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Protein

Protein FAM19A3

Gene

Fam19a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • negative regulation of microglial cell activation Source: MGI
  • positive regulation of microglial cell activation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A3
Alternative name(s):
Chemokine-like protein TAFA-3
Gene namesi
Name:Fam19a3
Synonyms:Tafa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3046463. Fam19a3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004272730 – 132Protein FAM19A3Add BLAST103

Proteomic databases

PaxDbiQ7TPG6.
PRIDEiQ7TPG6.

PTM databases

iPTMnetiQ7TPG6.
PhosphoSitePlusiQ7TPG6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055865.
GenevisibleiQ7TPG6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123514.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXED. Eukaryota.
ENOG410YKC5. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7TPG6.
OMAiLAGEECK.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ7TPG6.
TreeFamiTF331749.

Family and domain databases

InterProiView protein in InterPro
IPR020350. Chemokine-like_FAM19A2.
PfamiView protein in Pfam
PF12020. TAFA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD298472. Chemokine-like_2FAM19A2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPTSNWSA GSWVLALCLA WLWTCPASAS LQPPTSAVLV KQGTCEVIAA
60 70 80 90 100
HRCCNRNRIE ERSQTVKCSC LSGQVAGTTR AKPSCVDASI VLQKWWCQME
110 120 130
PCLLGEECKV LPDLSGWSCS SGHKVKTTKV TR
Length:132
Mass (Da):14,426
Last modified:October 1, 2003 - v1
Checksum:i2D60C45AE1BA3F00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325122 mRNA. Translation: AAP92414.1.
BC118531 mRNA. Translation: AAI18532.1.
CCDSiCCDS51032.1.
RefSeqiNP_899047.1. NM_183224.3.
XP_017175115.1. XM_017319626.1.
UniGeneiMm.389494.
Mm.408712.

Genome annotation databases

EnsembliENSMUST00000139783; ENSMUSP00000123514; ENSMUSG00000055865.
GeneIDi329731.
KEGGimmu:329731.
UCSCiuc008quj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325122 mRNA. Translation: AAP92414.1.
BC118531 mRNA. Translation: AAI18532.1.
CCDSiCCDS51032.1.
RefSeqiNP_899047.1. NM_183224.3.
XP_017175115.1. XM_017319626.1.
UniGeneiMm.389494.
Mm.408712.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123514.

PTM databases

iPTMnetiQ7TPG6.
PhosphoSitePlusiQ7TPG6.

Proteomic databases

PaxDbiQ7TPG6.
PRIDEiQ7TPG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000139783; ENSMUSP00000123514; ENSMUSG00000055865.
GeneIDi329731.
KEGGimmu:329731.
UCSCiuc008quj.2. mouse.

Organism-specific databases

CTDi284467.
MGIiMGI:3046463. Fam19a3.

Phylogenomic databases

eggNOGiENOG410IXED. Eukaryota.
ENOG410YKC5. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ7TPG6.
OMAiLAGEECK.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ7TPG6.
TreeFamiTF331749.

Miscellaneous databases

ChiTaRSiFam19a3. mouse.
PROiPR:Q7TPG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055865.
GenevisibleiQ7TPG6. MM.

Family and domain databases

InterProiView protein in InterPro
IPR020350. Chemokine-like_FAM19A2.
PfamiView protein in Pfam
PF12020. TAFA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD298472. Chemokine-like_2FAM19A2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF19A3_MOUSE
AccessioniPrimary (citable) accession number: Q7TPG6
Secondary accession number(s): Q147Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2003
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.