, probably binds calciumBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136252.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiQ7TQ48.
OMAiXGEITSK.
OrthoDBiEOG7W6WKK.
PhylomeDBiQ7TQ48.
TreeFamiTF324008.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TQ48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALLLLCCF LASLLLSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE
60 70 80 90 100
KERALYADAA PGDKNLLLHY PDGREAESLE QTPAGAPSTA NGQGSETEAS
110 120 130 140 150
LSNTSAAESA PPGDVEGPGE EEEGPHAAGT LPPGGIEGPE EERPQFSSGK
160 170 180 190 200
EPGQEEAGVG VPTEGAASME AEVQEGSSGV PEELQGLLGD GPMNEAAGTA
210 220 230 240 250
ESVVTQSSPP IEGKEAEGEG NTGSDHQSTE LDGTQDAIPA GDESEAREGA
260 270 280 290 300
EDKPQDYSLQ SEDTATPGPD HQPTDLHAAS DTASSGVEAE EGAEESKAEV
310 320 330 340 350
DTESGEKVED QGEPRPSLDA GSAIEANKQS EYTQARETEN DSPEGQVSGM
360 370 380 390 400
SEEGLAEASS EEEGGEEDGS ENGEVPFKEE SGEDSGDGAS SEEEGSTPGE
410 420 430 440 450
AGEPQKTPGA TGHEEEGPQL DVEDLNTGFE GSKTQDIEAE ASEERQQERG
460 470 480 490 500
NPVIAQWEEV EDASEEAPLR DRSHIDKTLM LNEDKPADDY SAVLQRLRKI
510 520 530 540 550
YHTSIKPLEQ SYKYNELRQH EITDGEITSK PMVLFLGPWS VGKSTMINYL
560 570 580 590 600
LGLEDTRYQL YTGAEPTTSE FTVLMHGPKL KTIEGIVMAA DSARSFSPLE
610 620 630 640 650
KFGQNFLEKL IGIEVPHKLL ERVTFVDTPG IIENRKQQER GYPFNDVCQW
660 670 680 690 700
FIDRADLIFV VFDPTKLDVG LELEMLFRQL KGRESQIRII LNKADNLATQ
710 720 730 740 750
MLMRVYGALF WSLAPLINVT EPPRVYVSSF WPQDYKPDTH RELFLKEEIS
760 770 780 790 800
LLEDLNQVIE NRLENKIAFI RQHAIRVRIH ALLVDRYLQT YKDKMTFFSD
810 820 830 840 850
GELVFKDIVE DPDKFYIFKT ILAKTNVSKF DLPNREAYKD FFGINPISNF
860 870 880 890 900
KLLSQQCSYM GGCFLEKIER AITQELPSLL GSIGLGKNPG APNCDKTGCG
910
ETPKNRYKKH
Length:910
Mass (Da):99,184
Last modified:October 1, 2003 - v1
Checksum:i410B2D11F3562DC1
GO
Isoform 2 (identifier: Q7TQ48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-459: Missing.

Show »
Length:472
Mass (Da):54,287
Checksum:i054AF34A741D09C7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 459438Missing in isoform 2. 1 PublicationVSP_016922Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113383 mRNA. Translation: BAC78629.1.
AK036394 mRNA. Translation: BAC29409.1.
BC145687 mRNA. Translation: AAI45688.1.
CCDSiCCDS27918.1. [Q7TQ48-1]
RefSeqiNP_780556.2. NM_175347.4. [Q7TQ48-1]
UniGeneiMm.35811.

Genome annotation databases

EnsembliENSMUST00000023161; ENSMUSP00000023161; ENSMUSG00000022519. [Q7TQ48-1]
ENSMUST00000090500; ENSMUSP00000087986; ENSMUSG00000022519. [Q7TQ48-2]
GeneIDi106393.
KEGGimmu:106393.
UCSCiuc007xzt.1. mouse. [Q7TQ48-1]
uc007xzu.1. mouse. [Q7TQ48-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113383 mRNA. Translation: BAC78629.1.
AK036394 mRNA. Translation: BAC29409.1.
BC145687 mRNA. Translation: AAI45688.1.
CCDSiCCDS27918.1. [Q7TQ48-1]
RefSeqiNP_780556.2. NM_175347.4. [Q7TQ48-1]
UniGeneiMm.35811.

3D structure databases

ProteinModelPortaliQ7TQ48.
SMRiQ7TQ48. Positions 493-880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223048. 1 interaction.
IntActiQ7TQ48. 1 interaction.
MINTiMINT-4112166.
STRINGi10090.ENSMUSP00000023161.

PTM databases

PhosphoSiteiQ7TQ48.

Proteomic databases

MaxQBiQ7TQ48.
PaxDbiQ7TQ48.
PRIDEiQ7TQ48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023161; ENSMUSP00000023161; ENSMUSG00000022519. [Q7TQ48-1]
ENSMUST00000090500; ENSMUSP00000087986; ENSMUSG00000022519. [Q7TQ48-2]
GeneIDi106393.
KEGGimmu:106393.
UCSCiuc007xzt.1. mouse. [Q7TQ48-1]
uc007xzu.1. mouse. [Q7TQ48-2]

Organism-specific databases

CTDi6345.
MGIiMGI:2146620. Srl.

Phylogenomic databases

eggNOGiNOG136252.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiQ7TQ48.
OMAiXGEITSK.
OrthoDBiEOG7W6WKK.
PhylomeDBiQ7TQ48.
TreeFamiTF324008.

Miscellaneous databases

NextBioi358189.
PROiQ7TQ48.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TQ48.
CleanExiMM_SRL.
GenevestigatoriQ7TQ48.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and characterization of sarcalumenin-deficient mice."
    Yoshida M., Komazaki S., Nishi M., Saito M., Yanagisawa T., Takeshima H.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSRCA_MOUSE
AccessioniPrimary (citable) accession number: Q7TQ48
Secondary accession number(s): A6H5Y7, Q8BS43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.