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Q7TPM9

- MTMRA_MOUSE

UniProt

Q7TPM9 - MTMRA_MOUSE

Protein

Myotubularin-related protein 10

Gene

Mtmr10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.Curated

    GO - Molecular functioni

    1. phosphatase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 10
    Gene namesi
    Name:Mtmr10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2142292. Mtmr10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 771771Myotubularin-related protein 10PRO_0000284361Add
    BLAST

    Proteomic databases

    PaxDbiQ7TPM9.
    PRIDEiQ7TPM9.

    PTM databases

    PhosphoSiteiQ7TPM9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TPM9.
    BgeeiQ7TPM9.
    CleanExiMM_MTMR10.
    GenevestigatoriQ7TPM9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032736.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TPM9.
    SMRiQ7TPM9. Positions 35-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini217 – 657441Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi198 – 2014Poly-Gly

    Sequence similaritiesi

    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322133.
    GeneTreeiENSGT00740000115440.
    HOGENOMiHOG000113684.
    HOVERGENiHBG108154.
    InParanoidiQ7TPM9.
    KOiK18085.
    OMAiVVNEVNF.
    OrthoDBiEOG7K0ZBZ.
    PhylomeDBiQ7TPM9.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR022587. Myotubularin_assoc.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view]
    PfamiPF12578. 3-PAP. 1 hit.
    PF06602. Myotub-related. 2 hits.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TPM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSLKPPRPS FRSYLLPPAQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF    50
    VRKCIATDTS QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV 100
    PLTCIEQIVT VNDHKRKQKV LGPNQKLKFN PTELIIYCKD FRIVRFRFDE 150
    SGPESAKKVC LAIAHYSQPT DLQLLFAFEY VGKKYHNSAN KVNGVSSGGG 200
    GVWSGAGSTG SQRTPLFETY SDWDRETKRT GASGWRVCSI NEGYMISTCL 250
    PEYFVVPSSL ADQDLKIFSH SFVGRRMPFW CWSHSNGSAL VRMALIKDAL 300
    QQRKIDQRIC NAITKSHPQR SDVYKSDLDK ALPNIQEIQA AFVKLKQLCV 350
    NEPFEETEEK WLSSLESTRW LEYVRAFLKH SAELVYILES QRLSVVLQEE 400
    EGRDLSCLVA SLIQVMMDPY FRTITGFQSL IQKEWVMAGY QFLDRCNHLK 450
    RSEKESPLFL LFLDTTWQLL EQYPAAFEFS ETYLAVLCDS TRISLFGTFL 500
    FNSPHQRVKQ STEFAISKNI QLGDEKGLKF PSVWDWALQF TAKDRTLFHN 550
    PFYIGKSTPC VQNGSRKSFK RTKKSYSSTL RGMPSCLKNG IITDQDLLPR 600
    RNSLVLKLKP DPPQHTDSQH SGAEQYFKEW FSRPANLHGI ILPRLSGTHI 650
    KLWKLCYFRW VPEAQINLGG SIMAFHKLSL LADEVDMLSR MLRQHRSGPL 700
    EACYAELDQS RMYFRATGPH DTLGTPEFLS SSFPFSPVGN LCRRSILGTP 750
    LSKFLSGAKI WLSTETLANE D 771
    Length:771
    Mass (Da):88,197
    Last modified:November 25, 2008 - v2
    Checksum:i26FD2B5CE5BCB0E8
    GO

    Sequence cautioni

    The sequence AAH55074.1 differs from that shown. Reason: Sequence of unknown origin in the N-terminal part.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CN669724 mRNA. No translation available.
    BC055074 mRNA. Translation: AAH55074.1. Sequence problems.
    BC058196 mRNA. Translation: AAH58196.1.
    CCDSiCCDS39976.1.
    RefSeqiNP_766330.2. NM_172742.2.
    UniGeneiMm.214959.

    Genome annotation databases

    EnsembliENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522.
    GeneIDi233315.
    KEGGimmu:233315.
    UCSCiuc009hgd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CN669724 mRNA. No translation available.
    BC055074 mRNA. Translation: AAH55074.1 . Sequence problems.
    BC058196 mRNA. Translation: AAH58196.1 .
    CCDSi CCDS39976.1.
    RefSeqi NP_766330.2. NM_172742.2.
    UniGenei Mm.214959.

    3D structure databases

    ProteinModelPortali Q7TPM9.
    SMRi Q7TPM9. Positions 35-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032736.

    PTM databases

    PhosphoSitei Q7TPM9.

    Proteomic databases

    PaxDbi Q7TPM9.
    PRIDEi Q7TPM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032736 ; ENSMUSP00000032736 ; ENSMUSG00000030522 .
    GeneIDi 233315.
    KEGGi mmu:233315.
    UCSCi uc009hgd.1. mouse.

    Organism-specific databases

    CTDi 54893.
    MGIi MGI:2142292. Mtmr10.

    Phylogenomic databases

    eggNOGi NOG322133.
    GeneTreei ENSGT00740000115440.
    HOGENOMi HOG000113684.
    HOVERGENi HBG108154.
    InParanoidi Q7TPM9.
    KOi K18085.
    OMAi VVNEVNF.
    OrthoDBi EOG7K0ZBZ.
    PhylomeDBi Q7TPM9.
    TreeFami TF315197.

    Miscellaneous databases

    NextBioi 381671.
    PROi Q7TPM9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TPM9.
    Bgeei Q7TPM9.
    CleanExi MM_MTMR10.
    Genevestigatori Q7TPM9.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR022587. Myotubularin_assoc.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view ]
    Pfami PF12578. 3-PAP. 1 hit.
    PF06602. Myotub-related. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-771.
      Strain: C57BL/6J and FVB/N.
      Tissue: Egg and Mammary tumor.

    Entry informationi

    Entry nameiMTMRA_MOUSE
    AccessioniPrimary (citable) accession number: Q7TPM9
    Secondary accession number(s): Q6PE99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3