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Q7TPQ3

- SHPRH_MOUSE

UniProt

Q7TPQ3 - SHPRH_MOUSE

Protein

E3 ubiquitin-protein ligase SHPRH

Gene

Shprh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63' By similarity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi368 – 3758ATPPROSITE-ProRule annotation
    Zinc fingeri649 – 70052PHD-typeAdd
    BLAST
    Zinc fingeri1423 – 147048RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. helicase activity Source: UniProtKB-KW
    4. ligase activity Source: UniProtKB-KW
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW
    2. nucleosome assembly Source: InterPro
    3. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Helicase, Hydrolase, Ligase

    Keywords - Biological processi

    DNA damage, DNA repair, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase SHPRH (EC:3.6.4.-, EC:6.3.2.-)
    Alternative name(s):
    SNF2, histone-linker, PHD and RING finger domain-containing helicase
    Gene namesi
    Name:Shprh
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1917581. Shprh.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleosome Source: InterPro
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16741674E3 ubiquitin-protein ligase SHPRHPRO_0000284919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei261 – 2611PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7TPQ3.
    PaxDbiQ7TPQ3.
    PRIDEiQ7TPQ3.

    PTM databases

    PhosphoSiteiQ7TPQ3.

    Expressioni

    Tissue specificityi

    Broadly expressed (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ7TPQ3.
    BgeeiQ7TPQ3.
    CleanExiMM_SHPRH.
    GenevestigatoriQ7TPQ3.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi234474. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TPQ3.
    SMRiQ7TPQ3. Positions 645-707, 709-980, 1420-1480, 1506-1672.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini302 – 38483Helicase ATP-binding; first partPROSITE-ProRule annotationAdd
    BLAST
    Domaini433 – 50775H15PROSITE-ProRule annotationAdd
    BLAST
    Domaini701 – 859159Helicase ATP-binding; second partPROSITE-ProRule annotationAdd
    BLAST
    Domaini1505 – 1663159Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi810 – 8134DEAQ box

    Domaini

    The RING finger mediates E3 ubiquitin ligase activity.By similarity

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri649 – 70052PHD-typeAdd
    BLAST
    Zinc fingeri1423 – 147048RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00730000111123.
    HOVERGENiHBG059171.
    InParanoidiQ7TPQ3.
    KOiK15710.
    OMAiFEGLVKQ.
    OrthoDBiEOG7ZD1TJ.
    PhylomeDBiQ7TPQ3.
    TreeFamiTF324273.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.40.10. 2 hits.
    3.40.50.300. 4 hits.
    InterProiIPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR005818. Histone_H1/H5_H15.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    IPR011991. WHTH_DNA-bd_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00271. Helicase_C. 1 hit.
    PF00538. Linker_histone. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00526. H15. 1 hit.
    SM00249. PHD. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 6 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51504. H15. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TPQ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS     50
    DCIIIDEGPP ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV 100
    DNSWKAFLGD FALQLLPKES LVEHFSERTF TLSPSESSSQ FLIYVHSECK 150
    NVEKQENVLE GSAGVCSKGI RVESSFSSDM LQDLAWLQKR RGIKLYQRPD 200
    GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM EKLHNFIIPD 250
    VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR 300
    PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI 350
    IRDFPHAGPQ LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG 400
    KVVNYFIPTH CPREKVKNRE IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG 450
    KKGVSILSIY KYVSSIFRYD VQRNRGLLKR MLKCLIFEGL VKQIKGHGFS 500
    GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA DSEYLPSNTS 550
    DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS 600
    TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF 650
    ECICGEFDQI GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA 700
    MEPVSTRATL IISPSSICHQ WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP 750
    HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS EDGRRLRNQK RYMAIPSPLV 800
    AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT PVQRGLEDLF 850
    GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI 900
    DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL 950
    SSLDRRTVSS ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ 1000
    KKCGTECEEA HRQLVCALNG LAGIHIIKGE YALAAELYRE VLRSSEEHKG 1050
    KLKTDSLQRL HATHNLMELL GAKHPGIPPT LRDGRLEEEA KQLREHYMSK 1100
    CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA MEFSVDEELV 1150
    QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE 1200
    AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF 1250
    NTVKGQTAIF EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR 1300
    SHRFDVEYVD EGSVSMDLFE AWKKEYKLLH EYWMTLRNRV SAVDELAMAT 1350
    ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR IKLVNDKAVA TSQLQKKLGQ 1400
    LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG HCFCNECTSI 1450
    IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS 1500
    TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS 1550
    RIKTFQENLS AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA 1600
    HELQAIGRVH RIGQTKPTIV HRFLIKATIE ERMQAMLKTA ERSHTSSSGK 1650
    HSEASVLTVA GLADLFTKEN EELE 1674
    Length:1,674
    Mass (Da):191,490
    Last modified:October 1, 2003 - v1
    Checksum:i2491B2F32F326393
    GO
    Isoform 2 (identifier: Q7TPQ3-2) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         1617-1674: Missing.

    Show »
    Length:1,616
    Mass (Da):185,068
    Checksum:i64D639BE774E29B6
    GO
    Isoform 3 (identifier: Q7TPQ3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1030-1031: EY → RR
         1032-1674: Missing.

    Show »
    Length:1,031
    Mass (Da):118,054
    Checksum:i08CB942E51F9AB41
    GO
    Isoform 4 (identifier: Q7TPQ3-5) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1617-1662: PTIVHRFLIK...EASVLTVAGL → SIRGLECLKTYRYTSTHDHTLSTYLVLLSI
         1663-1674: Missing.

    Show »
    Length:1,646
    Mass (Da):188,535
    Checksum:i02C9E8FD7E75B2E5
    GO

    Sequence cautioni

    The sequence AAO26655.1 differs from that shown. Reason: Probable cloning artifact.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771S → G in BAC38428. (PubMed:16141072)Curated
    Sequence conflicti582 – 5821Q → H in BAC38428. (PubMed:16141072)Curated
    Sequence conflicti928 – 9281Q → R in BAC38428. (PubMed:16141072)Curated
    Sequence conflicti1285 – 12851V → I in AAO26654. (PubMed:12837266)Curated
    Sequence conflicti1285 – 12851V → I in AAO26655. (PubMed:12837266)Curated
    Sequence conflicti1285 – 12851V → I in AAO26656. (PubMed:12837266)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1030 – 10312EY → RR in isoform 3. 1 PublicationVSP_024766
    Alternative sequencei1032 – 1674643Missing in isoform 3. 1 PublicationVSP_024767Add
    BLAST
    Alternative sequencei1617 – 167458Missing in isoform 2. 1 PublicationVSP_024768Add
    BLAST
    Alternative sequencei1617 – 166246PTIVH…TVAGL → SIRGLECLKTYRYTSTHDHT LSTYLVLLSI in isoform 4. 1 PublicationVSP_024769Add
    BLAST
    Alternative sequencei1663 – 167412Missing in isoform 4. 1 PublicationVSP_024770Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY162264 mRNA. Translation: AAO26654.1.
    AY162265 mRNA. Translation: AAO26655.1. Sequence problems.
    AY162266 mRNA. Translation: AAO26656.1.
    AK053448 mRNA. Translation: BAC35389.1.
    AK082160 mRNA. Translation: BAC38428.1.
    BC006883 mRNA. Translation: AAH06883.1.
    BC055003 mRNA. Translation: AAH55003.1.
    CCDSiCCDS35838.1. [Q7TPQ3-1]
    CCDS35839.1. [Q7TPQ3-2]
    CCDS70003.1. [Q7TPQ3-5]
    RefSeqiNP_001071175.1. NM_001077707.1. [Q7TPQ3-1]
    NP_001271283.1. NM_001284354.1. [Q7TPQ3-5]
    NP_766525.3. NM_172937.3. [Q7TPQ3-2]
    XP_006512803.1. XM_006512740.1. [Q7TPQ3-1]
    UniGeneiMm.133101.

    Genome annotation databases

    EnsembliENSMUST00000044053; ENSMUSP00000039422; ENSMUSG00000090112. [Q7TPQ3-1]
    ENSMUST00000054814; ENSMUSP00000125849; ENSMUSG00000090112. [Q7TPQ3-2]
    ENSMUST00000159541; ENSMUSP00000132870; ENSMUSG00000090112. [Q7TPQ3-5]
    ENSMUST00000159810; ENSMUSP00000125457; ENSMUSG00000090112. [Q7TPQ3-3]
    GeneIDi268281.
    KEGGimmu:268281.
    UCSCiuc007ejp.1. mouse. [Q7TPQ3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY162264 mRNA. Translation: AAO26654.1 .
    AY162265 mRNA. Translation: AAO26655.1 . Sequence problems.
    AY162266 mRNA. Translation: AAO26656.1 .
    AK053448 mRNA. Translation: BAC35389.1 .
    AK082160 mRNA. Translation: BAC38428.1 .
    BC006883 mRNA. Translation: AAH06883.1 .
    BC055003 mRNA. Translation: AAH55003.1 .
    CCDSi CCDS35838.1. [Q7TPQ3-1 ]
    CCDS35839.1. [Q7TPQ3-2 ]
    CCDS70003.1. [Q7TPQ3-5 ]
    RefSeqi NP_001071175.1. NM_001077707.1. [Q7TPQ3-1 ]
    NP_001271283.1. NM_001284354.1. [Q7TPQ3-5 ]
    NP_766525.3. NM_172937.3. [Q7TPQ3-2 ]
    XP_006512803.1. XM_006512740.1. [Q7TPQ3-1 ]
    UniGenei Mm.133101.

    3D structure databases

    ProteinModelPortali Q7TPQ3.
    SMRi Q7TPQ3. Positions 645-707, 709-980, 1420-1480, 1506-1672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234474. 5 interactions.

    PTM databases

    PhosphoSitei Q7TPQ3.

    Proteomic databases

    MaxQBi Q7TPQ3.
    PaxDbi Q7TPQ3.
    PRIDEi Q7TPQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044053 ; ENSMUSP00000039422 ; ENSMUSG00000090112 . [Q7TPQ3-1 ]
    ENSMUST00000054814 ; ENSMUSP00000125849 ; ENSMUSG00000090112 . [Q7TPQ3-2 ]
    ENSMUST00000159541 ; ENSMUSP00000132870 ; ENSMUSG00000090112 . [Q7TPQ3-5 ]
    ENSMUST00000159810 ; ENSMUSP00000125457 ; ENSMUSG00000090112 . [Q7TPQ3-3 ]
    GeneIDi 268281.
    KEGGi mmu:268281.
    UCSCi uc007ejp.1. mouse. [Q7TPQ3-1 ]

    Organism-specific databases

    CTDi 257218.
    MGIi MGI:1917581. Shprh.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00730000111123.
    HOVERGENi HBG059171.
    InParanoidi Q7TPQ3.
    KOi K15710.
    OMAi FEGLVKQ.
    OrthoDBi EOG7ZD1TJ.
    PhylomeDBi Q7TPQ3.
    TreeFami TF324273.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi SHPRH. mouse.
    NextBioi 392208.
    PROi Q7TPQ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TPQ3.
    Bgeei Q7TPQ3.
    CleanExi MM_SHPRH.
    Genevestigatori Q7TPQ3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.40.10. 2 hits.
    3.40.50.300. 4 hits.
    InterProi IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR005818. Histone_H1/H5_H15.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    IPR011991. WHTH_DNA-bd_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00271. Helicase_C. 1 hit.
    PF00538. Linker_histone. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00526. H15. 1 hit.
    SM00249. PHD. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 6 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51504. H15. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region."
      Sood R., Makalowska I., Galdzicki M., Hu P., Eddings E., Robbins C.M., Moses T., Namkoong J., Chen S., Trent J.M.
      Genomics 82:153-161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Eye.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6 and FVB/N.
      Tissue: Mammary tumor and Retina.

    Entry informationi

    Entry nameiSHPRH_MOUSE
    AccessioniPrimary (citable) accession number: Q7TPQ3
    Secondary accession number(s): Q7TQ27
    , Q7TQ28, Q7TQ29, Q8BKE2, Q8BUW0, Q922Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3