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Q7TPM9 (MTMRA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 10
Gene names
Name:Mtmr10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 myotubularin phosphatase domain.

Sequence caution

The sequence AAH55074.1 differs from that shown. Reason: Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 771771Myotubularin-related protein 10
PRO_0000284361

Regions

Domain217 – 657441Myotubularin phosphatase
Compositional bias198 – 2014Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q7TPM9 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 26FD2B5CE5BCB0E8

FASTA77188,197
        10         20         30         40         50         60 
MFSLKPPRPS FRSYLLPPAQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS 

        70         80         90        100        110        120 
QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV 

       130        140        150        160        170        180 
LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY 

       190        200        210        220        230        240 
VGKKYHNSAN KVNGVSSGGG GVWSGAGSTG SQRTPLFETY SDWDRETKRT GASGWRVCSI 

       250        260        270        280        290        300 
NEGYMISTCL PEYFVVPSSL ADQDLKIFSH SFVGRRMPFW CWSHSNGSAL VRMALIKDAL 

       310        320        330        340        350        360 
QQRKIDQRIC NAITKSHPQR SDVYKSDLDK ALPNIQEIQA AFVKLKQLCV NEPFEETEEK 

       370        380        390        400        410        420 
WLSSLESTRW LEYVRAFLKH SAELVYILES QRLSVVLQEE EGRDLSCLVA SLIQVMMDPY 

       430        440        450        460        470        480 
FRTITGFQSL IQKEWVMAGY QFLDRCNHLK RSEKESPLFL LFLDTTWQLL EQYPAAFEFS 

       490        500        510        520        530        540 
ETYLAVLCDS TRISLFGTFL FNSPHQRVKQ STEFAISKNI QLGDEKGLKF PSVWDWALQF 

       550        560        570        580        590        600 
TAKDRTLFHN PFYIGKSTPC VQNGSRKSFK RTKKSYSSTL RGMPSCLKNG IITDQDLLPR 

       610        620        630        640        650        660 
RNSLVLKLKP DPPQHTDSQH SGAEQYFKEW FSRPANLHGI ILPRLSGTHI KLWKLCYFRW 

       670        680        690        700        710        720 
VPEAQINLGG SIMAFHKLSL LADEVDMLSR MLRQHRSGPL EACYAELDQS RMYFRATGPH 

       730        740        750        760        770 
DTLGTPEFLS SSFPFSPVGN LCRRSILGTP LSKFLSGAKI WLSTETLANE D 

« Hide

References

[1]"Transcriptome analysis of mouse stem cells and early embryos."
Sharov A.A., Piao Y., Matoba R., Dudekula D.B., Qian Y., VanBuren V., Falco G., Martin P.R., Stagg C.A., Bassey U.C., Wang Y., Carter M.G., Hamatani T., Aiba K., Akutsu H., Sharova L., Tanaka T.S., Kimber W.L. expand/collapse author list , Yoshikawa T., Jaradat S.A., Pantano S., Nagaraja R., Boheler K.R., Taub D., Hodes R.J., Longo D.L., Schlessinger D., Keller J., Klotz E., Kelsoe G., Umezawa A., Vescovi A.L., Rossant J., Kunath T., Hogan B.L.M., Curci A., D'Urso M., Kelso J., Hide W., Ko M.S.H.
PLoS Biol. 1:410-419(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-771.
Strain: C57BL/6J and FVB/N.
Tissue: Egg and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CN669724 mRNA. No translation available.
BC055074 mRNA. Translation: AAH55074.1. Sequence problems.
BC058196 mRNA. Translation: AAH58196.1.
CCDSCCDS39976.1.
RefSeqNP_766330.2. NM_172742.2.
UniGeneMm.214959.

3D structure databases

ProteinModelPortalQ7TPM9.
SMRQ7TPM9. Positions 35-511.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032736.

PTM databases

PhosphoSiteQ7TPM9.

Proteomic databases

PaxDbQ7TPM9.
PRIDEQ7TPM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522.
GeneID233315.
KEGGmmu:233315.
UCSCuc009hgd.1. mouse.

Organism-specific databases

CTD54893.
MGIMGI:2142292. Mtmr10.

Phylogenomic databases

eggNOGNOG322133.
GeneTreeENSGT00740000115440.
HOGENOMHOG000113684.
HOVERGENHBG108154.
InParanoidQ7TPM9.
KOK18085.
OMAVVNEVNF.
OrthoDBEOG7K0ZBZ.
PhylomeDBQ7TPM9.
TreeFamTF315197.

Gene expression databases

ArrayExpressQ7TPM9.
BgeeQ7TPM9.
CleanExMM_MTMR10.
GenevestigatorQ7TPM9.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381671.
PROQ7TPM9.
SOURCESearch...

Entry information

Entry nameMTMRA_MOUSE
AccessionPrimary (citable) accession number: Q7TPM9
Secondary accession number(s): Q6PE99
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot