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Protein

Myb-binding protein 1A

Gene

Mybbp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230).3 Publications

GO - Molecular functioni

  • core promoter binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: InterPro
  • poly(A) RNA binding Source: MGI
  • sequence-specific DNA binding Source: Ensembl
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5250924. B-WICH complex positively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-binding protein 1A
Alternative name(s):
Myb-binding protein of 160 kDa
Gene namesi
Name:Mybbp1a
Synonyms:P160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106181. Mybbp1a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • NLS-dependent protein nuclear import complex Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi249L → A: Reduced nuclear export; when associated with A-251. 1 Publication1
Mutagenesisi251V → A: Reduced nuclear export; when associated with A-249. 1 Publication1
Mutagenesisi272L → A: Reduced nuclear export; when associated with A-274. 1 Publication1
Mutagenesisi274L → A: Reduced nuclear export; when associated with A-272. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000962562 – 1344Myb-binding protein 1AAdd BLAST1343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei156N6-acetyllysineBy similarity1
Modified residuei1160PhosphoserineBy similarity1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1191PhosphothreonineBy similarity1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1244PhosphoserineCombined sources1
Modified residuei1251PhosphothreonineBy similarity1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1256PhosphothreonineCombined sources1
Modified residuei1277PhosphothreonineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1303PhosphoserineBy similarity1
Modified residuei1318PhosphoserineBy similarity1
Modified residuei1322Citrulline1 Publication1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1329PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ7TPV4.
MaxQBiQ7TPV4.
PaxDbiQ7TPV4.
PRIDEiQ7TPV4.

PTM databases

iPTMnetiQ7TPV4.
PhosphoSitePlusiQ7TPV4.

Miscellaneous databases

PMAP-CutDBQ7TPV4.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000040463.
CleanExiMM_MYBBP1A.
ExpressionAtlasiQ7TPV4. baseline and differential.
GenevisibleiQ7TPV4. MM.

Interactioni

Subunit structurei

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr4a1P128133EBI-1373622,EBI-10896863

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi201999. 15 interactors.
DIPiDIP-39831N.
IntActiQ7TPV4. 14 interactors.
MINTiMINT-1868464.
STRINGi10090.ENSMUSP00000044827.

Structurei

3D structure databases

ProteinModelPortaliQ7TPV4.
SMRiQ7TPV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 580Interaction with MYB1 PublicationAdd BLAST579
Regioni1152 – 1344Required for nuclear and nucleolar localization1 PublicationAdd BLAST193

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 256Nuclear export signal 11 PublicationAdd BLAST19
Motifi261 – 279Nuclear export signal 21 PublicationAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 752Asp-richAdd BLAST55

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiQ7TPV4.
KOiK02331.
OMAiHEKLTMD.
OrthoDBiEOG091G00YE.
PhylomeDBiQ7TPV4.
TreeFamiTF317401.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMKSPTKA EPATPAEAAQ SDRHSLLEHS REFLDFFWDI AKPDQETRLR
60 70 80 90 100
ATEKLLEYLR TRPNDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS
110 120 130 140 150
FEDIPLCDIL DQIQEKYSLQ AMNKAMMRPS LFANLFGVLA LFQSGRLVKD
160 170 180 190 200
KEALMKSVQL LKILSQHPNH LQGQPIKALV DILSEVPESM FQEILPKVLK
210 220 230 240 250
GNMKVILRSP KYLELFLLAK QRVPTKLESL MGSVDLFSED NIPSLVNILK
260 270 280 290 300
VAANSVKKEH KLPNVALDLL RLALKESRFE LFWKKVLEEG LLKNPSWTSS
310 320 330 340 350
YMCFRLLGAS LPLLSEEQLQ LVMRGDLIRH FGENMVISKP QNLFKIIPEI
360 370 380 390 400
STYVGTFLEG CQDDPKRQLT MMVAFTTITN QGLPVMPTFW RVTRFLNAEA
410 420 430 440 450
LQSYVAWLRD MFLQPDLNSL VDFSTANQKR AQDASLNVPE RAVFRLRKWI
460 470 480 490 500
IHRLVSLVDH LHLEKDEAVV EQIARFCLFH AFFKTKKATP QIPETKQHFS
510 520 530 540 550
FPLDDRNRGV FVSAFFSLLQ TLSVKFRQTP DLAENGKPWT YRLVQLADML
560 570 580 590 600
LNHNRNVTSV TSLTTQQRQA WDQMMSTLKE LEARSSETRA IAFQHLLLLV
610 620 630 640 650
GLHIFKSPAE SCDVLGDIQT CIKKSMEQNP RRSRSRAKAS QEPVWVEVMV
660 670 680 690 700
EILLSLLAQP SNLMRQVVRS VFGHICPHLT PRCLQLILAV LSPVTNEDED
710 720 730 740 750
DNVVVTDDAD EKQLQHGEDE DSDNEDNKNS ESDMDSEDGE ESEEEDRDKD
760 770 780 790 800
VDPGFRQQLM EVLKAGNALG GVDNEEEEEL GDEAMMALDQ NLASLFKEQK
810 820 830 840 850
MRIQARNEEK NKLQKEKKLR RDFQIRALDL IEVLVTKQPE HPLILELLEP
860 870 880 890 900
LLNVIQHSMR SKGSTKQEQD LLHKTARIFM HHLCRARRYC HEVGPCAEAL
910 920 930 940 950
HAQVERLVQQ AGSQADASVA LYYFNASLYL LRVLKGNTNK RHQDGHKLHG
960 970 980 990 1000
ADTEDSEDQA ANCLDLDFVT RVYSASLESL LTKRNSSLTV PMFLSLFSRY
1010 1020 1030 1040 1050
PVICKNLLPV LAQHVAGPSR PRHQAQACLM LQKTLSAREL RVCFEDPEWE
1060 1070 1080 1090 1100
QLITQLLGKA TQTLQTLGEA QSKGEHQKEL SILELLNTLL RTVNHEKLSV
1110 1120 1130 1140 1150
DLTAPLGVLQ SKQQKLQQSL QQGNHSSGSN RLYDLYWQAM RMLGVQRPKS
1160 1170 1180 1190 1200
EKKNAKDIPS DTQSPVSTKR KKKGFLPETK KRKKLKSEGT TPEKNAASQQ
1210 1220 1230 1240 1250
DAVTEGAMPA ATGKDQPPST GKKKRKRVKA STPSQVNGIT GAKSPAPSNP
1260 1270 1280 1290 1300
TLSPSTPAKT PKLQKKKEKL SQVNGATPVS PIEPESKKHH QEALSTKEVI
1310 1320 1330 1340
RKSPHPQSAL PKKRARLSLV SRSPSLLQSG VKKRRVASRR VQTP
Length:1,344
Mass (Da):152,037
Last modified:July 19, 2005 - v2
Checksum:i64D3420981CD0767
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87R → T in AAC39954 (PubMed:9447996).Curated1
Sequence conflicti87R → T in AAL83748 (Ref. 2) Curated1
Sequence conflicti88P → A in AAC39954 (PubMed:9447996).Curated1
Sequence conflicti505 – 508DRNR → HASG in AAH04078 (PubMed:15489334).Curated4
Sequence conflicti1282I → V in AAH52889 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63648 mRNA. Translation: AAC39954.1.
AF345640 Genomic DNA. Translation: AAL83748.1.
AL662812 Genomic DNA. Translation: CAI52004.1.
BC004078 mRNA. Translation: AAH04078.1.
BC048858 mRNA. Translation: AAH48858.1.
BC052889 mRNA. Translation: AAH52889.1.
CCDSiCCDS24986.1.
PIRiT34188.
RefSeqiNP_058056.2. NM_016776.2.
UniGeneiMm.147946.

Genome annotation databases

EnsembliENSMUST00000045633; ENSMUSP00000044827; ENSMUSG00000040463.
GeneIDi18432.
KEGGimmu:18432.
UCSCiuc007jyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63648 mRNA. Translation: AAC39954.1.
AF345640 Genomic DNA. Translation: AAL83748.1.
AL662812 Genomic DNA. Translation: CAI52004.1.
BC004078 mRNA. Translation: AAH04078.1.
BC048858 mRNA. Translation: AAH48858.1.
BC052889 mRNA. Translation: AAH52889.1.
CCDSiCCDS24986.1.
PIRiT34188.
RefSeqiNP_058056.2. NM_016776.2.
UniGeneiMm.147946.

3D structure databases

ProteinModelPortaliQ7TPV4.
SMRiQ7TPV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201999. 15 interactors.
DIPiDIP-39831N.
IntActiQ7TPV4. 14 interactors.
MINTiMINT-1868464.
STRINGi10090.ENSMUSP00000044827.

PTM databases

iPTMnetiQ7TPV4.
PhosphoSitePlusiQ7TPV4.

Proteomic databases

EPDiQ7TPV4.
MaxQBiQ7TPV4.
PaxDbiQ7TPV4.
PRIDEiQ7TPV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045633; ENSMUSP00000044827; ENSMUSG00000040463.
GeneIDi18432.
KEGGimmu:18432.
UCSCiuc007jyy.1. mouse.

Organism-specific databases

CTDi10514.
MGIiMGI:106181. Mybbp1a.

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiQ7TPV4.
KOiK02331.
OMAiHEKLTMD.
OrthoDBiEOG091G00YE.
PhylomeDBiQ7TPV4.
TreeFamiTF317401.

Enzyme and pathway databases

ReactomeiR-MMU-5250924. B-WICH complex positively regulates rRNA expression.

Miscellaneous databases

ChiTaRSiMybbp1a. mouse.
PMAP-CutDBQ7TPV4.
PROiQ7TPV4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040463.
CleanExiMM_MYBBP1A.
ExpressionAtlasiQ7TPV4. baseline and differential.
GenevisibleiQ7TPV4. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMBB1A_MOUSE
AccessioniPrimary (citable) accession number: Q7TPV4
Secondary accession number(s): O35851
, Q80Y66, Q8R4X2, Q99KP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.