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Protein

Myb-binding protein 1A

Gene

Mybbp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230).3 Publications

GO - Molecular functioni

  • core promoter binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: InterPro
  • sequence-specific DNA binding Source: Ensembl
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-binding protein 1A
Alternative name(s):
Myb-binding protein of 160 kDa
Gene namesi
Name:Mybbp1a
Synonyms:P160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106181 Mybbp1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi249L → A: Reduced nuclear export; when associated with A-251. 1 Publication1
Mutagenesisi251V → A: Reduced nuclear export; when associated with A-249. 1 Publication1
Mutagenesisi272L → A: Reduced nuclear export; when associated with A-274. 1 Publication1
Mutagenesisi274L → A: Reduced nuclear export; when associated with A-272. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000962562 – 1344Myb-binding protein 1AAdd BLAST1343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei156N6-acetyllysineBy similarity1
Cross-linki1149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1160PhosphoserineBy similarity1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1191PhosphothreonineBy similarity1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1244PhosphoserineCombined sources1
Modified residuei1251PhosphothreonineBy similarity1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1256PhosphothreonineCombined sources1
Modified residuei1277PhosphothreonineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1303PhosphoserineBy similarity1
Modified residuei1318PhosphoserineBy similarity1
Modified residuei1322Citrulline1 Publication1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1329PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7TPV4
MaxQBiQ7TPV4
PaxDbiQ7TPV4
PRIDEiQ7TPV4

PTM databases

iPTMnetiQ7TPV4
PhosphoSitePlusiQ7TPV4

Miscellaneous databases

PMAP-CutDBiQ7TPV4

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000040463
CleanExiMM_MYBBP1A
ExpressionAtlasiQ7TPV4 baseline and differential
GenevisibleiQ7TPV4 MM

Interactioni

Subunit structurei

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr4a1P128133EBI-1373622,EBI-10896863

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi201999, 18 interactors
CORUMiQ7TPV4
DIPiDIP-39831N
IntActiQ7TPV4, 17 interactors
MINTiQ7TPV4
STRINGi10090.ENSMUSP00000044827

Structurei

3D structure databases

ProteinModelPortaliQ7TPV4
SMRiQ7TPV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 580Interaction with MYB1 PublicationAdd BLAST579
Regioni1152 – 1344Required for nuclear and nucleolar localization1 PublicationAdd BLAST193

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 256Nuclear export signal 11 PublicationAdd BLAST19
Motifi261 – 279Nuclear export signal 21 PublicationAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 752Asp-richAdd BLAST55

Phylogenomic databases

eggNOGiKOG1926 Eukaryota
ENOG410YFVF LUCA
GeneTreeiENSGT00390000017457
HOGENOMiHOG000113488
HOVERGENiHBG081961
InParanoidiQ7TPV4
KOiK02331
OMAiRDFQIRV
OrthoDBiEOG091G00YE
PhylomeDBiQ7TPV4
TreeFamiTF317401

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007015 DNA_pol_V
PANTHERiPTHR13213 PTHR13213, 1 hit
PfamiView protein in Pfam
PF04931 DNA_pol_phi, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMKSPTKA EPATPAEAAQ SDRHSLLEHS REFLDFFWDI AKPDQETRLR
60 70 80 90 100
ATEKLLEYLR TRPNDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS
110 120 130 140 150
FEDIPLCDIL DQIQEKYSLQ AMNKAMMRPS LFANLFGVLA LFQSGRLVKD
160 170 180 190 200
KEALMKSVQL LKILSQHPNH LQGQPIKALV DILSEVPESM FQEILPKVLK
210 220 230 240 250
GNMKVILRSP KYLELFLLAK QRVPTKLESL MGSVDLFSED NIPSLVNILK
260 270 280 290 300
VAANSVKKEH KLPNVALDLL RLALKESRFE LFWKKVLEEG LLKNPSWTSS
310 320 330 340 350
YMCFRLLGAS LPLLSEEQLQ LVMRGDLIRH FGENMVISKP QNLFKIIPEI
360 370 380 390 400
STYVGTFLEG CQDDPKRQLT MMVAFTTITN QGLPVMPTFW RVTRFLNAEA
410 420 430 440 450
LQSYVAWLRD MFLQPDLNSL VDFSTANQKR AQDASLNVPE RAVFRLRKWI
460 470 480 490 500
IHRLVSLVDH LHLEKDEAVV EQIARFCLFH AFFKTKKATP QIPETKQHFS
510 520 530 540 550
FPLDDRNRGV FVSAFFSLLQ TLSVKFRQTP DLAENGKPWT YRLVQLADML
560 570 580 590 600
LNHNRNVTSV TSLTTQQRQA WDQMMSTLKE LEARSSETRA IAFQHLLLLV
610 620 630 640 650
GLHIFKSPAE SCDVLGDIQT CIKKSMEQNP RRSRSRAKAS QEPVWVEVMV
660 670 680 690 700
EILLSLLAQP SNLMRQVVRS VFGHICPHLT PRCLQLILAV LSPVTNEDED
710 720 730 740 750
DNVVVTDDAD EKQLQHGEDE DSDNEDNKNS ESDMDSEDGE ESEEEDRDKD
760 770 780 790 800
VDPGFRQQLM EVLKAGNALG GVDNEEEEEL GDEAMMALDQ NLASLFKEQK
810 820 830 840 850
MRIQARNEEK NKLQKEKKLR RDFQIRALDL IEVLVTKQPE HPLILELLEP
860 870 880 890 900
LLNVIQHSMR SKGSTKQEQD LLHKTARIFM HHLCRARRYC HEVGPCAEAL
910 920 930 940 950
HAQVERLVQQ AGSQADASVA LYYFNASLYL LRVLKGNTNK RHQDGHKLHG
960 970 980 990 1000
ADTEDSEDQA ANCLDLDFVT RVYSASLESL LTKRNSSLTV PMFLSLFSRY
1010 1020 1030 1040 1050
PVICKNLLPV LAQHVAGPSR PRHQAQACLM LQKTLSAREL RVCFEDPEWE
1060 1070 1080 1090 1100
QLITQLLGKA TQTLQTLGEA QSKGEHQKEL SILELLNTLL RTVNHEKLSV
1110 1120 1130 1140 1150
DLTAPLGVLQ SKQQKLQQSL QQGNHSSGSN RLYDLYWQAM RMLGVQRPKS
1160 1170 1180 1190 1200
EKKNAKDIPS DTQSPVSTKR KKKGFLPETK KRKKLKSEGT TPEKNAASQQ
1210 1220 1230 1240 1250
DAVTEGAMPA ATGKDQPPST GKKKRKRVKA STPSQVNGIT GAKSPAPSNP
1260 1270 1280 1290 1300
TLSPSTPAKT PKLQKKKEKL SQVNGATPVS PIEPESKKHH QEALSTKEVI
1310 1320 1330 1340
RKSPHPQSAL PKKRARLSLV SRSPSLLQSG VKKRRVASRR VQTP
Length:1,344
Mass (Da):152,037
Last modified:July 19, 2005 - v2
Checksum:i64D3420981CD0767
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87R → T in AAC39954 (PubMed:9447996).Curated1
Sequence conflicti87R → T in AAL83748 (Ref. 2) Curated1
Sequence conflicti88P → A in AAC39954 (PubMed:9447996).Curated1
Sequence conflicti505 – 508DRNR → HASG in AAH04078 (PubMed:15489334).Curated4
Sequence conflicti1282I → V in AAH52889 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63648 mRNA Translation: AAC39954.1
AF345640 Genomic DNA Translation: AAL83748.1
AL662812 Genomic DNA Translation: CAI52004.1
BC004078 mRNA Translation: AAH04078.1
BC048858 mRNA Translation: AAH48858.1
BC052889 mRNA Translation: AAH52889.1
CCDSiCCDS24986.1
PIRiT34188
RefSeqiNP_058056.2, NM_016776.2
UniGeneiMm.147946

Genome annotation databases

EnsembliENSMUST00000045633; ENSMUSP00000044827; ENSMUSG00000040463
GeneIDi18432
KEGGimmu:18432
UCSCiuc007jyy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMBB1A_MOUSE
AccessioniPrimary (citable) accession number: Q7TPV4
Secondary accession number(s): O35851
, Q80Y66, Q8R4X2, Q99KP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health