Q7TPA5 (SPA11_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin A11

Alternative name(s):
Liver regeneration-related protein LRRG023

Gene names

Name:	Serpina11
ORF Names:	Ab1-046

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7TPA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7TPA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: P → PRKAQAGGAGNGGLHWDRVNEFPQNRVGKLSLKHLQMTQTW

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 422	398	Serpin A11		PRO_0000041975
Amino acid modifications
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	385	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	305	1	P → PRKAQAGGAGNGGLHWDRVN EFPQNRVGKLSLKHLQMTQT W in isoform 2.		VSP_021274

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 71F5EFF86B63E7B9	FASTA	422	47,024
	10 20 30 40 50 60 MGPVWLWLLI AELLLPVHYQ PSSAHGDKSL GAPQPASHQS LEPAPAYHKV TPTITNFALR 70 80 90 100 110 120 LYKQLAEEIP GNILFSPVSL SSTVALLSLG AHADTQAQIL QSLGFNLTET PAADIHRGFQ 130 140 150 160 170 180 SLLHTLDLPS PKLELKLGHS LFLDRQLKPQ QRFLDSAKEL YGALAFSANF TEAAATGQQI 190 200 210 220 230 240 NDLVRKQTYG QVVGCLPEFD RDTLMVLLNY IFFKAKWKHP FDRYQTRKQE SFFVDQRLQL 250 260 270 280 290 300 RIPMMRQKEM HRFLYDQEAS CTVLQIEYSG TALLLLVLPD PGKMQQVEAA LQPETLRRWG 310 320 330 340 350 360 QRFLPSLLDL HLPRFSVSAT YNLEEILPLV GLSSLFDVEA DLSGIMGQLN KTVSRVSHKA 370 380 390 400 410 420 VVDMNEKGTE AAAASGLLSQ PPSLNMTSAP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPA AG
	Isoform 2 [UniParc]. Checksum: 1FC58011A67F43E2	FASTA	462	51,494
	10 20 30 40 50 60 MGPVWLWLLI AELLLPVHYQ PSSAHGDKSL GAPQPASHQS LEPAPAYHKV TPTITNFALR 70 80 90 100 110 120 LYKQLAEEIP GNILFSPVSL SSTVALLSLG AHADTQAQIL QSLGFNLTET PAADIHRGFQ 130 140 150 160 170 180 SLLHTLDLPS PKLELKLGHS LFLDRQLKPQ QRFLDSAKEL YGALAFSANF TEAAATGQQI 190 200 210 220 230 240 NDLVRKQTYG QVVGCLPEFD RDTLMVLLNY IFFKAKWKHP FDRYQTRKQE SFFVDQRLQL 250 260 270 280 290 300 RIPMMRQKEM HRFLYDQEAS CTVLQIEYSG TALLLLVLPD PGKMQQVEAA LQPETLRRWG 310 320 330 340 350 360 QRFLPRKAQA GGAGNGGLHW DRVNEFPQNR VGKLSLKHLQ MTQTWSLLDL HLPRFSVSAT 370 380 390 400 410 420 YNLEEILPLV GLSSLFDVEA DLSGIMGQLN KTVSRVSHKA VVDMNEKGTE AAAASGLLSQ 430 440 450 460 PPSLNMTSAP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPA AG

References

[1]	"Liver regeneration after PH." Xu C.S., Li W.Q., Li Y.C., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY325135 mRNA. Translation: AAP92536.1. BC111708 mRNA. Translation: AAI11709.1.
IPI	IPI00365901. IPI00562633.
RefSeq	NP_001008776.1. NM_001008776.2. NP_001159824.1. NM_001166352.1.
UniGene	Rn.7875.
3D structure databases
ProteinModelPortal	Q7TPA5.
ModBase	Search...
Protein family/group databases
MEROPS	I04.955.
Proteomic databases
PaxDb	Q7TPA5.
PRIDE	Q7TPA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015516; ENSRNOP00000015516; ENSRNOG00000011141. ENSRNOT00000047324; ENSRNOP00000041705; ENSRNOG00000011141.
GeneID	362774.
KEGG	rno:362774.
UCSC	RGD:1359239. rat.
Organism-specific databases
CTD	256394.
RGD	1359239. Serpina11.
Phylogenomic databases
eggNOG	COG4826.
GeneTree	ENSGT00700000104474.
HOGENOM	HOG000238521.
HOVERGEN	HBG005957.
Gene expression databases
Genevestigator	Q7TPA5.
GermOnline	ENSRNOG00000011141. Rattus norvegicus.
Family and domain databases
InterPro	IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
ProtoNet	Search...
Other
NextBio	681209.

Entry information

Entry name

SPA11_RAT

Accession

Primary (citable) accession number: Q7TPA5
Secondary accession number(s): Q2M2R9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	October 31, 2006
Last modified:	April 3, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program