Reviewed, UniProtKB/Swiss-Prot Q7TPB0 (LPPR3_MOUSE)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 3
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 2 protein
      Short name=PRG-2

Gene names

Name:	Lppr3
Synonyms:	Kiaa4076, Prg2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7TPB0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7TPB0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     408-463: EWKQKSLEGR...EEEEEGPVPP → SSPAAHHRRR...KVAKHRSVNT
     464-716: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 716	716	Lipid phosphate phosphatase-related protein type 3		PRO_0000317530
Regions
	Transmembrane	18 – 38	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	231 – 251	21	Potential
	Transmembrane	261 – 281	21	Potential
	Compositional bias	435 – 458	24	Glu-rich
	Compositional bias	508 – 512	5	Poly-Ser
	Compositional bias	562 – 571	10	Poly-Ser
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	408 – 463	56	EWKQK…GPVPP → SSPAAHHRRRLGNPGNNRKQ KNRAVSWQRNSGSGKKKKWE GRGGKKKVAKHRSVNT in isoform 2.		VSP_031007
	Alternative sequence	464 – 716	253	Missing in isoform 2.		VSP_031008
Experimental info
	Sequence conflict	520	1	V → M in AAH66006. Ref.2
	Sequence conflict	520	1	V → M in AAH79534. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 86605748DED3F5B6	FASTA	716	76,693
	10 20 30 40 50 60 MLAMKEKNKT PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRALS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS RLWGRGPGGV EGSINAGGCN 130 140 150 160 170 180 FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ LATGYHTPFF LTVCKPNYTL LGTSCESNPY 190 200 210 220 230 240 ITQDICSGHD THAILSARKT FPSQHATLSA FAAVYVSMYF NAVISDTTKL LKPILVFAFA 250 260 270 280 290 300 IAAGVCGLTQ ITQYRSHPVD VYAGFLIGAG IAAYLACHAV GNFQAPPAEK VPTPAPAKDA 310 320 330 340 350 360 LRALTQRGHE SMYQQNKSVS TDELGPPGRL EGVPRPVARE KTSLGSLKRA SVDVDLLAPR 370 380 390 400 410 420 SPMGKEGMVT FSNTLPRVST PSLDDPARRH MTIHVPLDAS RSRQLIGEWK QKSLEGRGLG 430 440 450 460 470 480 LPDEASPVHL RAPAEQVAEE EEEEEEEEEE EEEEEEEEGP VPPSLYPTVQ ARPGLGPRVI 490 500 510 520 530 540 LPPRPGPQPL VHIPEEGVQA GAGLSPKSSS SSVRAKWLSV AEKGGGPVAV APSQPRVANP 550 560 570 580 590 600 PRLLQVIAMS KAAGGPKAET ASSSSASSDS SQYRSPSDRD SASIVTIDAH APHHPVVHLS 610 620 630 640 650 660 AGSTPWEWKA KVVEGEGSYE LGDLARGFRS SCKQPGMGPG SPVSDVDQEE PRFGAVATVN 670 680 690 700 710 LATGEGLPPP GASEGALGAG SRESTLRRQV GGLAEREVEA EAESYYRRMQ ARRYQD
	Isoform 2. Checksum: 88AC80991A9C10A6	FASTA	463	50,327
	10 20 30 40 50 60 MLAMKEKNKT PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRALS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS RLWGRGPGGV EGSINAGGCN 130 140 150 160 170 180 FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ LATGYHTPFF LTVCKPNYTL LGTSCESNPY 190 200 210 220 230 240 ITQDICSGHD THAILSARKT FPSQHATLSA FAAVYVSMYF NAVISDTTKL LKPILVFAFA 250 260 270 280 290 300 IAAGVCGLTQ ITQYRSHPVD VYAGFLIGAG IAAYLACHAV GNFQAPPAEK VPTPAPAKDA 310 320 330 340 350 360 LRALTQRGHE SMYQQNKSVS TDELGPPGRL EGVPRPVARE KTSLGSLKRA SVDVDLLAPR 370 380 390 400 410 420 SPMGKEGMVT FSNTLPRVST PSLDDPARRH MTIHVPLDAS RSRQLIGSSP AAHHRRRLGN 430 440 450 460 PGNNRKQKNR AVSWQRNSGS GKKKKWEGRG GKKKVAKHRS VNT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting." Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R. Nat. Neurosci. 6:572-578(2003) [PubMed: 12730698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF541278 mRNA. Translation: AAP57767.1. BC066006 mRNA. Translation: AAH66006.1. BC079534 mRNA. Translation: AAH79534.1. BC098099 mRNA. Translation: AAH98099.1.
IPI	IPI00117580. IPI00607990.
RefSeq	NP_859009.1.
UniGene	Mm.29678
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q7TPB0.
Proteomic databases
PRIDE	Q7TPB0.
Genome annotation databases
Ensembl	ENSMUST00000046458; ENSMUSP00000043447; ENSMUSG00000035835; Mus musculus. [Genome view] ENSMUST00000092325; ENSMUSP00000089979; ENSMUSG00000035835; Mus musculus. [Genome view]
GeneID	216152.
KEGG	mmu:216152.
Organism-specific databases
MGI	MGI:2388640. BC005764.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG06146.
HOGENOM	HBG443683.
HOVERGEN	Q7TPB0.
InParanoid	Q7TPB0.
Enzyme and pathway databases
BRENDA	3.1.3.4. 244.
Gene expression databases
ArrayExpress	Q7TPB0.
Bgee	Q7TPB0.
CleanEx	MM_BC005764. MM_PRG2.
Genevestigator	Q7TPB0.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	375016.
SOURCE	Search...

Entry information

Entry name

LPPR3_MOUSE

Accession

Primary (citable) accession number: Q7TPB0
Secondary accession number(s): Q4V781, Q68FN2, Q6NZQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2003
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)