Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome b-c1 complex subunit 8

Gene

Uqcrq

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Low molecular mass ubiquinone-binding protein
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:Uqcrq
Synonyms:Qpc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1562350. Uqcrq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6318HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8281Cytochrome b-c1 complex subunit 8PRO_0000346788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity
Modified residuei33 – 331N6-acetyllysine; alternateBy similarity
Modified residuei33 – 331N6-succinyllysine; alternateBy similarity
Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7TQ16.
PRIDEiQ7TQ16.

PTM databases

iPTMnetiQ7TQ16.
PhosphoSiteiQ7TQ16.

Expressioni

Gene expression databases

BgeeiENSRNOG00000048174.
GenevisibleiQ7TQ16. RN.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

IntActiQ7TQ16. 1 interaction.
STRINGi10116.ENSRNOP00000065074.

Structurei

3D structure databases

ProteinModelPortaliQ7TQ16.
SMRiQ7TQ16. Positions 2-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4116. Eukaryota.
ENOG41123BH. LUCA.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiQ7TQ16.
KOiK00418.
OMAiVYTWGTQ.
OrthoDBiEOG091G13Z0.
PhylomeDBiQ7TQ16.
TreeFamiTF300281.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREFGNLTR IRHVISYSLS PFEQRAFPHY FSKGIPNVLR RTRERILRVA
60 70 80
PPFVLFYLIY TWGNQEFAQS KRKNPAKYEN DK
Length:82
Mass (Da):9,849
Last modified:October 1, 2003 - v1
Checksum:iA50529450BA5762B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323237 mRNA. Translation: AAP84717.1.
RefSeqiNP_001020305.1. NM_001025134.1.
XP_006246378.1. XM_006246316.2.
UniGeneiRn.3472.

Genome annotation databases

EnsembliENSRNOT00000073964; ENSRNOP00000065074; ENSRNOG00000048174.
GeneIDi497902.
KEGGirno:497902.
UCSCiRGD:1562350. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323237 mRNA. Translation: AAP84717.1.
RefSeqiNP_001020305.1. NM_001025134.1.
XP_006246378.1. XM_006246316.2.
UniGeneiRn.3472.

3D structure databases

ProteinModelPortaliQ7TQ16.
SMRiQ7TQ16. Positions 2-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TQ16. 1 interaction.
STRINGi10116.ENSRNOP00000065074.

PTM databases

iPTMnetiQ7TQ16.
PhosphoSiteiQ7TQ16.

Proteomic databases

PaxDbiQ7TQ16.
PRIDEiQ7TQ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073964; ENSRNOP00000065074; ENSRNOG00000048174.
GeneIDi497902.
KEGGirno:497902.
UCSCiRGD:1562350. rat.

Organism-specific databases

CTDi27089.
RGDi1562350. Uqcrq.

Phylogenomic databases

eggNOGiKOG4116. Eukaryota.
ENOG41123BH. LUCA.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiQ7TQ16.
KOiK00418.
OMAiVYTWGTQ.
OrthoDBiEOG091G13Z0.
PhylomeDBiQ7TQ16.
TreeFamiTF300281.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Miscellaneous databases

PROiQ7TQ16.

Gene expression databases

BgeeiENSRNOG00000048174.
GenevisibleiQ7TQ16. RN.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR8_RAT
AccessioniPrimary (citable) accession number: Q7TQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.