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Protein

CD276 antigen

Gene

Cd276

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD276 antigen
Alternative name(s):
B7 homolog 3
Short name:
B7-H3
Costimulatory molecule
CD_antigen: CD276
Gene namesi
Name:Cd276
Synonyms:B7h3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi727815. Cd276.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 248220ExtracellularSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 31647CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 316288CD276 antigenPRO_0000045803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TPB4.

PTM databases

SwissPalmiQ7TPB4.

Expressioni

Gene expression databases

GenevisibleiQ7TPB4. RN.

Interactioni

Subunit structurei

Interacts with TREML2 and this interaction enhances T-cell activation.By similarity

Protein-protein interaction databases

BioGridi261125. 1 interaction.
STRINGi10116.ENSRNOP00000049249.

Structurei

3D structure databases

ProteinModelPortaliQ7TPB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 139111Ig-like V-typeAdd
BLAST
Domaini145 – 23894Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR2H. Eukaryota.
ENOG410ZB69. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000293131.
HOVERGENiHBG079786.
InParanoidiQ7TPB4.
KOiK06746.
OMAiCRRKIKE.
OrthoDBiEOG7FBRH9.
PhylomeDBiQ7TPB4.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGWGGPSV GVSMGTALGV LCLCLTGAVE VQVSEDPVVA LVDTDATLRC
60 70 80 90 100
SFSPEPGFSL RQLNLIWQLT DTKQLVHSFT EGRDQGSAYA NRTALFPDLL
110 120 130 140 150
VQGNASLRLQ RVRVTDEGSY TCFVSIQDFD SAAVSLQVAA PYSKPSMTLE
160 170 180 190 200
PNKDLRPGDM VTITCSSYQG YPEAEVFWKD GQGLPLTGNV TTSQMANERG
210 220 230 240 250
LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ PMTFPPEALW
260 270 280 290 300
VTVGLSVCLV ILLVALAFVC WRKIKQSCEE ENAGAEDQDG DGEGSKTALR
310
PLKHSENKED DGQEIA
Length:316
Mass (Da):34,075
Last modified:October 1, 2003 - v1
Checksum:i80FB9D68D0A4143B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190319 mRNA. Translation: AAP04008.1.
BC100064 mRNA. Translation: AAI00065.1.
RefSeqiNP_877976.1. NM_182824.2.
UniGeneiRn.76129.

Genome annotation databases

EnsembliENSRNOT00000042681; ENSRNOP00000049249; ENSRNOG00000033608.
GeneIDi315716.
KEGGirno:315716.
UCSCiRGD:727815. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190319 mRNA. Translation: AAP04008.1.
BC100064 mRNA. Translation: AAI00065.1.
RefSeqiNP_877976.1. NM_182824.2.
UniGeneiRn.76129.

3D structure databases

ProteinModelPortaliQ7TPB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi261125. 1 interaction.
STRINGi10116.ENSRNOP00000049249.

PTM databases

SwissPalmiQ7TPB4.

Proteomic databases

PaxDbiQ7TPB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042681; ENSRNOP00000049249; ENSRNOG00000033608.
GeneIDi315716.
KEGGirno:315716.
UCSCiRGD:727815. rat.

Organism-specific databases

CTDi80381.
RGDi727815. Cd276.

Phylogenomic databases

eggNOGiENOG410IR2H. Eukaryota.
ENOG410ZB69. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000293131.
HOVERGENiHBG079786.
InParanoidiQ7TPB4.
KOiK06746.
OMAiCRRKIKE.
OrthoDBiEOG7FBRH9.
PhylomeDBiQ7TPB4.
TreeFamiTF331083.

Miscellaneous databases

NextBioi669729.
PROiQ7TPB4.

Gene expression databases

GenevisibleiQ7TPB4. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiCD276_RAT
AccessioniPrimary (citable) accession number: Q7TPB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.