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Q7TPH6

- MYCB2_MOUSE

UniProt

Q7TPH6 - MYCB2_MOUSE

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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene
Mycbp2, Pam, Phr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 By similarity. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4461 – 451252RING-type; atypicalAdd
BLAST
Zinc fingeri4615 – 466551B box-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein homodimerization activity Source: MGI
  4. ubiquitin-protein transferase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. branchiomotor neuron axon guidance Source: MGI
  2. cell morphogenesis involved in neuron differentiation Source: MGI
  3. central nervous system projection neuron axonogenesis Source: MGI
  4. motor neuron axon guidance Source: MGI
  5. negative regulation of protein catabolic process Source: MGI
  6. regulation of cytoskeleton organization Source: MGI
  7. regulation of protein localization Source: MGI
  8. regulation of transcription, DNA-templated Source: UniProtKB-KW
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene namesi
Name:Mycbp2
Synonyms:Pam, Phr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2179432. Mycbp2.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. axon Source: MGI
  2. microtubule cytoskeleton Source: MGI
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display incomplete innervation of the diaphragm by the phrenic nerve. Intercostal muscles are completely innervated, but show dysmorphic nerve terminals. Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 47114711E3 ubiquitin-protein ligase MYCBP2PRO_0000055964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401Phosphoserine By similarity
Modified residuei143 – 1431Phosphoserine By similarity
Modified residuei145 – 1451Phosphoserine By similarity
Disulfide bondi1707 ↔ 1822 Inferred
Modified residuei2823 – 28231Phosphoserine By similarity
Modified residuei2954 – 29541Phosphoserine By similarity
Modified residuei3124 – 31241Phosphoserine By similarity
Modified residuei3512 – 35121Phosphoserine1 Publication
Modified residuei3539 – 35391Phosphoserine By similarity

Post-translational modificationi

Autoubiquitinated By similarity.

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ7TPH6.
PaxDbiQ7TPH6.
PRIDEiQ7TPH6.

PTM databases

PhosphoSiteiQ7TPH6.

Expressioni

Tissue specificityi

Dynamically expressed in embryonic nervous system from E8.5 through E18.5. During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina. Lower levels of expression are observed throughout the cerebral cortex.1 Publication

Gene expression databases

CleanExiMM_MYCBP2.
MM_PAM.
GenevestigatoriQ7TPH6.

Interactioni

Subunit structurei

Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) By similarity. Interacts with FBXO45.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc12a5Q636334EBI-1811542,EBI-1811510From a different organism.

Protein-protein interaction databases

BioGridi222897. 4 interactions.
IntActiQ7TPH6. 1 interaction.

Structurei

Secondary structure

1
4711
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1194 – 11974
Beta strandi1199 – 12024
Beta strandi1214 – 12229
Beta strandi1224 – 12329
Beta strandi1238 – 124811
Turni1249 – 12535
Beta strandi1259 – 12635
Beta strandi1267 – 12693
Beta strandi1276 – 128712
Beta strandi1292 – 130211
Beta strandi1307 – 13104
Beta strandi1312 – 13154
Beta strandi1321 – 13266
Beta strandi1335 – 13406
Beta strandi1343 – 13475
Beta strandi1686 – 16905
Beta strandi1692 – 16943
Helixi1699 – 17013
Beta strandi1704 – 171310
Beta strandi1715 – 17239
Beta strandi1729 – 17379
Beta strandi1753 – 176210
Beta strandi1770 – 178112
Beta strandi1788 – 179710
Beta strandi1802 – 18054
Beta strandi1807 – 18104
Beta strandi1816 – 18205
Beta strandi1831 – 18355
Beta strandi1838 – 18436

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1191-1352[»]
3HWJX-ray2.25A/B1685-1845[»]
ProteinModelPortaliQ7TPH6.
SMRiQ7TPH6. Positions 496-677, 886-1022, 1189-1349, 1685-1844, 2359-2400, 4454-4518.

Miscellaneous databases

EvolutionaryTraceiQ7TPH6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati562 – 61756RCC1 1Add
BLAST
Repeati661 – 71757RCC1 2Add
BLAST
Repeati869 – 91951RCC1 3Add
BLAST
Repeati920 – 97152RCC1 4Add
BLAST
Repeati973 – 102856RCC1 5Add
BLAST
Repeati2293 – 2400108FilaminAdd
BLAST
Domaini3751 – 3929179DOCAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1197 – 1348152PHR domain 1Add
BLAST
Regioni1685 – 1843159PHR domain 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 8824Lys-richAdd
BLAST
Compositional biasi728 – 77649Cys-richAdd
BLAST
Compositional biasi2754 – 2878125Ser-richAdd
BLAST
Compositional biasi2847 – 2955109Pro-richAdd
BLAST
Compositional biasi3228 – 324821Lys-richAdd
BLAST
Compositional biasi3296 – 332732Gly-richAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.1 Publication

Sequence similaritiesi

Belongs to the highwire family.
Contains 1 DOC domain.
Contains 1 filamin repeat.
Contains 5 RCC1 repeats.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240798.
HOGENOMiHOG000112908.
HOVERGENiHBG053153.
InParanoidiQ7TPH6.
KOiK10693.
PhylomeDBiQ7TPH6.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
PfamiPF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q7TPH6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPVPDGSVAA AGLGLGLPTT DSRGHYQLLL SGRALADRYR RIYTTALSDR     50
DQAGSSTGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NVENTVIIPD 100
IKLHSNPSAF NIYCNVRHCV LEWQKKETSL AAASKNSVQS GESDSDEEEE 150
SREPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP 200
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS 250
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQVQ 300
DWFSNGIKKA ALMHKWPLKE VSVDEDDQCL LQNDGFFLYL LCKDGLYKIG 350
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDL NNHSMTAIRI 400
SPETLEQDGT VLLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS 450
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR 500
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG 550
HDGSHALLVA EDGSVFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK 600
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVSDL KGHFVTQVAM 650
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE 700
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP 750
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL 800
DLLLAVPVPG VNIEEHLQLR QKEKRQRVIR RHRLEDGRGP LVFAGPIFMN 850
HREQALARLR SHPAQLKHKR DKHKDGSGDR GEKDASKITT YPPGSVRFDC 900
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA 950
LPGPSTQVTA CSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DIPYWNAKPA 1000
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG 1050
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVLW 1100
RFRPSTRELW CYNAVVADAR LPSATDMQSR CSILSPELAL PTGSRALTTR 1150
SHAALHILGC LDTLAAMQDL KMGIASTEEE TQAVMKVYSK EDYSVVNRFE 1200
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD 1250
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS 1300
GPSSDCGSHG QASITTDDGV IFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT 1350
SDGSTSKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV 1400
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV 1450
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLRLLEAV 1500
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQEANFK TSSSRLLAAV 1550
MSALCHTSVK LTSLFPIAYD GEVLLRSIVK QVSTENDSTL VHRFPLLVGH 1600
MEKLSQSEEN ISGMTSFREV LEKMLVIVVL PVRNSLRRES ELFSSHLVSN 1650
TCGLLASIVS ELTASALGSE VDGLNSLHSV KASANRFTKT SQGRSWNTGN 1700
GSPDAICFAV DKPGIVVVGF AVYGGGGIHE YELEVLVDDS EHAGDSTHSH 1750
RWTSLELVKG TYTTDDSPSD IAEIRLDKVV PLKENVKYAV RLSNYGSRTA 1800
NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL YYRSEFDGDL 1850
QSQLLSKANE EDKNCSRALS VVSTVVRAAK DLLHRALAVD ADDIPELLSS 1900
SSLFSMLLPL IIAYIGPVAA AIPKVAVEVF GLVQQLLPSV AILNQKYASP 1950
AFNPNQSTDS TTGNQPEQGL SACTTSNHYA VIESEHPYKP ACVMHYKVTF 2000
PECVRWMTIE FDPQCGTAQS EDVIRLLIPV RTIQNSGYGA KLTSVHENLN 2050
SWVELKKYSG SSGWPTMVLV LPGNEALFSL ETASDYVKDD KASFYGFKCF 2100
AIGYEFSPGP DEGVIQLEKE LANLGGVCAA ALMKKDLALP VGNELEEDLE 2150
ILEEAALQVC KTHSGILGKG LALSHSPTIL EALEGNLPLQ IQSNEQSFLD 2200
DFIACVPGSS GGRLARWLQP DSYADPQKTS LILNKDDIRC GWPTTITVQT 2250
KDQYGDVVHV PNMKVEVKAV PVSQKKTSLQ QDQGKKCQRI PGSPSAAASS 2300
ADMTFGGLAS PKLDVSYEPM IVKEARYIAI TMMKVYENYS FEELRFASPT 2350
PKRPSENMLI RVNNDGTYCA NWTPGAIGLY TVHVTIDGIE IDAGLEVKVK 2400
DPPKGMIPPG TQLVKPKADP QPNKIRKFVA KDSAGLRIRS HPSLQSEQIG 2450
IVRVNGTITF IDEIHNDDGV WLRLNEETIK KYVPNMNGYT EAWCLSFNQH 2500
LGKSLLVPVD NIFNASQGVR DLDVFSWTSK AFFPQEPKTN TDDFFKDMNS 2550
CGPQEATMQE RDHPFLRGGP GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV 2600
LGNKVKAVGE VTNSEGAWVQ LDKNSMVEFC ESDEGEAWSL ARDRGGNQYL 2650
RHEDEQVLLD QNSQPPPPSP FSVQAFNKGA SCSAQGFDYG LGNNKGDQLS 2700
AILNSIQSRP NLPAPSIFDQ AAKPPSSLVH SPFVFGQPLS FQQRQLQSDR 2750
GTISTSSRPV STSGKSELPS KHSRSVKPDG HVSRTPADQK KPRGTEGLSA 2800
SESLMLKSDA AKLRSDSHSR SLSPNHNTLQ TLKSDGRTSS GFRAESPGPG 2850
SRSSSPKPKP LPTPRSSPSG ASSPRSSSPQ DKNLPQKSTA PAKTKLDPPR 2900
ERSKSDSYTL DPDTLRKKKM PLTEPLRGRS TSPKPKPVPK DPKDSPGSEN 2950
RAPSPHVVQE NLHSEVVEVC TSSTLKTNGV TDSTCDDSGD LKSVDEGSNK 3000
VHFSIGKAPL KDEQEMRASP KISRKCANRH TRPKKEKSNF LFKGDGTKSL 3050
EPAKQAMSPS VAECARAVFA SFLWHEGIVH DAMACSSFLK FNPDLSKEHA 3100
PIRSSLNSQP PTEEKEIKLK NRHSLEISSA LNMFNIAPHG PDISKMGSIN 3150
KNKVLSMLKE PPLHEKCEDG KSEATFEMSM HHTMKSKSPL PLTLQHLVAF 3200
WEDISLATIK AASQNMIFPS PGSCAVLKKK ECEKENKKTK KEKKKKEKTE 3250
IRPRGNLFGE MAQLAVGGPE KDTICELCGE SHPYPVTYHM RQAHPGCGRY 3300
AGGQGYNSIG HFCGGWAGNC GDGGMGGSTW YLVCDRCREK YLREKQAAAR 3350
EKVKQSRRKP MQVKTPRALP TMEAHQVIKA NALFLLSLSS AAEPSILCYH 3400
PAKPFQSQLP IVKEGVSEDL PVKMPCLYLQ TLARHHHENF VGYQDDNLFQ 3450
DEMRYLRSTS VPAPYISVTP DASPNVFEEP ESNMKSMPPS LETSPITDTD 3500
LAKRTVFQRS YSVVASEYDK QHSILPARVK AIPRRRVNSG DTVGSSLLRH 3550
PSPELSRLIS AHSSLSKGER NFQWPVLAFV IQHHDLEGLE IAMKQALRKS 3600
ACRVFAMEAF NWLLCNVIQT TSLHDILWHF VAALTPSPVE AEEDEDGDNK 3650
SNKENAEQEK DTRVCEHPLS DIVIAGEAAH PLPHTFHRLL QTISDLMMSL 3700
PSGSSLQQMA LRCWSLKFKQ SDHQFLHQSN VFHHINNILS KSDDGDSEES 3750
FSISVQSGFE AMSQELCIVM CLKDLTSIVD IKTSSRPAMI GSLTDGSTET 3800
FWESGDEDKN KTKNITINCV KGINARYVSV HVDNSRDLGN KVTSMTFLTG 3850
KAVEELCRIK QVDLDSRHIG WVTSELPGGD NQIIKIELKG PENTLRVRQV 3900
KVLGWKDGES TKIAGQISAS VAQQRSCEAE TLRVFRLITS QVFGKLISGD 3950
AEPTPEQEEK ALLSSPEGEE KVYNATSDAD LKEHMVGIIF SRSKLTNLQK 4000
QVCAHIVQAI RMEATRVREE WEHAISSKEN ANSQPSDEDA SSDAYCFELL 4050
SMVLALSGSN VGRQYLAQQL TLLQDLFSLL HTASPRVQRQ VTSLLRRVLP 4100
EVTPNRLASI IGVKSLPPAD ISDIIHSTEK GDWNKLGILD MFLGCIAKAL 4150
TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG ESHWWMKGST 4200
PTQISEIIIR LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV 4250
RCIATTRLWL ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG 4300
ETAAIILCNI CGNLCTDCDR FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG 4350
CGRTKLFWLM ALADSKTMKA MVEFREHTGK PTTSSSEACR FCGSRSGTEL 4400
SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC GGVRNEEHCL PCLHGCDKSA 4450
TTLKQDADDM CMICFTEALS AAPAIQLDCS HVFHLQCCRR VLENRWLGPR 4500
ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS 4550
EAITTPGVRF YNDAAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGQEDD 4600
YDPRELICGA CSDVSRAQMC PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC 4650
NACHDDFQRM TSIPKEELPH CPAGPKGKQL EGTECPLHVV HPPTGEEFAL 4700
GCGVCRNAHT F 4711
Length:4,711
Mass (Da):517,738
Last modified:June 21, 2005 - v2
Checksum:i03C9A3975EED7552
GO
Isoform 2 (identifier: Q7TPH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3972-3974: Missing.

Show »
Length:4,708
Mass (Da):517,361
Checksum:iB9E8717F81DFD5F8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3972 – 39743Missing in isoform 2. VSP_014184

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3647 – 36471G → E in AAH59257. 1 Publication
Sequence conflicti4598 – 45981E → G in AAH59257. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325887 mRNA. Translation: AAP88591.1.
BC059257 mRNA. Translation: AAH59257.1.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

Genome annotation databases

GeneIDi105689.
KEGGimmu:105689.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325887 mRNA. Translation: AAP88591.1 .
BC059257 mRNA. Translation: AAH59257.1 .
RefSeqi NP_997098.2. NM_207215.2.
UniGenei Mm.6478.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GBW X-ray 1.32 A 1191-1352 [» ]
3HWJ X-ray 2.25 A/B 1685-1845 [» ]
ProteinModelPortali Q7TPH6.
SMRi Q7TPH6. Positions 496-677, 886-1022, 1189-1349, 1685-1844, 2359-2400, 4454-4518.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222897. 4 interactions.
IntActi Q7TPH6. 1 interaction.

PTM databases

PhosphoSitei Q7TPH6.

Proteomic databases

MaxQBi Q7TPH6.
PaxDbi Q7TPH6.
PRIDEi Q7TPH6.

Protocols and materials databases

DNASUi 105689.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 105689.
KEGGi mmu:105689.

Organism-specific databases

CTDi 23077.
MGIi MGI:2179432. Mycbp2.

Phylogenomic databases

eggNOGi NOG240798.
HOGENOMi HOG000112908.
HOVERGENi HBG053153.
InParanoidi Q7TPH6.
KOi K10693.
PhylomeDBi Q7TPH6.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi MYCBP2. mouse.
EvolutionaryTracei Q7TPH6.
NextBioi 357830.
PROi Q7TPH6.
SOURCEi Search...

Gene expression databases

CleanExi MM_MYCBP2.
MM_PAM.
Genevestigatori Q7TPH6.

Family and domain databases

Gene3Di 2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
Pfami PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice."
    Burgess R.W., Peterson K.A., Johnson M.J., Roix J.J., Welsh I.C., O'Brien T.P.
    Mol. Cell. Biol. 24:1096-1105(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2327-2352 AND 2866-2875, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3250-4711 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
    Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
    Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBXO45.
  7. "Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1."
    Sampathkumar P., Ozyurt S.A., Miller S.A., Bain K.T., Rutter M.E., Gheyi T., Abrams B., Wang Y., Atwell S., Luz J.G., Thompson D.A., Wasserman S.R., Emtage J.S., Park E.C., Rongo C., Jin Y., Klemke R.L., Sauder J.M., Burley S.K.
    J. Mol. Biol. 397:883-892(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.32 ANGSTROMS) OF 1191-1352, X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1685-1845, DOMAIN PHR, DISULFIDE BOND.

Entry informationi

Entry nameiMYCB2_MOUSE
AccessioniPrimary (citable) accession number: Q7TPH6
Secondary accession number(s): Q6PCM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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