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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

Pgd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6pdx)
  2. 6-phosphogluconolactonase (Pgls)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Kif1b), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Pentose shuntUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

SABIO-RKQ7TP11.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:PgdImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1583832. Pgd.

PTM / Processingi

Proteomic databases

PaxDbiQ7TP11.
PRIDEiQ7TP11.

Interactioni

Protein-protein interaction databases

IntActiQ7TP11. 1 interaction.
STRINGi10116.ENSRNOP00000049243.

Structurei

3D structure databases

ProteinModelPortaliQ7TP11.
SMRiQ7TP11. Positions 158-669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 15499PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili677 – 72650Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation
Contains 1 PH domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.10.20.10. 1 hit.
1.20.5.320. 1 hit.
2.30.29.30. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR029003. CENP-S/Mhf1.
IPR009072. Histone-fold.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF15630. CENP-S. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48179. SSF48179. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TP11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKTPEANS RASSPCQEFE QFQIIPTVET PYLARAGKNE FLNLVPDIEE
60 70 80 90 100
VRAGSVVSKK GYLHFKEPLS SNWAKHFVVV RRPYVFIYNS DKDPVERGII
110 120 130 140 150
NLSTAQVEYS EDQQAMLKTP NTFAVCTKHR GVLLQALNDK DMNDWLYAFN
160 170 180 190 200
PLLAGTIRAD IALIGLAVMG QNLILNMNDH GFVVCAFNRT VSKVDDFLAK
210 220 230 240 250
EAKGTKVIGA KSLKDMVSKL KKPRRVILLV KAGQAVDDFI EKLVPLLDTG
260 270 280 290 300
DIIIDGGNSE YRDTTRRCQD LKAKGILFVG SGVSGGEEGA RYGPSLMPGG
310 320 330 340 350
NKEAWPHIKT IFQAIAAKVG TGEPCCDWAS SGLPFDECTA GERTLWSQWL
360 370 380 390 400
ALCCEPLRLK SLSQLVPEVG DEGAGHFVKM VHNGIEYGDM QLICEAYHLM
410 420 430 440 450
KDVLGMRHEE MAQAFEDWNK TELDSFLIEI TANILKFQDT DGKELLPKIR
460 470 480 490 500
DSAGQKGTGK WTAISALEYG MPVTLIGEAV FARCLSSLKE ERVQASRKLK
510 520 530 540 550
GPKMVQLEGS KQAFLEDVRK ALYASKIISY AQGFMLLRQA ATEFGWTLNY
560 570 580 590 600
GGIALMWRGG CIIRSVFLGK IKDAFERNPE LQNLLLDDFF KSAVDDCQDS
610 620 630 640 650
WRRVISTGVQ AGIPMPCFTT ALSFYDGYRH EMLPANLIQA QRDYFGAHTY
660 670 680 690 700
ELLSKPGEFI HTNWTGHGGR GGKEEXEEEE EEEEEEEEEE EEEEEEEEEE
710 720 730 740 750
EKKKKKKKKK KEKKKKKEKV ERESRRTVAL LPGLSAVMEE VEAEEQQQYS
760 770 780 790 800
HRQRLKAAVH YTVGCLCQEV ELDKQVHLSK QTIAAISEVT FRQCENFAKD
810 820 830 840 850
LEMFARHAKR STITTDDVKL LLRRSNSLCV TEDSVGVTED SVSVTEDSVG
860 870 880 890 900
VTEDSVGVTE DSVTEDSVGV TEDSVTEDSV GVTEDSVSVT EDSVGVTEDS
910 920 930 940 950
VTEDSVGITE DSVGVTEDSV TEHSVGVTED SVSVTEDSVT EDSVSVTEDS
960 970 980 990 1000
VSVTEDSVSV TEDSVSVTED SVSVTEDSVS VTEDSVSVTE DSVSVTEDSH
1010 1020 1030 1040 1050
RLQVSKEDGW LQHKRQAAVS PQSAAAAAAL GDRSLCPPPG ERSHRPGQCE
1060 1070 1080
LSSVRLAVYS DMSWCNSKEA KRVSRLAVRY VVVTTTLCF
Length:1,089
Mass (Da):120,523
Last modified:October 1, 2003 - v1
Checksum:iEE1C89A207C96F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325247 mRNA. Translation: AAP92648.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325247 mRNA. Translation: AAP92648.1.

3D structure databases

ProteinModelPortaliQ7TP11.
SMRiQ7TP11. Positions 158-669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TP11. 1 interaction.
STRINGi10116.ENSRNOP00000049243.

Proteomic databases

PaxDbiQ7TP11.
PRIDEiQ7TP11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1583832. Pgd.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.
SABIO-RKQ7TP11.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.10.20.10. 1 hit.
1.20.5.320. 1 hit.
2.30.29.30. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR029003. CENP-S/Mhf1.
IPR009072. Histone-fold.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF15630. CENP-S. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48179. SSF48179. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Li W.Q., Li Y.C., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7TP11_RAT
AccessioniPrimary (citable) accession number: Q7TP11
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.