ID   Q7TPC5_MOUSE            Unreviewed;       806 AA.
AC   Q7TPC5;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   SubName: Full=Toll-like receptor 6 {ECO:0000313|EMBL:AAH55366.1};
GN   Name=Tlr6 {ECO:0000313|EMBL:AAH55366.1, ECO:0000313|MGI:MGI:1341296};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH55366.1};
RN   [1] {ECO:0000313|EMBL:AAH55366.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/He {ECO:0000313|EMBL:AAH55366.1};
RC   TISSUE=Osteoblast {ECO:0000313|EMBL:AAH55366.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR   EMBL; BC055366; AAH55366.1; -; mRNA.
DR   AlphaFoldDB; Q7TPC5; -.
DR   EPD; Q7TPC5; -.
DR   AGR; MGI:1341296; -.
DR   MGI; MGI:1341296; Tlr6.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR   GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 2.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        596..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          651..792
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   806 AA;  92408 MW;  24830B28EB3C3546 CRC64;
     MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS NRNLTHVPKD
     LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR SLDFHVFLFN QDLEYLDVSH
     NRLQNISCCP MASLRHLDLS FNDFDVLPVC KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL
     HLSCILLDLV SYHIKGGETE SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK
     LNDENCQRLM TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT
     ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS DTPFIHMVCP
     PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL KNFFKVALMT KNMSSLETLD
     VSLNSLNSHA YDRTCAWAES ILVLNLSSNM LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV
     THLQALQELN VASNSLTDLP GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN
     PFQCTCELRD FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI
     TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN LQFHAFVSYS
     EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII NFIEKSYKAI FVLSPHFIQS
     EWCHYELYFA HHNLFHEGSD NLILILLEPI LQNNIPSRYH KLRALMAQRT YLEWPTEKGK
     RGLFWANLRA SFIMKLALVN EDDVKT
//