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Q7TPC5

- Q7TPC5_MOUSE

UniProt

Q7TPC5 - Q7TPC5_MOUSE

Protein

Toll-like receptor

Gene

Tlr6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. diacyl lipopeptide binding Source: MGI
    2. protein heterodimerization activity Source: MGI
    3. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. detection of diacyl bacterial lipopeptide Source: InterPro
    2. inflammatory response Source: UniProtKB-KW
    3. innate immune response Source: UniProtKB-KW
    4. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    5. positive regulation of interleukin-6 biosynthetic process Source: InterPro
    6. regulation of cytokine secretion Source: InterPro
    7. T-helper 1 type immune response Source: InterPro
    8. toll-like receptor 6 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptorUniRule annotation
    Gene namesi
    Name:Tlr6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1341296. Tlr6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ7TPC5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TPC5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TPC5.
    SMRiQ7TPC5. Positions 641-796.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.UniRule annotation
    Contains TIR domain.SAAS annotation

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG023180.
    InParanoidiQ7TPC5.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
    PfamiPF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TPC5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS    50
    NRNLTHVPKD LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR 100
    SLDFHVFLFN QDLEYLDVSH NRLQNISCCP MASLRHLDLS FNDFDVLPVC 150
    KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL HLSCILLDLV SYHIKGGETE 200
    SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK LNDENCQRLM 250
    TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT 300
    ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS 350
    DTPFIHMVCP PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL 400
    KNFFKVALMT KNMSSLETLD VSLNSLNSHA YDRTCAWAES ILVLNLSSNM 450
    LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV THLQALQELN VASNSLTDLP 500
    GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN PFQCTCELRD 550
    FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI 600
    TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN 650
    LQFHAFVSYS EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII 700
    NFIEKSYKAI FVLSPHFIQS EWCHYELYFA HHNLFHEGSD NLILILLEPI 750
    LQNNIPSRYH KLRALMAQRT YLEWPTEKGK RGLFWANLRA SFIMKLALVN 800
    EDDVKT 806
    Length:806
    Mass (Da):92,408
    Last modified:October 1, 2003 - v1
    Checksum:i24830B28EB3C3546
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055366 mRNA. Translation: AAH55366.1.
    UniGeneiMm.42146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC055366 mRNA. Translation: AAH55366.1 .
    UniGenei Mm.42146.

    3D structure databases

    ProteinModelPortali Q7TPC5.
    SMRi Q7TPC5. Positions 641-796.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7TPC5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1341296. Tlr6.

    Phylogenomic databases

    HOVERGENi HBG023180.
    InParanoidi Q7TPC5.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q7TPC5.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
    Pfami PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/HeImported.
      Tissue: OsteoblastImported.

    Entry informationi

    Entry nameiQ7TPC5_MOUSE
    AccessioniPrimary (citable) accession number: Q7TPC5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)