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Protein

F-box only protein 11

Gene

Fbxo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri836 – 90772UBR-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • protein-arginine N-methyltransferase activity Source: MGI
  • ubiquitin-protein transferase activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular protein modification process Source: MGI
  • peptidyl-arginine N-methylation Source: MGI
  • sensory perception of sound Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 11
Gene namesi
Name:Fbxo11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147134. Fbxo11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi331 – 3311S → L in Mutt mutant; 13% of heterozygotes show a reduced startle response to a toneburst of 24 kHz and a mild craniofacial abnormality. 17% of homozygotes show perinatal lethality. Surviving homozygotes demonstrate a marked craniofacial abnormality and reduced hearing. 1 Publication
Mutagenesisi578 – 5781Q → L in Jeff mutant; heterozygotes are deaf with chronic proliferative otitis media, have a shortened snout and occipital region, and are smaller than wild-type littermates. Homozygotes demonstrate perinatal lethality due to respiratory problems, are born with upper eyelids open and show clefting of the hard or soft palate as well as facial clefting. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930F-box only protein 11PRO_0000119891Add
BLAST

Proteomic databases

EPDiQ7TPD1.
MaxQBiQ7TPD1.
PaxDbiQ7TPD1.
PeptideAtlasiQ7TPD1.
PRIDEiQ7TPD1.

PTM databases

iPTMnetiQ7TPD1.
PhosphoSiteiQ7TPD1.

Expressioni

Tissue specificityi

At E9.5 and E10.5, expression is restricted to developing heart tissue. By E11.5 and E12.5, detected in liver and subsequently in muscle by E13.5. At E14.5, still detected in heart, liver and muscle and also in the developing secondary palate including the nasal, medial and oral epithelia of the palatal shelves. At E15.5 and E16.5, expressed in lung, kidney, heart, liver, muscle and adrenal gland. At this time, fusion of the palate shelves has occurred, with expression confined to the nasal and oral epithelia. At E17.5, expression in the lung is confined to bronchial epithelial cells and is evident in bone marrow, skin, tissue macrophages, osteoblasts, kidney, liver and spleen. At E18.5, expressed in bone marrow, liver, kidney and muscle but decreases in heart and lung. At this time, first detected in the middle ear epithelium. At the newborn stage, expression is strong in the middle ear where it is confined to mucin-secreting cells, as well as persisting in bone marrow, kidney and liver. Middle ear expression persists in postnatal head tissue at 4 and 13 days after birth and has declined by 21 days after birth. In the adult, expression is seen in alveolar macrophages of the lung, glomeruli and collecting tubules of the kidney, midbrain, heart and muscle.1 Publication

Developmental stagei

Not detected at E8.5. Expressed from E9.5 throughout development and into adulthood (at protein level).1 Publication

Gene expression databases

BgeeiE9QP06.
CleanExiMM_FBXO11.
ExpressionAtlasiQ7TPD1. baseline and differential.
GenevisibleiQ7TPD1. MM.

Interactioni

Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.By similarity

Protein-protein interaction databases

BioGridi230356. 2 interactions.
DIPiDIP-59433N.
STRINGi10090.ENSMUSP00000005504.

Structurei

3D structure databases

ProteinModelPortaliQ7TPD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 20247F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati398 – 42023PbH1 1Add
BLAST
Repeati421 – 44323PbH1 2Add
BLAST
Repeati444 – 46623PbH1 3Add
BLAST
Repeati467 – 48923PbH1 4Add
BLAST
Repeati490 – 51223PbH1 5Add
BLAST
Repeati513 – 53523PbH1 6Add
BLAST
Repeati536 – 55823PbH1 7Add
BLAST
Repeati559 – 58123PbH1 8Add
BLAST
Repeati582 – 60423PbH1 9Add
BLAST
Repeati605 – 62723PbH1 10Add
BLAST
Repeati628 – 65023PbH1 11Add
BLAST
Repeati651 – 67323PbH1 12Add
BLAST
Repeati674 – 69623PbH1 13Add
BLAST
Repeati697 – 71923PbH1 14Add
BLAST
Repeati720 – 74223PbH1 15Add
BLAST
Repeati743 – 76523PbH1 16Add
BLAST
Repeati766 – 78823PbH1 17Add
BLAST
Repeati789 – 81123PbH1 18Add
BLAST
Repeati812 – 83322PbH1 19Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 19 PbH1 repeats.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri836 – 90772UBR-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1777. Eukaryota.
ENOG410YP8C. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000020584.
HOVERGENiHBG051565.
InParanoidiQ7TPD1.
KOiK10297.
OMAiSSRTYVR.
OrthoDBiEOG73803Z.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 4 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR029799. FBX11/DRE-1.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_UBR.
[Graphical view]
PANTHERiPTHR22990:SF20. PTHR22990:SF20. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TPD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PPQPPQQPPQ
60 70 80 90 100
QQPPPPPQQQ PPPPPPPPPP PPQDRNNAGE RDDVPADMVA EESGPGAQNS
110 120 130 140 150
PYQLRRKTLL PKRTACPTKS SMEGASTSTT ENFGHRAKRA RVSGKSQDLS
160 170 180 190 200
AAPAEQYLQE KLPDEVVLKI FSYLLEQDLC RAACVCKRFS ELANDPILWK
210 220 230 240 250
RLYMEVFEYT RPMMHPEPGK FYQINPEEYE HPNPWKESFQ QLYKGAHVKP
260 270 280 290 300
GFAEHFYSNP ARYKGRENML YYDTIEDALG GVQEAHFDGL IFVHSGIYTD
310 320 330 340 350
EWIYIESPIT MIGAAPGKVA DKVIIENTRD STFVFMEGSE DAYVGYMTIR
360 370 380 390 400
FNPDDKSAQH HNAHHCLEIT VNCSPIIDHC IIRSTCTVGS AVCVSGQGAC
410 420 430 440 450
PTIKHCNISD CENVGLYITD HAQGIYEDNE ISNNALAGIW VKNHGNPIIR
460 470 480 490 500
RNHIHHGRDV GVFTFDHGMG YFESCNIHRN RIAGFEVKAY ANPTVVRCEI
510 520 530 540 550
HHGQTGGIYV HEKGRGQFIE NKIYANNFAG VWITSNSDPT IRGNSIFNGN
560 570 580 590 600
QGGVYIFGDG RGLIEGNDIY GNALAGIQIR TNSCPIVRHN KIHDGQHGGI
610 620 630 640 650
YVHEKGQGVI EENEVYSNTL AGVWVTTGST PVLRRNRIHS GKQVGVYFYD
660 670 680 690 700
NGHGVLEDND IYNHMYSGVQ IRTGSNPKIR RNKIWGGQNG GILVYNSGLG
710 720 730 740 750
CIEDNEIFDN AMAGVWIKTD SNPTLRRNKI HDGRDGGICI FNGGRGLLEE
760 770 780 790 800
NDIFRNAQAG VLISTNSHPV LRKNRIFDGF AAGIEITNHA TATLEGNQIF
810 820 830 840 850
NNRFGGLFLA SGVNVTMKDN KIMNNQDAIE KAVSRGQCLY KISSYTSYPM
860 870 880 890 900
HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN
910 920 930
PCTLAGEPTH DTDTLYDSAP PIESNTLQHN
Length:930
Mass (Da):103,728
Last modified:October 16, 2013 - v3
Checksum:i0F644A34F1936393
GO
Isoform 2 (identifier: Q7TPD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:843
Mass (Da):94,015
Checksum:iB177B62DFEA5F524
GO
Isoform 3 (identifier: Q7TPD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     152-152: Missing.

Show »
Length:842
Mass (Da):93,944
Checksum:i7E3BB57A9C0BE237
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511G → R in AAI17886 (PubMed:15489334).Curated
Sequence conflicti694 – 6941V → F in AAH49946 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8787Missing in isoform 2 and isoform 3. 1 PublicationVSP_053353Add
BLAST
Alternative sequencei152 – 1521Missing in isoform 3. 1 PublicationVSP_053354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087233 Genomic DNA. No translation available.
AC154673 Genomic DNA. No translation available.
BC049946 mRNA. Translation: AAH49946.1.
BC055343 mRNA. Translation: AAH55343.1.
BC117884 mRNA. Translation: AAI17885.1.
BC117885 mRNA. Translation: AAI17886.1.
BC128479 mRNA. Translation: AAI28480.1.
CCDSiCCDS37717.1. [Q7TPD1-1]
RefSeqiNP_001074503.1. NM_001081034.1. [Q7TPD1-1]
XP_006524266.2. XM_006524203.2. [Q7TPD1-3]
XP_006524267.1. XM_006524204.2. [Q7TPD1-2]
UniGeneiMm.386857.

Genome annotation databases

EnsembliENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371. [Q7TPD1-1]
GeneIDi225055.
KEGGimmu:225055.
UCSCiuc008dvf.1. mouse. [Q7TPD1-1]
uc008dvg.1. mouse. [Q7TPD1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087233 Genomic DNA. No translation available.
AC154673 Genomic DNA. No translation available.
BC049946 mRNA. Translation: AAH49946.1.
BC055343 mRNA. Translation: AAH55343.1.
BC117884 mRNA. Translation: AAI17885.1.
BC117885 mRNA. Translation: AAI17886.1.
BC128479 mRNA. Translation: AAI28480.1.
CCDSiCCDS37717.1. [Q7TPD1-1]
RefSeqiNP_001074503.1. NM_001081034.1. [Q7TPD1-1]
XP_006524266.2. XM_006524203.2. [Q7TPD1-3]
XP_006524267.1. XM_006524204.2. [Q7TPD1-2]
UniGeneiMm.386857.

3D structure databases

ProteinModelPortaliQ7TPD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230356. 2 interactions.
DIPiDIP-59433N.
STRINGi10090.ENSMUSP00000005504.

PTM databases

iPTMnetiQ7TPD1.
PhosphoSiteiQ7TPD1.

Proteomic databases

EPDiQ7TPD1.
MaxQBiQ7TPD1.
PaxDbiQ7TPD1.
PeptideAtlasiQ7TPD1.
PRIDEiQ7TPD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371. [Q7TPD1-1]
GeneIDi225055.
KEGGimmu:225055.
UCSCiuc008dvf.1. mouse. [Q7TPD1-1]
uc008dvg.1. mouse. [Q7TPD1-3]

Organism-specific databases

CTDi80204.
MGIiMGI:2147134. Fbxo11.

Phylogenomic databases

eggNOGiKOG1777. Eukaryota.
ENOG410YP8C. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000020584.
HOVERGENiHBG051565.
InParanoidiQ7TPD1.
KOiK10297.
OMAiSSRTYVR.
OrthoDBiEOG73803Z.
TreeFamiTF313602.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiFbxo11. mouse.
PROiQ7TPD1.
SOURCEiSearch...

Gene expression databases

BgeeiE9QP06.
CleanExiMM_FBXO11.
ExpressionAtlasiQ7TPD1. baseline and differential.
GenevisibleiQ7TPD1. MM.

Family and domain databases

Gene3Di2.160.20.10. 4 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR029799. FBX11/DRE-1.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_UBR.
[Graphical view]
PANTHERiPTHR22990:SF20. PTHR22990:SF20. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J and FVB/N.
    Tissue: Fetal brain and Mammary tumor.
  3. Cited for: CHARACTERIZATION OF JEFF MUTANT.
  4. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, CHARACTERIZATION OF JEFF AND MUTT MUTANTS, MUTAGENESIS OF SER-331 AND GLN-578.

Entry informationi

Entry nameiFBX11_MOUSE
AccessioniPrimary (citable) accession number: Q7TPD1
Secondary accession number(s): A1A595
, E9QP06, Q08EB9, Q08EC0, Q80UP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 16, 2013
Last modified: July 6, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.