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Q7TPC5 (Q7TPC5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor PIRNR PIRNR037595
Gene names
Name:Tlr6 EMBL AAH55366.1 MGI 1341296
OrganismMus musculus (Mouse) EMBL AAH55366.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595

Contains TIR domain. SAAS SAAS000157

Ontologies

Keywords
   Biological processImmunity
Inflammatory response PIRNR PIRNR037595
Innate immunity PIRNR PIRNR037595
   Cellular componentMembrane
   DomainLeucine-rich repeat SAAS SAAS003591
Repeat SAAS SAAS003591
Transmembrane
Transmembrane helix SAAS SAAS000157
   Molecular functionReceptor PIRNR PIRNR037595 EMBL AAH55366.1
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

detection of triacyl bacterial lipopeptide

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

macrophage activation

Inferred from electronic annotation. Source: InterPro

regulation of cytokine secretion

Inferred from electronic annotation. Source: InterPro

toll-like receptor 1 signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentToll-like receptor 2-Toll-like receptor 6 protein complex

Inferred from direct assay PubMed 19931471. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondiacyl lipopeptide binding

Inferred from direct assay PubMed 19931471. Source: MGI

protein heterodimerization activity

Inferred from physical interaction PubMed 19931471. Source: MGI

transmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7TPC5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 24830B28EB3C3546

FASTA80692,408
        10         20         30         40         50         60 
MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS NRNLTHVPKD 

        70         80         90        100        110        120 
LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR SLDFHVFLFN QDLEYLDVSH 

       130        140        150        160        170        180 
NRLQNISCCP MASLRHLDLS FNDFDVLPVC KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL 

       190        200        210        220        230        240 
HLSCILLDLV SYHIKGGETE SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK 

       250        260        270        280        290        300 
LNDENCQRLM TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT 

       310        320        330        340        350        360 
ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS DTPFIHMVCP 

       370        380        390        400        410        420 
PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL KNFFKVALMT KNMSSLETLD 

       430        440        450        460        470        480 
VSLNSLNSHA YDRTCAWAES ILVLNLSSNM LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV 

       490        500        510        520        530        540 
THLQALQELN VASNSLTDLP GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN 

       550        560        570        580        590        600 
PFQCTCELRD FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI 

       610        620        630        640        650        660 
TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN LQFHAFVSYS 

       670        680        690        700        710        720 
EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII NFIEKSYKAI FVLSPHFIQS 

       730        740        750        760        770        780 
EWCHYELYFA HHNLFHEGSD NLILILLEPI LQNNIPSRYH KLRALMAQRT YLEWPTEKGK 

       790        800 
RGLFWANLRA SFIMKLALVN EDDVKT 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He EMBL AAH55366.1.
Tissue: Osteoblast EMBL AAH55366.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC055366 mRNA. Translation: AAH55366.1.
UniGeneMm.42146.

3D structure databases

ProteinModelPortalQ7TPC5.
SMRQ7TPC5. Positions 641-796.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7TPC5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1341296. Tlr6.

Phylogenomic databases

HOVERGENHBG023180.
InParanoidQ7TPC5.

Gene expression databases

GenevestigatorQ7TPC5.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ7TPC5_MOUSE
AccessionPrimary (citable) accession number: Q7TPC5
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)