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Protein

Carboxypeptidase A1

Gene

Cpa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.By similarity

Catalytic activityi

Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi179 – 1791Zinc; catalyticBy similarity
Metal bindingi182 – 1821Zinc; catalyticBy similarity
Binding sitei237 – 2371SubstrateBy similarity
Metal bindingi306 – 3061Zinc; catalyticBy similarity
Binding sitei358 – 3581SubstrateBy similarity
Active sitei380 – 3801Proton donor/acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A1 (EC:3.4.17.1)
Gene namesi
Name:Cpa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88478. Cpa1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Propeptidei17 – 11094Activation peptidePRO_0000004347Add
BLAST
Chaini111 – 419309Carboxypeptidase A1PRO_0000004348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi248 ↔ 271By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiQ7TPZ8.
PaxDbiQ7TPZ8.
PRIDEiQ7TPZ8.

PTM databases

iPTMnetiQ7TPZ8.
PhosphoSiteiQ7TPZ8.

Expressioni

Gene expression databases

BgeeiQ7TPZ8.
CleanExiMM_CPA1.
GenevisibleiQ7TPZ8. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031806.

Structurei

3D structure databases

ProteinModelPortaliQ7TPZ8.
SMRiQ7TPZ8. Positions 18-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 1824Substrate bindingBy similarity
Regioni254 – 2552Substrate bindingBy similarity
Regioni307 – 3082Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ7TPZ8.
KOiK08779.
OMAiSHGISYE.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ7TPZ8.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLLVLSVL LAAVFGNENF VGHQVLRISA TDEAQVQKVR ELEELEHLKL
60 70 80 90 100
DFWRDPARAG LPIDVRVPFP TIQSVKAFLE YHDISYEIMI EDVQSLLDEE
110 120 130 140 150
KQQMSAFQAR ALSTDAFNYA TYHTLDEIYE FMDLLVTEHP QLVSKIQIGS
160 170 180 190 200
TFEGRPINVL KFSTGGTNRP AIWIDTGIHS REWVTQASGV WFAKKITKDY
210 220 230 240 250
GQEPTLTAIL DNMDIFLEIV TNPDGFVYTH KTNRMWRKTR SHTEGSLCVG
260 270 280 290 300
VDPNRNWDAA FGMPGASSNP CSETYRGKFP NSEVEVKSIV DFVTSHGNIK
310 320 330 340 350
AFISIHSYSQ LLLYPYGYTS EPAPDKEELD QLAKSAVTAL TSLHGTKFKY
360 370 380 390 400
GSIIDTIYQA SGSTIDWTYS QGIKYSFTFE LRDTGLRGFL LPASQIIPTA
410
EETWLALLTI MDHTVKHPY
Length:419
Mass (Da):47,385
Last modified:October 1, 2003 - v1
Checksum:i837CD5FEA3FBBECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052661 mRNA. Translation: AAH52661.1.
CCDSiCCDS19977.1.
RefSeqiNP_079626.2. NM_025350.4.
UniGeneiMm.25377.

Genome annotation databases

EnsembliENSMUST00000031806; ENSMUSP00000031806; ENSMUSG00000054446.
GeneIDi109697.
KEGGimmu:109697.
UCSCiuc009bfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052661 mRNA. Translation: AAH52661.1.
CCDSiCCDS19977.1.
RefSeqiNP_079626.2. NM_025350.4.
UniGeneiMm.25377.

3D structure databases

ProteinModelPortaliQ7TPZ8.
SMRiQ7TPZ8. Positions 18-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031806.

Protein family/group databases

MEROPSiM14.001.

PTM databases

iPTMnetiQ7TPZ8.
PhosphoSiteiQ7TPZ8.

Proteomic databases

MaxQBiQ7TPZ8.
PaxDbiQ7TPZ8.
PRIDEiQ7TPZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031806; ENSMUSP00000031806; ENSMUSG00000054446.
GeneIDi109697.
KEGGimmu:109697.
UCSCiuc009bfq.1. mouse.

Organism-specific databases

CTDi1357.
MGIiMGI:88478. Cpa1.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ7TPZ8.
KOiK08779.
OMAiSHGISYE.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ7TPZ8.
TreeFamiTF317197.

Miscellaneous databases

ChiTaRSiCpa1. mouse.
PROiQ7TPZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TPZ8.
CleanExiMM_CPA1.
GenevisibleiQ7TPZ8. MM.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Pancreas and Spleen.

Entry informationi

Entry nameiCBPA1_MOUSE
AccessioniPrimary (citable) accession number: Q7TPZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.