ID   Q7TP99_RAT              Unreviewed;      2018 AA.
AC   Q7TP99;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   SubName: Full=Ab1-133 {ECO:0000313|EMBL:AAP92542.1};
DE   SubName: Full=Zinc finger, NFX1-type containing 1 {ECO:0000313|Ensembl:ENSRNOP00000068109.1};
GN   Name=Znfx1 {ECO:0000313|Ensembl:ENSRNOP00000068109.1,
GN   ECO:0000313|RGD:1306344};
GN   Synonyms=RGD1306344 {ECO:0000313|RGD:1306344};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAP92542.1};
RN   [1] {ECO:0000313|EMBL:AAP92542.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Wang S.F., Han H.P., Wang G.P., Chai L.Q.,
RA   Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000068109.1, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068109.1,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000068109.1}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068109.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AY325141; AAP92542.1; -; mRNA.
DR   RefSeq; NP_001041325.1; NM_001047860.1.
DR   STRING; 10116.ENSRNOP00000068109; -.
DR   PaxDb; 10116-ENSRNOP00000068109; -.
DR   Ensembl; ENSRNOT00000076833.3; ENSRNOP00000068109.1; ENSRNOG00000008194.9.
DR   UCSC; RGD:1306344; rat.
DR   AGR; RGD:1306344; -.
DR   RGD; 1306344; Znfx1.
DR   eggNOG; KOG1807; Eukaryota.
DR   GeneTree; ENSGT00940000155154; -.
DR   OMA; PVCQVPI; -.
DR   OrthoDB; 2971338at2759; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000008194; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR   GO; GO:0010494; C:cytoplasmic stress granule; ISO:RGD.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISO:RGD.
DR   GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; ISO:RGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0002218; P:activation of innate immune response; ISO:RGD.
DR   GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR   GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR   GO; GO:0045071; P:negative regulation of viral genome replication; ISO:RGD.
DR   GO; GO:0031048; P:regulatory ncRNA-mediated heterochromatin formation; IBA:GO_Central.
DR   CDD; cd17936; EEXXEc_NFX1; 1.
DR   CDD; cd06008; NF-X1-zinc-finger; 2.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR046439; ZF_RZ_dom.
DR   InterPro; IPR000967; Znf_NFX1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF341; NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF20173; ZnF_RZ-type; 1.
DR   SMART; SM00438; ZnF_NFX; 6.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51981; ZF_RZ; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q7TP99};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1928..1999
FT                   /note="RZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51981"
FT   REGION          85..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          898..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        911..928
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2018 AA;  230729 MW;  5889635A0436EBCA CRC64;
     MALCQCAAGT ERSSSSLCFG VSACEYDPAV YQLGEEPQNG KRESPKTALR LPNVKDFGCI
     NGERRPVTRV MEIGTCGARM SSIEKFPEGA SSSPSIRNRQ DRRKATRMLR AHLFSSGREQ
     EPVNCHVMKM PSPIDGEVPP RARNQANNPA ATNHAGRHPR ASNHAAPFRQ REERFRAMGR
     NPHQGRRNHE GHTSDEARDQ RQSQNDTRRR NDDQEGRNHR PPWSSDSFQQ WHTPLQKPAE
     QPQHTKRLGY KFLESLLQKE PSEVAITLAT SLGLKELLSH SYMKPSFLQL ICQVLRKACS
     SRIDRQSILH VLGILNNSKF LRVCLPAYVV GMITEPVPDI RNQYPEHISN IISLLQDLVS
     VFPASSVQET SMLISLLPTS LNALRASGVD IEEETEKNLE KVQAIIKHLQ EKRREGTLRV
     DTYTLVQAEV EGEVESYRAM PIYPTYNEVH LDERPFLRPN IISGKYESTA VYLDTHFRLL
     REDFVRPLRE GILKLLQSFE DQCLRKRKFD DIRIYFDARI ITPMCSASGI VYKVQFDTKP
     LKFVRWQNSK RLLYGSLVCM SKDNFETFLF ATVSNREHED LCQGIVQLCF NEQSQQLLAD
     VQPSDSFLMV ETTAYFEAYR HVLEGLQEVQ EEDVPFQRNI VECDSYVREP RYLLMGGKYD
     FTPLIENPSA IRKSLRGAEV LRRSKINVLD FSQWPVKEAL NLDDSQMKAL QFALTRELAI
     IQGPPGTGKT YVGLKIVQAL LTNKSVWQIS AQKFPILVVC YTNHALDQFL EGIYGCQKTS
     IVRVGGRSNS EILKQFTLRE LRNKREFRRT LPMHLRRAYM NIVTEMKESE QKLQVGAQTL
     ECTMHGVLRE QHLEKYIAPQ HWESLMNGPV QDADWLCVQP SKHSMIVEWL GLGVGSFTQS
     ASPAGPENTA QAEGEEEEEG EEEGSLIEIE EEADLIQADR VIEEEEVVRP RRRKKEENGA
     DQELAKMLLA MRLDQDVPGT TAGPEQAAEE WETQRSQKKK MKRRVKVELR KLNTITEAEA
     SAIQDVWQLD LSSRWQLYRL WLQMYQSDTR RKILSYERQY RTWAERMAEL RLQEDLHILK
     DAQVVGMTTT GAAKYRQILQ QVEPRIVIVE EAAEVLEAHT IATLSKACQH LILIGDHQQL
     RPSANVYDLA KNFNLEVSLF ERLVKVNVPF VRLNYQHRMR PEIARLLTPH IYQDLENHPS
     VLKYEQIKGV SSNLFFVEHN FPEQEIQEGK SHQNQHEAHF VVELCQYLLC QEYLPSQITI
     LTTYTGQLFC LRKLMPVKTF AGIKVHVVDK YQGEENDVIL LSLVRSNQEG KVGFLQIPNR
     ICVALSRAKK GMYCIGNMQM LAKVPLWSRI IHTLRENHQI GPSLRLCCQN HPETHTLVSK
     ASDFQKVPEG GCSLPCEFRL ACGHVCTRAC HPYDSSHKEF QCMKPCQKVI CQDGHRCPNV
     CFQECQPCQV KVPKIILKCG HKQMVPCSVS ESDFCCQEPC SKVLRCGHRC SHLCGENCVR
     LCPEKVTVKL NCGHSQLVKC GQVEDLKYGL PVKCTTKCDT TLDCGHACPG SCHSCFEGRF
     HERCQQACKR LLVCSHKCQE PCMGECPPCQ RTCQNRCVHS QCKKKCGELC SPCVEPCTWR
     CQHYQCTKLC SEPCNRPPCY VPCTKLLACG HPCIGLCGEP CPRKCRVCHL DEVTQIFFGF
     EDEPDARFVQ LEDCSHIFEV QALDRYMNEQ KDDEVAIKLK VCPICQVPIR KNLRYGTSIK
     QRLEEIETVK EKIQGSAGEI AASQERLKAL LKSKTLFHQL RPEEFLILQE KLTQKNLSVK
     DLCLVENSIS FYDHLANLEG SLEKVHQLER QKVRTRLEQV HEWLARRRLG FSSQELSDLQ
     SEIQRLTYLV NLLMRCKITE VKGSIAEEVS SIRNILEKTC KFTQEDEQLV QKKMDALKTT
     LPCSGLGISE EERVQIVTAL GVPRGHWFKC PNGHIYVITE CGGAMQRSTC PECQEVIGGE
     NHTLERSNHL APEMDGAQHP AWSDTANNLM NFEIHRMM
//