Q7TPC5 (Q7TPC5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Toll-like receptor PIRNR PIRNR037595

Gene names

Name:

Tlr6 MGI 1341296

Organism

Mus musculus (Mouse) EMBL AAH55366.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595 Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
Biological process	Immunity Inflammatory response PIRNR PIRNR037595 Innate immunity PIRNR PIRNR037595
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor PIRNR PIRNR037595 EMBL AAH55366.1
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro T-helper 1 type immune response Inferred from electronic annotation. Source: InterPro detection of diacyl bacterial lipopeptide Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of interleukin-6 biosynthetic process Inferred from electronic annotation. Source: InterPro regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro toll-like receptor 6 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	Toll-like receptor 2-Toll-like receptor 6 protein complex Inferred from direct assay PubMed 19931471. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	diacyl lipopeptide binding Inferred from direct assay PubMed 19931471. Source: MGI transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7TPC5 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 24830B28EB3C3546	FASTA	806	92,408
	10 20 30 40 50 60 MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS NRNLTHVPKD 70 80 90 100 110 120 LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR SLDFHVFLFN QDLEYLDVSH 130 140 150 160 170 180 NRLQNISCCP MASLRHLDLS FNDFDVLPVC KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL 190 200 210 220 230 240 HLSCILLDLV SYHIKGGETE SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK 250 260 270 280 290 300 LNDENCQRLM TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT 310 320 330 340 350 360 ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS DTPFIHMVCP 370 380 390 400 410 420 PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL KNFFKVALMT KNMSSLETLD 430 440 450 460 470 480 VSLNSLNSHA YDRTCAWAES ILVLNLSSNM LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV 490 500 510 520 530 540 THLQALQELN VASNSLTDLP GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN 550 560 570 580 590 600 PFQCTCELRD FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI 610 620 630 640 650 660 TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN LQFHAFVSYS 670 680 690 700 710 720 EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII NFIEKSYKAI FVLSPHFIQS 730 740 750 760 770 780 EWCHYELYFA HHNLFHEGSD NLILILLEPI LQNNIPSRYH KLRALMAQRT YLEWPTEKGK 790 800 RGLFWANLRA SFIMKLALVN EDDVKT

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He EMBL AAH55366.1. Tissue: Osteoblast EMBL AAH55366.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC055366 mRNA. Translation: AAH55366.1.
IPI	IPI00380390.
UniGene	Mm.42146.
3D structure databases
HSSP	HSSP built from PDB template 1FYV based on UniProtKB Q15399.
ProteinModelPortal	Q7TPC5.
SMR	Q7TPC5. Positions 641-796.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7TPC5.
Proteomic databases
PRIDE	Q7TPC5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1341296. Tlr6.
Phylogenomic databases
HOVERGEN	HBG023180.
InParanoid	Q7TPC5.
Gene expression databases
ArrayExpress	Q7TPC5.
Genevestigator	Q7TPC5.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027187. TLR6. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF130. PTHR24365:SF130. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00369. LRR_TYP. 1 hit. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 10 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q7TPC5_MOUSE

Accession

Primary (citable) accession number: Q7TPC5

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)