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Protein

Zinc finger protein ZIC 5

Gene

Zic5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri422 – 44423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: MGI
  • forebrain development Source: MGI
  • neural tube closure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 5
Alternative name(s):
Zinc finger protein of the cerebellum 5
Gene namesi
Name:Zic5
Synonyms:Opr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929518. Zic5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice exhibited insufficient neural tube closure at the rostral end and malformation of neural-crest-derived facial bones especially the mandible. After birth, mice were significantly smaller than their littermates and most of them died within 2 months.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Zinc finger protein ZIC 5PRO_0000406213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei537 – 5371PhosphoserineCombined sources
Modified residuei541 – 5411PhosphoserineCombined sources
Modified residuei559 – 5591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TQ40.
PaxDbiQ7TQ40.
PRIDEiQ7TQ40.

PTM databases

iPTMnetiQ7TQ40.
PhosphoSiteiQ7TQ40.

Expressioni

Developmental stagei

Expressed in the embryonic ectoderm before gastrulation, and gradually restricted to the anterior part from the mid to late streak stage. Becomes restricted to the dorsal side of the neural tube at 8 dpc. After neural tube closure, is expressed in the dorsal midline of the entire neural tube and in the roof plate. Also expressed in the developing limb buds.2 Publications

Gene expression databases

BgeeiENSMUSG00000041703.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035754.

Structurei

3D structure databases

ProteinModelPortaliQ7TQ40.
SMRiQ7TQ40. Positions 360-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 15070Pro-richAdd
BLAST
Compositional biasi260 – 35394Ala-richAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri422 – 44423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50425C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ7TQ40.
KOiK09226.
PhylomeDBiQ7TQ40.
TreeFamiTF351425.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPPLSKRN PPALRLADLA TAQAQQLQNM TGFPVLVGPP AHSQRRAVAM
60 70 80 90 100
HLHPRDLGTD PGVASTALGP EHMAQASGQG PCPPSQGLPG LFQVPAPAAR
110 120 130 140 150
SVASGTHPGA RTHPDGGGSS GAQASAPPPP APPLPPSQSS SPPPPPPPPP
160 170 180 190 200
ALSGYTATNS GGGSSSGKGH SRDFVLRRDL SATAPAAAMH GAPLGGEQRS
210 220 230 240 250
GSSSPQHPTP PPHPAGMFIS ASGTYAGRDG GGSALFPALH DSPGAPGGHP
260 270 280 290 300
LNGQMRLGLA AAAAAAAELY GRAEPPFAPR SGDAHYGAVA AAAAAALHGY
310 320 330 340 350
GAVNLNLNLA AAAAAAAAAG PGPHLQHHAP PPAPPPAPAP HPHHPHLPGA
360 370 380 390 400
AGAFLRYMRQ PIKRELICKW LDPEELAGPP ASADSGVKPC SKTFGTMHEL
410 420 430 440 450
VNHVTVEHVG GPEQSSHVCF WEDCPREGKP FKAKYKLINH IRVHTGEKPF
460 470 480 490 500
PCPFPGCGKV FARSENLKIH KRTHTGEKPF KCEFDGCDRK FANSSDRKKH
510 520 530 540 550
SHVHTSDKPY YCKIRGCDKS YTHPSSLRKH MKIHCKSPPP SPGALGYSSV
560 570 580 590 600
GTPVGDPLSP VLDPTRSRSS TLSPQVTNLN EWYVCQASGA PSHLHTPSSN
610 620
GTTSESEDEE MYGNPEVMRT IH
Length:622
Mass (Da):64,542
Last modified:October 1, 2003 - v1
Checksum:iE9D2B5D27DCAF640
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921F → S in BAB18579 (PubMed:11044622).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042155 mRNA. Translation: BAB18579.1.
AB114214 mRNA. Translation: BAC79075.1.
CCDSiCCDS27348.1.
RefSeqiNP_075363.1. NM_022987.3.
UniGeneiMm.390761.

Genome annotation databases

GeneIDi65100.
KEGGimmu:65100.
UCSCiuc007vbb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042155 mRNA. Translation: BAB18579.1.
AB114214 mRNA. Translation: BAC79075.1.
CCDSiCCDS27348.1.
RefSeqiNP_075363.1. NM_022987.3.
UniGeneiMm.390761.

3D structure databases

ProteinModelPortaliQ7TQ40.
SMRiQ7TQ40. Positions 360-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035754.

PTM databases

iPTMnetiQ7TQ40.
PhosphoSiteiQ7TQ40.

Proteomic databases

MaxQBiQ7TQ40.
PaxDbiQ7TQ40.
PRIDEiQ7TQ40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65100.
KEGGimmu:65100.
UCSCiuc007vbb.2. mouse.

Organism-specific databases

CTDi85416.
MGIiMGI:1929518. Zic5.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ7TQ40.
KOiK09226.
PhylomeDBiQ7TQ40.
TreeFamiTF351425.

Miscellaneous databases

PROiQ7TQ40.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041703.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZIC5_MOUSE
AccessioniPrimary (citable) accession number: Q7TQ40
Secondary accession number(s): Q9EQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.