Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphodiesterase

Gene

Pde10a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde10aImported
Synonyms:Pde10a Mus musculusImported
ORF Names:mCG_118831Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1345143. Pde10a.

PTM / Processingi

Proteomic databases

MaxQBiQ7TPG2.
PRIDEiQ7TPG2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086485.

Structurei

3D structure databases

ProteinModelPortaliQ7TPG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 255GAFInterPro annotationAdd BLAST154
Domaini277 – 433GAFInterPro annotationAdd BLAST157
Domaini523 – 689HDcInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
HOGENOMiHOG000007068.
HOVERGENiHBG082113.
PhylomeDBiQ7TPG2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 2 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TPG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGGFQQAQ LCFGFPSPSA TTQGLTDEKV KAYLSLHPQV LDEFVSESVS
60 70 80 90 100
AETVEKWLKR KTNKAKDEPS PKEVSRYQDT NMQGVVYELN SYIEQRLDTG
110 120 130 140 150
GDNHLLLYEL SSIIRIATKA DGFALYFLGE CNNSLCVFIP PGMKEGQPRL
160 170 180 190 200
IPAGPITQGT TISAYVAKSR KTLLVEDILG DERFPRGTGL ESGTRIQSVL
210 220 230 240 250
CLPIVTAIGD LIGILELYRH WGKEAFCLSH QEVATANLAW ASVAIHQVQV
260 270 280 290 300
CRGLAKQTEL NDFLLDVSKT YFDNIVAIDS LLEHIMIYAK NLVNADRCAL
310 320 330 340 350
FQVDHKNKEL YSDLFDIGEE KEGKPIFKKT KEIRFSIEKG IAGQVARTGE
360 370 380 390 400
VLNIPDAYAD PRFNREVDLY TGYTTRNILC MPIVSRGSVI GVVQMVNKIS
410 420 430 440 450
GSAFSKTDEN NFKMFAVFCA LALHCANMYH RIRHSECIYR VTMEKLSYHS
460 470 480 490 500
ICTSEEWQGL MRFNLPARIC RDIELFHFDI GPFENMWPGI FVYMIHRSCG
510 520 530 540 550
TSCFELEKLC RFIMSVKKNY RRVPYHNWKH AVTVAHCMYA ILQNNNGLFT
560 570 580 590 600
DLERKGLLIA CLCHDLDHRG FSNSYLQKFD HPLAALYSTS TMEQHHFSQT
610 620 630 640 650
VSILQLEGHN IFSTLSSSEY EQVLEIIRKA IIATDLALYF GNRKQLEEMY
660 670 680 690 700
QTGSLNLHNQ SHRDRVIGLM MTACDLCSVT KLWPVTKLTA NDIYAEFWAE
710 720 730 740 750
GDEMKKLGIQ PIPMMDRDKR DEVPQGQLGF YNAVAIPCYT TLTQILPPTE
760 770 780 790
PLLKACRDNL NQWEKVIRGE ETAMWISGPG PAPSKSTPEK LNVKVED
Length:797
Mass (Da):90,280
Last modified:October 1, 2003 - v1
Checksum:iBEE1442A95131C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104323 Genomic DNA. Translation: AAP94049.1.
CH466619 Genomic DNA. Translation: EDL02100.1.
RefSeqiXP_006523383.1. XM_006523320.3.
UniGeneiMm.87161.

Genome annotation databases

GeneIDi23984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104323 Genomic DNA. Translation: AAP94049.1.
CH466619 Genomic DNA. Translation: EDL02100.1.
RefSeqiXP_006523383.1. XM_006523320.3.
UniGeneiMm.87161.

3D structure databases

ProteinModelPortaliQ7TPG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086485.

Proteomic databases

MaxQBiQ7TPG2.
PRIDEiQ7TPG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23984.

Organism-specific databases

CTDi10846.
MGIiMGI:1345143. Pde10a.

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
HOGENOMiHOG000007068.
HOVERGENiHBG082113.
PhylomeDBiQ7TPG2.

Miscellaneous databases

ChiTaRSiPde10a. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 2 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TPG2_MOUSE
AccessioniPrimary (citable) accession number: Q7TPG2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.