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Protein

E3 ubiquitin-protein ligase DZIP3

Gene

Dzip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1144 – 1184RING-type; atypicalPROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DZIP3 (EC:2.3.2.27By similarity)
Alternative name(s):
DAZ-interacting protein 3 homolog
RING-type E3 ubiquitin transferase DZIP3Curated
Gene namesi
Name:Dzip3
Synonyms:Kiaa0675
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1917433 Dzip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558991 – 1204E3 ubiquitin-protein ligase DZIP3Add BLAST1204

Proteomic databases

PaxDbiQ7TPV2
PRIDEiQ7TPV2

PTM databases

iPTMnetiQ7TPV2
PhosphoSitePlusiQ7TPV2

Expressioni

Gene expression databases

BgeeiENSMUSG00000064061
CleanExiMM_DZIP3
ExpressionAtlasiQ7TPV2 baseline and differential
GenevisibleiQ7TPV2 MM

Interactioni

Subunit structurei

Probably interacts with DAZL.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230255, 5 interactors
IntActiQ7TPV2, 2 interactors
MINTiQ7TPV2
STRINGi10090.ENSMUSP00000113344

Structurei

3D structure databases

ProteinModelPortaliQ7TPV2
SMRiQ7TPV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili746 – 861Sequence analysisAdd BLAST116
Coiled coili906 – 941Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi657 – 664Poly-Lys8
Compositional biasi954 – 960Poly-Pro7
Compositional biasi1137 – 1142Poly-Glu6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1144 – 1184RING-type; atypicalPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFEY Eukaryota
ENOG410Y41H LUCA
GeneTreeiENSGT00530000063254
HOGENOMiHOG000112306
HOVERGENiHBG051428
InParanoidiQ7TPV2
PhylomeDBiQ7TPV2

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR033103 DZIP3
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45405 PTHR45405, 1 hit
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TPV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLAEEFFV SGNPDVEEQT KEETEIIAEK PVTQLDKQKM DISADPEPVN
60 70 80 90 100
ALLEIKKVLN PISALPKGVF PNIEKFIQED FSFQTMQREV TTHSQTGEEI
110 120 130 140 150
VPALTLHFLI TQLEMALRNI QASNYTAQQI NVGYYLTLLF LYGVALTERA
160 170 180 190 200
KKEDCIEAEN KFLVMKMVIQ ESEICENFMC LVYFGRGLLR CAQKRYNGAL
210 220 230 240 250
LEFYKSLQEI GDTDDNWFEV DPTDDEDLPT TFKDSLNNFI KTTESNIMKE
260 270 280 290 300
TICSYLDCER SCEADILKNT NYKGFFQLMC SKSCCIYFHK ICWKKFKNLK
310 320 330 340 350
YPGESDQSFS GQKCLKEGCP GDMVRMLQCD VPGIVKILFE VVRKDEYITI
360 370 380 390 400
ENLGASYKNL MSLELTDTDI RPKFNLKPNT KDEVPIFKLD YNYFYHLLHI
410 420 430 440 450
IIISGTDMVR QIFDEAMPPT LLKKELLIHK NVLEPYYNHL WTNHPLGGSW
460 470 480 490 500
HLLYPPNKEL PQSKQFDLCL LLALIKHLNV FPAPRKGWDM EPPSSDLSKS
510 520 530 540 550
ADILRLCKYR DILLSEILMN GLTELQFNSI WKKVSDILLR LGMKQDDLDK
560 570 580 590 600
VKENPIENIS LDYHQLSIYL GIPVPEIIQR MLSCYQQGIT LQSITGSQRL
610 620 630 640 650
DVEEFQNDEE DLSPPVMEYN IDVKSNTEIQ LAEINKDVAS IPSESSTESV
660 670 680 690 700
KDLQEVKSKT KKKKRTKSNK KDKDSEDEQV SYMVEKDDQL ETEQVDVNTL
710 720 730 740 750
STYMKTDTSD AQEDSAAEDK FCSLDELHIL DMVEQGSSGK ESTDFKETEK
760 770 780 790 800
ERLAHQHQLY KLQYECEDYK RQLKTVTFRW QENQMLIKKK EKIIVSLNQQ
810 820 830 840 850
VAFGINKMSK LQRQIHAKDD EIKNLKDQLS LKRSQWEMEK HNLESTVKTY
860 870 880 890 900
LNKLNAETSR ALTAEVYFLQ CRRDFGLLHL EQTEKECLNQ LARVTHMAAS
910 920 930 940 950
NLESLQLKAA VDSWNAIVAD VRNKIAFLRT QYNEQINKVK QGFALSTLPP
960 970 980 990 1000
VQLPPPPPSP EILIQQFLGR PLVKESFFRP ILTVPQMPAV CPGVISAAVQ
1010 1020 1030 1040 1050
PRPPLMPGIT WAMPTPIGDT VSPSASLCSE PLMINWERIT DRLKTAFPQQ
1060 1070 1080 1090 1100
TRKELTDFLQ QLKDSHGKSV SRLTFDEIVY KISQMIEPKK SESEEKSAQD
1110 1120 1130 1140 1150
GNNASPSHTA SQPNAPQDPK SAQGSATWEG DKDMDNEEEE EEPCVICHEN
1160 1170 1180 1190 1200
LSPENLSVLP CAHKFHSQCI RPWLMQQGTC PTCRLHVLQP EEFPGHPNGQ

LPKI
Length:1,204
Mass (Da):138,021
Last modified:July 19, 2004 - v2
Checksum:i9522730708DB570C
GO
Isoform 2 (identifier: Q7TPV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-587: Missing.

Note: No experimental confirmation available.
Show »
Length:998
Mass (Da):113,900
Checksum:i4ACB0822FE571D4D
GO
Isoform 3 (identifier: Q7TPV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-889: Missing.
     890-899: QLARVTHMAA → MFPLCLLFYI
     1135-1153: DNEEEEEEPCVICHENLSP → VRPNLLTVNTFRSERKRMV
     1154-1204: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,436
Checksum:i18E5907AC9A64DFC
GO

Sequence cautioni

The sequence BAC65626 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306D → G in AAH52893 (PubMed:15489334).Curated1
Sequence conflicti650V → I in AAH52893 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109731 – 889Missing in isoform 3. 1 PublicationAdd BLAST889
Alternative sequenceiVSP_010977382 – 587Missing in isoform 2. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_010974890 – 899QLARVTHMAA → MFPLCLLFYI in isoform 3. 1 Publication10
Alternative sequenceiVSP_0109751135 – 1153DNEEE…ENLSP → VRPNLLTVNTFRSERKRMV in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0109761154 – 1204Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122344 mRNA Translation: BAC65626.1 Different initiation.
BC052893 mRNA Translation: AAH52893.1
BC117953 mRNA Translation: AAI17954.1
BC117954 mRNA Translation: AAI17955.1
AK039172 mRNA Translation: BAC30265.1
BI736207 mRNA No translation available.
CN535823 mRNA No translation available.
BG070132 mRNA No translation available.
CCDSiCCDS37353.1 [Q7TPV2-2]
CCDS49866.1 [Q7TPV2-1]
RefSeqiNP_081617.1, NM_027341.2 [Q7TPV2-2]
UniGeneiMm.275138

Genome annotation databases

EnsembliENSMUST00000114516; ENSMUSP00000110161; ENSMUSG00000064061 [Q7TPV2-2]
GeneIDi224170
UCSCiuc007zjy.1 mouse [Q7TPV2-3]
uc007zjz.2 mouse [Q7TPV2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDZIP3_MOUSE
AccessioniPrimary (citable) accession number: Q7TPV2
Secondary accession number(s): Q148V3, Q80TU4, Q8BYK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health