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Protein

T-complex protein 1 subunit delta

Gene

Cct4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: Ensembl
  • unfolded protein binding Source: RGD

GO - Biological processi

  • binding of sperm to zona pellucida Source: Ensembl
  • chaperone mediated protein folding requiring cofactor Source: RGD
  • protein folding Source: RGD
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-390471. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:Cct4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi727937. Cct4.

Subcellular locationi

  • Cytoplasm By similarity
  • Melanosome By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Cytoplasmcytoskeletoncilium basal body By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Cct4 are a cause of an early onset sensory neuropathy knowm as mutilated foot (mf). The main clinical features include ataxia, insensitivity to pain and foot ulceration. The pathological features include a severe reduction in the number of sensory ganglia and fibers.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 539538T-complex protein 1 subunit deltaPRO_0000128335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211N6-acetyllysineBy similarity
Modified residuei288 – 2881N6-acetyllysineBy similarity
Modified residuei302 – 3021N6-acetyllysineBy similarity
Modified residuei319 – 3191N6-acetyllysineBy similarity
Modified residuei326 – 3261N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7TPB1.
PRIDEiQ7TPB1.

PTM databases

iPTMnetiQ7TPB1.
PhosphoSiteiQ7TPB1.

Expressioni

Gene expression databases

GenevisibleiQ7TPB1. RN.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity). Interacts with DYX1C1 (By similarity).By similarity

GO - Molecular functioni

  • unfolded protein binding Source: RGD

Protein-protein interaction databases

BioGridi248027. 2 interactions.
IntActiQ7TPB1. 2 interactions.
MINTiMINT-4576863.
STRINGi10116.ENSRNOP00000012847.

Structurei

3D structure databases

ProteinModelPortaliQ7TPB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074956.
HOGENOMiHOG000226735.
HOVERGENiHBG106507.
InParanoidiQ7TPB1.
KOiK09496.
OMAiAYCVRAY.
OrthoDBiEOG722J8B.
PhylomeDBiQ7TPB1.
TreeFamiTF106332.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012717. Chap_CCT_delta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02342. chap_CCT_delta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TPB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENVASRSG PPAAGPGNRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT
60 70 80 90 100
SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI
110 120 130 140 150
EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGLEILTD
160 170 180 190 200
MSRPVQLSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA
210 220 230 240 250
TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVANSGITR VEKAKIGLIQ
260 270 280 290 300
FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
310 320 330 340 350
QKSILRDALS DLALHFLNKM KIMVVKDIER EDIEFICKTI GTKPVAHIDQ
360 370 380 390 400
FTPDMLGSAE LAEEVSLNGS GKLFKITGCT SPGKTVTIVV RGSNKLVIEE
410 420 430 440 450
AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC
460 470 480 490 500
VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT TGINVRKGGI
510 520 530
SNILEEMVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR
Length:539
Mass (Da):58,099
Last modified:January 23, 2007 - v3
Checksum:i0BD821D08733CDF8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501C → Y in mf. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223861 mRNA. Translation: AAP46161.1.
BC079283 mRNA. Translation: AAH79283.1.
RefSeqiNP_877966.1. NM_182814.2.
UniGeneiRn.97889.

Genome annotation databases

EnsembliENSRNOT00000012847; ENSRNOP00000012847; ENSRNOG00000009642.
GeneIDi29374.
KEGGirno:29374.
UCSCiRGD:727937. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223861 mRNA. Translation: AAP46161.1.
BC079283 mRNA. Translation: AAH79283.1.
RefSeqiNP_877966.1. NM_182814.2.
UniGeneiRn.97889.

3D structure databases

ProteinModelPortaliQ7TPB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248027. 2 interactions.
IntActiQ7TPB1. 2 interactions.
MINTiMINT-4576863.
STRINGi10116.ENSRNOP00000012847.

PTM databases

iPTMnetiQ7TPB1.
PhosphoSiteiQ7TPB1.

Proteomic databases

PaxDbiQ7TPB1.
PRIDEiQ7TPB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012847; ENSRNOP00000012847; ENSRNOG00000009642.
GeneIDi29374.
KEGGirno:29374.
UCSCiRGD:727937. rat.

Organism-specific databases

CTDi10575.
RGDi727937. Cct4.

Phylogenomic databases

eggNOGiKOG0358. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074956.
HOGENOMiHOG000226735.
HOVERGENiHBG106507.
InParanoidiQ7TPB1.
KOiK09496.
OMAiAYCVRAY.
OrthoDBiEOG722J8B.
PhylomeDBiQ7TPB1.
TreeFamiTF106332.

Enzyme and pathway databases

ReactomeiR-RNO-390471. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

NextBioi608939.
PROiQ7TPB1.

Gene expression databases

GenevisibleiQ7TPB1. RN.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012717. Chap_CCT_delta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02342. chap_CCT_delta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing T-complex peptide-1 (Cct4) gene."
    Lee M.J., Stephenson D.A., Groves M.J., Sweeney M.G., Davis M.B., An S.F., Houlden H., Salih M.A.M., Timmerman V., De Jonghe P., Auer-Grumbach M., Di Maria E., Scaravilli F., Wood N.W., Reilly M.M.
    Hum. Mol. Genet. 12:1917-1925(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MF TYR-450.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTCPD_RAT
AccessioniPrimary (citable) accession number: Q7TPB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.