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Protein

Phospholipid phosphatase-related protein type 3

Gene

Plppr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 3By similarity (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 3By similarity
Plasticity-related gene 2 protein1 Publication
Short name:
PRG-21 Publication
Gene namesi
Name:Plppr3Imported
Synonyms:Kiaa4076, Lppr3By similarity, Prg2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2388640. Plppr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Phospholipid phosphatase-related protein type 3PRO_0000317530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Modified residuei320 – 3201PhosphoserineCombined sources
Modified residuei351 – 3511PhosphoserineCombined sources
Modified residuei374 – 3741PhosphothreonineCombined sources
Modified residuei426 – 4261PhosphoserineCombined sources
Modified residuei505 – 5051PhosphoserineCombined sources
Modified residuei641 – 6411PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7TPB0.
PaxDbiQ7TPB0.
PRIDEiQ7TPB0.

PTM databases

iPTMnetiQ7TPB0.
PhosphoSiteiQ7TPB0.

Expressioni

Gene expression databases

BgeeiQ7TPB0.
CleanExiMM_BC005764.
MM_PRG2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089979.

Structurei

3D structure databases

ProteinModelPortaliQ7TPB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi435 – 45824Glu-richAdd
BLAST
Compositional biasi508 – 5125Poly-Ser
Compositional biasi562 – 57110Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TPB0.
KOiK19582.
OrthoDBiEOG771272.
PhylomeDBiQ7TPB0.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TPB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAMKEKNKT PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV
60 70 80 90 100
GFQCYDRALS MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS
110 120 130 140 150
RLWGRGPGGV EGSINAGGCN FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ
160 170 180 190 200
LATGYHTPFF LTVCKPNYTL LGTSCESNPY ITQDICSGHD THAILSARKT
210 220 230 240 250
FPSQHATLSA FAAVYVSMYF NAVISDTTKL LKPILVFAFA IAAGVCGLTQ
260 270 280 290 300
ITQYRSHPVD VYAGFLIGAG IAAYLACHAV GNFQAPPAEK VPTPAPAKDA
310 320 330 340 350
LRALTQRGHE SMYQQNKSVS TDELGPPGRL EGVPRPVARE KTSLGSLKRA
360 370 380 390 400
SVDVDLLAPR SPMGKEGMVT FSNTLPRVST PSLDDPARRH MTIHVPLDAS
410 420 430 440 450
RSRQLIGEWK QKSLEGRGLG LPDEASPVHL RAPAEQVAEE EEEEEEEEEE
460 470 480 490 500
EEEEEEEEGP VPPSLYPTVQ ARPGLGPRVI LPPRPGPQPL VHIPEEGVQA
510 520 530 540 550
GAGLSPKSSS SSVRAKWLSV AEKGGGPVAV APSQPRVANP PRLLQVIAMS
560 570 580 590 600
KAAGGPKAET ASSSSASSDS SQYRSPSDRD SASIVTIDAH APHHPVVHLS
610 620 630 640 650
AGSTPWEWKA KVVEGEGSYE LGDLARGFRS SCKQPGMGPG SPVSDVDQEE
660 670 680 690 700
PRFGAVATVN LATGEGLPPP GASEGALGAG SRESTLRRQV GGLAEREVEA
710
EAESYYRRMQ ARRYQD
Length:716
Mass (Da):76,693
Last modified:October 1, 2003 - v1
Checksum:i86605748DED3F5B6
GO
Isoform 2 (identifier: Q7TPB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-463: EWKQKSLEGR...EEEEEGPVPP → SSPAAHHRRR...KVAKHRSVNT
     464-716: Missing.

Show »
Length:463
Mass (Da):50,327
Checksum:i88AC80991A9C10A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti520 – 5201V → M in AAH66006 (PubMed:15489334).Curated
Sequence conflicti520 – 5201V → M in AAH79534 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei408 – 46356EWKQK…GPVPP → SSPAAHHRRRLGNPGNNRKQ KNRAVSWQRNSGSGKKKKWE GRGGKKKVAKHRSVNT in isoform 2. 1 PublicationVSP_031007Add
BLAST
Alternative sequencei464 – 716253Missing in isoform 2. 1 PublicationVSP_031008Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541278 mRNA. Translation: AAP57767.1.
BC066006 mRNA. Translation: AAH66006.1.
BC079534 mRNA. Translation: AAH79534.1.
BC098099 mRNA. Translation: AAH98099.1.
CCDSiCCDS35971.1. [Q7TPB0-1]
RefSeqiNP_001164406.1. NM_001170935.1.
NP_859009.2. NM_181681.2.
XP_006513549.1. XM_006513486.2.
UniGeneiMm.29678.

Genome annotation databases

GeneIDi216152.
KEGGimmu:216152.
UCSCiuc007gaf.1. mouse. [Q7TPB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541278 mRNA. Translation: AAP57767.1.
BC066006 mRNA. Translation: AAH66006.1.
BC079534 mRNA. Translation: AAH79534.1.
BC098099 mRNA. Translation: AAH98099.1.
CCDSiCCDS35971.1. [Q7TPB0-1]
RefSeqiNP_001164406.1. NM_001170935.1.
NP_859009.2. NM_181681.2.
XP_006513549.1. XM_006513486.2.
UniGeneiMm.29678.

3D structure databases

ProteinModelPortaliQ7TPB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089979.

PTM databases

iPTMnetiQ7TPB0.
PhosphoSiteiQ7TPB0.

Proteomic databases

MaxQBiQ7TPB0.
PaxDbiQ7TPB0.
PRIDEiQ7TPB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi216152.
KEGGimmu:216152.
UCSCiuc007gaf.1. mouse. [Q7TPB0-1]

Organism-specific databases

CTDi79948.
MGIiMGI:2388640. Plppr3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ITB3. Eukaryota.
ENOG410ZZ6F. LUCA.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TPB0.
KOiK19582.
OrthoDBiEOG771272.
PhylomeDBiQ7TPB0.
TreeFamiTF316040.

Miscellaneous databases

PROiQ7TPB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TPB0.
CleanExiMM_BC005764.
MM_PRG2.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028685. LPPR3.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF14. PTHR10165:SF14. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting."
    Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R.
    Nat. Neurosci. 6:572-578(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-351; THR-374; SER-426; SER-505 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPLPR3_MOUSE
AccessioniPrimary (citable) accession number: Q7TPB0
Secondary accession number(s): Q4V781, Q68FN2, Q6NZQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.