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Protein

Corneodesmosin

Gene

Cdsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important for the epidermal barrier integrity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Corneodesmosin
Gene namesi
Name:Cdsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3505689 Cdsn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002091433 – 561CorneodesmosinAdd BLAST529

Proteomic databases

MaxQBiQ7TPC1
PaxDbiQ7TPC1
PeptideAtlasiQ7TPC1
PRIDEiQ7TPC1

PTM databases

iPTMnetiQ7TPC1
PhosphoSitePlusiQ7TPC1

Expressioni

Gene expression databases

BgeeiENSMUSG00000039518
CleanExiMM_CDSN
GenevisibleiQ7TPC1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi239715, 1 interactor
STRINGi10090.ENSMUSP00000048596

Structurei

3D structure databases

ProteinModelPortaliQ7TPC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 493Ser-richAdd BLAST432

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IENZ Eukaryota
ENOG41118PZ LUCA
GeneTreeiENSGT00730000111474
HOGENOMiHOG000168434
HOVERGENiHBG081074
InParanoidiQ7TPC1
OMAiLQPCGSK
OrthoDBiEOG091G0HWG

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSRAPRMG SVGGHGLMAL LMAGLILPGI LAKSIGTLSD PCKDPTRITS
60 70 80 90 100
PNDPCLIGKT GSNSISSQGG SSSFSSQGGS SSFSSHGGSS SSQGSSSGSL
110 120 130 140 150
IYKPGTGYSQ SSYSYGSGGS RPGGSGSQSG SSGSQSGSSG SQSGSSGSQS
160 170 180 190 200
GSSGSQSGSS GSQSGSSGSQ SGSSGSQSGS SGSQSGRWVS SSSQWVSSSS
210 220 230 240 250
QSGSSGSSRD RPGSGSALPT GDKTSGMSQS GGSSTSQSSS SNLRPCSSNV
260 270 280 290 300
PDSPCSGGPV ITHSGPYISG THTVSGGQRP VVVVVEQHGS GGPGFQGMPC
310 320 330 340 350
SNGGPAGKPC PPITSVQKPY GGYEVVGGSA NSYLVPGMTY SGGKIYPVGY
360 370 380 390 400
FTKDNPIRGS PGAPSFAAGP PVSEGKYFSS NPIIPSRGSS SSSGYPVGVA
410 420 430 440 450
FQPVGSGGVQ PCGTGSVSSK GPCSGTRIQI TSSSSSTSYH PCSGGPSQGP
460 470 480 490 500
CSSPGTGSIS GGSSSLSSGK IVLQPCGSKS TSSGYPCLSV PSSPLNGGLN
510 520 530 540 550
GSPQPVPSVG VKLCGLNSPG RVPCRSIRNI LTQVKPLGPQ LMDPKVSLPQ
560
GEPQGEPLEK S
Length:561
Mass (Da):54,313
Last modified:July 27, 2011 - v2
Checksum:iD48586A99DA2A1E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → Q in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti129S → T in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti133G → S in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti136S → T in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti140G → S in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti287Q → H in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti291G → A in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti400A → V in AAH55373 (PubMed:15489334).Curated1
Sequence conflicti446P → S in AAH55373 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA No translation available.
BC055373 mRNA Translation: AAH55373.1
CCDSiCCDS28699.1
RefSeqiNP_001008424.2, NM_001008424.2
UniGeneiMm.426664

Genome annotation databases

EnsembliENSMUST00000044804; ENSMUSP00000048596; ENSMUSG00000039518
GeneIDi386463
KEGGimmu:386463
UCSCiuc008cia.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCDSN_MOUSE
AccessioniPrimary (citable) accession number: Q7TPC1
Secondary accession number(s): E9QLN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health