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Protein

Fibronectin type III and SPRY domain-containing protein 1

Gene

Fsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in microtubule organization and stabilization.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 1
Gene namesi
Name:Fsd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1934858. Fsd1.

Subcellular locationi

  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cleavage furrow By similarity

  • Note: Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Fibronectin type III and SPRY domain-containing protein 1PRO_0000316539Add
BLAST

Proteomic databases

MaxQBiQ7TPM6.
PaxDbiQ7TPM6.
PeptideAtlasiQ7TPM6.
PRIDEiQ7TPM6.

PTM databases

iPTMnetiQ7TPM6.
PhosphoSiteiQ7TPM6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000011589.
GenevisibleiQ7TPM6. MM.

Interactioni

Subunit structurei

Oligomerization is required for binding to microtubules.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011733.

Structurei

3D structure databases

ProteinModelPortaliQ7TPM6.
SMRiQ7TPM6. Positions 332-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16258COSPROSITE-ProRule annotationAdd
BLAST
Domaini164 – 268105Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini290 – 477188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 9996Sequence analysisAdd
BLAST

Domaini

B30.2 box contains a microtubule-binding site.

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KDQH. Eukaryota.
ENOG410ZECU. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231656.
HOVERGENiHBG107931.
InParanoidiQ7TPM6.
OMAiAFMVWNG.
OrthoDBiEOG091G072W.
PhylomeDBiQ7TPM6.
TreeFamiTF333654.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00060. FN3. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TPM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDQREALRK IITTLAMKNE ETQTFIYSLK QMLLNVEANS AKVQEDLEAE
60 70 80 90 100
FQSLTSVLEE LKESMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET
110 120 130 140 150
ANQTLQASDS EDFSQAAKEI KDGITMAPAF RLSLKAKVSD NMSHLMVDFA
160 170 180 190 200
QERQMLQALK FLPVPSAPTI DLAESLVSDN CVTLVWHMPD EDSKIDHYVL
210 220 230 240 250
EYRKTNFEGP PRLKEDHPWM VVEGIRQTEH TLTGLKFDMK YMNIRVKACN
260 270 280 290 300
KAVAGEFSEP VTLETPAFMF RLDGSTSHQN LRVEDLSAEW DAMGGKVQDI
310 320 330 340 350
KAREKEGKGR TASPVNSPAR GTPSPKRMSS GRGGRDRFTA ESYTVLGDTL
360 370 380 390 400
IDGGEHYWEV RFEPDSKAFG LGVAYRSLGR FEQLGKTAAS WCLHANNWLQ
410 420 430 440 450
ASFTAKHANK VKVLDSPVPD CLGVHCDFHQ GLLSFYNART KQLLHTFKAK
460 470 480 490
FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC LQKRGSATSS SNTSLT
Length:496
Mass (Da):55,525
Last modified:October 1, 2003 - v1
Checksum:iA5CBCBDA3015E8FF
GO
Isoform 2 (identifier: Q7TPM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-97: Missing.

Note: No experimental confirmation available.
Show »
Length:479
Mass (Da):53,680
Checksum:i2B3F3D16DC874F27
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 9717Missing in isoform 2. 1 PublicationVSP_030767Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140132 mRNA. Translation: BAE24249.1.
AK144257 mRNA. Translation: BAE25801.1.
BC055106 mRNA. Translation: AAH55106.1.
CCDSiCCDS37661.1. [Q7TPM6-1]
RefSeqiNP_899001.1. NM_183178.2. [Q7TPM6-1]
UniGeneiMm.270660.

Genome annotation databases

EnsembliENSMUST00000011733; ENSMUSP00000011733; ENSMUSG00000011589. [Q7TPM6-1]
GeneIDi240121.
KEGGimmu:240121.
UCSCiuc008dan.1. mouse. [Q7TPM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140132 mRNA. Translation: BAE24249.1.
AK144257 mRNA. Translation: BAE25801.1.
BC055106 mRNA. Translation: AAH55106.1.
CCDSiCCDS37661.1. [Q7TPM6-1]
RefSeqiNP_899001.1. NM_183178.2. [Q7TPM6-1]
UniGeneiMm.270660.

3D structure databases

ProteinModelPortaliQ7TPM6.
SMRiQ7TPM6. Positions 332-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011733.

PTM databases

iPTMnetiQ7TPM6.
PhosphoSiteiQ7TPM6.

Proteomic databases

MaxQBiQ7TPM6.
PaxDbiQ7TPM6.
PeptideAtlasiQ7TPM6.
PRIDEiQ7TPM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011733; ENSMUSP00000011733; ENSMUSG00000011589. [Q7TPM6-1]
GeneIDi240121.
KEGGimmu:240121.
UCSCiuc008dan.1. mouse. [Q7TPM6-1]

Organism-specific databases

CTDi79187.
MGIiMGI:1934858. Fsd1.

Phylogenomic databases

eggNOGiENOG410KDQH. Eukaryota.
ENOG410ZECU. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231656.
HOVERGENiHBG107931.
InParanoidiQ7TPM6.
OMAiAFMVWNG.
OrthoDBiEOG091G072W.
PhylomeDBiQ7TPM6.
TreeFamiTF333654.

Miscellaneous databases

PROiQ7TPM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011589.
GenevisibleiQ7TPM6. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00060. FN3. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSD1_MOUSE
AccessioniPrimary (citable) accession number: Q7TPM6
Secondary accession number(s): Q3UNE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.