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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Gene

Kctd10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Alternative name(s):
BTB/POZ domain-containing protein KCTD10
Gene namesi
Name:Kctd10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1591979. Kctd10.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242 – 244VEF → AEA: Loss of PCNA binding. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474231 – 315BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TPL3.
PRIDEiQ7TPL3.

PTM databases

PhosphoSitePlusiQ7TPL3.

Expressioni

Tissue specificityi

Expressed at highest levels in lung. Also detected in testis and heart. Very low expression, if any, in brain, liver, spleen, kidney and skeletal muscle.1 Publication

Inductioni

By tumor necrosis factor/TNF in cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000047896.
GenevisibleiQ7TPL3. RN.

Interactioni

Subunit structurei

Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with PCNA and DNA polymerase delta subunit 2/POLD2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi268948. 2 interactors.
STRINGi10116.ENSRNOP00000065635.

Structurei

3D structure databases

ProteinModelPortaliQ7TPL3.
SMRiQ7TPL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 100BTBPROSITE-ProRule annotationAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 245Interaction with PCNA7

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716. Eukaryota.
ENOG410XQYZ. LUCA.
GeneTreeiENSGT00530000063071.
HOVERGENiHBG052219.
InParanoidiQ7TPL3.
KOiK15074.
OMAiQGLADEC.
OrthoDBiEOG091G0L1Y.
PhylomeDBiQ7TPL3.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TPL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMSGESVV TSAVPAAATR TTSFKGASPS SKYVKLNVGG ALYYTTMQTL
60 70 80 90 100
TKQDTMLKAM FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE
110 120 130 140 150
SRREIEELLA EAKYYLVQGL LEECQAALQN KDTYEPFCKV PVITSSKEEQ
160 170 180 190 200
RLIATSDKPA VKLLYNRSNN KYSYTSNSDD NMLKNIELFD KLSLRFNGRV
210 220 230 240 250
LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIY
260 270 280 290 300
EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERERIERVR
310
RIHIKRPDDR AHLHQ
Length:315
Mass (Da):35,745
Last modified:October 1, 2003 - v1
Checksum:i469FEA48EE6FA7A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318756 mRNA. Translation: AAP79438.1.
RefSeqiNP_001009973.1. NM_001009973.1.
UniGeneiRn.185282.

Genome annotation databases

EnsembliENSRNOT00000073019; ENSRNOP00000065635; ENSRNOG00000047896.
GeneIDi494521.
KEGGirno:494521.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBACD3_RAT
AccessioniPrimary (citable) accession number: Q7TPL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families