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Protein

Cytochrome b-c1 complex subunit 8

Gene

Uqcrq

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Low molecular mass ubiquinone-binding protein
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:Uqcrq
Synonyms:Qpc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1562350. Uqcrq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6318HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8281Cytochrome b-c1 complex subunit 8PRO_0000346788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysine; alternateBy similarity
Modified residuei33 – 331N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7TQ16.
PRIDEiQ7TQ16.

PTM databases

iPTMnetiQ7TQ16.

Expressioni

Gene expression databases

GenevisibleiQ7TQ16. RN.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

IntActiQ7TQ16. 1 interaction.
STRINGi10116.ENSRNOP00000065074.

Structurei

3D structure databases

ProteinModelPortaliQ7TQ16.
SMRiQ7TQ16. Positions 2-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4116. Eukaryota.
ENOG41123BH. LUCA.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiQ7TQ16.
KOiK00418.
OMAiVYTWGTQ.
OrthoDBiEOG7K3TPV.
PhylomeDBiQ7TQ16.
TreeFamiTF300281.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREFGNLTR IRHVISYSLS PFEQRAFPHY FSKGIPNVLR RTRERILRVA
60 70 80
PPFVLFYLIY TWGNQEFAQS KRKNPAKYEN DK
Length:82
Mass (Da):9,849
Last modified:October 1, 2003 - v1
Checksum:iA50529450BA5762B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323237 mRNA. Translation: AAP84717.1.
RefSeqiNP_001020305.1. NM_001025134.1.
XP_006246378.1. XM_006246316.2.
UniGeneiRn.3472.

Genome annotation databases

EnsembliENSRNOT00000073964; ENSRNOP00000065074; ENSRNOG00000048174.
GeneIDi497902.
KEGGirno:497902.
UCSCiRGD:1562350. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323237 mRNA. Translation: AAP84717.1.
RefSeqiNP_001020305.1. NM_001025134.1.
XP_006246378.1. XM_006246316.2.
UniGeneiRn.3472.

3D structure databases

ProteinModelPortaliQ7TQ16.
SMRiQ7TQ16. Positions 2-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TQ16. 1 interaction.
STRINGi10116.ENSRNOP00000065074.

PTM databases

iPTMnetiQ7TQ16.

Proteomic databases

PaxDbiQ7TQ16.
PRIDEiQ7TQ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073964; ENSRNOP00000065074; ENSRNOG00000048174.
GeneIDi497902.
KEGGirno:497902.
UCSCiRGD:1562350. rat.

Organism-specific databases

CTDi27089.
RGDi1562350. Uqcrq.

Phylogenomic databases

eggNOGiKOG4116. Eukaryota.
ENOG41123BH. LUCA.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiQ7TQ16.
KOiK00418.
OMAiVYTWGTQ.
OrthoDBiEOG7K3TPV.
PhylomeDBiQ7TQ16.
TreeFamiTF300281.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi697973.
PROiQ7TQ16.

Gene expression databases

GenevisibleiQ7TQ16. RN.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Shan Y.X., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiQCR8_RAT
AccessioniPrimary (citable) accession number: Q7TQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: January 20, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.