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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

Mycbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (By similarity). May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4461 – 4512RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri4615 – 4665B box-typeAdd BLAST51

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • protein homodimerization activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • branchiomotor neuron axon guidance Source: MGI
  • cell morphogenesis involved in neuron differentiation Source: MGI
  • central nervous system projection neuron axonogenesis Source: MGI
  • motor neuron axon guidance Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of cytoskeleton organization Source: MGI
  • regulation of protein localization Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene namesi
Name:Mycbp2By similarity
Synonyms:Pam1 Publication, Phr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2179432. Mycbp2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • membrane Source: MGI
  • microtubule cytoskeleton Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display incomplete innervation of the diaphragm by the phrenic nerve. Intercostal muscles are completely innervated, but show dysmorphic nerve terminals. Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559641 – 4711E3 ubiquitin-protein ligase MYCBP2Add BLAST4711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei1583PhosphoserineBy similarity1
Disulfide bondi1707 ↔ 18221 Publication
Modified residuei2803PhosphoserineBy similarity1
Modified residuei2821PhosphoserineBy similarity1
Modified residuei2823PhosphoserineBy similarity1
Modified residuei2867PhosphoserineBy similarity1
Modified residuei2873PhosphoserineBy similarity1
Modified residuei2903PhosphoserineCombined sources1
Modified residuei2905PhosphoserineBy similarity1
Modified residuei2954PhosphoserineCombined sources1
Modified residuei3019PhosphoserineBy similarity1
Modified residuei3124PhosphoserineBy similarity1
Modified residuei3512PhosphoserineCombined sources1
Modified residuei3539PhosphoserineBy similarity1
Modified residuei3954PhosphothreonineCombined sources1
Modified residuei3964PhosphoserineBy similarity1
Modified residuei3965PhosphoserineBy similarity1

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7TPH6.
PaxDbiQ7TPH6.
PRIDEiQ7TPH6.

PTM databases

iPTMnetiQ7TPH6.
PhosphoSitePlusiQ7TPH6.

Expressioni

Tissue specificityi

Dynamically expressed in embryonic nervous system from E8.5 through E18.5. During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina. Lower levels of expression are observed throughout the cerebral cortex.1 Publication

Gene expression databases

CleanExiMM_MYCBP2.
MM_PAM.

Interactioni

Subunit structurei

Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with MYC (By similarity). Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) (By similarity). Interacts with FBXO45 (PubMed:19398581). Interacts with RAE1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc12a5Q636334EBI-1811542,EBI-1811510From a different organism.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi222897. 6 interactors.
IntActiQ7TPH6. 1 interactor.
STRINGi10090.ENSMUSP00000124710.

Structurei

Secondary structure

14711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1194 – 1197Combined sources4
Beta strandi1199 – 1202Combined sources4
Beta strandi1214 – 1222Combined sources9
Beta strandi1224 – 1232Combined sources9
Beta strandi1238 – 1248Combined sources11
Turni1249 – 1253Combined sources5
Beta strandi1259 – 1263Combined sources5
Beta strandi1267 – 1269Combined sources3
Beta strandi1276 – 1287Combined sources12
Beta strandi1292 – 1302Combined sources11
Beta strandi1307 – 1310Combined sources4
Beta strandi1312 – 1315Combined sources4
Beta strandi1321 – 1326Combined sources6
Beta strandi1335 – 1340Combined sources6
Beta strandi1343 – 1347Combined sources5
Beta strandi1686 – 1690Combined sources5
Beta strandi1692 – 1694Combined sources3
Helixi1699 – 1701Combined sources3
Beta strandi1704 – 1713Combined sources10
Beta strandi1715 – 1723Combined sources9
Beta strandi1729 – 1737Combined sources9
Beta strandi1753 – 1762Combined sources10
Beta strandi1770 – 1781Combined sources12
Beta strandi1788 – 1797Combined sources10
Beta strandi1802 – 1805Combined sources4
Beta strandi1807 – 1810Combined sources4
Beta strandi1816 – 1820Combined sources5
Beta strandi1831 – 1835Combined sources5
Beta strandi1838 – 1843Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1191-1352[»]
3HWJX-ray2.25A/B1685-1845[»]
ProteinModelPortaliQ7TPH6.
SMRiQ7TPH6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7TPH6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati562 – 617RCC1 1Sequence analysisAdd BLAST56
Repeati661 – 717RCC1 2Sequence analysisAdd BLAST57
Repeati869 – 919RCC1 3Sequence analysisAdd BLAST51
Repeati920 – 971RCC1 4Sequence analysisAdd BLAST52
Repeati973 – 1028RCC1 5Sequence analysisAdd BLAST56
Repeati2293 – 2400FilaminSequence analysisAdd BLAST108
Domaini3751 – 3929DOCPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1197 – 1348PHR domain 1Add BLAST152
Regioni1685 – 1843PHR domain 2Add BLAST159
Regioni1980 – 2506RAE1 bindingBy similarityAdd BLAST527

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 88Lys-richSequence analysisAdd BLAST24
Compositional biasi728 – 776Cys-richSequence analysisAdd BLAST49
Compositional biasi2754 – 2878Ser-richSequence analysisAdd BLAST125
Compositional biasi2847 – 2955Pro-richSequence analysisAdd BLAST109
Compositional biasi3228 – 3248Lys-richSequence analysisAdd BLAST21
Compositional biasi3296 – 3327Gly-richSequence analysisAdd BLAST32

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.1 Publication

Sequence similaritiesi

Belongs to the highwire family.Curated
Contains 1 B box-type zinc finger.Sequence analysis
Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 5 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4461 – 4512RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri4615 – 4665B box-typeAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1428. Eukaryota.
ENOG410XP1T. LUCA.
HOGENOMiHOG000112908.
HOVERGENiHBG053153.
InParanoidiQ7TPH6.
KOiK10693.
PhylomeDBiQ7TPH6.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7TPH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPDGSVAA AGLGLGLPTT DSRGHYQLLL SGRALADRYR RIYTTALSDR
60 70 80 90 100
DQAGSSTGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NVENTVIIPD
110 120 130 140 150
IKLHSNPSAF NIYCNVRHCV LEWQKKETSL AAASKNSVQS GESDSDEEEE
160 170 180 190 200
SREPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP
210 220 230 240 250
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS
260 270 280 290 300
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQVQ
310 320 330 340 350
DWFSNGIKKA ALMHKWPLKE VSVDEDDQCL LQNDGFFLYL LCKDGLYKIG
360 370 380 390 400
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDL NNHSMTAIRI
410 420 430 440 450
SPETLEQDGT VLLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS
460 470 480 490 500
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR
510 520 530 540 550
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG
560 570 580 590 600
HDGSHALLVA EDGSVFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK
610 620 630 640 650
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVSDL KGHFVTQVAM
660 670 680 690 700
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE
710 720 730 740 750
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP
760 770 780 790 800
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL
810 820 830 840 850
DLLLAVPVPG VNIEEHLQLR QKEKRQRVIR RHRLEDGRGP LVFAGPIFMN
860 870 880 890 900
HREQALARLR SHPAQLKHKR DKHKDGSGDR GEKDASKITT YPPGSVRFDC
910 920 930 940 950
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA
960 970 980 990 1000
LPGPSTQVTA CSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DIPYWNAKPA
1010 1020 1030 1040 1050
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG
1060 1070 1080 1090 1100
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVLW
1110 1120 1130 1140 1150
RFRPSTRELW CYNAVVADAR LPSATDMQSR CSILSPELAL PTGSRALTTR
1160 1170 1180 1190 1200
SHAALHILGC LDTLAAMQDL KMGIASTEEE TQAVMKVYSK EDYSVVNRFE
1210 1220 1230 1240 1250
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD
1260 1270 1280 1290 1300
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS
1310 1320 1330 1340 1350
GPSSDCGSHG QASITTDDGV IFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT
1360 1370 1380 1390 1400
SDGSTSKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV
1410 1420 1430 1440 1450
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV
1460 1470 1480 1490 1500
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLRLLEAV
1510 1520 1530 1540 1550
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQEANFK TSSSRLLAAV
1560 1570 1580 1590 1600
MSALCHTSVK LTSLFPIAYD GEVLLRSIVK QVSTENDSTL VHRFPLLVGH
1610 1620 1630 1640 1650
MEKLSQSEEN ISGMTSFREV LEKMLVIVVL PVRNSLRRES ELFSSHLVSN
1660 1670 1680 1690 1700
TCGLLASIVS ELTASALGSE VDGLNSLHSV KASANRFTKT SQGRSWNTGN
1710 1720 1730 1740 1750
GSPDAICFAV DKPGIVVVGF AVYGGGGIHE YELEVLVDDS EHAGDSTHSH
1760 1770 1780 1790 1800
RWTSLELVKG TYTTDDSPSD IAEIRLDKVV PLKENVKYAV RLSNYGSRTA
1810 1820 1830 1840 1850
NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL YYRSEFDGDL
1860 1870 1880 1890 1900
QSQLLSKANE EDKNCSRALS VVSTVVRAAK DLLHRALAVD ADDIPELLSS
1910 1920 1930 1940 1950
SSLFSMLLPL IIAYIGPVAA AIPKVAVEVF GLVQQLLPSV AILNQKYASP
1960 1970 1980 1990 2000
AFNPNQSTDS TTGNQPEQGL SACTTSNHYA VIESEHPYKP ACVMHYKVTF
2010 2020 2030 2040 2050
PECVRWMTIE FDPQCGTAQS EDVIRLLIPV RTIQNSGYGA KLTSVHENLN
2060 2070 2080 2090 2100
SWVELKKYSG SSGWPTMVLV LPGNEALFSL ETASDYVKDD KASFYGFKCF
2110 2120 2130 2140 2150
AIGYEFSPGP DEGVIQLEKE LANLGGVCAA ALMKKDLALP VGNELEEDLE
2160 2170 2180 2190 2200
ILEEAALQVC KTHSGILGKG LALSHSPTIL EALEGNLPLQ IQSNEQSFLD
2210 2220 2230 2240 2250
DFIACVPGSS GGRLARWLQP DSYADPQKTS LILNKDDIRC GWPTTITVQT
2260 2270 2280 2290 2300
KDQYGDVVHV PNMKVEVKAV PVSQKKTSLQ QDQGKKCQRI PGSPSAAASS
2310 2320 2330 2340 2350
ADMTFGGLAS PKLDVSYEPM IVKEARYIAI TMMKVYENYS FEELRFASPT
2360 2370 2380 2390 2400
PKRPSENMLI RVNNDGTYCA NWTPGAIGLY TVHVTIDGIE IDAGLEVKVK
2410 2420 2430 2440 2450
DPPKGMIPPG TQLVKPKADP QPNKIRKFVA KDSAGLRIRS HPSLQSEQIG
2460 2470 2480 2490 2500
IVRVNGTITF IDEIHNDDGV WLRLNEETIK KYVPNMNGYT EAWCLSFNQH
2510 2520 2530 2540 2550
LGKSLLVPVD NIFNASQGVR DLDVFSWTSK AFFPQEPKTN TDDFFKDMNS
2560 2570 2580 2590 2600
CGPQEATMQE RDHPFLRGGP GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV
2610 2620 2630 2640 2650
LGNKVKAVGE VTNSEGAWVQ LDKNSMVEFC ESDEGEAWSL ARDRGGNQYL
2660 2670 2680 2690 2700
RHEDEQVLLD QNSQPPPPSP FSVQAFNKGA SCSAQGFDYG LGNNKGDQLS
2710 2720 2730 2740 2750
AILNSIQSRP NLPAPSIFDQ AAKPPSSLVH SPFVFGQPLS FQQRQLQSDR
2760 2770 2780 2790 2800
GTISTSSRPV STSGKSELPS KHSRSVKPDG HVSRTPADQK KPRGTEGLSA
2810 2820 2830 2840 2850
SESLMLKSDA AKLRSDSHSR SLSPNHNTLQ TLKSDGRTSS GFRAESPGPG
2860 2870 2880 2890 2900
SRSSSPKPKP LPTPRSSPSG ASSPRSSSPQ DKNLPQKSTA PAKTKLDPPR
2910 2920 2930 2940 2950
ERSKSDSYTL DPDTLRKKKM PLTEPLRGRS TSPKPKPVPK DPKDSPGSEN
2960 2970 2980 2990 3000
RAPSPHVVQE NLHSEVVEVC TSSTLKTNGV TDSTCDDSGD LKSVDEGSNK
3010 3020 3030 3040 3050
VHFSIGKAPL KDEQEMRASP KISRKCANRH TRPKKEKSNF LFKGDGTKSL
3060 3070 3080 3090 3100
EPAKQAMSPS VAECARAVFA SFLWHEGIVH DAMACSSFLK FNPDLSKEHA
3110 3120 3130 3140 3150
PIRSSLNSQP PTEEKEIKLK NRHSLEISSA LNMFNIAPHG PDISKMGSIN
3160 3170 3180 3190 3200
KNKVLSMLKE PPLHEKCEDG KSEATFEMSM HHTMKSKSPL PLTLQHLVAF
3210 3220 3230 3240 3250
WEDISLATIK AASQNMIFPS PGSCAVLKKK ECEKENKKTK KEKKKKEKTE
3260 3270 3280 3290 3300
IRPRGNLFGE MAQLAVGGPE KDTICELCGE SHPYPVTYHM RQAHPGCGRY
3310 3320 3330 3340 3350
AGGQGYNSIG HFCGGWAGNC GDGGMGGSTW YLVCDRCREK YLREKQAAAR
3360 3370 3380 3390 3400
EKVKQSRRKP MQVKTPRALP TMEAHQVIKA NALFLLSLSS AAEPSILCYH
3410 3420 3430 3440 3450
PAKPFQSQLP IVKEGVSEDL PVKMPCLYLQ TLARHHHENF VGYQDDNLFQ
3460 3470 3480 3490 3500
DEMRYLRSTS VPAPYISVTP DASPNVFEEP ESNMKSMPPS LETSPITDTD
3510 3520 3530 3540 3550
LAKRTVFQRS YSVVASEYDK QHSILPARVK AIPRRRVNSG DTVGSSLLRH
3560 3570 3580 3590 3600
PSPELSRLIS AHSSLSKGER NFQWPVLAFV IQHHDLEGLE IAMKQALRKS
3610 3620 3630 3640 3650
ACRVFAMEAF NWLLCNVIQT TSLHDILWHF VAALTPSPVE AEEDEDGDNK
3660 3670 3680 3690 3700
SNKENAEQEK DTRVCEHPLS DIVIAGEAAH PLPHTFHRLL QTISDLMMSL
3710 3720 3730 3740 3750
PSGSSLQQMA LRCWSLKFKQ SDHQFLHQSN VFHHINNILS KSDDGDSEES
3760 3770 3780 3790 3800
FSISVQSGFE AMSQELCIVM CLKDLTSIVD IKTSSRPAMI GSLTDGSTET
3810 3820 3830 3840 3850
FWESGDEDKN KTKNITINCV KGINARYVSV HVDNSRDLGN KVTSMTFLTG
3860 3870 3880 3890 3900
KAVEELCRIK QVDLDSRHIG WVTSELPGGD NQIIKIELKG PENTLRVRQV
3910 3920 3930 3940 3950
KVLGWKDGES TKIAGQISAS VAQQRSCEAE TLRVFRLITS QVFGKLISGD
3960 3970 3980 3990 4000
AEPTPEQEEK ALLSSPEGEE KVYNATSDAD LKEHMVGIIF SRSKLTNLQK
4010 4020 4030 4040 4050
QVCAHIVQAI RMEATRVREE WEHAISSKEN ANSQPSDEDA SSDAYCFELL
4060 4070 4080 4090 4100
SMVLALSGSN VGRQYLAQQL TLLQDLFSLL HTASPRVQRQ VTSLLRRVLP
4110 4120 4130 4140 4150
EVTPNRLASI IGVKSLPPAD ISDIIHSTEK GDWNKLGILD MFLGCIAKAL
4160 4170 4180 4190 4200
TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG ESHWWMKGST
4210 4220 4230 4240 4250
PTQISEIIIR LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV
4260 4270 4280 4290 4300
RCIATTRLWL ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG
4310 4320 4330 4340 4350
ETAAIILCNI CGNLCTDCDR FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG
4360 4370 4380 4390 4400
CGRTKLFWLM ALADSKTMKA MVEFREHTGK PTTSSSEACR FCGSRSGTEL
4410 4420 4430 4440 4450
SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC GGVRNEEHCL PCLHGCDKSA
4460 4470 4480 4490 4500
TTLKQDADDM CMICFTEALS AAPAIQLDCS HVFHLQCCRR VLENRWLGPR
4510 4520 4530 4540 4550
ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS
4560 4570 4580 4590 4600
EAITTPGVRF YNDAAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGQEDD
4610 4620 4630 4640 4650
YDPRELICGA CSDVSRAQMC PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC
4660 4670 4680 4690 4700
NACHDDFQRM TSIPKEELPH CPAGPKGKQL EGTECPLHVV HPPTGEEFAL
4710
GCGVCRNAHT F
Length:4,711
Mass (Da):517,738
Last modified:June 21, 2005 - v2
Checksum:i03C9A3975EED7552
GO
Isoform 2Curated (identifier: Q7TPH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3972-3974: Missing.

Show »
Length:4,708
Mass (Da):517,361
Checksum:iB9E8717F81DFD5F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3647G → E in AAH59257 (PubMed:15489334).Curated1
Sequence conflicti4598E → G in AAH59257 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141843972 – 3974Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325887 mRNA. Translation: AAP88591.1.
BC059257 mRNA. Translation: AAH59257.1.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

Genome annotation databases

GeneIDi105689.
KEGGimmu:105689.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325887 mRNA. Translation: AAP88591.1.
BC059257 mRNA. Translation: AAH59257.1.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1191-1352[»]
3HWJX-ray2.25A/B1685-1845[»]
ProteinModelPortaliQ7TPH6.
SMRiQ7TPH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222897. 6 interactors.
IntActiQ7TPH6. 1 interactor.
STRINGi10090.ENSMUSP00000124710.

PTM databases

iPTMnetiQ7TPH6.
PhosphoSitePlusiQ7TPH6.

Proteomic databases

EPDiQ7TPH6.
PaxDbiQ7TPH6.
PRIDEiQ7TPH6.

Protocols and materials databases

DNASUi105689.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105689.
KEGGimmu:105689.

Organism-specific databases

CTDi23077.
MGIiMGI:2179432. Mycbp2.

Phylogenomic databases

eggNOGiKOG1428. Eukaryota.
ENOG410XP1T. LUCA.
HOGENOMiHOG000112908.
HOVERGENiHBG053153.
InParanoidiQ7TPH6.
KOiK10693.
PhylomeDBiQ7TPH6.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiMycbp2. mouse.
EvolutionaryTraceiQ7TPH6.
PROiQ7TPH6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYCBP2.
MM_PAM.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYCB2_MOUSE
AccessioniPrimary (citable) accession number: Q7TPH6
Secondary accession number(s): Q6PCM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.