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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6pdx)
  2. 6-phosphogluconolactonase (Pgls)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Kif1b), 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGluconate utilizationUniRule annotation, Pentose shuntUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

SABIO-RKiQ7TP11
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ7TP11

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7TP11 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ7TP11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 154PHInterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili677 – 726Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA

Family and domain databases

Gene3Di1.10.1040.101 hit
1.10.20.101 hit
2.30.29.301 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR029003 CENP-S/Mhf1
IPR009072 Histone-fold
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF15630 CENP-S, 1 hit
PF03446 NAD_binding_2, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TP11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKTPEANS RASSPCQEFE QFQIIPTVET PYLARAGKNE FLNLVPDIEE
60 70 80 90 100
VRAGSVVSKK GYLHFKEPLS SNWAKHFVVV RRPYVFIYNS DKDPVERGII
110 120 130 140 150
NLSTAQVEYS EDQQAMLKTP NTFAVCTKHR GVLLQALNDK DMNDWLYAFN
160 170 180 190 200
PLLAGTIRAD IALIGLAVMG QNLILNMNDH GFVVCAFNRT VSKVDDFLAK
210 220 230 240 250
EAKGTKVIGA KSLKDMVSKL KKPRRVILLV KAGQAVDDFI EKLVPLLDTG
260 270 280 290 300
DIIIDGGNSE YRDTTRRCQD LKAKGILFVG SGVSGGEEGA RYGPSLMPGG
310 320 330 340 350
NKEAWPHIKT IFQAIAAKVG TGEPCCDWAS SGLPFDECTA GERTLWSQWL
360 370 380 390 400
ALCCEPLRLK SLSQLVPEVG DEGAGHFVKM VHNGIEYGDM QLICEAYHLM
410 420 430 440 450
KDVLGMRHEE MAQAFEDWNK TELDSFLIEI TANILKFQDT DGKELLPKIR
460 470 480 490 500
DSAGQKGTGK WTAISALEYG MPVTLIGEAV FARCLSSLKE ERVQASRKLK
510 520 530 540 550
GPKMVQLEGS KQAFLEDVRK ALYASKIISY AQGFMLLRQA ATEFGWTLNY
560 570 580 590 600
GGIALMWRGG CIIRSVFLGK IKDAFERNPE LQNLLLDDFF KSAVDDCQDS
610 620 630 640 650
WRRVISTGVQ AGIPMPCFTT ALSFYDGYRH EMLPANLIQA QRDYFGAHTY
660 670 680 690 700
ELLSKPGEFI HTNWTGHGGR GGKEEXEEEE EEEEEEEEEE EEEEEEEEEE
710 720 730 740 750
EKKKKKKKKK KEKKKKKEKV ERESRRTVAL LPGLSAVMEE VEAEEQQQYS
760 770 780 790 800
HRQRLKAAVH YTVGCLCQEV ELDKQVHLSK QTIAAISEVT FRQCENFAKD
810 820 830 840 850
LEMFARHAKR STITTDDVKL LLRRSNSLCV TEDSVGVTED SVSVTEDSVG
860 870 880 890 900
VTEDSVGVTE DSVTEDSVGV TEDSVTEDSV GVTEDSVSVT EDSVGVTEDS
910 920 930 940 950
VTEDSVGITE DSVGVTEDSV TEHSVGVTED SVSVTEDSVT EDSVSVTEDS
960 970 980 990 1000
VSVTEDSVSV TEDSVSVTED SVSVTEDSVS VTEDSVSVTE DSVSVTEDSH
1010 1020 1030 1040 1050
RLQVSKEDGW LQHKRQAAVS PQSAAAAAAL GDRSLCPPPG ERSHRPGQCE
1060 1070 1080
LSSVRLAVYS DMSWCNSKEA KRVSRLAVRY VVVTTTLCF
Length:1,089
Mass (Da):120,523
Last modified:October 1, 2003 - v1
Checksum:iEE1C89A207C96F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325247 mRNA Translation: AAP92648.1

Similar proteinsi

Entry informationi

Entry nameiQ7TP11_RAT
AccessioniPrimary (citable) accession number: Q7TP11
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)