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Q7TPC5

- Q7TPC5_MOUSE

UniProt

Q7TPC5 - Q7TPC5_MOUSE

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Protein

Toll-like receptor

Gene

Tlr6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: MGI
  2. protein heterodimerization activity Source: MGI
  3. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. detection of diacyl bacterial lipopeptide Source: InterPro
  2. inflammatory response Source: UniProtKB-KW
  3. innate immune response Source: UniProtKB-KW
  4. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  5. positive regulation of interleukin-6 biosynthetic process Source: InterPro
  6. regulation of cytokine secretion Source: InterPro
  7. T-helper 1 type immune response Source: InterPro
  8. toll-like receptor 6 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:Tlr6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1341296. Tlr6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ7TPC5.

Expressioni

Gene expression databases

GenevestigatoriQ7TPC5.

Structurei

3D structure databases

ProteinModelPortaliQ7TPC5.
SMRiQ7TPC5. Positions 641-796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation
Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG023180.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TPC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS
60 70 80 90 100
NRNLTHVPKD LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR
110 120 130 140 150
SLDFHVFLFN QDLEYLDVSH NRLQNISCCP MASLRHLDLS FNDFDVLPVC
160 170 180 190 200
KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL HLSCILLDLV SYHIKGGETE
210 220 230 240 250
SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK LNDENCQRLM
260 270 280 290 300
TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT
310 320 330 340 350
ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS
360 370 380 390 400
DTPFIHMVCP PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL
410 420 430 440 450
KNFFKVALMT KNMSSLETLD VSLNSLNSHA YDRTCAWAES ILVLNLSSNM
460 470 480 490 500
LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV THLQALQELN VASNSLTDLP
510 520 530 540 550
GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN PFQCTCELRD
560 570 580 590 600
FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI
610 620 630 640 650
TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN
660 670 680 690 700
LQFHAFVSYS EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII
710 720 730 740 750
NFIEKSYKAI FVLSPHFIQS EWCHYELYFA HHNLFHEGSD NLILILLEPI
760 770 780 790 800
LQNNIPSRYH KLRALMAQRT YLEWPTEKGK RGLFWANLRA SFIMKLALVN

EDDVKT
Length:806
Mass (Da):92,408
Last modified:October 1, 2003 - v1
Checksum:i24830B28EB3C3546
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055366 mRNA. Translation: AAH55366.1.
UniGeneiMm.42146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC055366 mRNA. Translation: AAH55366.1 .
UniGenei Mm.42146.

3D structure databases

ProteinModelPortali Q7TPC5.
SMRi Q7TPC5. Positions 641-796.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7TPC5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1341296. Tlr6.

Phylogenomic databases

HOVERGENi HBG023180.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q7TPC5.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
Pfami PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeImported.
    Tissue: OsteoblastImported.

Entry informationi

Entry nameiQ7TPC5_MOUSE
AccessioniPrimary (citable) accession number: Q7TPC5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)