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Q7TQ48 (SRCA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sarcalumenin
Gene names
Name:Srl
Synonyms:Sar
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the regulation of calcium transport.

Subcellular location

Sarcoplasmic reticulum lumen By similarity. Note: Associated through calcium with the membrane By similarity.

Sequence similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Cellular componentSarcoplasmic reticulum
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentsarcoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: InterPro

GTPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7TQ48-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7TQ48-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-459: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 910890Sarcalumenin
PRO_0000045427

Regions

Domain527 – 768242Dynamin-type G
Region21 – 459439Acidic domain, probably binds calcium By similarity

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation7181N-linked (GlcNAc...) Potential
Glycosylation8261N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence22 – 459438Missing in isoform 2.
VSP_016922

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 410B2D11F3562DC1

FASTA91099,184
        10         20         30         40         50         60 
MKALLLLCCF LASLLLSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE KERALYADAA 

        70         80         90        100        110        120 
PGDKNLLLHY PDGREAESLE QTPAGAPSTA NGQGSETEAS LSNTSAAESA PPGDVEGPGE 

       130        140        150        160        170        180 
EEEGPHAAGT LPPGGIEGPE EERPQFSSGK EPGQEEAGVG VPTEGAASME AEVQEGSSGV 

       190        200        210        220        230        240 
PEELQGLLGD GPMNEAAGTA ESVVTQSSPP IEGKEAEGEG NTGSDHQSTE LDGTQDAIPA 

       250        260        270        280        290        300 
GDESEAREGA EDKPQDYSLQ SEDTATPGPD HQPTDLHAAS DTASSGVEAE EGAEESKAEV 

       310        320        330        340        350        360 
DTESGEKVED QGEPRPSLDA GSAIEANKQS EYTQARETEN DSPEGQVSGM SEEGLAEASS 

       370        380        390        400        410        420 
EEEGGEEDGS ENGEVPFKEE SGEDSGDGAS SEEEGSTPGE AGEPQKTPGA TGHEEEGPQL 

       430        440        450        460        470        480 
DVEDLNTGFE GSKTQDIEAE ASEERQQERG NPVIAQWEEV EDASEEAPLR DRSHIDKTLM 

       490        500        510        520        530        540 
LNEDKPADDY SAVLQRLRKI YHTSIKPLEQ SYKYNELRQH EITDGEITSK PMVLFLGPWS 

       550        560        570        580        590        600 
VGKSTMINYL LGLEDTRYQL YTGAEPTTSE FTVLMHGPKL KTIEGIVMAA DSARSFSPLE 

       610        620        630        640        650        660 
KFGQNFLEKL IGIEVPHKLL ERVTFVDTPG IIENRKQQER GYPFNDVCQW FIDRADLIFV 

       670        680        690        700        710        720 
VFDPTKLDVG LELEMLFRQL KGRESQIRII LNKADNLATQ MLMRVYGALF WSLAPLINVT 

       730        740        750        760        770        780 
EPPRVYVSSF WPQDYKPDTH RELFLKEEIS LLEDLNQVIE NRLENKIAFI RQHAIRVRIH 

       790        800        810        820        830        840 
ALLVDRYLQT YKDKMTFFSD GELVFKDIVE DPDKFYIFKT ILAKTNVSKF DLPNREAYKD 

       850        860        870        880        890        900 
FFGINPISNF KLLSQQCSYM GGCFLEKIER AITQELPSLL GSIGLGKNPG APNCDKTGCG 

       910 
ETPKNRYKKH 

« Hide

Isoform 2 [UniParc].

Checksum: 054AF34A741D09C7
Show »

FASTA47254,287

References

« Hide 'large scale' references
[1]"Generation and characterization of sarcalumenin-deficient mice."
Yoshida M., Komazaki S., Nishi M., Saito M., Yanagisawa T., Takeshima H.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Skeletal muscle.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Bone.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB113383 mRNA. Translation: BAC78629.1.
AK036394 mRNA. Translation: BAC29409.1.
BC145687 mRNA. Translation: AAI45688.1.
CCDSCCDS27918.1. [Q7TQ48-1]
RefSeqNP_780556.2. NM_175347.4. [Q7TQ48-1]
UniGeneMm.35811.

3D structure databases

ProteinModelPortalQ7TQ48.
SMRQ7TQ48. Positions 493-880.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid223048. 1 interaction.
IntActQ7TQ48. 1 interaction.
MINTMINT-4112166.
STRING10090.ENSMUSP00000023161.

PTM databases

PhosphoSiteQ7TQ48.

Proteomic databases

MaxQBQ7TQ48.
PaxDbQ7TQ48.
PRIDEQ7TQ48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023161; ENSMUSP00000023161; ENSMUSG00000022519. [Q7TQ48-1]
ENSMUST00000090500; ENSMUSP00000087986; ENSMUSG00000022519. [Q7TQ48-2]
GeneID106393.
KEGGmmu:106393.
UCSCuc007xzt.1. mouse. [Q7TQ48-1]
uc007xzu.1. mouse. [Q7TQ48-2]

Organism-specific databases

CTD6345.
MGIMGI:2146620. Srl.

Phylogenomic databases

eggNOGNOG136252.
GeneTreeENSGT00750000117558.
HOGENOMHOG000290639.
HOVERGENHBG017848.
InParanoidA6H5Y7.
OMAXGEITSK.
OrthoDBEOG7W6WKK.
PhylomeDBQ7TQ48.
TreeFamTF324008.

Gene expression databases

BgeeQ7TQ48.
CleanExMM_SRL.
GenevestigatorQ7TQ48.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR001401. Dynamin_GTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00350. Dynamin_N. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio358189.
PROQ7TQ48.
SOURCESearch...

Entry information

Entry nameSRCA_MOUSE
AccessionPrimary (citable) accession number: Q7TQ48
Secondary accession number(s): A6H5Y7, Q8BS43
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot