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Protein

Myotubularin-related protein 10

Gene

Mtmr10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10
Gene namesi
Name:Mtmr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142292. Mtmr10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771Myotubularin-related protein 10PRO_0000284361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei603 – 6031PhosphoserineBy similarity
Modified residuei745 – 7451PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TPM9.
PaxDbiQ7TPM9.
PRIDEiQ7TPM9.

PTM databases

PhosphoSiteiQ7TPM9.

Expressioni

Gene expression databases

BgeeiQ7TPM9.
CleanExiMM_MTMR10.
ExpressionAtlasiQ7TPM9. baseline and differential.
GenevisibleiQ7TPM9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032736.

Structurei

3D structure databases

ProteinModelPortaliQ7TPM9.
SMRiQ7TPM9. Positions 35-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 657441Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 2014Poly-Gly

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322133.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ7TPM9.
KOiK18085.
OMAiGRIPMWC.
OrthoDBiEOG7K0ZBZ.
PhylomeDBiQ7TPM9.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030573. MTMR10.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH-like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF39. PTHR10807:SF39. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TPM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLKPPRPS FRSYLLPPAQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF
60 70 80 90 100
VRKCIATDTS QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV
110 120 130 140 150
PLTCIEQIVT VNDHKRKQKV LGPNQKLKFN PTELIIYCKD FRIVRFRFDE
160 170 180 190 200
SGPESAKKVC LAIAHYSQPT DLQLLFAFEY VGKKYHNSAN KVNGVSSGGG
210 220 230 240 250
GVWSGAGSTG SQRTPLFETY SDWDRETKRT GASGWRVCSI NEGYMISTCL
260 270 280 290 300
PEYFVVPSSL ADQDLKIFSH SFVGRRMPFW CWSHSNGSAL VRMALIKDAL
310 320 330 340 350
QQRKIDQRIC NAITKSHPQR SDVYKSDLDK ALPNIQEIQA AFVKLKQLCV
360 370 380 390 400
NEPFEETEEK WLSSLESTRW LEYVRAFLKH SAELVYILES QRLSVVLQEE
410 420 430 440 450
EGRDLSCLVA SLIQVMMDPY FRTITGFQSL IQKEWVMAGY QFLDRCNHLK
460 470 480 490 500
RSEKESPLFL LFLDTTWQLL EQYPAAFEFS ETYLAVLCDS TRISLFGTFL
510 520 530 540 550
FNSPHQRVKQ STEFAISKNI QLGDEKGLKF PSVWDWALQF TAKDRTLFHN
560 570 580 590 600
PFYIGKSTPC VQNGSRKSFK RTKKSYSSTL RGMPSCLKNG IITDQDLLPR
610 620 630 640 650
RNSLVLKLKP DPPQHTDSQH SGAEQYFKEW FSRPANLHGI ILPRLSGTHI
660 670 680 690 700
KLWKLCYFRW VPEAQINLGG SIMAFHKLSL LADEVDMLSR MLRQHRSGPL
710 720 730 740 750
EACYAELDQS RMYFRATGPH DTLGTPEFLS SSFPFSPVGN LCRRSILGTP
760 770
LSKFLSGAKI WLSTETLANE D
Length:771
Mass (Da):88,197
Last modified:November 25, 2008 - v2
Checksum:i26FD2B5CE5BCB0E8
GO

Sequence cautioni

The sequence AAH55074.1 differs from that shown.Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CN669724 mRNA. No translation available.
BC055074 mRNA. Translation: AAH55074.1. Sequence problems.
BC058196 mRNA. Translation: AAH58196.1.
CCDSiCCDS39976.1.
RefSeqiNP_766330.2. NM_172742.2.
UniGeneiMm.214959.

Genome annotation databases

EnsembliENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522.
GeneIDi233315.
KEGGimmu:233315.
UCSCiuc009hgd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CN669724 mRNA. No translation available.
BC055074 mRNA. Translation: AAH55074.1. Sequence problems.
BC058196 mRNA. Translation: AAH58196.1.
CCDSiCCDS39976.1.
RefSeqiNP_766330.2. NM_172742.2.
UniGeneiMm.214959.

3D structure databases

ProteinModelPortaliQ7TPM9.
SMRiQ7TPM9. Positions 35-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032736.

PTM databases

PhosphoSiteiQ7TPM9.

Proteomic databases

MaxQBiQ7TPM9.
PaxDbiQ7TPM9.
PRIDEiQ7TPM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522.
GeneIDi233315.
KEGGimmu:233315.
UCSCiuc009hgd.1. mouse.

Organism-specific databases

CTDi54893.
MGIiMGI:2142292. Mtmr10.

Phylogenomic databases

eggNOGiNOG322133.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ7TPM9.
KOiK18085.
OMAiGRIPMWC.
OrthoDBiEOG7K0ZBZ.
PhylomeDBiQ7TPM9.
TreeFamiTF315197.

Miscellaneous databases

NextBioi381671.
PROiQ7TPM9.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TPM9.
CleanExiMM_MTMR10.
ExpressionAtlasiQ7TPM9. baseline and differential.
GenevisibleiQ7TPM9. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030573. MTMR10.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH-like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF39. PTHR10807:SF39. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-771.
    Strain: C57BL/6J and FVB/N.
    Tissue: Egg and Mammary tumor.

Entry informationi

Entry nameiMTMRA_MOUSE
AccessioniPrimary (citable) accession number: Q7TPM9
Secondary accession number(s): Q6PE99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.