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Protein

E3 ubiquitin-protein ligase DZIP3

Gene

Dzip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1144 – 118441RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DZIP3 (EC:6.3.2.-)
Alternative name(s):
DAZ-interacting protein 3 homolog
Gene namesi
Name:Dzip3
Synonyms:Kiaa0675
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1917433. Dzip3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12041204E3 ubiquitin-protein ligase DZIP3PRO_0000055899Add
BLAST

Proteomic databases

EPDiQ7TPV2.
MaxQBiQ7TPV2.
PaxDbiQ7TPV2.
PRIDEiQ7TPV2.

PTM databases

PhosphoSiteiQ7TPV2.

Expressioni

Gene expression databases

BgeeiQ7TPV2.
CleanExiMM_DZIP3.
ExpressionAtlasiQ7TPV2. baseline and differential.
GenevisibleiQ7TPV2. MM.

Interactioni

Subunit structurei

Probably interacts with DAZL.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230255. 3 interactions.
IntActiQ7TPV2. 1 interaction.
MINTiMINT-4093781.
STRINGi10090.ENSMUSP00000113344.

Structurei

3D structure databases

ProteinModelPortaliQ7TPV2.
SMRiQ7TPV2. Positions 1144-1184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili746 – 861116Sequence analysisAdd
BLAST
Coiled coili906 – 94136Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi657 – 6648Poly-Lys
Compositional biasi954 – 9607Poly-Pro
Compositional biasi1137 – 11426Poly-Glu

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1144 – 118441RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFEY. Eukaryota.
ENOG410Y41H. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000112306.
HOVERGENiHBG051428.
InParanoidiQ7TPV2.
KOiK10642.
PhylomeDBiQ7TPV2.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033103. DZIP3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22763:SF55. PTHR22763:SF55. 1 hit.
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TPV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLAEEFFV SGNPDVEEQT KEETEIIAEK PVTQLDKQKM DISADPEPVN
60 70 80 90 100
ALLEIKKVLN PISALPKGVF PNIEKFIQED FSFQTMQREV TTHSQTGEEI
110 120 130 140 150
VPALTLHFLI TQLEMALRNI QASNYTAQQI NVGYYLTLLF LYGVALTERA
160 170 180 190 200
KKEDCIEAEN KFLVMKMVIQ ESEICENFMC LVYFGRGLLR CAQKRYNGAL
210 220 230 240 250
LEFYKSLQEI GDTDDNWFEV DPTDDEDLPT TFKDSLNNFI KTTESNIMKE
260 270 280 290 300
TICSYLDCER SCEADILKNT NYKGFFQLMC SKSCCIYFHK ICWKKFKNLK
310 320 330 340 350
YPGESDQSFS GQKCLKEGCP GDMVRMLQCD VPGIVKILFE VVRKDEYITI
360 370 380 390 400
ENLGASYKNL MSLELTDTDI RPKFNLKPNT KDEVPIFKLD YNYFYHLLHI
410 420 430 440 450
IIISGTDMVR QIFDEAMPPT LLKKELLIHK NVLEPYYNHL WTNHPLGGSW
460 470 480 490 500
HLLYPPNKEL PQSKQFDLCL LLALIKHLNV FPAPRKGWDM EPPSSDLSKS
510 520 530 540 550
ADILRLCKYR DILLSEILMN GLTELQFNSI WKKVSDILLR LGMKQDDLDK
560 570 580 590 600
VKENPIENIS LDYHQLSIYL GIPVPEIIQR MLSCYQQGIT LQSITGSQRL
610 620 630 640 650
DVEEFQNDEE DLSPPVMEYN IDVKSNTEIQ LAEINKDVAS IPSESSTESV
660 670 680 690 700
KDLQEVKSKT KKKKRTKSNK KDKDSEDEQV SYMVEKDDQL ETEQVDVNTL
710 720 730 740 750
STYMKTDTSD AQEDSAAEDK FCSLDELHIL DMVEQGSSGK ESTDFKETEK
760 770 780 790 800
ERLAHQHQLY KLQYECEDYK RQLKTVTFRW QENQMLIKKK EKIIVSLNQQ
810 820 830 840 850
VAFGINKMSK LQRQIHAKDD EIKNLKDQLS LKRSQWEMEK HNLESTVKTY
860 870 880 890 900
LNKLNAETSR ALTAEVYFLQ CRRDFGLLHL EQTEKECLNQ LARVTHMAAS
910 920 930 940 950
NLESLQLKAA VDSWNAIVAD VRNKIAFLRT QYNEQINKVK QGFALSTLPP
960 970 980 990 1000
VQLPPPPPSP EILIQQFLGR PLVKESFFRP ILTVPQMPAV CPGVISAAVQ
1010 1020 1030 1040 1050
PRPPLMPGIT WAMPTPIGDT VSPSASLCSE PLMINWERIT DRLKTAFPQQ
1060 1070 1080 1090 1100
TRKELTDFLQ QLKDSHGKSV SRLTFDEIVY KISQMIEPKK SESEEKSAQD
1110 1120 1130 1140 1150
GNNASPSHTA SQPNAPQDPK SAQGSATWEG DKDMDNEEEE EEPCVICHEN
1160 1170 1180 1190 1200
LSPENLSVLP CAHKFHSQCI RPWLMQQGTC PTCRLHVLQP EEFPGHPNGQ

LPKI
Length:1,204
Mass (Da):138,021
Last modified:July 19, 2004 - v2
Checksum:i9522730708DB570C
GO
Isoform 2 (identifier: Q7TPV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-587: Missing.

Note: No experimental confirmation available.
Show »
Length:998
Mass (Da):113,900
Checksum:i4ACB0822FE571D4D
GO
Isoform 3 (identifier: Q7TPV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-889: Missing.
     890-899: QLARVTHMAA → MFPLCLLFYI
     1135-1153: DNEEEEEEPCVICHENLSP → VRPNLLTVNTFRSERKRMV
     1154-1204: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,436
Checksum:i18E5907AC9A64DFC
GO

Sequence cautioni

The sequence BAC65626.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti306 – 3061D → G in AAH52893 (PubMed:15489334).Curated
Sequence conflicti650 – 6501V → I in AAH52893 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 889889Missing in isoform 3. 1 PublicationVSP_010973Add
BLAST
Alternative sequencei382 – 587206Missing in isoform 2. 1 PublicationVSP_010977Add
BLAST
Alternative sequencei890 – 89910QLARVTHMAA → MFPLCLLFYI in isoform 3. 1 PublicationVSP_010974
Alternative sequencei1135 – 115319DNEEE…ENLSP → VRPNLLTVNTFRSERKRMV in isoform 3. 1 PublicationVSP_010975Add
BLAST
Alternative sequencei1154 – 120451Missing in isoform 3. 1 PublicationVSP_010976Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122344 mRNA. Translation: BAC65626.1. Different initiation.
BC052893 mRNA. Translation: AAH52893.1.
BC117953 mRNA. Translation: AAI17954.1.
BC117954 mRNA. Translation: AAI17955.1.
AK039172 mRNA. Translation: BAC30265.1.
BI736207 mRNA. No translation available.
CN535823 mRNA. No translation available.
BG070132 mRNA. No translation available.
CCDSiCCDS37353.1. [Q7TPV2-2]
CCDS49866.1. [Q7TPV2-1]
RefSeqiNP_001103487.1. NM_001110017.1.
NP_081617.1. NM_027341.2. [Q7TPV2-2]
UniGeneiMm.275138.

Genome annotation databases

EnsembliENSMUST00000114516; ENSMUSP00000110161; ENSMUSG00000064061. [Q7TPV2-2]
GeneIDi224170.
KEGGimmu:224170.
UCSCiuc007zjy.1. mouse. [Q7TPV2-3]
uc007zjz.2. mouse. [Q7TPV2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122344 mRNA. Translation: BAC65626.1. Different initiation.
BC052893 mRNA. Translation: AAH52893.1.
BC117953 mRNA. Translation: AAI17954.1.
BC117954 mRNA. Translation: AAI17955.1.
AK039172 mRNA. Translation: BAC30265.1.
BI736207 mRNA. No translation available.
CN535823 mRNA. No translation available.
BG070132 mRNA. No translation available.
CCDSiCCDS37353.1. [Q7TPV2-2]
CCDS49866.1. [Q7TPV2-1]
RefSeqiNP_001103487.1. NM_001110017.1.
NP_081617.1. NM_027341.2. [Q7TPV2-2]
UniGeneiMm.275138.

3D structure databases

ProteinModelPortaliQ7TPV2.
SMRiQ7TPV2. Positions 1144-1184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230255. 3 interactions.
IntActiQ7TPV2. 1 interaction.
MINTiMINT-4093781.
STRINGi10090.ENSMUSP00000113344.

PTM databases

PhosphoSiteiQ7TPV2.

Proteomic databases

EPDiQ7TPV2.
MaxQBiQ7TPV2.
PaxDbiQ7TPV2.
PRIDEiQ7TPV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114516; ENSMUSP00000110161; ENSMUSG00000064061. [Q7TPV2-2]
GeneIDi224170.
KEGGimmu:224170.
UCSCiuc007zjy.1. mouse. [Q7TPV2-3]
uc007zjz.2. mouse. [Q7TPV2-2]

Organism-specific databases

CTDi9666.
MGIiMGI:1917433. Dzip3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IFEY. Eukaryota.
ENOG410Y41H. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000112306.
HOVERGENiHBG051428.
InParanoidiQ7TPV2.
KOiK10642.
PhylomeDBiQ7TPV2.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiDzip3. mouse.
NextBioi377121.
PROiQ7TPV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TPV2.
CleanExiMM_DZIP3.
ExpressionAtlasiQ7TPV2. baseline and differential.
GenevisibleiQ7TPV2. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033103. DZIP3.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22763:SF55. PTHR22763:SF55. 1 hit.
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C3H/He.
    Tissue: Osteoblast.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-787 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  4. The MGC Project Team
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 767-1133 (ISOFORM 1).
    Tissue: Head and Retina.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1062-1204 (ISOFORM 1).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiDZIP3_MOUSE
AccessioniPrimary (citable) accession number: Q7TPV2
Secondary accession number(s): Q148V3, Q80TU4, Q8BYK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 11, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.