Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM17

Gene

Trim17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a ubiquitin E3 ligase.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:6.3.2.-)
Alternative name(s):
Tripartite motif-containing protein 17
Gene namesi
Name:Trim17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1861440. Trim17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562251 – 477E3 ubiquitin-protein ligase TRIM17Add BLAST477

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ7TPM3.
PRIDEiQ7TPM3.

PTM databases

PhosphoSitePlusiQ7TPM3.

Expressioni

Tissue specificityi

Almost exclusively in the testis.

Gene expression databases

BgeeiENSMUSG00000036964.
CleanExiMM_TRIM17.
ExpressionAtlasiQ7TPM3. baseline and differential.
GenevisibleiQ7TPM3. MM.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208111. 3 interactors.
STRINGi10090.ENSMUSP00000074639.

Structurei

3D structure databases

ProteinModelPortaliQ7TPM3.
SMRiQ7TPM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 475B30.2/SPRYPROSITE-ProRule annotationAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 226Sequence analysisAdd BLAST92

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ7TPM3.
KOiK12007.
OMAiCAVGQKS.
OrthoDBiEOG091G05W2.
PhylomeDBiQ7TPM3.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR032918. TRIM17.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF397. PTHR24103:SF397. 1 hit.
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TPM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVELARRL QEEATCSICL DYFTDPVMTA CGHNFCRECI QMSWEKGKVK
60 70 80 90 100
KGKKKQKGSF PCPECREMSP QRNLRPNRLL TKVAEMARQH PGLQKRDLCQ
110 120 130 140 150
AHQEPLKLFC QDDQSPICVV CREAQEHRMH RVLPLDEAAR EYKLKLEEDI
160 170 180 190 200
KYLREEMMKT ETLQAKEEQT LTEWQERVKE RRERILEEFQ KVVLFLVEEE
210 220 230 240 250
RRILQVLKKE EEDTLGKLQD SKASLDHQSR SLDLILLQLE ERSQQEPLQM
260 270 280 290 300
LQDVKDTLNR KESFSVQYPE VVLPAAIKTL CRVPGQIEVL KSFQEDVMPD
310 320 330 340 350
PSSAYPYLLL YESRQRRYLS PPPEGSAPYS KDRFVAYPCA VGQKSFSSGR
360 370 380 390 400
HYWEVGMNLT GDALWALGVC RDNVSRKDRV LKSPENGFWV VQLSKGKKQL
410 420 430 440 450
SLLPNSTLVT LTEPPSHMGI FLDFQAGEVS FYSVNDGSHL HSFSQAAFPG
460 470
PLLPFFCLGA PKSGQMVIST VTMWVKG
Length:477
Mass (Da):54,863
Last modified:October 1, 2003 - v1
Checksum:iE05066304224A1AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662809 Genomic DNA. Translation: CAM24487.1.
BC055112 mRNA. Translation: AAH55112.1.
AF220135 mRNA. Translation: AAG53508.1.
CCDSiCCDS24756.1.
RefSeqiNP_112449.1. NM_031172.2.
XP_006533874.1. XM_006533811.3.
XP_006533875.1. XM_006533812.3.
XP_011247459.1. XM_011249157.2.
UniGeneiMm.179733.

Genome annotation databases

EnsembliENSMUST00000075141; ENSMUSP00000074639; ENSMUSG00000036964.
GeneIDi56631.
KEGGimmu:56631.
UCSCiuc007jcv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662809 Genomic DNA. Translation: CAM24487.1.
BC055112 mRNA. Translation: AAH55112.1.
AF220135 mRNA. Translation: AAG53508.1.
CCDSiCCDS24756.1.
RefSeqiNP_112449.1. NM_031172.2.
XP_006533874.1. XM_006533811.3.
XP_006533875.1. XM_006533812.3.
XP_011247459.1. XM_011249157.2.
UniGeneiMm.179733.

3D structure databases

ProteinModelPortaliQ7TPM3.
SMRiQ7TPM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208111. 3 interactors.
STRINGi10090.ENSMUSP00000074639.

PTM databases

PhosphoSitePlusiQ7TPM3.

Proteomic databases

PaxDbiQ7TPM3.
PRIDEiQ7TPM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075141; ENSMUSP00000074639; ENSMUSG00000036964.
GeneIDi56631.
KEGGimmu:56631.
UCSCiuc007jcv.1. mouse.

Organism-specific databases

CTDi51127.
MGIiMGI:1861440. Trim17.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ7TPM3.
KOiK12007.
OMAiCAVGQKS.
OrthoDBiEOG091G05W2.
PhylomeDBiQ7TPM3.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ7TPM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036964.
CleanExiMM_TRIM17.
ExpressionAtlasiQ7TPM3. baseline and differential.
GenevisibleiQ7TPM3. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR032918. TRIM17.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF397. PTHR24103:SF397. 1 hit.
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI17_MOUSE
AccessioniPrimary (citable) accession number: Q7TPM3
Secondary accession number(s): A2AB82, Q99PP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.