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Protein

Corneodesmosin

Gene

Cdsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Important for the epidermal barrier integrity.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Corneodesmosin
Gene namesi
Name:Cdsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3505689. Cdsn.

Subcellular locationi

  • Secreted

  • Note: Found in corneodesmosomes, the intercellular structures that are involved in desquamation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 561529CorneodesmosinPRO_0000020914Add
BLAST

Proteomic databases

MaxQBiQ7TPC1.
PaxDbiQ7TPC1.
PRIDEiQ7TPC1.

Expressioni

Gene expression databases

BgeeiQ7TPC1.
CleanExiMM_CDSN.
GenevisibleiQ7TPC1. MM.

Structurei

3D structure databases

ProteinModelPortaliQ7TPC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 493432Ser-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IENZ. Eukaryota.
ENOG41118PZ. LUCA.
GeneTreeiENSGT00730000111474.
HOGENOMiHOG000168434.
HOVERGENiHBG081074.
InParanoidiQ7TPC1.
OMAiHSGPYIS.
OrthoDBiEOG7QNVMS.

Family and domain databases

InterProiIPR026087. Corneodesmosin.
[Graphical view]
PANTHERiPTHR23207. PTHR23207. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSRAPRMG SVGGHGLMAL LMAGLILPGI LAKSIGTLSD PCKDPTRITS
60 70 80 90 100
PNDPCLIGKT GSNSISSQGG SSSFSSQGGS SSFSSHGGSS SSQGSSSGSL
110 120 130 140 150
IYKPGTGYSQ SSYSYGSGGS RPGGSGSQSG SSGSQSGSSG SQSGSSGSQS
160 170 180 190 200
GSSGSQSGSS GSQSGSSGSQ SGSSGSQSGS SGSQSGRWVS SSSQWVSSSS
210 220 230 240 250
QSGSSGSSRD RPGSGSALPT GDKTSGMSQS GGSSTSQSSS SNLRPCSSNV
260 270 280 290 300
PDSPCSGGPV ITHSGPYISG THTVSGGQRP VVVVVEQHGS GGPGFQGMPC
310 320 330 340 350
SNGGPAGKPC PPITSVQKPY GGYEVVGGSA NSYLVPGMTY SGGKIYPVGY
360 370 380 390 400
FTKDNPIRGS PGAPSFAAGP PVSEGKYFSS NPIIPSRGSS SSSGYPVGVA
410 420 430 440 450
FQPVGSGGVQ PCGTGSVSSK GPCSGTRIQI TSSSSSTSYH PCSGGPSQGP
460 470 480 490 500
CSSPGTGSIS GGSSSLSSGK IVLQPCGSKS TSSGYPCLSV PSSPLNGGLN
510 520 530 540 550
GSPQPVPSVG VKLCGLNSPG RVPCRSIRNI LTQVKPLGPQ LMDPKVSLPQ
560
GEPQGEPLEK S
Length:561
Mass (Da):54,313
Last modified:July 27, 2011 - v2
Checksum:iD48586A99DA2A1E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → Q in AAH55373 (PubMed:15489334).Curated
Sequence conflicti129 – 1291S → T in AAH55373 (PubMed:15489334).Curated
Sequence conflicti133 – 1331G → S in AAH55373 (PubMed:15489334).Curated
Sequence conflicti136 – 1361S → T in AAH55373 (PubMed:15489334).Curated
Sequence conflicti140 – 1401G → S in AAH55373 (PubMed:15489334).Curated
Sequence conflicti287 – 2871Q → H in AAH55373 (PubMed:15489334).Curated
Sequence conflicti291 – 2911G → A in AAH55373 (PubMed:15489334).Curated
Sequence conflicti400 – 4001A → V in AAH55373 (PubMed:15489334).Curated
Sequence conflicti446 – 4461P → S in AAH55373 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA. No translation available.
BC055373 mRNA. Translation: AAH55373.1.
CCDSiCCDS28699.1.
RefSeqiNP_001008424.2. NM_001008424.2.
UniGeneiMm.426664.

Genome annotation databases

EnsembliENSMUST00000044804; ENSMUSP00000048596; ENSMUSG00000039518.
GeneIDi386463.
KEGGimmu:386463.
UCSCiuc008cia.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA. No translation available.
BC055373 mRNA. Translation: AAH55373.1.
CCDSiCCDS28699.1.
RefSeqiNP_001008424.2. NM_001008424.2.
UniGeneiMm.426664.

3D structure databases

ProteinModelPortaliQ7TPC1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ7TPC1.
PaxDbiQ7TPC1.
PRIDEiQ7TPC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044804; ENSMUSP00000048596; ENSMUSG00000039518.
GeneIDi386463.
KEGGimmu:386463.
UCSCiuc008cia.1. mouse.

Organism-specific databases

CTDi1041.
MGIiMGI:3505689. Cdsn.

Phylogenomic databases

eggNOGiENOG410IENZ. Eukaryota.
ENOG41118PZ. LUCA.
GeneTreeiENSGT00730000111474.
HOGENOMiHOG000168434.
HOVERGENiHBG081074.
InParanoidiQ7TPC1.
OMAiHSGPYIS.
OrthoDBiEOG7QNVMS.

Miscellaneous databases

ChiTaRSiCdsn. mouse.
NextBioi405480.
PROiQ7TPC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TPC1.
CleanExiMM_CDSN.
GenevisibleiQ7TPC1. MM.

Family and domain databases

InterProiIPR026087. Corneodesmosin.
[Graphical view]
PANTHERiPTHR23207. PTHR23207. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Osteoblast.

Entry informationi

Entry nameiCDSN_MOUSE
AccessioniPrimary (citable) accession number: Q7TPC1
Secondary accession number(s): E9QLN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.