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Protein

CD276 antigen

Gene

Cd276

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD276 antigen
Alternative name(s):
B7 homolog 3
Short name:
B7-H3
Costimulatory molecule
CD_antigen: CD276
Gene namesi
Name:Cd276
Synonyms:B7h3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi727815 Cd276

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 248ExtracellularSequence analysisAdd BLAST220
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 316CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004580329 – 316CD276 antigenAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TPB4
PRIDEiQ7TPB4

PTM databases

SwissPalmiQ7TPB4

Expressioni

Gene expression databases

BgeeiENSRNOG00000033608
GenevisibleiQ7TPB4 RN

Interactioni

Subunit structurei

Interacts with TREML2 and this interaction enhances T-cell activation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi261125, 1 interactor
STRINGi10116.ENSRNOP00000049249

Structurei

3D structure databases

ProteinModelPortaliQ7TPB4
SMRiQ7TPB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 139Ig-like V-typeAdd BLAST111
Domaini145 – 238Ig-like C2-typeAdd BLAST94

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR2H Eukaryota
ENOG410ZB69 LUCA
GeneTreeiENSGT00700000104325
HOGENOMiHOG000293131
HOVERGENiHBG079786
InParanoidiQ7TPB4
KOiK06746
OMAiYTCFVRV
OrthoDBiEOG091G0IEZ
PhylomeDBiQ7TPB4
TreeFamiTF331083

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGWGGPSV GVSMGTALGV LCLCLTGAVE VQVSEDPVVA LVDTDATLRC
60 70 80 90 100
SFSPEPGFSL RQLNLIWQLT DTKQLVHSFT EGRDQGSAYA NRTALFPDLL
110 120 130 140 150
VQGNASLRLQ RVRVTDEGSY TCFVSIQDFD SAAVSLQVAA PYSKPSMTLE
160 170 180 190 200
PNKDLRPGDM VTITCSSYQG YPEAEVFWKD GQGLPLTGNV TTSQMANERG
210 220 230 240 250
LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ PMTFPPEALW
260 270 280 290 300
VTVGLSVCLV ILLVALAFVC WRKIKQSCEE ENAGAEDQDG DGEGSKTALR
310
PLKHSENKED DGQEIA
Length:316
Mass (Da):34,075
Last modified:October 1, 2003 - v1
Checksum:i80FB9D68D0A4143B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190319 mRNA Translation: AAP04008.1
BC100064 mRNA Translation: AAI00065.1
RefSeqiNP_877976.1, NM_182824.2
UniGeneiRn.76129

Genome annotation databases

EnsembliENSRNOT00000042681; ENSRNOP00000049249; ENSRNOG00000033608
GeneIDi315716
KEGGirno:315716
UCSCiRGD:727815 rat

Similar proteinsi

Entry informationi

Entry nameiCD276_RAT
AccessioniPrimary (citable) accession number: Q7TPB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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