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Q7TPH6 (MYCB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase MYCBP2

EC=6.3.2.-
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene names
Name:Mycbp2
Synonyms:Pam, Phr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4711 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 By similarity. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC. Ref.1

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) By similarity. Interacts with FBXO45. Ref.6 UniProtKB O75592

Subcellular location

Nucleus By similarity UniProtKB O75592.

Tissue specificity

Dynamically expressed in embryonic nervous system from E8.5 through E18.5. During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina. Lower levels of expression are observed throughout the cerebral cortex. Ref.1

Domain

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners. Ref.7

Post-translational modification

Autoubiquitinated By similarity.

Disruption phenotype

Mice display incomplete innervation of the diaphragm by the phrenic nerve. Intercostal muscles are completely innervated, but show dysmorphic nerve terminals. Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle. Ref.1

Sequence similarities

Belongs to the highwire family.

Contains 1 B box-type zinc finger.

Contains 1 DOC domain.

Contains 1 filamin repeat.

Contains 5 RCC1 repeats.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Ubl conjugation pathway
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMDisulfide bond
Phosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processbranchiomotor neuron axon guidance

Inferred from mutant phenotype PubMed 18031680. Source: MGI

cell morphogenesis involved in neuron differentiation

Inferred from mutant phenotype PubMed 18031680. Source: MGI

central nervous system projection neuron axonogenesis

Inferred from mutant phenotype PubMed 18031680. Source: MGI

motor neuron axon guidance

Inferred from mutant phenotype PubMed 18031680. Source: MGI

negative regulation of protein catabolic process

Inferred from direct assay Ref.6. Source: MGI

regulation of cytoskeleton organization

Inferred from mutant phenotype PubMed 18031680. Source: MGI

regulation of protein localization

Inferred from mutant phenotype PubMed 18031680. Source: MGI

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentaxon

Inferred from direct assay PubMed 18031680. Source: MGI

microtubule cytoskeleton

Inferred from direct assay PubMed 18031680. Source: MGI

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 18769030. Source: IntAct

protein homodimerization activity

Inferred from physical interaction PubMed 15976448. Source: MGI

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Slc12a5Q636334EBI-1811542,EBI-1811510From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q7TPH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7TPH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3972-3974: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 47114711E3 ubiquitin-protein ligase MYCBP2
PRO_0000055964

Regions

Repeat562 – 61756RCC1 1
Repeat661 – 71757RCC1 2
Repeat869 – 91951RCC1 3
Repeat920 – 97152RCC1 4
Repeat973 – 102856RCC1 5
Repeat2293 – 2400108Filamin
Domain3751 – 3929179DOC
Zinc finger4461 – 451252RING-type; atypical
Zinc finger4615 – 466551B box-type
Region1197 – 1348152PHR domain 1
Region1685 – 1843159PHR domain 2
Compositional bias65 – 8824Lys-rich
Compositional bias728 – 77649Cys-rich
Compositional bias2754 – 2878125Ser-rich
Compositional bias2847 – 2955109Pro-rich
Compositional bias3228 – 324821Lys-rich
Compositional bias3296 – 332732Gly-rich

Amino acid modifications

Modified residue1401Phosphoserine By similarity
Modified residue1431Phosphoserine By similarity
Modified residue1451Phosphoserine By similarity
Modified residue28231Phosphoserine By similarity
Modified residue29541Phosphoserine By similarity
Modified residue31241Phosphoserine By similarity
Modified residue35121Phosphoserine Ref.5
Modified residue35391Phosphoserine By similarity
Disulfide bond1707 ↔ 1822 Probable

Natural variations

Alternative sequence3972 – 39743Missing in isoform 2.
VSP_014184

Experimental info

Sequence conflict36471G → E in AAH59257. Ref.3
Sequence conflict45981E → G in AAH59257. Ref.3

Secondary structure

.......................................................... 4711
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 03C9A3975EED7552

FASTA4,711517,738
        10         20         30         40         50         60 
MPVPDGSVAA AGLGLGLPTT DSRGHYQLLL SGRALADRYR RIYTTALSDR DQAGSSTGHP 

        70         80         90        100        110        120 
ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NVENTVIIPD IKLHSNPSAF NIYCNVRHCV 

       130        140        150        160        170        180 
LEWQKKETSL AAASKNSVQS GESDSDEEEE SREPPIKLPK IIEVGLCEVF ELIKETRFSH 

       190        200        210        220        230        240 
PSLCLRSLQA LLNVLQGQQP EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS 

       250        260        270        280        290        300 
CACLFSLVAS WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQVQ 

       310        320        330        340        350        360 
DWFSNGIKKA ALMHKWPLKE VSVDEDDQCL LQNDGFFLYL LCKDGLYKIG SGYSGTVRGH 

       370        380        390        400        410        420 
IYNSTSRIRN RKEKKSWLGY AQGYLLYRDL NNHSMTAIRI SPETLEQDGT VLLPDCHTEG 

       430        440        450        460        470        480 
QNILFTDGEY INQIAASRDD GFVVRIFATS TEPVLQQELQ LKLARKCLHA CGISLFDLEK 

       490        500        510        520        530        540 
DLHIISTGFD EESAILGAGR EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK 

       550        560        570        580        590        600 
SPKIVHFSVG HDGSHALLVA EDGSVFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK 

       610        620        630        640        650        660 
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVSDL KGHFVTQVAM GKAHTCVLMK 

       670        680        690        700        710        720 
NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE DLEEELDEKD EKSMMCPPGM 

       730        740        750        760        770        780 
HKWKLEQCMV CTVCGDCTGY GASCVSSGRP DRVPGGICGC GSGESGCAVC GCCKACAREL 

       790        800        810        820        830        840 
DGQEARQRGI LDAVKEMIPL DLLLAVPVPG VNIEEHLQLR QKEKRQRVIR RHRLEDGRGP 

       850        860        870        880        890        900 
LVFAGPIFMN HREQALARLR SHPAQLKHKR DKHKDGSGDR GEKDASKITT YPPGSVRFDC 

       910        920        930        940        950        960 
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA LPGPSTQVTA 

       970        980        990       1000       1010       1020 
CSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DIPYWNAKPA PMPNIGSKYG RKATWIGASG 

      1030       1040       1050       1060       1070       1080 
DQTFLRIDEA LINSHVLATS EIFASKHIIG LVPASISEPP PFKCLLINKV DGSCKTFNDS 

      1090       1100       1110       1120       1130       1140 
EQEDLQGFGV CLDPVYDVLW RFRPSTRELW CYNAVVADAR LPSATDMQSR CSILSPELAL 

      1150       1160       1170       1180       1190       1200 
PTGSRALTTR SHAALHILGC LDTLAAMQDL KMGIASTEEE TQAVMKVYSK EDYSVVNRFE 

      1210       1220       1230       1240       1250       1260 
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD GGDHETDGDL 

      1270       1280       1290       1300       1310       1320 
LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS GPSSDCGSHG QASITTDDGV 

      1330       1340       1350       1360       1370       1380 
IFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT SDGSTSKGKQ QTSEPVHILK RSFARTVSVE 

      1390       1400       1410       1420       1430       1440 
CFESLLSILH WSWTTLVLGV EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY 

      1450       1460       1470       1480       1490       1500 
PVSATGKAVV EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLRLLEAV 

      1510       1520       1530       1540       1550       1560 
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQEANFK TSSSRLLAAV MSALCHTSVK 

      1570       1580       1590       1600       1610       1620 
LTSLFPIAYD GEVLLRSIVK QVSTENDSTL VHRFPLLVGH MEKLSQSEEN ISGMTSFREV 

      1630       1640       1650       1660       1670       1680 
LEKMLVIVVL PVRNSLRRES ELFSSHLVSN TCGLLASIVS ELTASALGSE VDGLNSLHSV 

      1690       1700       1710       1720       1730       1740 
KASANRFTKT SQGRSWNTGN GSPDAICFAV DKPGIVVVGF AVYGGGGIHE YELEVLVDDS 

      1750       1760       1770       1780       1790       1800 
EHAGDSTHSH RWTSLELVKG TYTTDDSPSD IAEIRLDKVV PLKENVKYAV RLSNYGSRTA 

      1810       1820       1830       1840       1850       1860 
NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL YYRSEFDGDL QSQLLSKANE 

      1870       1880       1890       1900       1910       1920 
EDKNCSRALS VVSTVVRAAK DLLHRALAVD ADDIPELLSS SSLFSMLLPL IIAYIGPVAA 

      1930       1940       1950       1960       1970       1980 
AIPKVAVEVF GLVQQLLPSV AILNQKYASP AFNPNQSTDS TTGNQPEQGL SACTTSNHYA 

      1990       2000       2010       2020       2030       2040 
VIESEHPYKP ACVMHYKVTF PECVRWMTIE FDPQCGTAQS EDVIRLLIPV RTIQNSGYGA 

      2050       2060       2070       2080       2090       2100 
KLTSVHENLN SWVELKKYSG SSGWPTMVLV LPGNEALFSL ETASDYVKDD KASFYGFKCF 

      2110       2120       2130       2140       2150       2160 
AIGYEFSPGP DEGVIQLEKE LANLGGVCAA ALMKKDLALP VGNELEEDLE ILEEAALQVC 

      2170       2180       2190       2200       2210       2220 
KTHSGILGKG LALSHSPTIL EALEGNLPLQ IQSNEQSFLD DFIACVPGSS GGRLARWLQP 

      2230       2240       2250       2260       2270       2280 
DSYADPQKTS LILNKDDIRC GWPTTITVQT KDQYGDVVHV PNMKVEVKAV PVSQKKTSLQ 

      2290       2300       2310       2320       2330       2340 
QDQGKKCQRI PGSPSAAASS ADMTFGGLAS PKLDVSYEPM IVKEARYIAI TMMKVYENYS 

      2350       2360       2370       2380       2390       2400 
FEELRFASPT PKRPSENMLI RVNNDGTYCA NWTPGAIGLY TVHVTIDGIE IDAGLEVKVK 

      2410       2420       2430       2440       2450       2460 
DPPKGMIPPG TQLVKPKADP QPNKIRKFVA KDSAGLRIRS HPSLQSEQIG IVRVNGTITF 

      2470       2480       2490       2500       2510       2520 
IDEIHNDDGV WLRLNEETIK KYVPNMNGYT EAWCLSFNQH LGKSLLVPVD NIFNASQGVR 

      2530       2540       2550       2560       2570       2580 
DLDVFSWTSK AFFPQEPKTN TDDFFKDMNS CGPQEATMQE RDHPFLRGGP GMYKVVKTGP 

      2590       2600       2610       2620       2630       2640 
SGHNIRSCPN LRGIPIGMLV LGNKVKAVGE VTNSEGAWVQ LDKNSMVEFC ESDEGEAWSL 

      2650       2660       2670       2680       2690       2700 
ARDRGGNQYL RHEDEQVLLD QNSQPPPPSP FSVQAFNKGA SCSAQGFDYG LGNNKGDQLS 

      2710       2720       2730       2740       2750       2760 
AILNSIQSRP NLPAPSIFDQ AAKPPSSLVH SPFVFGQPLS FQQRQLQSDR GTISTSSRPV 

      2770       2780       2790       2800       2810       2820 
STSGKSELPS KHSRSVKPDG HVSRTPADQK KPRGTEGLSA SESLMLKSDA AKLRSDSHSR 

      2830       2840       2850       2860       2870       2880 
SLSPNHNTLQ TLKSDGRTSS GFRAESPGPG SRSSSPKPKP LPTPRSSPSG ASSPRSSSPQ 

      2890       2900       2910       2920       2930       2940 
DKNLPQKSTA PAKTKLDPPR ERSKSDSYTL DPDTLRKKKM PLTEPLRGRS TSPKPKPVPK 

      2950       2960       2970       2980       2990       3000 
DPKDSPGSEN RAPSPHVVQE NLHSEVVEVC TSSTLKTNGV TDSTCDDSGD LKSVDEGSNK 

      3010       3020       3030       3040       3050       3060 
VHFSIGKAPL KDEQEMRASP KISRKCANRH TRPKKEKSNF LFKGDGTKSL EPAKQAMSPS 

      3070       3080       3090       3100       3110       3120 
VAECARAVFA SFLWHEGIVH DAMACSSFLK FNPDLSKEHA PIRSSLNSQP PTEEKEIKLK 

      3130       3140       3150       3160       3170       3180 
NRHSLEISSA LNMFNIAPHG PDISKMGSIN KNKVLSMLKE PPLHEKCEDG KSEATFEMSM 

      3190       3200       3210       3220       3230       3240 
HHTMKSKSPL PLTLQHLVAF WEDISLATIK AASQNMIFPS PGSCAVLKKK ECEKENKKTK 

      3250       3260       3270       3280       3290       3300 
KEKKKKEKTE IRPRGNLFGE MAQLAVGGPE KDTICELCGE SHPYPVTYHM RQAHPGCGRY 

      3310       3320       3330       3340       3350       3360 
AGGQGYNSIG HFCGGWAGNC GDGGMGGSTW YLVCDRCREK YLREKQAAAR EKVKQSRRKP 

      3370       3380       3390       3400       3410       3420 
MQVKTPRALP TMEAHQVIKA NALFLLSLSS AAEPSILCYH PAKPFQSQLP IVKEGVSEDL 

      3430       3440       3450       3460       3470       3480 
PVKMPCLYLQ TLARHHHENF VGYQDDNLFQ DEMRYLRSTS VPAPYISVTP DASPNVFEEP 

      3490       3500       3510       3520       3530       3540 
ESNMKSMPPS LETSPITDTD LAKRTVFQRS YSVVASEYDK QHSILPARVK AIPRRRVNSG 

      3550       3560       3570       3580       3590       3600 
DTVGSSLLRH PSPELSRLIS AHSSLSKGER NFQWPVLAFV IQHHDLEGLE IAMKQALRKS 

      3610       3620       3630       3640       3650       3660 
ACRVFAMEAF NWLLCNVIQT TSLHDILWHF VAALTPSPVE AEEDEDGDNK SNKENAEQEK 

      3670       3680       3690       3700       3710       3720 
DTRVCEHPLS DIVIAGEAAH PLPHTFHRLL QTISDLMMSL PSGSSLQQMA LRCWSLKFKQ 

      3730       3740       3750       3760       3770       3780 
SDHQFLHQSN VFHHINNILS KSDDGDSEES FSISVQSGFE AMSQELCIVM CLKDLTSIVD 

      3790       3800       3810       3820       3830       3840 
IKTSSRPAMI GSLTDGSTET FWESGDEDKN KTKNITINCV KGINARYVSV HVDNSRDLGN 

      3850       3860       3870       3880       3890       3900 
KVTSMTFLTG KAVEELCRIK QVDLDSRHIG WVTSELPGGD NQIIKIELKG PENTLRVRQV 

      3910       3920       3930       3940       3950       3960 
KVLGWKDGES TKIAGQISAS VAQQRSCEAE TLRVFRLITS QVFGKLISGD AEPTPEQEEK 

      3970       3980       3990       4000       4010       4020 
ALLSSPEGEE KVYNATSDAD LKEHMVGIIF SRSKLTNLQK QVCAHIVQAI RMEATRVREE 

      4030       4040       4050       4060       4070       4080 
WEHAISSKEN ANSQPSDEDA SSDAYCFELL SMVLALSGSN VGRQYLAQQL TLLQDLFSLL 

      4090       4100       4110       4120       4130       4140 
HTASPRVQRQ VTSLLRRVLP EVTPNRLASI IGVKSLPPAD ISDIIHSTEK GDWNKLGILD 

      4150       4160       4170       4180       4190       4200 
MFLGCIAKAL TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG ESHWWMKGST 

      4210       4220       4230       4240       4250       4260 
PTQISEIIIR LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV RCIATTRLWL 

      4270       4280       4290       4300       4310       4320 
ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG ETAAIILCNI CGNLCTDCDR 

      4330       4340       4350       4360       4370       4380 
FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG CGRTKLFWLM ALADSKTMKA MVEFREHTGK 

      4390       4400       4410       4420       4430       4440 
PTTSSSEACR FCGSRSGTEL SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC GGVRNEEHCL 

      4450       4460       4470       4480       4490       4500 
PCLHGCDKSA TTLKQDADDM CMICFTEALS AAPAIQLDCS HVFHLQCCRR VLENRWLGPR 

      4510       4520       4530       4540       4550       4560 
ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS EAITTPGVRF 

      4570       4580       4590       4600       4610       4620 
YNDAAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGQEDD YDPRELICGA CSDVSRAQMC 

      4630       4640       4650       4660       4670       4680 
PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC NACHDDFQRM TSIPKEELPH CPAGPKGKQL 

      4690       4700       4710 
EGTECPLHVV HPPTGEEFAL GCGVCRNAHT F 

« Hide

Isoform 2 [UniParc].

Checksum: B9E8717F81DFD5F8
Show »

FASTA4,708517,361

References

« Hide 'large scale' references
[1]"Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice."
Burgess R.W., Peterson K.A., Johnson M.J., Roix J.J., Welsh I.C., O'Brien T.P.
Mol. Cell. Biol. 24:1096-1105(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
Strain: C57BL/6J.
Tissue: Embryo.
[2]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2327-2352 AND 2866-2875, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3250-4711 (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[4]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FBXO45.
[7]"Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1."
Sampathkumar P., Ozyurt S.A., Miller S.A., Bain K.T., Rutter M.E., Gheyi T., Abrams B., Wang Y., Atwell S., Luz J.G., Thompson D.A., Wasserman S.R., Emtage J.S., Park E.C., Rongo C., Jin Y., Klemke R.L., Sauder J.M., Burley S.K.
J. Mol. Biol. 397:883-892(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.32 ANGSTROMS) OF 1191-1352, X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1685-1845, DOMAIN PHR, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY325887 mRNA. Translation: AAP88591.1.
BC059257 mRNA. Translation: AAH59257.1.
RefSeqNP_997098.2. NM_207215.2.
UniGeneMm.6478.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1191-1352[»]
3HWJX-ray2.25A/B1685-1845[»]
ProteinModelPortalQ7TPH6.
SMRQ7TPH6. Positions 496-677, 886-1022, 1189-1349, 1685-1844, 2359-2400, 4454-4518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid222897. 4 interactions.
IntActQ7TPH6. 1 interaction.

PTM databases

PhosphoSiteQ7TPH6.

Proteomic databases

MaxQBQ7TPH6.
PaxDbQ7TPH6.
PRIDEQ7TPH6.

Protocols and materials databases

DNASU105689.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID105689.
KEGGmmu:105689.

Organism-specific databases

CTD23077.
MGIMGI:2179432. Mycbp2.

Phylogenomic databases

eggNOGNOG240798.
HOGENOMHOG000112908.
HOVERGENHBG053153.
InParanoidQ7TPH6.
KOK10693.
PhylomeDBQ7TPH6.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

CleanExMM_MYCBP2.
MM_PAM.
GenevestigatorQ7TPH6.

Family and domain databases

Gene3D2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR12846:SF14. PTHR12846:SF14. 1 hit.
PfamPF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
SMARTSM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYCBP2. mouse.
EvolutionaryTraceQ7TPH6.
NextBio357830.
PROQ7TPH6.
SOURCESearch...

Entry information

Entry nameMYCB2_MOUSE
AccessionPrimary (citable) accession number: Q7TPH6
Secondary accession number(s): Q6PCM8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 11, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot