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Q7TPN3

- PIGV_MOUSE

UniProt

Q7TPN3 - PIGV_MOUSE

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Protein

GPI mannosyltransferase 2

Gene
Pigv
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly By similarity.

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: Ensembl

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT76. Glycosyltransferase Family 76.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 2 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase II
Short name:
GPI-MT-II
Phosphatidylinositol-glycan biosynthesis class V protein
Short name:
PIG-V
Gene namesi
Name:Pigv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2442480. Pigv.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei14 – 3421Helical; Reviewed predictionAdd
BLAST
Topological domaini35 – 7743Lumenal Reviewed predictionAdd
BLAST
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Topological domaini99 – 11315Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Topological domaini135 – 1362Lumenal Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed predictionAdd
BLAST
Topological domaini158 – 1614Cytoplasmic Reviewed prediction
Transmembranei162 – 18221Helical; Reviewed predictionAdd
BLAST
Topological domaini183 – 19210Lumenal Reviewed prediction
Transmembranei193 – 21321Helical; Reviewed predictionAdd
BLAST
Topological domaini214 – 23421Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST
Topological domaini256 – 32772Lumenal Reviewed predictionAdd
BLAST
Transmembranei328 – 34821Helical; Reviewed predictionAdd
BLAST
Topological domaini349 – 37830Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei379 – 39921Helical; Reviewed predictionAdd
BLAST
Topological domaini400 – 46970Lumenal Reviewed predictionAdd
BLAST
Transmembranei470 – 49021Helical; Reviewed predictionAdd
BLAST
Topological domaini491 – 4933Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493GPI mannosyltransferase 2PRO_0000246235Add
BLAST

Post-translational modificationi

Not N-glycosylated By similarity.

Proteomic databases

PRIDEiQ7TPN3.

PTM databases

PhosphoSiteiQ7TPN3.

Expressioni

Gene expression databases

BgeeiQ7TPN3.
GenevestigatoriQ7TPN3.

Structurei

3D structure databases

ProteinModelPortaliQ7TPN3.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGV family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5542.
GeneTreeiENSGT00390000013174.
HOGENOMiHOG000232162.
HOVERGENiHBG080592.
InParanoidiQ7TPN3.
KOiK07542.
OMAiLNAGYIC.
OrthoDBiEOG7VDXPB.
PhylomeDBiQ7TPN3.
TreeFamiTF314515.

Family and domain databases

InterProiIPR007315. GPI_Mannosyltransferase_2.
[Graphical view]
PANTHERiPTHR12468. PTHR12468. 1 hit.
PfamiPF04188. Mannosyl_trans2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7TPN3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLLDPSQKE VLRFAVNCRI LTLVLQALFN LIIPDHHADA FCPPRLAPSG    50
SADQLVEGLL GGLSRWDAEH FLFIAEHGYL YEHNFAFFPG FPLALLMGTE 100
LLRPLQGLLS QRSCLLVSVA LLNLLFSVLA AVALHDLGCL VLHCPRQALC 150
AALLFCISPA NVFLAAGYSE ALFAFLTFSA MGQLERGRGW ASGLLFALAA 200
GVRSNGLVSL GFLLHSQCRG FCSSLAVLSP WKPLVKLMAS VCLSVLIVSL 250
PFALFQYRAY IQFCSPGSAP SIPEPLLQLA ADKGYRLAGE NAPPWCSWDL 300
PLIYNYIQDV YWNVGLLRYY ELKQVPNFLL ATPVTVLVVW ATWTYVTTHP 350
WLCLTLGLQR TKDRENPEKP HRGFLSPKVF VYLVHAAALL VFGGLCMHVQ 400
VLTRFLASST PIMYWFPAHL LQDQEPLLRC VDTEPGKLPQ EKSPPGQKAP 450
RNCLMKLFYD WKRCSPVTRC VLVYFLTYWL LGLILHCNFL PWT 493
Length:493
Mass (Da):55,026
Last modified:July 25, 2006 - v2
Checksum:i8A176D43F3CB7F4C
GO
Isoform 2 (identifier: Q7TPN3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-400: Missing.

Note: No experimental confirmation available.

Show »
Length:119
Mass (Da):13,882
Checksum:i0B052659B20754C8
GO

Sequence cautioni

The sequence BAC33023.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 400374Missing in isoform 2. VSP_019840Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181C → F in BAC34995. 1 Publication
Sequence conflicti460 – 4601D → N in AAH55060. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046527 mRNA. Translation: BAC32773.1.
AK047322 mRNA. Translation: BAC33023.1. Different initiation.
AK052446 mRNA. Translation: BAC34995.1.
AK080590 mRNA. Translation: BAC37950.1.
AK080858 mRNA. Translation: BAC38047.1.
AK148285 mRNA. Translation: BAE28458.1.
BC055060 mRNA. Translation: AAH55060.1.
CCDSiCCDS18755.1. [Q7TPN3-1]
CCDS51322.1. [Q7TPN3-2]
RefSeqiNP_001139427.1. NM_001145955.1.
NP_001139428.1. NM_001145956.1. [Q7TPN3-2]
NP_848813.3. NM_178698.5. [Q7TPN3-1]
XP_006538810.1. XM_006538747.1. [Q7TPN3-1]
UniGeneiMm.217004.

Genome annotation databases

EnsembliENSMUST00000062118; ENSMUSP00000050647; ENSMUSG00000043257. [Q7TPN3-1]
ENSMUST00000067902; ENSMUSP00000065601; ENSMUSG00000043257. [Q7TPN3-2]
GeneIDi230801.
KEGGimmu:230801.
UCSCiuc008vdf.2. mouse. [Q7TPN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046527 mRNA. Translation: BAC32773.1 .
AK047322 mRNA. Translation: BAC33023.1 . Different initiation.
AK052446 mRNA. Translation: BAC34995.1 .
AK080590 mRNA. Translation: BAC37950.1 .
AK080858 mRNA. Translation: BAC38047.1 .
AK148285 mRNA. Translation: BAE28458.1 .
BC055060 mRNA. Translation: AAH55060.1 .
CCDSi CCDS18755.1. [Q7TPN3-1 ]
CCDS51322.1. [Q7TPN3-2 ]
RefSeqi NP_001139427.1. NM_001145955.1.
NP_001139428.1. NM_001145956.1. [Q7TPN3-2 ]
NP_848813.3. NM_178698.5. [Q7TPN3-1 ]
XP_006538810.1. XM_006538747.1. [Q7TPN3-1 ]
UniGenei Mm.217004.

3D structure databases

ProteinModelPortali Q7TPN3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT76. Glycosyltransferase Family 76.

PTM databases

PhosphoSitei Q7TPN3.

Proteomic databases

PRIDEi Q7TPN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062118 ; ENSMUSP00000050647 ; ENSMUSG00000043257 . [Q7TPN3-1 ]
ENSMUST00000067902 ; ENSMUSP00000065601 ; ENSMUSG00000043257 . [Q7TPN3-2 ]
GeneIDi 230801.
KEGGi mmu:230801.
UCSCi uc008vdf.2. mouse. [Q7TPN3-1 ]

Organism-specific databases

CTDi 55650.
MGIi MGI:2442480. Pigv.

Phylogenomic databases

eggNOGi COG5542.
GeneTreei ENSGT00390000013174.
HOGENOMi HOG000232162.
HOVERGENi HBG080592.
InParanoidi Q7TPN3.
KOi K07542.
OMAi LNAGYIC.
OrthoDBi EOG7VDXPB.
PhylomeDBi Q7TPN3.
TreeFami TF314515.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

ChiTaRSi PIGV. mouse.
NextBioi 380172.
PROi Q7TPN3.
SOURCEi Search...

Gene expression databases

Bgeei Q7TPN3.
Genevestigatori Q7TPN3.

Family and domain databases

InterProi IPR007315. GPI_Mannosyltransferase_2.
[Graphical view ]
PANTHERi PTHR12468. PTHR12468. 1 hit.
Pfami PF04188. Mannosyl_trans2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Adrenal gland, Cerebellum, Corpora quadrigemina and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPIGV_MOUSE
AccessioniPrimary (citable) accession number: Q7TPN3
Secondary accession number(s): Q8BGL2
, Q8BJR5, Q8BWH9, Q8BXF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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