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Protein

Arrestin domain-containing protein 4

Gene

Arrdc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 4
Alternative name(s):
Liver regeneration-related protein LRRG041/LRRGT00117
Gene namesi
Name:Arrdc4
ORF Names:Ab1-209
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311763 Arrdc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443541 – 300Arrestin domain-containing protein 4Add BLAST300

Proteomic databases

PaxDbiQ7TP90
PRIDEiQ7TP90

Expressioni

Gene expression databases

BgeeiENSRNOG00000010775
ExpressionAtlasiQ7TP90 baseline and differential
GenevisibleiQ7TP90 RN

Interactioni

Subunit structurei

Interacts with ADRB2. Interacts (via PPxY motifs) with ITCH, NEDD4L and WWP2. Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS. Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045721

Structurei

3D structure databases

ProteinModelPortaliQ7TP90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi231 – 234PPxY motif 1Curated4
Motifi276 – 279PPxY motif 2Curated4

Sequence similaritiesi

Belongs to the arrestin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3780 Eukaryota
ENOG41102NY LUCA
GeneTreeiENSGT00550000074356
HOGENOMiHOG000237328
HOVERGENiHBG066469
InParanoidiQ7TP90

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits

Sequencei

Sequence statusi: Complete.

Q7TP90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQSSILVD FRPLATSFTG KYGSIQYCVR AVLERPQVPD QSVRRELQVV
60 70 80 90 100
SHVDVNTPPL LTPMLKTQEK MVGCWLFTSG PVSLSVKIER KGYCNGEAIP
110 120 130 140 150
IYAEIENCSS RLVVPKAAIF QTQTYLASGK TKTVRHMVAN VRGNHIGSGS
160 170 180 190 200
TDTWNGKMLK IPPVTPSILD CCIIRVYIHI PGAKKLMLEL PLVIGTIPYS
210 220 230 240 250
GFGRRNSSMA SQFSMDMCWL ALALPEQPEA PPNYADVVSE EEFSRHIPPY
260 270 280 290 300
PQPSACDGEA CYSMFACIQE FRFQPPPLYS ESHAQLFCLQ PVGPTNRAHF
Length:300
Mass (Da):33,275
Last modified:October 1, 2003 - v1
Checksum:i1EA8AA47BBD27E8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325151 mRNA Translation: AAP92552.1
AY539868 mRNA Translation: AAS66208.1
RefSeqiNP_001041318.1, NM_001047853.1
UniGeneiRn.14864

Genome annotation databases

EnsembliENSRNOT00000051402; ENSRNOP00000045721; ENSRNOG00000010775
GeneIDi293019
KEGGirno:293019

Similar proteinsi

Entry informationi

Entry nameiARRD4_RAT
AccessioniPrimary (citable) accession number: Q7TP90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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