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Protein

Interleukin enhancer-binding factor 2

Gene

Ilf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 2
Alternative name(s):
Liver regeneration-related protein LRRG031
Gene namesi
Name:Ilf2
ORF Names:Ab1-143
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305734. Ilf2.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Interleukin enhancer-binding factor 2PRO_0000126066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731PhosphoserineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei461 – 4611PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TP98.
PRIDEiQ7TP98.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014154.
GenevisibleiQ7TP98. RN.

Interactioni

Subunit structurei

Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi259671. 1 interaction.
STRINGi10116.ENSRNOP00000045539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 444337DZFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi439 – 4457Poly-Glu
Compositional biasi454 – 4574Poly-Glu

Sequence similaritiesi

Contains 1 DZF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3793. Eukaryota.
ENOG410XQCJ. LUCA.
HOGENOMiHOG000067801.
HOVERGENiHBG052120.
InParanoidiQ7TP98.
KOiK13089.
OrthoDBiEOG091G0HP1.
PhylomeDBiQ7TP98.
TreeFamiTF320194.

Family and domain databases

InterProiIPR006116. 2-5-oligoadenylate_synth_N.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF07528. DZF. 2 hits.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TP98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTHLTSTT LPDCYRSLIV NSELGSSALM DLNSPSFLYP LLHTPADKGT
60 70 80 90 100
LCTYQAALGK VYASLEVIGV GDDKLQAVHG LNGGKPHRDI LGSRITRPTG
110 120 130 140 150
IKPLCLPRHI LAYDWLAQSL LGIVIGSISL AYNELLMMEK LKGFRPFVPH
160 170 180 190 200
IPFDFYLCEM AFPRVKPAPD ETSFSEALLK RNQDLAPNSA EQQIEEVRQV
210 220 230 240 250
GSYKKGTMTT GHNVADLVVI LKILPTFLTM LTNETGFEIS SSDATVKILI
260 270 280 290 300
TTVPPNLRKL DPELHLDIKV LQSALAAIRH ARWFEENASQ STVKVLIRLL
310 320 330 340 350
KDLRIRFPGF EPLTPWILDL LGHYAVMNNP TRQPLALNVA YRRCLQILAA
360 370 380 390 400
GLFLPGSVGI TDPCESGNFR VHTVMTLEQQ DMVCYTAQTL VRILSHGGFR
410 420 430 440 450
KILGQEGDAS YLASEISTWD GVIVTPSEKA YEKPPEKKEG EEEEENTEEP
460
PQGEEEESME TQE
Length:463
Mass (Da):51,381
Last modified:October 1, 2003 - v1
Checksum:iC33E6F88C9FC2195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325142 mRNA. Translation: AAP92543.1.
RefSeqiNP_001041351.1. NM_001047886.1.
UniGeneiRn.137428.

Genome annotation databases

GeneIDi310612.
KEGGirno:310612.
UCSCiRGD:1305734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325142 mRNA. Translation: AAP92543.1.
RefSeqiNP_001041351.1. NM_001047886.1.
UniGeneiRn.137428.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259671. 1 interaction.
STRINGi10116.ENSRNOP00000045539.

Proteomic databases

PaxDbiQ7TP98.
PRIDEiQ7TP98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi310612.
KEGGirno:310612.
UCSCiRGD:1305734. rat.

Organism-specific databases

CTDi3608.
RGDi1305734. Ilf2.

Phylogenomic databases

eggNOGiKOG3793. Eukaryota.
ENOG410XQCJ. LUCA.
HOGENOMiHOG000067801.
HOVERGENiHBG052120.
InParanoidiQ7TP98.
KOiK13089.
OrthoDBiEOG091G0HP1.
PhylomeDBiQ7TP98.
TreeFamiTF320194.

Miscellaneous databases

PROiQ7TP98.

Gene expression databases

BgeeiENSRNOG00000014154.
GenevisibleiQ7TP98. RN.

Family and domain databases

InterProiIPR006116. 2-5-oligoadenylate_synth_N.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF07528. DZF. 2 hits.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILF2_RAT
AccessioniPrimary (citable) accession number: Q7TP98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.