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Q7TQ48

- SRCA_MOUSE

UniProt

Q7TQ48 - SRCA_MOUSE

Protein

Sarcalumenin

Gene

Srl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of calcium transport.

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcalumenin
    Gene namesi
    Name:Srl
    Synonyms:Sar
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2146620. Srl.

    Subcellular locationi

    Sarcoplasmic reticulum lumen By similarity
    Note: Associated through calcium with the membrane.By similarity

    GO - Cellular componenti

    1. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Sarcoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 910890SarcalumeninPRO_0000045427Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi826 – 8261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ7TQ48.
    PaxDbiQ7TQ48.
    PRIDEiQ7TQ48.

    PTM databases

    PhosphoSiteiQ7TQ48.

    Expressioni

    Gene expression databases

    BgeeiQ7TQ48.
    CleanExiMM_SRL.
    GenevestigatoriQ7TQ48.

    Interactioni

    Protein-protein interaction databases

    BioGridi223048. 1 interaction.
    IntActiQ7TQ48. 1 interaction.
    MINTiMINT-4112166.
    STRINGi10090.ENSMUSP00000023161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TQ48.
    SMRiQ7TQ48. Positions 493-880.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini527 – 768242Dynamin-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 459439Acidic domain, probably binds calciumBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG136252.
    GeneTreeiENSGT00750000117558.
    HOGENOMiHOG000290639.
    HOVERGENiHBG017848.
    InParanoidiA6H5Y7.
    OMAiXGEITSK.
    OrthoDBiEOG7W6WKK.
    PhylomeDBiQ7TQ48.
    TreeFamiTF324008.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR001401. Dynamin_GTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00350. Dynamin_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TQ48-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKALLLLCCF LASLLLSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE    50
    KERALYADAA PGDKNLLLHY PDGREAESLE QTPAGAPSTA NGQGSETEAS 100
    LSNTSAAESA PPGDVEGPGE EEEGPHAAGT LPPGGIEGPE EERPQFSSGK 150
    EPGQEEAGVG VPTEGAASME AEVQEGSSGV PEELQGLLGD GPMNEAAGTA 200
    ESVVTQSSPP IEGKEAEGEG NTGSDHQSTE LDGTQDAIPA GDESEAREGA 250
    EDKPQDYSLQ SEDTATPGPD HQPTDLHAAS DTASSGVEAE EGAEESKAEV 300
    DTESGEKVED QGEPRPSLDA GSAIEANKQS EYTQARETEN DSPEGQVSGM 350
    SEEGLAEASS EEEGGEEDGS ENGEVPFKEE SGEDSGDGAS SEEEGSTPGE 400
    AGEPQKTPGA TGHEEEGPQL DVEDLNTGFE GSKTQDIEAE ASEERQQERG 450
    NPVIAQWEEV EDASEEAPLR DRSHIDKTLM LNEDKPADDY SAVLQRLRKI 500
    YHTSIKPLEQ SYKYNELRQH EITDGEITSK PMVLFLGPWS VGKSTMINYL 550
    LGLEDTRYQL YTGAEPTTSE FTVLMHGPKL KTIEGIVMAA DSARSFSPLE 600
    KFGQNFLEKL IGIEVPHKLL ERVTFVDTPG IIENRKQQER GYPFNDVCQW 650
    FIDRADLIFV VFDPTKLDVG LELEMLFRQL KGRESQIRII LNKADNLATQ 700
    MLMRVYGALF WSLAPLINVT EPPRVYVSSF WPQDYKPDTH RELFLKEEIS 750
    LLEDLNQVIE NRLENKIAFI RQHAIRVRIH ALLVDRYLQT YKDKMTFFSD 800
    GELVFKDIVE DPDKFYIFKT ILAKTNVSKF DLPNREAYKD FFGINPISNF 850
    KLLSQQCSYM GGCFLEKIER AITQELPSLL GSIGLGKNPG APNCDKTGCG 900
    ETPKNRYKKH 910
    Length:910
    Mass (Da):99,184
    Last modified:October 1, 2003 - v1
    Checksum:i410B2D11F3562DC1
    GO
    Isoform 2 (identifier: Q7TQ48-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-459: Missing.

    Show »
    Length:472
    Mass (Da):54,287
    Checksum:i054AF34A741D09C7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 459438Missing in isoform 2. 1 PublicationVSP_016922Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB113383 mRNA. Translation: BAC78629.1.
    AK036394 mRNA. Translation: BAC29409.1.
    BC145687 mRNA. Translation: AAI45688.1.
    CCDSiCCDS27918.1. [Q7TQ48-1]
    RefSeqiNP_780556.2. NM_175347.4. [Q7TQ48-1]
    UniGeneiMm.35811.

    Genome annotation databases

    EnsembliENSMUST00000023161; ENSMUSP00000023161; ENSMUSG00000022519. [Q7TQ48-1]
    ENSMUST00000090500; ENSMUSP00000087986; ENSMUSG00000022519. [Q7TQ48-2]
    GeneIDi106393.
    KEGGimmu:106393.
    UCSCiuc007xzt.1. mouse. [Q7TQ48-1]
    uc007xzu.1. mouse. [Q7TQ48-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB113383 mRNA. Translation: BAC78629.1 .
    AK036394 mRNA. Translation: BAC29409.1 .
    BC145687 mRNA. Translation: AAI45688.1 .
    CCDSi CCDS27918.1. [Q7TQ48-1 ]
    RefSeqi NP_780556.2. NM_175347.4. [Q7TQ48-1 ]
    UniGenei Mm.35811.

    3D structure databases

    ProteinModelPortali Q7TQ48.
    SMRi Q7TQ48. Positions 493-880.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223048. 1 interaction.
    IntActi Q7TQ48. 1 interaction.
    MINTi MINT-4112166.
    STRINGi 10090.ENSMUSP00000023161.

    PTM databases

    PhosphoSitei Q7TQ48.

    Proteomic databases

    MaxQBi Q7TQ48.
    PaxDbi Q7TQ48.
    PRIDEi Q7TQ48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023161 ; ENSMUSP00000023161 ; ENSMUSG00000022519 . [Q7TQ48-1 ]
    ENSMUST00000090500 ; ENSMUSP00000087986 ; ENSMUSG00000022519 . [Q7TQ48-2 ]
    GeneIDi 106393.
    KEGGi mmu:106393.
    UCSCi uc007xzt.1. mouse. [Q7TQ48-1 ]
    uc007xzu.1. mouse. [Q7TQ48-2 ]

    Organism-specific databases

    CTDi 6345.
    MGIi MGI:2146620. Srl.

    Phylogenomic databases

    eggNOGi NOG136252.
    GeneTreei ENSGT00750000117558.
    HOGENOMi HOG000290639.
    HOVERGENi HBG017848.
    InParanoidi A6H5Y7.
    OMAi XGEITSK.
    OrthoDBi EOG7W6WKK.
    PhylomeDBi Q7TQ48.
    TreeFami TF324008.

    Miscellaneous databases

    NextBioi 358189.
    PROi Q7TQ48.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TQ48.
    CleanExi MM_SRL.
    Genevestigatori Q7TQ48.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR001401. Dynamin_GTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00350. Dynamin_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51718. G_DYNAMIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and characterization of sarcalumenin-deficient mice."
      Yoshida M., Komazaki S., Nishi M., Saito M., Yanagisawa T., Takeshima H.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Bone.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSRCA_MOUSE
    AccessioniPrimary (citable) accession number: Q7TQ48
    Secondary accession number(s): A6H5Y7, Q8BS43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3