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Q7TPH6

- MYCB2_MOUSE

UniProt

Q7TPH6 - MYCB2_MOUSE

Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

Mycbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 By similarity. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.By similarity1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4461 – 451252RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri4615 – 466551B box-typeAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: MGI
    4. ubiquitin-protein transferase activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. branchiomotor neuron axon guidance Source: MGI
    2. cell morphogenesis involved in neuron differentiation Source: MGI
    3. central nervous system projection neuron axonogenesis Source: MGI
    4. motor neuron axon guidance Source: MGI
    5. negative regulation of protein catabolic process Source: MGI
    6. regulation of cytoskeleton organization Source: MGI
    7. regulation of protein localization Source: MGI
    8. regulation of transcription, DNA-templated Source: UniProtKB-KW
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
    Alternative name(s):
    Myc-binding protein 2
    Pam/highwire/rpm-1 protein
    Protein associated with Myc
    Gene namesi
    Name:Mycbp2By similarity
    Synonyms:Pam1 Publication, Phr1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2179432. Mycbp2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. axon Source: MGI
    2. microtubule cytoskeleton Source: MGI
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice display incomplete innervation of the diaphragm by the phrenic nerve. Intercostal muscles are completely innervated, but show dysmorphic nerve terminals. Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 47114711E3 ubiquitin-protein ligase MYCBP2PRO_0000055964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei140 – 1401PhosphoserineBy similarity
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei145 – 1451PhosphoserineBy similarity
    Disulfide bondi1707 ↔ 18221 Publication
    Modified residuei2823 – 28231PhosphoserineBy similarity
    Modified residuei2954 – 29541PhosphoserineBy similarity
    Modified residuei3124 – 31241PhosphoserineBy similarity
    Modified residuei3512 – 35121Phosphoserine1 Publication
    Modified residuei3539 – 35391PhosphoserineBy similarity

    Post-translational modificationi

    Autoubiquitinated.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ7TPH6.
    PaxDbiQ7TPH6.
    PRIDEiQ7TPH6.

    PTM databases

    PhosphoSiteiQ7TPH6.

    Expressioni

    Tissue specificityi

    Dynamically expressed in embryonic nervous system from E8.5 through E18.5. During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina. Lower levels of expression are observed throughout the cerebral cortex.1 Publication

    Gene expression databases

    CleanExiMM_MYCBP2.
    MM_PAM.
    GenevestigatoriQ7TPH6.

    Interactioni

    Subunit structurei

    Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) By similarity. Interacts with FBXO45.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Slc12a5Q636334EBI-1811542,EBI-1811510From a different organism.

    Protein-protein interaction databases

    BioGridi222897. 4 interactions.
    IntActiQ7TPH6. 1 interaction.

    Structurei

    Secondary structure

    1
    4711
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1194 – 11974
    Beta strandi1199 – 12024
    Beta strandi1214 – 12229
    Beta strandi1224 – 12329
    Beta strandi1238 – 124811
    Turni1249 – 12535
    Beta strandi1259 – 12635
    Beta strandi1267 – 12693
    Beta strandi1276 – 128712
    Beta strandi1292 – 130211
    Beta strandi1307 – 13104
    Beta strandi1312 – 13154
    Beta strandi1321 – 13266
    Beta strandi1335 – 13406
    Beta strandi1343 – 13475
    Beta strandi1686 – 16905
    Beta strandi1692 – 16943
    Helixi1699 – 17013
    Beta strandi1704 – 171310
    Beta strandi1715 – 17239
    Beta strandi1729 – 17379
    Beta strandi1753 – 176210
    Beta strandi1770 – 178112
    Beta strandi1788 – 179710
    Beta strandi1802 – 18054
    Beta strandi1807 – 18104
    Beta strandi1816 – 18205
    Beta strandi1831 – 18355
    Beta strandi1838 – 18436

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3GBWX-ray1.32A1191-1352[»]
    3HWJX-ray2.25A/B1685-1845[»]
    ProteinModelPortaliQ7TPH6.
    SMRiQ7TPH6. Positions 496-677, 886-1022, 1189-1349, 1685-1844, 2359-2400, 4454-4518.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7TPH6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati562 – 61756RCC1 1Sequence AnalysisAdd
    BLAST
    Repeati661 – 71757RCC1 2Sequence AnalysisAdd
    BLAST
    Repeati869 – 91951RCC1 3Sequence AnalysisAdd
    BLAST
    Repeati920 – 97152RCC1 4Sequence AnalysisAdd
    BLAST
    Repeati973 – 102856RCC1 5Sequence AnalysisAdd
    BLAST
    Repeati2293 – 2400108FilaminSequence AnalysisAdd
    BLAST
    Domaini3751 – 3929179DOCPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1197 – 1348152PHR domain 1Add
    BLAST
    Regioni1685 – 1843159PHR domain 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi65 – 8824Lys-richSequence AnalysisAdd
    BLAST
    Compositional biasi728 – 77649Cys-richSequence AnalysisAdd
    BLAST
    Compositional biasi2754 – 2878125Ser-richSequence AnalysisAdd
    BLAST
    Compositional biasi2847 – 2955109Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi3228 – 324821Lys-richSequence AnalysisAdd
    BLAST
    Compositional biasi3296 – 332732Gly-richSequence AnalysisAdd
    BLAST

    Domaini

    The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.1 Publication

    Sequence similaritiesi

    Belongs to the highwire family.Curated
    Contains 1 B box-type zinc finger.Sequence Analysis
    Contains 1 DOC domain.PROSITE-ProRule annotation
    Contains 1 filamin repeat.PROSITE-ProRule annotation
    Contains 5 RCC1 repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4461 – 451252RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri4615 – 466551B box-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG240798.
    HOGENOMiHOG000112908.
    HOVERGENiHBG053153.
    InParanoidiQ7TPH6.
    KOiK10693.
    PhylomeDBiQ7TPH6.

    Family and domain databases

    Gene3Di2.130.10.30. 2 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
    PfamiPF00630. Filamin. 1 hit.
    PF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    PRINTSiPR00633. RCCNDNSATION.
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEiPS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 1 hit.
    PS50012. RCC1_3. 3 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q7TPH6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVPDGSVAA AGLGLGLPTT DSRGHYQLLL SGRALADRYR RIYTTALSDR     50
    DQAGSSTGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NVENTVIIPD 100
    IKLHSNPSAF NIYCNVRHCV LEWQKKETSL AAASKNSVQS GESDSDEEEE 150
    SREPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP 200
    EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS 250
    WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQVQ 300
    DWFSNGIKKA ALMHKWPLKE VSVDEDDQCL LQNDGFFLYL LCKDGLYKIG 350
    SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDL NNHSMTAIRI 400
    SPETLEQDGT VLLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS 450
    TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR 500
    EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG 550
    HDGSHALLVA EDGSVFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK 600
    IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVSDL KGHFVTQVAM 650
    GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE 700
    DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP 750
    DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL 800
    DLLLAVPVPG VNIEEHLQLR QKEKRQRVIR RHRLEDGRGP LVFAGPIFMN 850
    HREQALARLR SHPAQLKHKR DKHKDGSGDR GEKDASKITT YPPGSVRFDC 900
    ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA 950
    LPGPSTQVTA CSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DIPYWNAKPA 1000
    PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG 1050
    LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVLW 1100
    RFRPSTRELW CYNAVVADAR LPSATDMQSR CSILSPELAL PTGSRALTTR 1150
    SHAALHILGC LDTLAAMQDL KMGIASTEEE TQAVMKVYSK EDYSVVNRFE 1200
    SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD 1250
    GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS 1300
    GPSSDCGSHG QASITTDDGV IFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT 1350
    SDGSTSKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV 1400
    EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV 1450
    EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLRLLEAV 1500
    LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQEANFK TSSSRLLAAV 1550
    MSALCHTSVK LTSLFPIAYD GEVLLRSIVK QVSTENDSTL VHRFPLLVGH 1600
    MEKLSQSEEN ISGMTSFREV LEKMLVIVVL PVRNSLRRES ELFSSHLVSN 1650
    TCGLLASIVS ELTASALGSE VDGLNSLHSV KASANRFTKT SQGRSWNTGN 1700
    GSPDAICFAV DKPGIVVVGF AVYGGGGIHE YELEVLVDDS EHAGDSTHSH 1750
    RWTSLELVKG TYTTDDSPSD IAEIRLDKVV PLKENVKYAV RLSNYGSRTA 1800
    NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL YYRSEFDGDL 1850
    QSQLLSKANE EDKNCSRALS VVSTVVRAAK DLLHRALAVD ADDIPELLSS 1900
    SSLFSMLLPL IIAYIGPVAA AIPKVAVEVF GLVQQLLPSV AILNQKYASP 1950
    AFNPNQSTDS TTGNQPEQGL SACTTSNHYA VIESEHPYKP ACVMHYKVTF 2000
    PECVRWMTIE FDPQCGTAQS EDVIRLLIPV RTIQNSGYGA KLTSVHENLN 2050
    SWVELKKYSG SSGWPTMVLV LPGNEALFSL ETASDYVKDD KASFYGFKCF 2100
    AIGYEFSPGP DEGVIQLEKE LANLGGVCAA ALMKKDLALP VGNELEEDLE 2150
    ILEEAALQVC KTHSGILGKG LALSHSPTIL EALEGNLPLQ IQSNEQSFLD 2200
    DFIACVPGSS GGRLARWLQP DSYADPQKTS LILNKDDIRC GWPTTITVQT 2250
    KDQYGDVVHV PNMKVEVKAV PVSQKKTSLQ QDQGKKCQRI PGSPSAAASS 2300
    ADMTFGGLAS PKLDVSYEPM IVKEARYIAI TMMKVYENYS FEELRFASPT 2350
    PKRPSENMLI RVNNDGTYCA NWTPGAIGLY TVHVTIDGIE IDAGLEVKVK 2400
    DPPKGMIPPG TQLVKPKADP QPNKIRKFVA KDSAGLRIRS HPSLQSEQIG 2450
    IVRVNGTITF IDEIHNDDGV WLRLNEETIK KYVPNMNGYT EAWCLSFNQH 2500
    LGKSLLVPVD NIFNASQGVR DLDVFSWTSK AFFPQEPKTN TDDFFKDMNS 2550
    CGPQEATMQE RDHPFLRGGP GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV 2600
    LGNKVKAVGE VTNSEGAWVQ LDKNSMVEFC ESDEGEAWSL ARDRGGNQYL 2650
    RHEDEQVLLD QNSQPPPPSP FSVQAFNKGA SCSAQGFDYG LGNNKGDQLS 2700
    AILNSIQSRP NLPAPSIFDQ AAKPPSSLVH SPFVFGQPLS FQQRQLQSDR 2750
    GTISTSSRPV STSGKSELPS KHSRSVKPDG HVSRTPADQK KPRGTEGLSA 2800
    SESLMLKSDA AKLRSDSHSR SLSPNHNTLQ TLKSDGRTSS GFRAESPGPG 2850
    SRSSSPKPKP LPTPRSSPSG ASSPRSSSPQ DKNLPQKSTA PAKTKLDPPR 2900
    ERSKSDSYTL DPDTLRKKKM PLTEPLRGRS TSPKPKPVPK DPKDSPGSEN 2950
    RAPSPHVVQE NLHSEVVEVC TSSTLKTNGV TDSTCDDSGD LKSVDEGSNK 3000
    VHFSIGKAPL KDEQEMRASP KISRKCANRH TRPKKEKSNF LFKGDGTKSL 3050
    EPAKQAMSPS VAECARAVFA SFLWHEGIVH DAMACSSFLK FNPDLSKEHA 3100
    PIRSSLNSQP PTEEKEIKLK NRHSLEISSA LNMFNIAPHG PDISKMGSIN 3150
    KNKVLSMLKE PPLHEKCEDG KSEATFEMSM HHTMKSKSPL PLTLQHLVAF 3200
    WEDISLATIK AASQNMIFPS PGSCAVLKKK ECEKENKKTK KEKKKKEKTE 3250
    IRPRGNLFGE MAQLAVGGPE KDTICELCGE SHPYPVTYHM RQAHPGCGRY 3300
    AGGQGYNSIG HFCGGWAGNC GDGGMGGSTW YLVCDRCREK YLREKQAAAR 3350
    EKVKQSRRKP MQVKTPRALP TMEAHQVIKA NALFLLSLSS AAEPSILCYH 3400
    PAKPFQSQLP IVKEGVSEDL PVKMPCLYLQ TLARHHHENF VGYQDDNLFQ 3450
    DEMRYLRSTS VPAPYISVTP DASPNVFEEP ESNMKSMPPS LETSPITDTD 3500
    LAKRTVFQRS YSVVASEYDK QHSILPARVK AIPRRRVNSG DTVGSSLLRH 3550
    PSPELSRLIS AHSSLSKGER NFQWPVLAFV IQHHDLEGLE IAMKQALRKS 3600
    ACRVFAMEAF NWLLCNVIQT TSLHDILWHF VAALTPSPVE AEEDEDGDNK 3650
    SNKENAEQEK DTRVCEHPLS DIVIAGEAAH PLPHTFHRLL QTISDLMMSL 3700
    PSGSSLQQMA LRCWSLKFKQ SDHQFLHQSN VFHHINNILS KSDDGDSEES 3750
    FSISVQSGFE AMSQELCIVM CLKDLTSIVD IKTSSRPAMI GSLTDGSTET 3800
    FWESGDEDKN KTKNITINCV KGINARYVSV HVDNSRDLGN KVTSMTFLTG 3850
    KAVEELCRIK QVDLDSRHIG WVTSELPGGD NQIIKIELKG PENTLRVRQV 3900
    KVLGWKDGES TKIAGQISAS VAQQRSCEAE TLRVFRLITS QVFGKLISGD 3950
    AEPTPEQEEK ALLSSPEGEE KVYNATSDAD LKEHMVGIIF SRSKLTNLQK 4000
    QVCAHIVQAI RMEATRVREE WEHAISSKEN ANSQPSDEDA SSDAYCFELL 4050
    SMVLALSGSN VGRQYLAQQL TLLQDLFSLL HTASPRVQRQ VTSLLRRVLP 4100
    EVTPNRLASI IGVKSLPPAD ISDIIHSTEK GDWNKLGILD MFLGCIAKAL 4150
    TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG ESHWWMKGST 4200
    PTQISEIIIR LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV 4250
    RCIATTRLWL ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG 4300
    ETAAIILCNI CGNLCTDCDR FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG 4350
    CGRTKLFWLM ALADSKTMKA MVEFREHTGK PTTSSSEACR FCGSRSGTEL 4400
    SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC GGVRNEEHCL PCLHGCDKSA 4450
    TTLKQDADDM CMICFTEALS AAPAIQLDCS HVFHLQCCRR VLENRWLGPR 4500
    ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS 4550
    EAITTPGVRF YNDAAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGQEDD 4600
    YDPRELICGA CSDVSRAQMC PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC 4650
    NACHDDFQRM TSIPKEELPH CPAGPKGKQL EGTECPLHVV HPPTGEEFAL 4700
    GCGVCRNAHT F 4711
    Length:4,711
    Mass (Da):517,738
    Last modified:June 21, 2005 - v2
    Checksum:i03C9A3975EED7552
    GO
    Isoform 2Curated (identifier: Q7TPH6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3972-3974: Missing.

    Show »
    Length:4,708
    Mass (Da):517,361
    Checksum:iB9E8717F81DFD5F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3647 – 36471G → E in AAH59257. (PubMed:15489334)Curated
    Sequence conflicti4598 – 45981E → G in AAH59257. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3972 – 39743Missing in isoform 2. 1 PublicationVSP_014184

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325887 mRNA. Translation: AAP88591.1.
    BC059257 mRNA. Translation: AAH59257.1.
    RefSeqiNP_997098.2. NM_207215.2.
    UniGeneiMm.6478.

    Genome annotation databases

    GeneIDi105689.
    KEGGimmu:105689.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325887 mRNA. Translation: AAP88591.1 .
    BC059257 mRNA. Translation: AAH59257.1 .
    RefSeqi NP_997098.2. NM_207215.2.
    UniGenei Mm.6478.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3GBW X-ray 1.32 A 1191-1352 [» ]
    3HWJ X-ray 2.25 A/B 1685-1845 [» ]
    ProteinModelPortali Q7TPH6.
    SMRi Q7TPH6. Positions 496-677, 886-1022, 1189-1349, 1685-1844, 2359-2400, 4454-4518.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222897. 4 interactions.
    IntActi Q7TPH6. 1 interaction.

    PTM databases

    PhosphoSitei Q7TPH6.

    Proteomic databases

    MaxQBi Q7TPH6.
    PaxDbi Q7TPH6.
    PRIDEi Q7TPH6.

    Protocols and materials databases

    DNASUi 105689.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 105689.
    KEGGi mmu:105689.

    Organism-specific databases

    CTDi 23077.
    MGIi MGI:2179432. Mycbp2.

    Phylogenomic databases

    eggNOGi NOG240798.
    HOGENOMi HOG000112908.
    HOVERGENi HBG053153.
    InParanoidi Q7TPH6.
    KOi K10693.
    PhylomeDBi Q7TPH6.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi MYCBP2. mouse.
    EvolutionaryTracei Q7TPH6.
    NextBioi 357830.
    PROi Q7TPH6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MYCBP2.
    MM_PAM.
    Genevestigatori Q7TPH6.

    Family and domain databases

    Gene3Di 2.130.10.30. 2 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
    Pfami PF00630. Filamin. 1 hit.
    PF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00633. RCCNDNSATION.
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEi PS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 1 hit.
    PS50012. RCC1_3. 3 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice."
      Burgess R.W., Peterson K.A., Johnson M.J., Roix J.J., Welsh I.C., O'Brien T.P.
      Mol. Cell. Biol. 24:1096-1105(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
      Strain: C57BL/6JImported.
      Tissue: Embryo1 Publication.
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2327-2352 AND 2866-2875, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3250-4711 (ISOFORM 2).
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
      Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
      Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FBXO45.
    7. "Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1."
      Sampathkumar P., Ozyurt S.A., Miller S.A., Bain K.T., Rutter M.E., Gheyi T., Abrams B., Wang Y., Atwell S., Luz J.G., Thompson D.A., Wasserman S.R., Emtage J.S., Park E.C., Rongo C., Jin Y., Klemke R.L., Sauder J.M., Burley S.K.
      J. Mol. Biol. 397:883-892(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.32 ANGSTROMS) OF 1191-1352, X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1685-1845, DOMAIN PHR, DISULFIDE BOND.

    Entry informationi

    Entry nameiMYCB2_MOUSE
    AccessioniPrimary (citable) accession number: Q7TPH6
    Secondary accession number(s): Q6PCM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3