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Protein

Myotubularin-related protein 10

Gene

Mtmr10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10
Gene namesi
Name:Mtmr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142292 Mtmr10

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843611 – 771Myotubularin-related protein 10Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei603PhosphoserineBy similarity1
Modified residuei745PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TPM9
PaxDbiQ7TPM9
PeptideAtlasiQ7TPM9
PRIDEiQ7TPM9

PTM databases

iPTMnetiQ7TPM9
PhosphoSitePlusiQ7TPM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000030522
CleanExiMM_MTMR10
ExpressionAtlasiQ7TPM9 baseline and differential
GenevisibleiQ7TPM9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032736

Structurei

3D structure databases

ProteinModelPortaliQ7TPM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 657Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST441

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 201Poly-Gly4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000113684
HOVERGENiHBG108154
InParanoidiQ7TPM9
KOiK18085
OMAiTSQYDLW
OrthoDBiEOG091G0DYN
PhylomeDBiQ7TPM9
TreeFamiTF315197

Family and domain databases

CDDicd13346 PH-GRAM_MTMR10, 1 hit
InterProiView protein in InterPro
IPR030573 MTMR10
IPR036004 MTMR10_PH-GRAM
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF39 PTHR10807:SF39, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 2 hits
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TPM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLKPPRPS FRSYLLPPAQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF
60 70 80 90 100
VRKCIATDTS QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV
110 120 130 140 150
PLTCIEQIVT VNDHKRKQKV LGPNQKLKFN PTELIIYCKD FRIVRFRFDE
160 170 180 190 200
SGPESAKKVC LAIAHYSQPT DLQLLFAFEY VGKKYHNSAN KVNGVSSGGG
210 220 230 240 250
GVWSGAGSTG SQRTPLFETY SDWDRETKRT GASGWRVCSI NEGYMISTCL
260 270 280 290 300
PEYFVVPSSL ADQDLKIFSH SFVGRRMPFW CWSHSNGSAL VRMALIKDAL
310 320 330 340 350
QQRKIDQRIC NAITKSHPQR SDVYKSDLDK ALPNIQEIQA AFVKLKQLCV
360 370 380 390 400
NEPFEETEEK WLSSLESTRW LEYVRAFLKH SAELVYILES QRLSVVLQEE
410 420 430 440 450
EGRDLSCLVA SLIQVMMDPY FRTITGFQSL IQKEWVMAGY QFLDRCNHLK
460 470 480 490 500
RSEKESPLFL LFLDTTWQLL EQYPAAFEFS ETYLAVLCDS TRISLFGTFL
510 520 530 540 550
FNSPHQRVKQ STEFAISKNI QLGDEKGLKF PSVWDWALQF TAKDRTLFHN
560 570 580 590 600
PFYIGKSTPC VQNGSRKSFK RTKKSYSSTL RGMPSCLKNG IITDQDLLPR
610 620 630 640 650
RNSLVLKLKP DPPQHTDSQH SGAEQYFKEW FSRPANLHGI ILPRLSGTHI
660 670 680 690 700
KLWKLCYFRW VPEAQINLGG SIMAFHKLSL LADEVDMLSR MLRQHRSGPL
710 720 730 740 750
EACYAELDQS RMYFRATGPH DTLGTPEFLS SSFPFSPVGN LCRRSILGTP
760 770
LSKFLSGAKI WLSTETLANE D
Length:771
Mass (Da):88,197
Last modified:November 25, 2008 - v2
Checksum:i26FD2B5CE5BCB0E8
GO

Sequence cautioni

The sequence AAH55074 differs from that shown. Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CN669724 mRNA No translation available.
BC055074 mRNA Translation: AAH55074.1 Sequence problems.
BC058196 mRNA Translation: AAH58196.1
CCDSiCCDS39976.1
RefSeqiNP_766330.2, NM_172742.2
UniGeneiMm.214959

Genome annotation databases

EnsembliENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522
GeneIDi233315
KEGGimmu:233315
UCSCiuc009hgd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTMRA_MOUSE
AccessioniPrimary (citable) accession number: Q7TPM9
Secondary accession number(s): Q6PE99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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