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Protein

Arrestin domain-containing protein 4

Gene

Arrdc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs). When overexpressed, inhibits glucose uptake.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 4
Alternative name(s):
Liver regeneration-related protein LRRG041/LRRGT00117
Gene namesi
Name:Arrdc4
ORF Names:Ab1-209
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311763. Arrdc4.

Subcellular locationi

  • Early endosome By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmic vesicle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Arrestin domain-containing protein 4PRO_0000244354Add
BLAST

Proteomic databases

PaxDbiQ7TP90.
PRIDEiQ7TP90.

Expressioni

Gene expression databases

ExpressionAtlasiQ7TP90. baseline and differential.
GenevisibleiQ7TP90. RN.

Interactioni

Subunit structurei

Interacts with ADRB2. Interacts (via PPXY motifs) with ITCH, NEDD4L and WWP2. Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045721.

Structurei

3D structure databases

ProteinModelPortaliQ7TP90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2344PPXY 1Curated
Motifi276 – 2794PPXY 2Curated

Sequence similaritiesi

Belongs to the arrestin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ7TP90.
OMAiLYSESHA.
OrthoDBiEOG7P02HT.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7TP90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQSSILVD FRPLATSFTG KYGSIQYCVR AVLERPQVPD QSVRRELQVV
60 70 80 90 100
SHVDVNTPPL LTPMLKTQEK MVGCWLFTSG PVSLSVKIER KGYCNGEAIP
110 120 130 140 150
IYAEIENCSS RLVVPKAAIF QTQTYLASGK TKTVRHMVAN VRGNHIGSGS
160 170 180 190 200
TDTWNGKMLK IPPVTPSILD CCIIRVYIHI PGAKKLMLEL PLVIGTIPYS
210 220 230 240 250
GFGRRNSSMA SQFSMDMCWL ALALPEQPEA PPNYADVVSE EEFSRHIPPY
260 270 280 290 300
PQPSACDGEA CYSMFACIQE FRFQPPPLYS ESHAQLFCLQ PVGPTNRAHF
Length:300
Mass (Da):33,275
Last modified:October 1, 2003 - v1
Checksum:i1EA8AA47BBD27E8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325151 mRNA. Translation: AAP92552.1.
AY539868 mRNA. Translation: AAS66208.1.
RefSeqiNP_001041318.1. NM_001047853.1.
UniGeneiRn.14864.

Genome annotation databases

EnsembliENSRNOT00000051402; ENSRNOP00000045721; ENSRNOG00000010775.
GeneIDi293019.
KEGGirno:293019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325151 mRNA. Translation: AAP92552.1.
AY539868 mRNA. Translation: AAS66208.1.
RefSeqiNP_001041318.1. NM_001047853.1.
UniGeneiRn.14864.

3D structure databases

ProteinModelPortaliQ7TP90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045721.

Proteomic databases

PaxDbiQ7TP90.
PRIDEiQ7TP90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051402; ENSRNOP00000045721; ENSRNOG00000010775.
GeneIDi293019.
KEGGirno:293019.

Organism-specific databases

CTDi91947.
RGDi1311763. Arrdc4.

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ7TP90.
OMAiLYSESHA.
OrthoDBiEOG7P02HT.

Miscellaneous databases

NextBioi635192.
PROiQ7TP90.

Gene expression databases

ExpressionAtlasiQ7TP90. baseline and differential.
GenevisibleiQ7TP90. RN.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiARRD4_RAT
AccessioniPrimary (citable) accession number: Q7TP90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: March 16, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.