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Q7TPH6

- MYCB2_MOUSE

UniProt

Q7TPH6 - MYCB2_MOUSE

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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

Mycbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (By similarity). May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.By similarity1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4461 – 451252RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri4615 – 466551B box-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein homodimerization activity Source: MGI
  3. ubiquitin-protein transferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. branchiomotor neuron axon guidance Source: MGI
  2. cell morphogenesis involved in neuron differentiation Source: MGI
  3. central nervous system projection neuron axonogenesis Source: MGI
  4. motor neuron axon guidance Source: MGI
  5. negative regulation of protein catabolic process Source: MGI
  6. regulation of cytoskeleton organization Source: MGI
  7. regulation of protein localization Source: MGI
  8. regulation of transcription, DNA-templated Source: UniProtKB-KW
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene namesi
Name:Mycbp2By similarity
Synonyms:Pam1 Publication, Phr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2179432. Mycbp2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. axon Source: MGI
  2. microtubule cytoskeleton Source: MGI
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display incomplete innervation of the diaphragm by the phrenic nerve. Intercostal muscles are completely innervated, but show dysmorphic nerve terminals. Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 47114711E3 ubiquitin-protein ligase MYCBP2PRO_0000055964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Disulfide bondi1707 ↔ 18221 Publication
Modified residuei2823 – 28231PhosphoserineBy similarity
Modified residuei2954 – 29541PhosphoserineBy similarity
Modified residuei3124 – 31241PhosphoserineBy similarity
Modified residuei3512 – 35121Phosphoserine1 Publication
Modified residuei3539 – 35391PhosphoserineBy similarity

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ7TPH6.
PaxDbiQ7TPH6.
PRIDEiQ7TPH6.

PTM databases

PhosphoSiteiQ7TPH6.

Expressioni

Tissue specificityi

Dynamically expressed in embryonic nervous system from E8.5 through E18.5. During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina. Lower levels of expression are observed throughout the cerebral cortex.1 Publication

Gene expression databases

CleanExiMM_MYCBP2.
MM_PAM.
GenevestigatoriQ7TPH6.

Interactioni

Subunit structurei

Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) (By similarity). Interacts with FBXO45.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc12a5Q636334EBI-1811542,EBI-1811510From a different organism.

Protein-protein interaction databases

BioGridi222897. 4 interactions.
IntActiQ7TPH6. 1 interaction.

Structurei

Secondary structure

1
4711
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1194 – 11974
Beta strandi1199 – 12024
Beta strandi1214 – 12229
Beta strandi1224 – 12329
Beta strandi1238 – 124811
Turni1249 – 12535
Beta strandi1259 – 12635
Beta strandi1267 – 12693
Beta strandi1276 – 128712
Beta strandi1292 – 130211
Beta strandi1307 – 13104
Beta strandi1312 – 13154
Beta strandi1321 – 13266
Beta strandi1335 – 13406
Beta strandi1343 – 13475
Beta strandi1686 – 16905
Beta strandi1692 – 16943
Helixi1699 – 17013
Beta strandi1704 – 171310
Beta strandi1715 – 17239
Beta strandi1729 – 17379
Beta strandi1753 – 176210
Beta strandi1770 – 178112
Beta strandi1788 – 179710
Beta strandi1802 – 18054
Beta strandi1807 – 18104
Beta strandi1816 – 18205
Beta strandi1831 – 18355
Beta strandi1838 – 18436

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1191-1352[»]
3HWJX-ray2.25A/B1685-1845[»]
ProteinModelPortaliQ7TPH6.
SMRiQ7TPH6. Positions 496-677, 886-986, 1189-1349, 1685-1844, 2325-2352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7TPH6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati562 – 61756RCC1 1Sequence AnalysisAdd
BLAST
Repeati661 – 71757RCC1 2Sequence AnalysisAdd
BLAST
Repeati869 – 91951RCC1 3Sequence AnalysisAdd
BLAST
Repeati920 – 97152RCC1 4Sequence AnalysisAdd
BLAST
Repeati973 – 102856RCC1 5Sequence AnalysisAdd
BLAST
Repeati2293 – 2400108FilaminSequence AnalysisAdd
BLAST
Domaini3751 – 3929179DOCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1197 – 1348152PHR domain 1Add
BLAST
Regioni1685 – 1843159PHR domain 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 8824Lys-richSequence AnalysisAdd
BLAST
Compositional biasi728 – 77649Cys-richSequence AnalysisAdd
BLAST
Compositional biasi2754 – 2878125Ser-richSequence AnalysisAdd
BLAST
Compositional biasi2847 – 2955109Pro-richSequence AnalysisAdd
BLAST
Compositional biasi3228 – 324821Lys-richSequence AnalysisAdd
BLAST
Compositional biasi3296 – 332732Gly-richSequence AnalysisAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.1 Publication

Sequence similaritiesi

Belongs to the highwire family.Curated
Contains 1 B box-type zinc finger.Sequence Analysis
Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 5 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4461 – 451252RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri4615 – 466551B box-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240798.
HOGENOMiHOG000112908.
HOVERGENiHBG053153.
InParanoidiQ7TPH6.
KOiK10693.
PhylomeDBiQ7TPH6.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
PfamiPF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q7TPH6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPDGSVAA AGLGLGLPTT DSRGHYQLLL SGRALADRYR RIYTTALSDR
60 70 80 90 100
DQAGSSTGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NVENTVIIPD
110 120 130 140 150
IKLHSNPSAF NIYCNVRHCV LEWQKKETSL AAASKNSVQS GESDSDEEEE
160 170 180 190 200
SREPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP
210 220 230 240 250
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS
260 270 280 290 300
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQVQ
310 320 330 340 350
DWFSNGIKKA ALMHKWPLKE VSVDEDDQCL LQNDGFFLYL LCKDGLYKIG
360 370 380 390 400
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDL NNHSMTAIRI
410 420 430 440 450
SPETLEQDGT VLLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS
460 470 480 490 500
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR
510 520 530 540 550
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG
560 570 580 590 600
HDGSHALLVA EDGSVFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK
610 620 630 640 650
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVSDL KGHFVTQVAM
660 670 680 690 700
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE
710 720 730 740 750
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP
760 770 780 790 800
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL
810 820 830 840 850
DLLLAVPVPG VNIEEHLQLR QKEKRQRVIR RHRLEDGRGP LVFAGPIFMN
860 870 880 890 900
HREQALARLR SHPAQLKHKR DKHKDGSGDR GEKDASKITT YPPGSVRFDC
910 920 930 940 950
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA
960 970 980 990 1000
LPGPSTQVTA CSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DIPYWNAKPA
1010 1020 1030 1040 1050
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG
1060 1070 1080 1090 1100
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVLW
1110 1120 1130 1140 1150
RFRPSTRELW CYNAVVADAR LPSATDMQSR CSILSPELAL PTGSRALTTR
1160 1170 1180 1190 1200
SHAALHILGC LDTLAAMQDL KMGIASTEEE TQAVMKVYSK EDYSVVNRFE
1210 1220 1230 1240 1250
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD
1260 1270 1280 1290 1300
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS
1310 1320 1330 1340 1350
GPSSDCGSHG QASITTDDGV IFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT
1360 1370 1380 1390 1400
SDGSTSKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV
1410 1420 1430 1440 1450
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV
1460 1470 1480 1490 1500
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLRLLEAV
1510 1520 1530 1540 1550
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQEANFK TSSSRLLAAV
1560 1570 1580 1590 1600
MSALCHTSVK LTSLFPIAYD GEVLLRSIVK QVSTENDSTL VHRFPLLVGH
1610 1620 1630 1640 1650
MEKLSQSEEN ISGMTSFREV LEKMLVIVVL PVRNSLRRES ELFSSHLVSN
1660 1670 1680 1690 1700
TCGLLASIVS ELTASALGSE VDGLNSLHSV KASANRFTKT SQGRSWNTGN
1710 1720 1730 1740 1750
GSPDAICFAV DKPGIVVVGF AVYGGGGIHE YELEVLVDDS EHAGDSTHSH
1760 1770 1780 1790 1800
RWTSLELVKG TYTTDDSPSD IAEIRLDKVV PLKENVKYAV RLSNYGSRTA
1810 1820 1830 1840 1850
NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL YYRSEFDGDL
1860 1870 1880 1890 1900
QSQLLSKANE EDKNCSRALS VVSTVVRAAK DLLHRALAVD ADDIPELLSS
1910 1920 1930 1940 1950
SSLFSMLLPL IIAYIGPVAA AIPKVAVEVF GLVQQLLPSV AILNQKYASP
1960 1970 1980 1990 2000
AFNPNQSTDS TTGNQPEQGL SACTTSNHYA VIESEHPYKP ACVMHYKVTF
2010 2020 2030 2040 2050
PECVRWMTIE FDPQCGTAQS EDVIRLLIPV RTIQNSGYGA KLTSVHENLN
2060 2070 2080 2090 2100
SWVELKKYSG SSGWPTMVLV LPGNEALFSL ETASDYVKDD KASFYGFKCF
2110 2120 2130 2140 2150
AIGYEFSPGP DEGVIQLEKE LANLGGVCAA ALMKKDLALP VGNELEEDLE
2160 2170 2180 2190 2200
ILEEAALQVC KTHSGILGKG LALSHSPTIL EALEGNLPLQ IQSNEQSFLD
2210 2220 2230 2240 2250
DFIACVPGSS GGRLARWLQP DSYADPQKTS LILNKDDIRC GWPTTITVQT
2260 2270 2280 2290 2300
KDQYGDVVHV PNMKVEVKAV PVSQKKTSLQ QDQGKKCQRI PGSPSAAASS
2310 2320 2330 2340 2350
ADMTFGGLAS PKLDVSYEPM IVKEARYIAI TMMKVYENYS FEELRFASPT
2360 2370 2380 2390 2400
PKRPSENMLI RVNNDGTYCA NWTPGAIGLY TVHVTIDGIE IDAGLEVKVK
2410 2420 2430 2440 2450
DPPKGMIPPG TQLVKPKADP QPNKIRKFVA KDSAGLRIRS HPSLQSEQIG
2460 2470 2480 2490 2500
IVRVNGTITF IDEIHNDDGV WLRLNEETIK KYVPNMNGYT EAWCLSFNQH
2510 2520 2530 2540 2550
LGKSLLVPVD NIFNASQGVR DLDVFSWTSK AFFPQEPKTN TDDFFKDMNS
2560 2570 2580 2590 2600
CGPQEATMQE RDHPFLRGGP GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV
2610 2620 2630 2640 2650
LGNKVKAVGE VTNSEGAWVQ LDKNSMVEFC ESDEGEAWSL ARDRGGNQYL
2660 2670 2680 2690 2700
RHEDEQVLLD QNSQPPPPSP FSVQAFNKGA SCSAQGFDYG LGNNKGDQLS
2710 2720 2730 2740 2750
AILNSIQSRP NLPAPSIFDQ AAKPPSSLVH SPFVFGQPLS FQQRQLQSDR
2760 2770 2780 2790 2800
GTISTSSRPV STSGKSELPS KHSRSVKPDG HVSRTPADQK KPRGTEGLSA
2810 2820 2830 2840 2850
SESLMLKSDA AKLRSDSHSR SLSPNHNTLQ TLKSDGRTSS GFRAESPGPG
2860 2870 2880 2890 2900
SRSSSPKPKP LPTPRSSPSG ASSPRSSSPQ DKNLPQKSTA PAKTKLDPPR
2910 2920 2930 2940 2950
ERSKSDSYTL DPDTLRKKKM PLTEPLRGRS TSPKPKPVPK DPKDSPGSEN
2960 2970 2980 2990 3000
RAPSPHVVQE NLHSEVVEVC TSSTLKTNGV TDSTCDDSGD LKSVDEGSNK
3010 3020 3030 3040 3050
VHFSIGKAPL KDEQEMRASP KISRKCANRH TRPKKEKSNF LFKGDGTKSL
3060 3070 3080 3090 3100
EPAKQAMSPS VAECARAVFA SFLWHEGIVH DAMACSSFLK FNPDLSKEHA
3110 3120 3130 3140 3150
PIRSSLNSQP PTEEKEIKLK NRHSLEISSA LNMFNIAPHG PDISKMGSIN
3160 3170 3180 3190 3200
KNKVLSMLKE PPLHEKCEDG KSEATFEMSM HHTMKSKSPL PLTLQHLVAF
3210 3220 3230 3240 3250
WEDISLATIK AASQNMIFPS PGSCAVLKKK ECEKENKKTK KEKKKKEKTE
3260 3270 3280 3290 3300
IRPRGNLFGE MAQLAVGGPE KDTICELCGE SHPYPVTYHM RQAHPGCGRY
3310 3320 3330 3340 3350
AGGQGYNSIG HFCGGWAGNC GDGGMGGSTW YLVCDRCREK YLREKQAAAR
3360 3370 3380 3390 3400
EKVKQSRRKP MQVKTPRALP TMEAHQVIKA NALFLLSLSS AAEPSILCYH
3410 3420 3430 3440 3450
PAKPFQSQLP IVKEGVSEDL PVKMPCLYLQ TLARHHHENF VGYQDDNLFQ
3460 3470 3480 3490 3500
DEMRYLRSTS VPAPYISVTP DASPNVFEEP ESNMKSMPPS LETSPITDTD
3510 3520 3530 3540 3550
LAKRTVFQRS YSVVASEYDK QHSILPARVK AIPRRRVNSG DTVGSSLLRH
3560 3570 3580 3590 3600
PSPELSRLIS AHSSLSKGER NFQWPVLAFV IQHHDLEGLE IAMKQALRKS
3610 3620 3630 3640 3650
ACRVFAMEAF NWLLCNVIQT TSLHDILWHF VAALTPSPVE AEEDEDGDNK
3660 3670 3680 3690 3700
SNKENAEQEK DTRVCEHPLS DIVIAGEAAH PLPHTFHRLL QTISDLMMSL
3710 3720 3730 3740 3750
PSGSSLQQMA LRCWSLKFKQ SDHQFLHQSN VFHHINNILS KSDDGDSEES
3760 3770 3780 3790 3800
FSISVQSGFE AMSQELCIVM CLKDLTSIVD IKTSSRPAMI GSLTDGSTET
3810 3820 3830 3840 3850
FWESGDEDKN KTKNITINCV KGINARYVSV HVDNSRDLGN KVTSMTFLTG
3860 3870 3880 3890 3900
KAVEELCRIK QVDLDSRHIG WVTSELPGGD NQIIKIELKG PENTLRVRQV
3910 3920 3930 3940 3950
KVLGWKDGES TKIAGQISAS VAQQRSCEAE TLRVFRLITS QVFGKLISGD
3960 3970 3980 3990 4000
AEPTPEQEEK ALLSSPEGEE KVYNATSDAD LKEHMVGIIF SRSKLTNLQK
4010 4020 4030 4040 4050
QVCAHIVQAI RMEATRVREE WEHAISSKEN ANSQPSDEDA SSDAYCFELL
4060 4070 4080 4090 4100
SMVLALSGSN VGRQYLAQQL TLLQDLFSLL HTASPRVQRQ VTSLLRRVLP
4110 4120 4130 4140 4150
EVTPNRLASI IGVKSLPPAD ISDIIHSTEK GDWNKLGILD MFLGCIAKAL
4160 4170 4180 4190 4200
TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG ESHWWMKGST
4210 4220 4230 4240 4250
PTQISEIIIR LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV
4260 4270 4280 4290 4300
RCIATTRLWL ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG
4310 4320 4330 4340 4350
ETAAIILCNI CGNLCTDCDR FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG
4360 4370 4380 4390 4400
CGRTKLFWLM ALADSKTMKA MVEFREHTGK PTTSSSEACR FCGSRSGTEL
4410 4420 4430 4440 4450
SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC GGVRNEEHCL PCLHGCDKSA
4460 4470 4480 4490 4500
TTLKQDADDM CMICFTEALS AAPAIQLDCS HVFHLQCCRR VLENRWLGPR
4510 4520 4530 4540 4550
ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS
4560 4570 4580 4590 4600
EAITTPGVRF YNDAAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGQEDD
4610 4620 4630 4640 4650
YDPRELICGA CSDVSRAQMC PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC
4660 4670 4680 4690 4700
NACHDDFQRM TSIPKEELPH CPAGPKGKQL EGTECPLHVV HPPTGEEFAL
4710
GCGVCRNAHT F
Length:4,711
Mass (Da):517,738
Last modified:June 21, 2005 - v2
Checksum:i03C9A3975EED7552
GO
Isoform 2Curated (identifier: Q7TPH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3972-3974: Missing.

Show »
Length:4,708
Mass (Da):517,361
Checksum:iB9E8717F81DFD5F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3647 – 36471G → E in AAH59257. (PubMed:15489334)Curated
Sequence conflicti4598 – 45981E → G in AAH59257. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3972 – 39743Missing in isoform 2. 1 PublicationVSP_014184

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325887 mRNA. Translation: AAP88591.1.
BC059257 mRNA. Translation: AAH59257.1.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

Genome annotation databases

GeneIDi105689.
KEGGimmu:105689.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY325887 mRNA. Translation: AAP88591.1 .
BC059257 mRNA. Translation: AAH59257.1 .
RefSeqi NP_997098.2. NM_207215.2.
UniGenei Mm.6478.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GBW X-ray 1.32 A 1191-1352 [» ]
3HWJ X-ray 2.25 A/B 1685-1845 [» ]
ProteinModelPortali Q7TPH6.
SMRi Q7TPH6. Positions 496-677, 886-986, 1189-1349, 1685-1844, 2325-2352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222897. 4 interactions.
IntActi Q7TPH6. 1 interaction.

PTM databases

PhosphoSitei Q7TPH6.

Proteomic databases

MaxQBi Q7TPH6.
PaxDbi Q7TPH6.
PRIDEi Q7TPH6.

Protocols and materials databases

DNASUi 105689.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 105689.
KEGGi mmu:105689.

Organism-specific databases

CTDi 23077.
MGIi MGI:2179432. Mycbp2.

Phylogenomic databases

eggNOGi NOG240798.
HOGENOMi HOG000112908.
HOVERGENi HBG053153.
InParanoidi Q7TPH6.
KOi K10693.
PhylomeDBi Q7TPH6.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi MYCBP2. mouse.
EvolutionaryTracei Q7TPH6.
NextBioi 357830.
PROi Q7TPH6.
SOURCEi Search...

Gene expression databases

CleanExi MM_MYCBP2.
MM_PAM.
Genevestigatori Q7TPH6.

Family and domain databases

Gene3Di 2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
Pfami PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice."
    Burgess R.W., Peterson K.A., Johnson M.J., Roix J.J., Welsh I.C., O'Brien T.P.
    Mol. Cell. Biol. 24:1096-1105(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: C57BL/6JImported.
    Tissue: Embryo1 Publication.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2327-2352 AND 2866-2875, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3250-4711 (ISOFORM 2).
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
    Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
    Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBXO45.
  7. "Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1."
    Sampathkumar P., Ozyurt S.A., Miller S.A., Bain K.T., Rutter M.E., Gheyi T., Abrams B., Wang Y., Atwell S., Luz J.G., Thompson D.A., Wasserman S.R., Emtage J.S., Park E.C., Rongo C., Jin Y., Klemke R.L., Sauder J.M., Burley S.K.
    J. Mol. Biol. 397:883-892(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.32 ANGSTROMS) OF 1191-1352, X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1685-1845, DOMAIN PHR, DISULFIDE BOND.

Entry informationi

Entry nameiMYCB2_MOUSE
AccessioniPrimary (citable) accession number: Q7TPH6
Secondary accession number(s): Q6PCM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3