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Protein

CD276 antigen

Gene

Cd276

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD276 antigen
Alternative name(s):
B7 homolog 3
Short name:
B7-H3
Costimulatory molecule
CD_antigen: CD276
Gene namesi
Name:Cd276
Synonyms:B7h3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi727815. Cd276.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 248ExtracellularSequence analysisAdd BLAST220
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 316CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004580329 – 316CD276 antigenAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TPB4.
PRIDEiQ7TPB4.

PTM databases

SwissPalmiQ7TPB4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033608.
GenevisibleiQ7TPB4. RN.

Interactioni

Subunit structurei

Interacts with TREML2 and this interaction enhances T-cell activation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi261125. 1 interactor.
STRINGi10116.ENSRNOP00000049249.

Structurei

3D structure databases

ProteinModelPortaliQ7TPB4.
SMRiQ7TPB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 139Ig-like V-typeAdd BLAST111
Domaini145 – 238Ig-like C2-typeAdd BLAST94

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR2H. Eukaryota.
ENOG410ZB69. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000293131.
HOVERGENiHBG079786.
InParanoidiQ7TPB4.
KOiK06746.
OMAiYTCFVRV.
OrthoDBiEOG091G0IEZ.
PhylomeDBiQ7TPB4.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGWGGPSV GVSMGTALGV LCLCLTGAVE VQVSEDPVVA LVDTDATLRC
60 70 80 90 100
SFSPEPGFSL RQLNLIWQLT DTKQLVHSFT EGRDQGSAYA NRTALFPDLL
110 120 130 140 150
VQGNASLRLQ RVRVTDEGSY TCFVSIQDFD SAAVSLQVAA PYSKPSMTLE
160 170 180 190 200
PNKDLRPGDM VTITCSSYQG YPEAEVFWKD GQGLPLTGNV TTSQMANERG
210 220 230 240 250
LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ PMTFPPEALW
260 270 280 290 300
VTVGLSVCLV ILLVALAFVC WRKIKQSCEE ENAGAEDQDG DGEGSKTALR
310
PLKHSENKED DGQEIA
Length:316
Mass (Da):34,075
Last modified:October 1, 2003 - v1
Checksum:i80FB9D68D0A4143B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190319 mRNA. Translation: AAP04008.1.
BC100064 mRNA. Translation: AAI00065.1.
RefSeqiNP_877976.1. NM_182824.2.
UniGeneiRn.76129.

Genome annotation databases

EnsembliENSRNOT00000042681; ENSRNOP00000049249; ENSRNOG00000033608.
GeneIDi315716.
KEGGirno:315716.
UCSCiRGD:727815. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD276_RAT
AccessioniPrimary (citable) accession number: Q7TPB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families